CT-P15 (cetuximab biosimilar) / Celltrion - LARVOL DELTA

C1q Complement/Tumor Necrosis Factor-Associated Proteins in Cardiovascular Disease and COVID-19. (PubMed, Proteomes) - "CTRPs, which are comprised of 15 members, CTRP1 to CTRP15, are secreted from different organs/tissues and exhibit diverse functions, have attracted increasing attention because of their roles in maintaining inner homeostasis by regulating metabolism, inflammation, and immune surveillance...Additionally, the recently emerged novel coronavirus (COVID-19), officially known as severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has been found to trigger severe cardiovascular injury in some patients, and evidence indicates that the mortality of COVID-19 is much higher in patients with CVD than without CVD. Understanding the relationship of CTRPs and the SARS-CoV-2-related damage to the cardiovascular system, as well as the potential mechanisms, will achieve a profound insight into a therapeutic strategy to effectively control CVD and reduce the mortality rate."

Journal • Review • Cardiovascular • Diabetes • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Novel Coronavirus Disease • Respiratory Diseases • TNFA

[VIRTUAL] Protocol For Laser - Lixiana Acute Stroke Evaluation Registry - A Randomized Controlled Trial With An Associated Registry Of Early Anticoagulation After Ischemic Stroke In Patients With Atrial Fibrillation [Board No. CTP15] (ISC 2021) - P4 | "Secondary outcomes include new HT, recurrent ischemic stroke, recurrent sub-clinical infarcts on follow up imaging, systemic hemorrhagic complication rate, and predictors of HT, including RNA expression in 6 preidentified candidate genes. Event rates for both HT and recurrent ischemic events, in patients treated with early versus delayed edoxaban initiation are unknown. This study will provide data required for a definitive safety/efficacy study sample size power calculation."

Clinical • Atrial Fibrillation • Cardiovascular • Hematological Disorders • Ischemic stroke

The impacts of C1q/TNF-related protein-15 and adiponectin on Interleukin-6 and tumor necrosis factor-α in primary macrophages of patients with coronary artery diseases. (PubMed, Cytokine) - "The results of the present study indicate anti-inflammatory impact of adiponectin and CTRP15, while this property was stronger for CTRP15. In addition, it seems likely that anti-inflammatory CTRP15's impact on macrophages in the CAD patients was weaker than macrophages from the controls."

Clinical • Journal • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Dyslipidemia • Immunology • Inflammation • Oncology • GLI2 • IL6 • TNFA

The Feasibility of Contrast-to-Noise Ratio on Measurements to Evaluate CT Image Quality in Terms of Low-Contrast Detailed Detectability. (PubMed, Med Sci (Basel)) - " An LCD phantom module (CTP515) was utilised in the study... The objective LCD appraisal method, based on CNR measurements, was confirmed as being useful for checking the different impacts of kVp, mAs and section thickness on the nature of the picture. This procedure was similarly viable in assessing the impacts of the different reconstruction calculations and the different differentiation questions on the nature of the image."

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Protein modifications critical for myonectin/erythroferrone secretion and oligomer assembly. (PubMed, Biochemistry) - "Myonectin/erythroferrone (also known as CTRP15) is a secreted hormone with metabolic function and a role in stress erythropoiesis...Inhibiting Pro hydroxylation or deleting the collagen domain markedly reduced protein secretion. Together, our results reveal key determinants important for myonectin folding, secretion, and multimeric assembly and provide a basis for future structure/function studies."

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CTRP15 derived from cardiac myocytes attenuates TGFβ1-induced fibrotic response in cardiac fibroblasts. (PubMed, Cardiovasc Drugs Ther) - "CTRP15 exerts an anti-fibrotic effect on pressure overload-induced cardiac remodeling. The activation of IR/IRS-1/Akt pathway contributes to the anti-fibrotic effect of CTRP15 through targeting Smad3."

Journal • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Immunology • TNFA

Lipid and insulin inversely regulate C1Q Tumor Necrosis Factor-Related Protein 15 in healthy and women with PCOS. (QDEM-4 2020) - "Background: C1Q Tumor Necrosis Factor-Related Proteins 15 (CTRP 15) also referred as myonectin/ erythroferrone is a nutrient-responsive myokine involved in regulation of fatty acid metabolism... This is the first study to show that myonectin is higher in PCOS subjects and exercise does not alter circulating myonectin levels. Intra-lipids suppress myonectin in both control and PCOS subjects. Lipid mediated suppression in myonectin was reversed by insulin."

Clinical

Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease. (PubMed, Sci Rep) - "CTRP7, CTRP15 may serve as more suitable biomarker for the diagnosis of CAD patients, whereas CTRP5 may serve as an independent predictor for CAD. These findings suggest CTRPs may be the superior predictive factors for the vascular lesion of CAD and represent novel therapeutic targets against CAD."

Clinical • Journal

Higher serum level of CTRP15 in patients with coronary artery disease is associated with disease severity, body mass index and insulin resistance. (PubMed, Arch Physiol Biochem) - "In CAD patients, CTRP15 showed a positive correlation with BMI, FBS, insulin, HOMA-IR, IL-6, and TNF-α and a negative correlation with HDL-C and adiponectin. Elevated levels of CTRP15 in CAD patients and the relation of CTRP15 with pathogenic conditions such as insulin resistance, inflammation, and decreased adiponectin and HDL-C suggest a possible compensatory response to these conditions in CAD patients."

Clinical • Journal

Quantitative evaluation of image quality of megavoltage computed tomography for guiding helical tomotherapy (PubMed, Beijing Da Xue Xue Bao Yi Xue Ban) - "Superiority and inferiority of three image modes in terms of the three image quality index was not consistent. Evaluation results above could provide reference for more rational decision on scanning modes selection of helical tomotherapy, which was based on image visualization demands in clinical practice. The proposed method could also provide guidance for similar image quality assessment and periodic quality assurance."

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