cefaclor / Generic mfg. - LARVOL DELTA

Rhabdomyolysis in a 10-month-old child: A case report and literature review. (PubMed, Medicine (Baltimore)) - "The recognition of RM in children should be improved. Clinicians should be vigilant when encountering atypical symptoms in conjunction with substantially elevated serum CK. Early and accurate diagnosis, along with active fluid resuscitation, can effectively reduce the incidence of ARF and improve prognosis."

Journal • Review • Acute Kidney Injury • Cough • Infectious Disease • Musculoskeletal Pain • Nephrology • Pain • Pediatrics • Renal Disease • Respiratory Diseases • MB

Comparison of oral third- versus first-/ second-generation cephalosporins for acute uncomplicated cystitis: a nationwide retrospective cohort study. (PubMed, Eur J Clin Microbiol Infect Dis) - "Oral third-generation cephalosporins may be associated with more frequent additional antibiotic treatment compared with cephalexin or cefaclor in the management of uncomplicated cystitis."

Journal • Retrospective data • Infectious Disease • Nephrology

Repurposing Success: Real-World Validation of a Novel Cephalosporin Decontamination Protocol Using Chlorine Dioxide and Disc Diffusion Testing. (PubMed, Appl Biosaf) - "Antimicrobial susceptibility discs (ASDs) contaminated with cephalosporins (Cefalexin, Cefaclor, Cefixime, Cefuroxime) were exposed to both aqueous (400 ppm for 24 h) and gaseous ClO2 (5 mg/L for >5 h) in separate cycles, achieving a minimum cumulative exposure of 9600 ppm-hours in both. Analysis confirmed that cephalosporin residues were degraded to levels below the acceptable limits (<1 μg/disc) with microbial challenge testing supporting the success of the cycle, with no significant biological activity remaining in the discs placed throughout the facility. This study presents the first successful protocol for cephalosporin facility decontamination using gaseous ClO2 in a real-world setting."

Journal • Real-world evidence

Anterior ST-Segment Elevation Myocardial Infarction Shortly After Cefaclor Exposure: A Case Report Highlighting Kounis Syndrome as a Differential Diagnosis. (PubMed, Am J Case Rep) - "He had no rash, urticaria, wheezing, angioedema, oropharyngeal edema, hypotension, or dyspnea; no prehospital antihistamines, corticosteroids, or epinephrine were administered. CONCLUSIONS The temporal association prompted consideration of Kounis syndrome, but severe fixed coronary stenosis makes coincidental plaque-related STEMI a major alternative diagnosis. Early allergy biomarker sampling and careful causal assessment are important in similar cases."

Journal • Acute Coronary Syndrome • Allergy • Cardiovascular • Dental Disorders • Dermatology • Hypotension • Immunology • Myocardial Infarction • Pain • Pulmonary Disease • Urticaria • TNNI3

Association between phenotypes and genotypes of antimicrobial resistance in E. coli and Salmonella isolates from retail chicken meat and live bird market sewage in Bangladesh. (PubMed, Microbiol Spectr) - "Strong associations between phenotypic resistance and corresponding resistance genes were observed for cefepime/bla_CTX-M-1, ceftazidime/bla_CTX-M-1, aztreonam/bla_CTX-M-1, cefuroxime/qnrA, ceftriaxone/qnrA, cefoxitin/qnrB, cefixime/qnrB, cefaclor/qnrB, trimethoprim-sulfamethoxazole/qnrS, ampicillin/qnrS, and amoxicillin-clavulanic acid/qnrS (P < 0.05). Understanding the associations among resistance genes may provide critical insights for developing effective antimicrobial stewardship and prudent-use guidelines. Moreover, these findings could serve as a foundation for future research addressing public health and food safety challenges associated with AMR foodborne bacteria."

Journal

A case of granulomatous mastitis (JBCS 2026) - "She was treated with oral cefaclor...Regarding future treatment, steroids were discussed, but due to concerns about side effects and the possibility of missed doses because she had young children, oral minocycline was prescribed...Conservative treatment is employed, with doxycycline and bristinamycin reported to be effective, and steroid administration is also used...The treatment period lasted one year, but improvement was achieved through monitoring with drainage and other methods. The patient has now transitioned to regular breast cancer screenings."

Clinical • Breast Cancer • Fibrosis • Immunology • Solid Tumor

Verification of 3 cases of granulomatous mastitis experienced at our hospital (JBCS 2026) - "Subsequently, it partially ruptured and discharged pus, so she was given cefaclor 250 mg for 5 days and observed with topical gentamicin. Case 2: A 43-year-old woman presented with bilateral nipple discharge and a lump in her right breast after taking risperidone for schizophrenia...The effectiveness of macrolide and tetracycline antibiotics has been reported in cases positive for C. kroppenstedtii, but in this case, macrolides were ineffective, and steroids were effective...[Conclusion] Many aspects of the causes and treatment of granulomatous mastitis remain unclear. Further accumulation of cases and consideration of treatment strategies are necessary."

Clinical • Breast Cancer • CNS Disorders • Crohn's disease • Gastroenterology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Schizophrenia • Solid Tumor

Vagus nerve is essential for the anxiolytic effect of YL-IPA08, a potent ligand for the translocator protein (18 kDa). (PubMed, Int Immunopharmacol) - "Furthermore, vagotomy impaired YL-IPA08's ability to counteract cefaclor-induced microglial activation and inflammatory responses in the prefrontal cortex (PFC). The present study shows that YL-IPA08 exerts significant anxiolytic effects, which are associated with the vagus nerve signaling pathway, suggesting that the vagus nerve may be involved in partial regulation of these effects."

Journal • CNS Disorders • Depression • Inflammation • Mood Disorders • Psychiatry

Preventive Effect of Prophylactic Oral Antibiotics Against Cholangitis After Kasai Portoenterostomy (clinicaltrials.gov) - P=N/A | N=356 | Recruiting | Sponsor: Children's Hospital of Fudan University | Trial completion date: Jul 2027 ➔ Dec 2029 | Trial primary completion date: Dec 2025 ➔ Dec 2027

Trial completion date • Trial primary completion date • Hepatology

Fulminant eosinophilic myocarditis treated by venoarterial extracorporeal membrane oxygenation and adjunctive immunosuppressive therapy: a case report. (PubMed, Eur Heart J Case Rep) - "Review of history revealed recent cefaclor use for a hand injury as the probable cause. The patient's condition quickly improved after initiation of high-dose intravenous methylprednisolone, allowing weaning from VA-ECMO...Subcutaneous mepolizumab, an anti-interleukin-5 monoclonal antibody, was initiated as an adjunctive immunosuppressive therapy...Fluorodeoxyglucose positron emission tomography imaging helped detect residual inflammation and assess treatment response. Immunosuppressive therapy allowed a reduction of steroid dose, mitigating the risk of steroid-related side effects."

Journal • Cardiovascular • Eosinophilia • Immunology • Inflammation • Pulmonary Disease • IL5

Drug supply shortages and their perceived consequences for patients: a questionnaire survey of German and Austrian physicians. (PubMed, Eur J Clin Pharmacol) - "Supply shortages can foster antimicrobial resistance through the use of antibacterials with a higher potential for resistance. The success of alternative treatments was not always considered to be very good in comparison to the original medication."

Journal • Infectious Disease • Novel Coronavirus Disease • Pain

Preparation, molecular docking, and biological evaluation of radioiodinated cefaclor for inflammation detection. (PubMed, BMC Pharmacol Toxicol) - No abstract available

Journal • Inflammation

SUCCESSFUL SALVAGE OF A PERITONEAL DIALYSIS CATHETER IN A CASE OF NONTUBERCULOUS MYCOBACTERIAL INFECTION (ISN-WCN 2026) - "Despite topical gentamicin, the discharge worsened. On Day -8, ultrasound showed a peri-catheter hypoechoic area consistent with TI, a swab for culture was obtained, and oral cefaclor was started...Empiric therapy with linezolid, amikacin, and clarithromycin was started on Day 1...Current guidance highlights NTM among atypical causes of refractory ESI, encourages individualized salvage strategies including exit-site relocationConclusion In PD patients with refractory ESI/TI, clinicians should obtain early AFB cultures and species identification to guide management. Early exit-site revision/debridement with an oral dual regimen of clarithromycin and sitafloxacin can salvage the catheter and maintain PD when cardiac dysfunction and obesity limit alternatives, demonstrating a practicalt success where evidence remains limited."

Clinical • Nontuberculous mycobacteria • Cardiovascular • Genetic Disorders • Heart Failure • Hematological Disorders • Infectious Disease • Nontuberculous Mycobacterial Disease • Obesity • Respiratory Diseases • Thrombocytopenia

Drug hypersensitivity leading to emergency department visit: a comprehensive analysis of clinical features and management. (PubMed, Korean J Intern Med) - "Immediate-type DHRs were the predominant presentation in the ED and were predominantly caused by radiocontrast media and NSAIDs. Given the low rate of outpatient follow-up, early referral to allergists is essential to improve patient safety and prevent reexposure."

Journal • Retrospective data • Allergy • Immunology

Predicting oral cephalosporin susceptibility in Escherichia coli blood isolates using parenteral cephalosporin susceptibility testing. (PubMed, J Antimicrob Chemother) - "Prediction of oral second-generation cephalosporins may warrant cefazolin MIC ≤2 mg/L, despite limitations regarding false resistance and susceptibility discordant. Ceftriaxone/cefotaxime demonstrates a more reliable surrogate for predicting oral third-generation cephalosporins susceptibility. Future investigations are necessary to clinically corroborate these findings."

Journal • Infectious Disease

Drug-likeness prioritised selection identifies anti-Escherichia coli candidates confirmed by molecular docking, dynamics simulations, and antibacterial assays. (PubMed, J Enzyme Inhib Med Chem) - "Molecular analyses further demonstrated that M3 achieved superior binding stability relative to the reference drug Cefaclor through a multimodal, high-affinity interaction network with the target protein. This strategy reduces late-stage attrition risk and provides a robust paradigm for rational antibacterial drug discovery."

Journal

Self-reported health history from 70,724 individuals reveals novel HLA associations with allergy and other frequently underreported conditions. (PubMed, medRxiv) - "Of particular translational importance, we identified a previously undetected yet very strong association between HLA-DRB1*04:01 and sensitivity to cefaclor, a specific class of cephalosporin (OR = 3.74, p-value 5.10E-28)...Collectively, our findings demonstrate the value of integrating population-scale, high-resolution HLA genotypes with phenotyping beyond the EHR to reveal immunogenetic influences on common health outcomes. They also point to immediate translational avenues - particularly for drug hypersensitivity - while motivating future functional studies and prospective clinical validation to refine mechanistic understanding and clinical utility."

Journal • Allergic Rhinitis • Allergy • Dermatology • Immunology • Inflammation • HLA-B • HLA-C • HLA-DQB1 • HLA-DRB1

Description of antibiotic prophylaxis practices in pediatric congenital anomalies of the kidneys and urinary tract. (PubMed, Arch Pediatr) - "Based on our observational (real-world) data, there is no evidence for the benefit of antibiotic prophylaxis in children with VUR or other CAKUT."

Journal • Infectious Disease • Nephrology • Pediatrics

Structural Interactions of β-Lactam Antibiotics with Mammalian Serum Albumins. (PubMed, Int J Mol Sci) - "In this study, we structurally investigate the ability of three serum albumins-equine (ESA), caprine (CSA), and ovine (OSA)-to bind two penicillins, ampicillin (Amp) and oxacillin (Oxa), and two cephalosporins, cefaclor (Cef) and cephalosporin C (Csc). It was surprising that these antibiotics are not bound in the main drug binding site. However, cephalosporin C is bound in OSA Drug Site 1 (DS1)."

Journal

Plasmids of the multidrug-resistant Citrobacter portucalensis KOS1-1 strain isolated from a wastewater treatment plant harbor antibiotic resistance genes and gene clusters involved in carbon metabolism. (PubMed, Microbiol Spectr) - "This strain was resistant to ampicillin, cefazolin, cefaclor, cefatrizine, ciprofloxacin, kanamycin, streptomycin, spectinomycin, erythromycin, chloramphenicol, tetracycline, sulfamethoxazole, and trimethoprim. These plasmids may not only confer a selective advantage to host strains but also promote transfer of resistance determinants in high-density microbial communities of activated sludge at wastewater treatment plants. This work contributes to the understanding of the mechanisms of dissemination of bacterial resistance and virulence factors in municipal wastewater environments."

Journal • Gene Therapies

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Kuwait and the United Arab Emirates: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Pneumococci were susceptible to fluoroquinolones (>98%), amoxicillin and amoxicillin/clavulanic acid (>79%-94%), ceftriaxone and cefotaxime (>73%-94%). Susceptibility was lower to oral/low-dose penicillin (20%-27%), macrolides (33%-51%), tetracyclines (53%-59%) and trimethoprim/sulfamethoxazole (33%-61%). Susceptibility was generally >80% in H. influenzae except for trimethoprim/sulfamethoxazole (47%-56%)."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Pakistan: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Although antimicrobial resistance was observed, many therapeutic options remain to treat S. pneumoniae and H. influenzae from CA-RTI in Pakistan despite concerns about high levels of inappropriate antibiotic use. Continued surveillance of antibiotic susceptibility is important for guiding empiric therapy of CA-RTIs."

Journal • PK/PD data • Infectious Disease • Influenza • Oncology • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Ukraine: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "For H. influenzae, 100% susceptibility (CLSI) was observed to amoxicillin/clavulanic acid, macrolides, most cephalosporins and tetracycline. S. pneumoniae susceptibility was 100% to fluoroquinolones, 90.6%-96.9% to third-generation cephalosporins and 96.9% to amoxicillin and amoxicillin/clavulanic acid. This is consistent with previous resistance surveillance in Ukraine. Continued surveillance of antibiotic susceptibility is important for guiding empiric therapy of CA-RTIs."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Italy and Spain: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Susceptibility of S. pneumoniae to many antibiotics was low in both countries, with susceptibility > 90% observed only with high-dose penicillin and fluoroquinolones (CLSI and EUCAST) and high-dose amoxicillin or amoxicillin/clavulanic acid (PK/PD). Higher susceptibility was seen with H. influenzae in both countries. Continued surveillance of antimicrobial resistance is important for guiding therapy of CA-RTIs."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Results from the Survey of Antibiotic Resistance (SOAR) 2018-21 in Türkiye: data based on CLSI, EUCAST (dose-specific) and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. (PubMed, J Antimicrob Chemother) - "Susceptibility in S. pneumoniae was 90% except for trimethoprim/sulfamethoxazole and ampicillin. These data are similar to recent surveillance of antibiotic resistance data in Türkiye."

Journal • PK/PD data • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases