VX 759 / Vertex - LARVOL DELTA

Anti-hepatitis-C virus activity and QSAR study of certain thiazolidinone and thiazolotriazine derivatives as potential NS5B polymerase inhibitors. (PubMed, Eur J Med Chem) - "The results of NS5B polymerase inhibition assay revealed compound 4e, as the most active inhibitor (IC = 0.035 μM), which is four folds greater than that of the reference agent, VCH-759, (IC = 0.14 μM)...Moreover, QSAR models were established for the studied thiazolidinones and thiazolotriazines to investigate the molecular characteristics contributing to the observed NS5B polymerase inhibition activity. The obtained results inspire further investigations of thiazolidinones and thiazolotriazine aiming at affording more potent, safe and orally active non-nucleoside NS5B polymerase inhibitors as anti-HCV drug candidates."

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