moxifloxacin intravenous / Generic mfg. - LARVOL DELTA

Development, Validation, and Clinical Application of a Simultaneous Quantification Method of Seventeen Antituberculosis Drugs in Plasma, Serum, or Saliva Using LC-MS/MS. (PubMed, Ther Drug Monit) - "This validated LC-MS/MS method allows simultaneous analysis of multiple anti-TB drugs in plasma, serum, and saliva, facilitating clinical and research applications. The method has been successfully applied in clinical practice."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Toxic Posterior Segment Syndrome Following Dropless Cataract Surgery With Compounded Triamcinolone-Moxifloxacin. (PubMed, Ophthalmic Surg Lasers Imaging Retina) - "Ordinal logistic regression showed worse presenting visual acuity (< 20/150; OR 7.00, P < .001) and male sex predicted severe disease (OR 3.22, P < .001), while a normal fluorescein angiography (FA) appearance was protective (coefficient -8.395, P = .001). This large case series describes TPSS prognostic risk factors and underscores the urgent need for standardized Food and Drug Administration (FDA)-approved intraocular formulations."

Journal • Cataract • Ophthalmology

Efficacy, Safety, and Economic Evaluation of Originator Versus Generic Moxifloxacin Hydrochloride Injection in the Treatment of Community-Acquired Pneumonia Under China's National Centralized Drug Procurement Policy: A Retrospective Study. (PubMed, Clin Ther) - "Under the centralized procurement policy, the NCDP-selected generic moxifloxacin showed clinical efficacy and safety not significantly different from those of the originator, while being associated with lower total medical costs. These findings require further validation in large‑sample studies."

HEOR • Journal • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Moxifloxacin-Induced Bullous Acute Generalized Exanthematous Pustulosis (AGEP): A Case Report of a Rare Clinical Presentation. (PubMed, Case Rep Dermatol Med) - "Despite intensive treatment, the patient succumbed to sepsis on Day 15. This case underscores the importance of recognizing atypical AGEP presentations to avoid diagnostic confusion with Stevens-Johnson syndrome (SJS)/TEN and highlights a novel severe reaction to a widely used fluoroquinolone."

Journal • Immunology • Infectious Disease • Septic Shock • Steven-Johnson Syndrome

Incidence and Time to Onset of Pseudophakic Cystoid Macular Edema (Irvine-Gass Syndrome) After 1,325 Consecutive Cataract Surgeries Performed by a Single Surgeon Over Four Years. (PubMed, Cureus) - "Of the 27 eyes that developed macular cysts, 13 eyes with no preoperative or intraoperative risk factors for inflammation received topical 0.1% bromfenac twice daily as the only postoperative anti-inflammatory treatment, together with topical antibacterial 0.5% moxifloxacin four times daily...They also developed later in the postoperative course after the combination of topical bromfenac and betamethasone was discontinued in eyes with risk factors for inflammation. The macular cysts disappeared following the initiation or resumption of topical betamethasone, accompanied by recovery of visual acuity and resolution of symptoms."

Journal • Cataract • Diabetes • Inflammation • Macular Edema • Metabolic Disorders • Ophthalmology

Treatment shortening and relapse control in drug-susceptible pulmonary tuberculosis: a network meta-analysis of randomized trials. (PubMed, Front Cell Infect Microbiol) - "Treatment success was close to that of the standard regimen for the 4-month daily rifapentine-moxifloxacin regimen evaluated in Study 31/A5349 (RR = 0.98, 95% CI 0.94-1.01) and the 6-month regimen with once-weekly rifapentine-moxifloxacin continuation therapy evaluated in RIFAQUIN (RR = 1.01, 95% CI 0.93-1.09)...Because no closed loop was formed by independent trial evidence, formal inconsistency assessment was not feasible. https://www.crd.york.ac.uk/PROSPERO/, identifier CRD420251267175."

Clinical • Journal • Retrospective data • Review • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Antimicrobial susceptibility and the distribution characteristics of Mycoplasma pneumoniae isolates in Beijing, China, from 2017 to 2025 (ERS 2026) - " All 197 clinical isolates harbored the A2063G mutation in the 23S rRNA gene and were in vitro resistant to erythromycin and azithromycin, with the MIC50 and MIC90 of erythromycin being 8-fold and 4-fold higher than those of azithromycin, respectively. The strains remained highly susceptible to tetracycline, levofloxacin and moxifloxacin... The resistance of MP to macrolides in children is relatively high. It is imperative to strengthen the prevention and control of cluster MP infections during epidemic phase."

Infectious Disease • Pneumonia

Heteroresistance and Clinical Characteristics of Pulmonary and Extrapulmonary Multisite Tuberculosis (ERS 2026) - "Of these, 38 cases (65.52%) showed consistent drug susceptibility results across specimens, while 20 cases (34.48%) showed heteroresistance, which was observed for the following drugs: isoniazid(11.94%), moxifloxacin (11.94%) , rifabutine (5.97%), ofloxacin (5.97%), cycloserine (5.97%), ethambutol (4.48%), kanamycin (2.99%), PZA(2.99%), and streptomycin(2.99%), ethionamide (1.49%),rifampin(1.49%). Heteroresistance is present in pulmonary and extrapulmonary multisite TB patients. Patients with heteroresistance tend to be younger and experience more unstable clinical courses, highlighting the need for careful clinical monitoring."

Clinical • Infectious Disease • Respiratory Diseases • Tuberculosis

Pleural effusion caused by Rickettsia felis infection. (PubMed, J Infect Dev Ctries) - "This case report aims to enhance early diagnosis and therapeutic strategies for R. felis infections by sharing the diagnostic and management experience."

Journal • Pleural effusion • Fatigue • Infectious Disease • Pain • Respiratory Diseases

Real-world treatment outcomes and adverse events during BPaLM therapy for rifampicin-resistant TB. (PubMed, IJTLD Open) - "BPaLM/BPaL achieved excellent early effectiveness but required frequent regimen modifications. Successful implementation of short-course RR/MDR-TB regimens requires anticipatory toxicity monitoring, flexible regimen management, and robust treatment support systems."

Adverse events • HEOR • Journal • Real-world evidence • Hematological Disorders • Infectious Disease • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Multicenter Efficacy and Safety Evaluation Study of Ultra-Short Regimens for Drug-Resistant Pulmonary Tuberculosis (ChiCTR) - P=N/A | N=330 | Not yet recruiting | Sponsor: Shenzhen Third People's Hospital; Shenzhen Third People's Hospital

New trial • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Resveratrol attenuates moxifloxacin-induced oxidative damage in the liver, kidneys, brain, and serum of Wistar rats. (PubMed, J Int Med Res) - "However, the absence of a resveratrol-only group and the preconditioning design limit the interpretation of its independent effects and clinical applicability. Further pharmacokinetic, mechanistic, and clinical studies are required."

Journal • Preclinical • CASP3

Biocompatibility and antibacterial properties of ordered PLA fiber membranes fabricated via electrospinning technology. (PubMed, iScience) - "Antibacterial evaluations showed that the moxifloxacin-loaded ordered PLA membranes achieved nearly complete eradication of bacteria within 2 h, with the mechanism closely associated with disruption of bacterial membrane structures and induction of reactive oxygen species (ROS) accumulation. This work provides a design strategy and experimental basis for multifunctional scaffold materials integrating nerve repair and antibacterial functions."

Journal • Infectious Disease

Antibiotic resistance mutations in Mycoplasma genitalium and non-gonococcal urethritis treatment outcomes. (PubMed, Sex Transm Dis) - "Sequential azithromycin and moxifloxacin achieved limited microbiological cure and NGU resolution. Symptom improvement despite persistent infection highlights discordance between microbiological and clinical outcomes. ParC S83I was common but did not consistently predict moxifloxacin failure. Persistent infections with combined parC, parE, and gyrB mutations suggest cumulative effects, requiring further studies."

Journal • Infectious Disease

Sex Differences in Helicobacter pylori Antimicrobial Resistance among 890 Subjects over 20 Years in a Korean Tertiary Hospital. (PubMed, Gut Liver) - P=N/A | "Minimum inhibitory concentration tests were performed for amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin, and moxifloxacin using the agar dilution method. These findings highlight the importance of considering sex differences when interpreting antimicrobial resistance patterns and selecting eradication strategies. (ClinicalTrials.gov identifier NCT05247112)."

Journal • Infectious Disease

Various antibiotics susceptibility of acute hematogenous osteomyelitis caused by Staphylococcus aureus in children: A retrospective study. (PubMed, Medicine (Baltimore)) - "The MRSA group showed significantly higher resistance rates to levofloxacin, moxifloxacin, gentamicin, erythromycin, clindamycin, tigecycline, and sulfamethoxazole/trimethoprim compared with the MSSA group (P < .05). Currently, children with acute hematogenous osteomyelitis infected with MRSA show resistance to multiple antibiotics. MRSA infection is associated with more severe inflammatory responses, higher fever, longer hospital stays, higher medical costs, and a greater risk of complications."

Journal • Retrospective data • Anesthesia • Infectious Disease • Inflammation • Pediatrics • Septic Shock • CRP

AIE-Active Hf-MOF as Multifunctional Fluorescent Probe for Detection of Antibiotics, Pesticides and Vitamin B2 in Food. (PubMed, Inorg Chem) - "Notably, Hf-MOF-1 was selected as a versatile fluorescent probe, displaying differentiated luminescent behaviors: fluorescence quenching toward metamitron (MMT) and nitrofurazone (NFZ), luminescence turn-on for moxifloxacin (MXF), and ratiometric fluorescent response toward riboflavin (VB2)...Satisfactory recoveries ranging from 96.3% to 104.2% and RSD below 3.5% in various real food samples confirm its practical applicability. This study enriches high-stability luminescent Hf-MOF resources and supplies a reliable analytical tool for multicontaminant monitoring in food and environmental fields."

Journal

Endogenous Klebsiella pneumoniae Endophthalmitis With Iris Abscess and Discordant Systemic and Ocular Culture Susceptibilities. (PubMed, J Vitreoretin Dis) - "Initial treatment included intravitreal (IVT) vancomycin and ceftazidime with anterior chamber paracentesis. Postoperatively, weekly IVT moxifloxacin injections were administered for 3 weeks, resulting in resolution of infection. This case demonstrates rare iris abscess formation in K. pneumoniae endogenous endophthalmitis and underscores the importance of intraocular cultures in guiding targeted antimicrobial therapy."

Journal • Diabetes • Hepatology • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Ocular Infections • Ocular Inflammation • Ophthalmology • Pneumonia • Septic Shock

Acute effects of direct exposure to moxifloxacin on the porcine corneal endothelium: An ex vivo study. (PubMed, Res Vet Sci) - "Direct exposure of the corneal endothelium to moxifloxacin ophthalmic solution at concentrations ≥0.5% may induce endothelial toxicity. Therefore, during intracameral administration, care should be taken to avoid direct contact between moxifloxacin and the corneal endothelium in order to minimize potential endothelial damage."

Journal • Preclinical • Ocular Infections • Ocular Inflammation • Ophthalmology

A Study in Healthy People to Measure How Different Doses of Verducatib Affect the Heart (clinicaltrials.gov) - P1 | N=56 | Recruiting | Sponsor: Boehringer Ingelheim | Not yet recruiting ➔ Recruiting

Enrollment open

Mechanistic Insights into Moxifloxacin HCl Permeability from Nitrocellulose-Based In Situ Gels via Confocal Imaging and DFT Modeling. (PubMed, AAPS PharmSciTech) - "DFT analysis revealed that Nc-Mx complex exhibited the most apparent binding energy (-2.43 eV) compared to Mx-solvent and Nc-solvent interactions, supporting a polymer-drug affinity-driven release mechanism. Collectively, these results establish Nc-based ISG as a promising platform for targeted mucosa-retentive delivery of antibiotics in periodontal therapy, combining tunable matrix formation with molecular-level control over drug diffusion."

Journal • Dental Disorders • Periodontitis

Novel ?-lactam/ ?-lactamase inhibitor combination imipenem/ avibactam shows potent activity against multidrug resistant Gramnegative pathogens from the cystic fibrosis lung (NACFC 2026) - " Ralstonia and Pandoraea isolates were multidrug resistant, including towards many antibiotics used in management of respiratory infection in PWCF, such as: amikacin, colistin, meropenem, moxifloxacin, and tigecycline. FCRs showed BL/BLI combinations in clinical use were unable to sensitize all isolates to BLs: piperacillin/tazobactam sensitized only two, whilst amoxicillin/clavulanate and ceftazidime/avibactam sensitized none; however, all isolates were sensitized to amoxicillin, meropenem and imipenem when tested in non-traditional combination with the inhibitor avibactam (Table 1)... The most potent activity against these multidrug resistant pathogens was observed for imipenem/avibactam. Both drugs are in widespread clinical use in other combinations, so our data strongly support including this novel combination in clinical AST panels and repurposing these antibiotics as a viable treatment option in PWCF for refractory Gramnegative infections, such as with Ralstonia..."

Gram negative • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Respiratory Diseases

Bioorthogonal Polymer Nanozymes for Effective Treatment of Bacterial Wound Biofilm Infections. (PubMed, ACS Appl Mater Interfaces) - "The polyzyme-mediated localized activation of the prodrug was highly effective, resulting in significantly more bacterial killing compared to the free drug moxifloxacin. These results demonstrate the therapeutic potential of bioorthogonal polyzymes for treating wound biofilm infections, with enhanced local activity and improved treatment outcomes compared to standard clinical treatment methods."

Journal • Infectious Disease

Drug-Induced Liver Injury During First-Line Anti-Tubercular Therapy (Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol): A Case Report with De-challenge and Rechallenge. (PubMed, EJIFCC) - "After discontinuing the hepatotoxic treatment and starting alternative medications (Moxifloxacin, Streptomycin, and Ethambutol), liver function tests improved significantly within 3-5 days...This case illustrates that early detection of liver injury from anti-tubercular therapy, prompt de-challenge, use of alternative non-hepatotoxic drugs, and a carefully monitored stepwise rechallenge can enable the safe continuation of tuberculosis treatment in elderly patients. Close biochemical monitoring, along with consideration of therapeutic drug monitoring, may further improve patient safety."

Journal • Cardiovascular • Hepatology • Hypertension • Infectious Disease • Liver Failure • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Experimental Study on Anti-Infection and Promotion of Macrophage Polarization for the Treatment of Traumatic Bone Infection Using Rifampicin/Moxifloxacin-Loaded PLGA Microspheres. (PubMed, Front Biosci (Landmark Ed)) - "Collectively, these findings suggest that rifampicin/moxifloxacin-loaded PLGA microspheres may represent a promising local therapeutic strategy for traumatic osteomyelitis by alleviating infection-related pathological changes and promoting favorable changes in macrophage polarization markers."

IO biomarker • Journal • Infectious Disease • Inflammation • Musculoskeletal Diseases • Orthopedics • CD38 • IL10 • IL1B • IL6 • MRC1 • PACERR • PDPK1 • PTGS2 • YTHDC1