Movicol (polyethylene glycol/sodium bicarbonate/sodium chloride/potassium chloride) / Mochida, Eisai, Norgine - LARVOL DELTA

PERSONALISED PHARMACOTHERAPY REGIMEN: EMPOWERING A PATIENT AND FAMILY WITH LEARNING DISABILITIES (ESPN 2025) - "Visual aids e.g picture information leaflets • The MDT (pharmacists, dietitian, LD team, social worker, psychologist, nurses and doctors) developed materials and training to empower Medication • Pill School for the patient to learn to swallow tablets with fluids e.g movicol, which were not included in her fluid restriction • Reducing home medication burden... Our intervention improves health literacy, medication and diet adherence, improves patient experience and leads to earlier discharge. This approach supports patients and families, even those with LD, enhances health outcomes, reduces bed occupancy and costs. Work is needed to ensure developmentally appropriate care is available to empower patients and families."

Clinical • Cognitive Disorders • Developmental Disorders • Infectious Disease • Renal Disease

PRIMA-KOST: Effects of Changing Intestinal Transit Time on Gut Microbial Composition and Metabolism (clinicaltrials.gov) - P=N/A | N=22 | Completed | Sponsor: University of Copenhagen | Recruiting ➔ Completed | N=50 ➔ 22 | Trial completion date: Jan 2030 ➔ Nov 2024

Enrollment change • Trial completion • Trial completion date • Metabolic Disorders

A single-centre observational study of delayed defaecation in brain-injured patients in an adult intensive care unit. (PubMed, Aust Crit Care) - "Delayed defaecation was common, and compliance with the guideline was low. Movicol® and phosphate enemas were effective in stool production."

Journal • Observational data • CNS Disorders • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases • Vascular Neurology

Are we using best practice to guide laxative use in post-partum patients with obstetric anal sphincter injuries - A retrospective review. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "Considerable variation existed in laxatives prescription. Bulking agents was not associated with higher rates of AI. Further research is required to improve post-partum care in women following repair of OASIs."

Journal • Retrospective data • Review • Obstetrics

An unusual genotypic case of very early onset inflammatory bowel disease (BSPGHAN 2023) - "She was treated for 6 months with Movicol and sodium picosulfate with partial resolution...She was started on infliximab infusions, azathioprine, and topical tacrolimus (for rectal lesions)...She is currently on 4 weekly vedolizumab treatment, with steroids, following poor response to high dose infliximab and is being considered for colostomy and colectomy if current treatment fails...As highlighted above, our patient is currently on vedolizumab therapy, some authors suggest ‘considering anakinra, an IL-1 receptor antagonist, in patients with IL-10 signalling defects who are too ill to undergo transplant or while searching for a suitable donor, as this has led to marked clinical, endoscopic, and histologic improvement in some patients’.(Schwartz et al, 2022)4 It remains to be seen if our patient would respond to a particular type of treatment, in preference over another...In conclusion, this case highlights a rare direct IL-27 association with VEOIBD. We hope that this..."

Clinical • Constipation • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Pediatrics • Transplantation • IL10

The impact of using a multistrain probiotic supplement on gastrointestinal function in children and adolescents with severe recessive dystrophic epidermolysis bullosa. (PubMed, Clin Exp Dermatol) - "We have shown in this case series that giving a multistrain probiotic supplement in patients with RDEB-S has the potential to improve stool consistency and reduce or prevent the need for chronic macrogol gel use. Future larger-scale, placebo-controlled trials are needed to confirm these results."

Journal • Constipation • Dermatology • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Pain • Pediatrics

"There should be a Movicol®-scale for shitty systematical reviews and a brown sticker for journals whose peer review fail to prevent SR-diarrhea" (@mdlhenning)

Review

Resolution of severe constipation following a switch from calcium carbonate to recombinant human PTH therapy: A case report (ESPE 2022) - "She developed constipation at 4-years-old when she was commenced on Movicol...Unfortunately, the patient developed soiling and management was escalated to Picolax and then Botox and manual extraction...She was admitted at 12 years of age for rhPTH (Terrosa) therapy subcutaneously...Recombinant human PTH therapy can be used successfully to wean calcium supplements and reduce severe complications secondary to the oral medication. It also improves compliance and overall bone biochemistry."

Clinical • CNS Disorders • Constipation • Endocrine Disorders • Epilepsy • Gastroenterology • Gastrointestinal Disorder • Hypoparathyroidism • Renal Disease

Prevention of opioid-induced constipation in patients with metastatic cancer Voorkomen van obstipatie als gevolg van gebruik van morfine-achtige pijnstillers bij patiënten met pijn bij uitgezaaide kanker (clinicaltrialsregister.eu) - P3 | N=330 | Ongoing | Sponsor: ZonMw

New P3 trial • Constipation • Gastroenterology • Gastrointestinal Disorder • Oncology • Pain

Exanthematous Drug eruption induced by polyethylene glycol (MOVICOL®) in a 3-year-old girl (JSPACI 2022) - No abstract available

THE EFFECT OF A SINGLE DOSE 2 MG PRUCALOPRIDE ON THE COMPLETION RATE OF COLON CAPSULE ENDOSCOPIES IN COLORECTAL CANCER SCREENING (DDW 2022) - "Methods : In a randomized clinical trial, participants have undergone CCE using a bowel preparation regimen consisting of Movicol and two doses of MoviPrep consumed prior to capsule ingestion followed by three boosters of Eziclen (control group). The higher PDR may therefore be attributed to the increased completion rate and thereby better visualization of the mucosa. A 2 mg single dose Prucalopride tablet 45-60 minutes prior to capsule ingestion is a simple and easy compliable way of increasing the completion rate of CCE in a CRC screening population."

Colorectal Cancer • Gastrointestinal Cancer • Infectious Disease • Oncology • Solid Tumor

"What about movicol?" (@meyne_helen)

"Yes! And also a prescription of Movicol (bulk agent) to all my patients for a week after MIS" (@ManouMKaur)

Clinical

Antibiotic Combination Therapy Improves Symptoms of Parkinson’s Disease in Individuals With Chronic Constipation (ACG 2021) - "Here we explore the effects of a novel antibiotic combination therapy (ACT) comprising Metronidazole, Vancomycin and Rifaximin for the treatment of constipation, which improved symptoms of PD in two cases...Before commencing ACT, preliminary MDS-UPDRS was 38 and symptoms included asymmetric tremor, cogwheel rigidity, bradykinesia and shuffling gait despite treatment with Levodopa and Carbidopa. At 1yr review on ACT, constipation had abated with daily bowel motions not requiring Movicol...Before ACT with added Colchicine was commenced, baseline MDS-UPDRS was 37 and symptoms included asymmetric tremor, rigidity, postural instability and decreased arm swing despite treatment with Pramipexole and Rasagiline... ACT successfully treated constipation and improved neurological symptoms of PD in two cases. Our findings suggest that treatments modulating the gut microbiota may play a role in reducing the severity and progression of PD as well as ameliorating non-motor symptoms..."

Clinical • Combination therapy • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Movement Disorders • Parkinson's Disease

Efficacy of macrogol 4000 plus electrolytes in bowel preparation for colonoscopy in patients with chronic constipation. (PubMed, BMC Gastroenterol) - "Intake of macrogol 4000 in addition to PEG is effective and safe for colonoscopy in patients with chronic constipation. Clinical trial registration statement This study was registered in the UMIN-CTR database (UMIN-ID000038315)."

Clinical • Journal • Constipation • Gastroenterology • Gastrointestinal Disorder

"Movicol Allergy: diarrhea" (@AhmedFullMD)

Allergy • Immunology

[VIRTUAL] Getting to the root of it: contact anaphylaxis from polyethylene glycol in a dental lubricant (BAD 2021) - "SPT to other high-weight macrogol-containing products showed positive reactions to a 5% lidocaine ointment, Movicol®, EMLA cream® and Depomedrone®. We report this case to raise awareness of severe immediate hypersensitivity to these apparently innocuous ingredients and a novel source of exposure. A low index of suspicion, lack of standardized nomenclature and commercial reagents for testing are current barriers to diagnosis."

Allergy • Anesthesia • Dermatology • Immunology • Infectious Disease • Novel Coronavirus Disease • Urticaria

"Dear @pfizer & @AstraZeneca please can you now make an easier to stomach potion for pre colonoscopy. Movicol etc are vile. Why so sweet & craggy? 😘" (@sieveheads)

Utilisation and Safety of Polyethylene Glycol 3350 with Electrolytes in Children Under 2 Years: A Retrospective Cohort. (PubMed, J Pediatr Gastroenterol Nutr) - "The safety aspect of this study did not identify any signals of concern in the constipation cohort. The number of patients in the FI cohort were too small for robust conclusions. If information were available, then a safety study would ideally assess treatment intake per kg, including electrolyte intake, before reaching safety conclusions. Nevertheless, these data contribute to real-world evidence on use of PEG 3350+E in this population."

Journal • Retrospective data • Constipation • Gastroenterology • Gastrointestinal Disorder • Pain • Pediatrics

[VIRTUAL] Stimulant and Osmotic Laxatives to Improve Recovery of Gastrointestinal Function after Colorectal Surgery: A Randomized Controlled Trial (ACS-CLINCON 2020) - "The intervention (STIMULAX) group received daily Coloxyl Senna + Movicol + Fleet enema from day 0 until bowel action or discharge... Routine postoperative laxatives use after elective colorectal surgery results in earlier recovery of gastrointestinal function."

Clinical • Late-breaking abstract • Gastrointestinal Disorder

[VIRTUAL] Multi‐modal stimulant and osmotic laxatives to improve recovery of gastrointestinal function after colorectal surgery – the STIMULAX randomised controlled trial (ESCP 2020) - "The study group (STIMULAX) received daily Coloxyl Senna + Movicol + Fleet enema from day 0 until bowel action or discharge... Routine post-operative laxatives use after elective colorectal surgery results in earlier recovery of gastrointestinal function."

Clinical • Gastrointestinal Disorder

Bowel management post major joint arthroplasty: A randomised controlled trial to test two pre-admission bowel regimens. (PubMed, Int J Orthop Trauma Nurs) - "Despite not reaching statistical significance, the results are considered clinically significant. The authors recommend patients commence macrogol one sachet in the morning for the two days prior to admission for major joint arthroplasty and the Murdoch Bowel Protocol® continue to be followed for inpatients."

Clinical • Journal • Constipation • Gastroenterology • Gastrointestinal Disorder • Orthopedics

"Plenty of Movicol and refer to Colorectal..." (@bernardstacey)

Polyethylene glycol: an underrecognized compound in certolizumab pegol and Movicol that may cause anaphylaxis. (PubMed, Rheumatology (Oxford)) - No abstract available

Journal

Comparative efficacy and safety of lactulose plus paraffin vs polyethylene glycol in functional constipation: a randomised clinical study. (PubMed, United European Gastroenterol J) - "Lactulose plus paraffin may be used interchangeably with polyethylene glycol for the pharmacological treatment of functional constipation. Trial registration: EudraCT number 2015-003021-34."

Clinical • Journal • Constipation