clomifene citrate / Generic mfg. - LARVOL DELTA

RETRACTION: Short-Term Metformin Treatment for Clomiphene Citrate-Resistant Women with Polycystic Ovary Syndrome. (PubMed, Int J Gynaecol Obstet) - "As a result, the data and conclusions are considered by the editors to be unreliable. Therefore, the article must be retracted."

Journal • Gynecology • Obstetrics • Polyendocrine Metabolic Ovarian Syndrome

Acute giant urticaria of the erythema marginatum type (Marfan-like), induced by the use of Lomifen (Clomiphene citrate) for primary infertility: an unusual case report. (EADV 2026) - No abstract available

Case report • Clinical • Dermatology • Immunology • Infertility • Sexual Disorders • Urticaria

Optimizing outcomes of micro-TESE for men with nonobstructive azoospermia. (PubMed, Curr Opin Urol) - "Surpassing the current ceiling of micro-TESE success requires a highly individualized, multidisciplinary strategy. This encompasses rigorous genetic and endocrine profiling, phenotype-specific preoperative optimization, and meticulous, tissue-sparing microsurgical techniques. As noninvasive biomarkers and artificial intelligence transition into clinical maturity, their integration will further refine patient selection and intraoperative decision-making, ultimately elevating the standard of care for this severe cohort of male infertility."

Journal • Infertility • Sexual Disorders

One-shot Ovarian Stimulation Protocol (One-shot) (clinicaltrials.gov) - P=N/A | N=20 | Completed | Sponsor: Fundación Santiago Dexeus Font | Recruiting ➔ Completed | Trial completion date: Apr 2025 ➔ Nov 2025 | Trial primary completion date: Apr 2025 ➔ Nov 2025

Trial completion • Trial completion date • Trial primary completion date • Infertility • Sexual Disorders

Live Sextuplet Birth After Ovulation Induction in a Patient With Secondary Infertility: A Case Report. (PubMed, Cureus) - "In this article, we report a rare case of high-order multiple pregnancy following the induction of clomiphene citrate in a woman with unexplained secondary infertility...She was kept on progesterone support and was placed on dexamethasone for fetal lung maturation at 24 weeks...A rare situation with an extremely serious management challenge of high-order multiple pregnancy, including the complications post-ovulation induction and management challenges that this case presents. To facilitate these outcomes, it is critical that intensive monitoring, timely intervention, complex management, multidisciplinary effort, as well as neonatal support occur."

Journal • Critical care • Infertility • Sexual Disorders

Repurposing of Clomiphene Citrate and Its Antileishmanial and Antifungal Activities: In Silico and In Vitro Studies. (PubMed, Biomolecules) - "Experimental assays demonstrated that clomiphene inhibited the early stages of C. albicans biofilm formation and exhibited potent leishmanicidal activity against L. amazonensis promastigotes, with a high selectivity index in macrophages. Together, these findings indicate that clomiphene citrate represents a promising candidate for further investigation as a potential therapeutic agent against tegumentary leishmaniasis and candidiasis."

Journal • Preclinical • Candidiasis • Dermatology • Infectious Disease

Comparison of Clomiphene Alone Versus Clomiphene Plus Sildenafil for Ovulation in Women With Polycystic Ovary Syndrome (clinicaltrials.gov) - P4 | N=98 | Completed | Sponsor: Nishtar Medical University

New P4 trial • Polyendocrine Metabolic Ovarian Syndrome

Micro-TESE in Non-Obstructive Azoospermia: Phenotype-Guided Hormonal Optimization and Testosterone Response-Prognostic Biomarker or Therapeutic Target? (PubMed, J Clin Med) - "A larger testosterone rise during stimulation has been positively associated with retrieval and may reflect residual Leydig-cell reserve, although causality and transferable thresholds remain unproven. Preoperative endocrine therapy should therefore remain individualized, phenotype-guided, off-label, closely monitored, and preferably investigated within clinical trials; the testosterone response is best regarded as a candidate prognostic biomarker rather than a validated therapeutic target or decision rule."

Biomarker • Journal • Review • Infertility • Sexual Disorders

Modified clomiphene citrate protocol versus gonadotropin-releasing hormone antagonist protocol in in vitro fertilization: a propensity score-matched retrospective study on cost and efficacy. (PubMed, Front Endocrinol (Lausanne)) - "The modified CC protocol was associated with ovarian stimulation effects and clinical outcomes comparable to those of the GnRH-ant protocol. Furthermore, it represented a more cost-effective ovarian stimulation strategy, significantly reducing treatment costs while maintaining a clinical pregnancy rate comparable to that of the GnRH-ant protocol."

Clinical • Journal • Preclinical • Retrospective data • Gynecology • Infertility • Sexual Disorders

The effects of clomiphene citrate on reproductive parameters in the mare. (PubMed, J Equine Vet Sci) - "Treated mares had higher luteinizing hormone (LH, P=0.04) and anti-müllerian hormone (AMH, P=0.05) compared to control mares. While CC treated mares had higher uterine edema and serum LH and AMH, significant changes in follicle stimulating hormone, estradiol, and follicular development were not demonstrated."

Journal

Expression of Concern: Metformin in the treatment of clomiphene citrate-resistant women with polycystic ovary syndrome undergoing in vitro fertilisation treatment: A randomised controlled trial. (PubMed, J Obstet Gynaecol) - No abstract available

Journal • Preclinical • Gynecology • Polyendocrine Metabolic Ovarian Syndrome

Dose-dependent perinatal risks of clomiphene citrate in US IVF cycles: a national cohort study, 2004-2021. (PubMed, BMJ Open) - "Our findings extend previous findings on the association between CC exposure and adverse perinatal outcomes by demonstrating a dose-dependent relationship."

Journal • Retrospective data • Gynecology

Outcomes and Predictors in Hypogonadal Oligospermic Men Treated with Clomiphene Citrate. (PubMed, World J Mens Health) - "Clomiphene citrate 50 mg daily normalized testosterone in 9 of 10 men with hypogonadism and oligospermia. Baseline estradiol predicted testosterone response, while sperm improvements were more likely in men with lower baseline counts. Although sperm concentration increased in most patients, clinical relevance was modest and nearly one-third worsened. Clomiphene citrate may be considered for testosterone optimization, particularly in men with higher estradiol, but fertility expectations should be managed."

Journal • Endocrine Disorders • Infertility • Sexual Disorders

Stair-step versus traditional clomiphene citrate protocols in polycystic ovary syndrome: a systematic review and meta-analysis. (PubMed, Reprod Biomed Online) - "Endometrial thickness was similar (mean difference 0.32 mm, 95% CI -0.95 to 1.59 mm; four RCTs, n = 460, I² = 91%). SSP improves ovulation rate and shortens treatment without affecting endometrial thickness and may increase clinical pregnancy rates."

Journal • Retrospective data • Review • Polyendocrine Metabolic Ovarian Syndrome

Impact of antral follicular count on ovulation and pregnancy rate in sub infertile women with polycystic ovarian syndrome undergoing ovulation induction by clomiphene citrate and gonadotropins. (PubMed, Ginekol Pol) - "Antral follicular count can be used to assess response to treatment of subfertile polycystic ovarian syndrome women to ovulation induction by drugs, the rate of ovulation and pregnancy."

Journal • Infertility • Polyendocrine Metabolic Ovarian Syndrome • Sexual Disorders

Retraction Notice: Rosiglitazone as Treatment for Clomiphene Citrate-Resistant Polycystic Ovary Syndrome: Factors Associated with Clinical Response. (PubMed, J Womens Health (Larchmt)) - No abstract available

Journal • Polyendocrine Metabolic Ovarian Syndrome

Real-World Prescribing Patterns of Clomiphene Citrate for Male Infertility: A National Cross-Sectional Survey of Urologists in Türkiye. (PubMed, J Clin Med) - " CC prescribing for male infertility remains heterogeneous among responding urologists and was associated with clinician experience, practice setting, and infertility case volume rather than standardized protocols. The predominance of laboratory-based endpoints, together with the frequent inclusion of spontaneous pregnancy as a perceived success definition and the absence of separate live-birth assessment, underscores the need for clearer terminology, standardized prescribing frameworks, structured risk counseling, and future studies incorporating clinically meaningful reproductive endpoints."

Journal • Real-world evidence • Endocrine Disorders • Infertility • Sexual Disorders • Urology

Identification of predictors of the ovarian response to clomiphene citrate in infertile women with polycystic ovary syndrome: A post-hoc analysis of a randomized controlled trial. (PubMed, Front Endocrinol (Lausanne)) - P=N/A | "This strategy avoids ineffective treatment cycles and enables personalized ovulation induction. The study was registered on ClinicalTrials.gov under the identification number NCT01573858 on July 6, 2012."

Clinical • Journal • Retrospective data • Infertility • Polyendocrine Metabolic Ovarian Syndrome

Identifying carcinogenic hazards among pharmaceutical agents: An update from the IARC Monographs programme. (PubMed, Cancer Epidemiol) - "Pharmacoepidemiology data with cancer or mechanistic endpoints can largely contribute to cancer hazard identification of pharmaceuticals within the IARC Monographs programme. These data can inform policy decision-making for patients and workers protection."

Journal • Review • Hematological Disorders • Oncology • Solid Tumor

Reproduction and fertility issues in women with congenital adrenal hyperplasia: pathophysiology, management, and recent clinical advances. (PubMed, Hormones (Athens)) - "Fertility is generally reduced in women with classical CAH compared to the general population, owing to a combination of anatomical alterations from prenatal androgen exposure and reconstructive surgery, hypothalamic-pituitary-ovarian (HPO) axis dysregulation driven by excess adrenal androgens and progesterone, anovulation, and psychosexual factors, including altered gender-related behaviour and reduced reproductive intent...When ovulation fails to occur, induction with clomiphene citrate or gonadotropins may be employed; in vitro fertilisation with preimplantation genetic testing represents an option for refractory cases at high genetic risk...Prenatal treatment with dexamethasone to prevent virilisation of possibly affected female foetuses remains a subject of ongoing ethical and clinical debate. A multidisciplinary approach-encompassing endocrinology, reproductive medicine, surgery, and psychological support-is essential for optimising reproductive outcomes and..."

Journal • Review • Congenital Adrenal Hyperplasia • Endocrine Disorders • Gynecology • Obstetrics

Medically Assisted Reproduction and Hormone-Related Cancers. (PubMed, JAMA Netw Open) - "Exposures were defined from Medicare records: assisted reproduction therapy, intrauterine insemination or ovarian stimulation, and ovulation induction with clomiphene citrate...Some treatments were associated with decreased lung cancer risk (HRs, 0.72-0.82). In this cohort study of MAR and cancer using a target trial emulation design, although associations between MAR and some hormone-related cancers were observed, the estimated difference in the number of expected cancers was small and may be explained by unmeasured confounding and detection bias."

Journal • Breast Cancer • Colorectal Cancer • Endometriosis • Gynecology • Hematological Disorders • Hematological Malignancies • Infertility • Lung Cancer • Melanoma • Oncology • Ovarian Cancer • Pancreatic Cancer • Polyendocrine Metabolic Ovarian Syndrome • Sexual Disorders • Solid Tumor • Thyroid Gland Carcinoma • Women's Health

Expression of Concern: Supplementation of clomiphene citrate cycles with Cimicifuga racemosa or ethinyl oestradiol - a randomized trial. [Reproductive BioMedicine Online, 2009, Vol 19. No 4. p501-507]. (PubMed, Reprod Biomed Online) - No abstract available

Journal

Clomiphene citrate versus testosterone replacement therapy in male hypogonadism: a systematic review of literature and meta-analysis. (PubMed, Eur J Clin Pharmacol) - "No statistically significant difference in serum testosterone levels was observed between clomiphene citrate and testosterone gel, although the evidence is limited by high heterogeneity and some concerns to high risk of bias. TRT was associated with greater improvements in libido. These findings should be interpreted as preliminary, and large-scale randomized trials incorporating clinical and fertility endpoints are needed."

Clinical • Journal • Retrospective data • Review • Endocrine Disorders • Genetic Disorders • Obesity

Pituitary Axis Impacts and Effectiveness of Clomiphene and Human Chorionic Gonadotropin in Treating Hypogonadism: Cohort Study. (PubMed, World J Mens Health) - "This study revealed distinct patterns in the natural history of pituitary hormone levels across different fertility-sparing strategies for TD, while observing comparable benefits in testosterone levels and quality of life. Future studies should prospectively correlate longitudinal trends in pituitary hormones with semen parameters and other fertility outcomes to enable personalised treatment selection."

Journal • Endocrine Disorders

Clomiphene Citrate in off-Label Post-Cycle Therapy: Mechanisms, Efficacy and Diagnostic Challenges in Endocrine Recovery Following Anabolic Steroid Use. (PubMed, Andrology) - "Emerging approaches, including kisspeptin analogues, the enclomiphene isomer, and genotype-guided interventions, suggest potential future directions but lack validation in ASIH populations. This narrative review synthesizes current evidence on CC in post-cycle therapy and highlights key challenges in defining safe and standardized approaches to endocrine recovery following AAS use."

Journal • Review • Endocrine Disorders