clomifene citrate / Generic mfg. - LARVOL DELTA

Analysis of Laparoscopic and Transvaginal Ovarian Drilling on Polycystic Ovarian Syndrome: A Narrative Review of Outcomes. (PubMed, Cureus) - "Laparoscopic ovarian drilling (LOD) and transvaginal ovarian drilling (TVOD) are widely used second-line treatments for ovulation induction in PCOS patients who do not respond to clomiphene citrate (CC)...LOD may be more suitable for patients with elevated luteinizing hormone (LH) levels and shorter durations of infertility. In contrast, TVOD may be preferred for patients who would benefit from a less invasive approach with a lower risk of adhesion formation."

Journal • Review • Gynecology • Infertility • Polycystic Ovary Syndrome • Sexual Disorders

Ursolic acid, a pentacyclic triterpene from Ochrosia elliptica Labill leaves and its role in the management of polycystic ovary syndrome (PCOS). (PubMed, Inflammopharmacology) - "Using adult female Wistar Albino rats, PCOS was induced through letrozole administration. The rats were then treated with UA at two different doses (25 and 50 mg/kg), alongside a control group and a standard ovulation-inducing medication, clomiphene citrate (1 mg/kg)...Furthermore, UA downregulated key genes involved in steroidogenesis and oxidative stress response, suggesting a multifaceted mechanism of action. The findings highlight UA's potential as a novel therapeutic option for managing PCOS symptoms, emphasizing the need for further research into its efficacy and safety in clinical applications."

Journal • Endocrine Disorders • Inflammation • Polycystic Ovary Syndrome • CAT

From tablets to targeted therapy: the APHRODITE era in male infertility. (PubMed, Hum Reprod) - "While clomiphene citrate and aromatase inhibitors retain a role in specific endocrine profiles, the new positioning of exogenous gonadotropins-LH/hCG and FSH-as targeted, earlier-line interventions holds promise to improve outcomes and efficacy in male fertility care. Future progress will depend on prospective trials that apply the APHRODITE criteria and on comparative analyses of oral agents versus injectable gonadotropin regimens in well-defined patient phenotypes."

Journal • Endocrine Disorders • Infertility • Sexual Disorders

Sex Hormone Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial (clinicaltrials.gov) - P2 | N=58 | Recruiting | Sponsor: University of Utah | Trial completion date: Apr 2027 ➔ Jan 2029 | Trial primary completion date: Dec 2026 ➔ Jul 2028

Trial completion date • Trial primary completion date

Effectiveness of clomiphene citrate on total motile sperm count and hormonal profile in men with clinical infertility. (PubMed, Can Urol Assoc J) - "CC was associated with higher TMSC and reproductive hormones. Response was independent of age, BMI, baseline hormones, and duration. Larger, prospective studies are needed to confirm findings and guide candidate selection."

Journal • Infertility • Sexual Disorders

Phenotype-specific efficacy of letrozole versus clomiphene citrate in polycystic ovary syndrome: a prospective cohort study. (PubMed, BMC Womens Health) - No abstract available

Journal • Polycystic Ovary Syndrome

FSH Recovery and Sperm Production in Men with TTh-Induced Azoospermia: Comparison of hCG Monotherapy versus hCG with Clomiphene Citrate (AUA 2026) - No abstract available

Monotherapy • Infertility • Sexual Disorders

Clomiphene Citrate Therapy and Lipid Profile Changes in Men with Hypogonadism: Findings from an Expanded Cohort (AUA 2026) - No abstract available

Endocrine Disorders

Effect Clomiphene vs Clomiphene Along With Pioglitazone on Ovarian Stimulation Rate (clinicaltrials.gov) - P4 | N=62 | Recruiting | Sponsor: PAEC General Hospital, Islamabad

New P4 trial • Infertility • Polycystic Ovary Syndrome • Sexual Disorders

Cancer Incidence in Women After Medically Assisted Reproduction. (PubMed, JAMA Netw Open) - "Three MAR cohorts were created: assisted reproductive therapy (ART), intrauterine insemination with ovarian stimulation (IUI/OS), and ovulation induction using clomiphene citrate (clomiphene citrate)...The incidence of certain cancers appeared elevated; however, the excess numbers of these cancers were small, and there was reduced incidence of other cancers. Causation cannot be inferred from this descriptive evidence, but findings may guide women and their health care practitioners."

Journal • Breast Cancer • Cervical Cancer • Melanoma • Oncology • Ovarian Cancer • Solid Tumor • Uterine Cancer

Outcomes from a trainee-run ovulation induction program at a large urban safety net hospital. (PubMed, J Assist Reprod Genet) - "PRs from this low-resource OI program are comparable to published data, demonstrating that fellow and resident-run initiatives can be successful in bridging the gap in fertility care."

Journal • Endocrine Disorders • Infertility • Polycystic Ovary Syndrome • Sexual Disorders

Luteal Phase Support in Ovulation Induction Cycles: Current Evidence and Controversies (ISGE 2026) - "While gonadotropin-stimulated cycles are known to cause luteal phase insufficiency, the need for progesterone supplementation in cycles using oral agents such as clomiphene citrate or letrozole is less clear. Luteal phase support is beneficial and recommended for gonadotropin-stimulated OI-IUI cycles. However, its routine use in clomiphene or letrozole cycles is not supported by current evidence. Further well-designed randomized studies are needed to clarify the role of LPS in aromatase inhibitor–based stimulation and to determine the optimal dose and duration across different stimulation protocols Keywords: luteal phase support, ovulation induction, progesterone, clomiphene, letrozole, intrauterine insemination"

Infertility • Sexual Disorders

Heterotopic Pregnancy With Intrauterine 7 Weeks Twin Implantation After Clomiphene Citrate Treatment. (PubMed, J Clin Ultrasound) - "We aim to present a rare case of HP, characterized by the presence of intrauterine twin implantation. This case highlights the importance of maintaining a high index of suspicion for HP even in the presence of a viable intrauterine twin gestation, particularly following ovulation induction with clomiphene citrate."

Journal

The Effect Of Polycystic Ovarian Syndrome Treatment On Ocular Surface. (clinicaltrials.gov) - P=N/A | N=90 | Completed | Sponsor: Cairo University

New trial • Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome - exploring the therapeutic and biomedical insights into the role of Silver nanoparticles. (PubMed, J Steroid Biochem Mol Biol) - "Conventional medicines, such as metformin, clomiphene citrate, letrozole, flutamide, and rosiglitazone, can regulate menstrual irregularities, improve ovulation, reduce insulin resistance, and decrease androgen levels, but may also cause various side effects. The review includes evidence from insulin, inflammation, oxidative processes, neuroendocrine factors and cystogenic pathways to combine and provide an overview. The review also discusses how to approach toxicity, especially dose-dependent, and the reproductive safety of AgNPs and their translational limitations to define the boundaries of AgNPs in the treatment of PCOS."

Journal • Review • Endocrine Disorders • Inflammation • Polycystic Ovary Syndrome • Women's Health

Effectiveness of minimal stimulation versus conventional GnRH antagonist protocols in controlled ovarian hyperstimulation: a retrospective analysis of 10769 IVF/ICSI cycles. (PubMed, Minerva Obstet Gynecol) - "Compared to the standard treatment, the minimal stimulation group's live birth rate was much higher, indicating that some patient populations might benefit from fewer drugs and less stimulation."

Journal • Retrospective data • Infertility

Heterotopic Pregnancy After Ovulation Induction by Clomiphene Citrate: A Case Report. (PubMed, Cureus) - "Heterotopic pregnancy (HP), when intrauterine and ectopic pregnancies occur together, is uncommon but dangerous. With timely recognition and proper management, including progesterone support, good outcomes are possible. Vigilance is essential for all patients undergoing ovulation induction."

Journal • Cardiovascular • Gynecology • Hypotension • Infertility • Musculoskeletal Pain • Pain • Sexual Disorders

CC-OVI: Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction (clinicaltrials.gov) - P=N/A | N=90 | Completed | Sponsor: Yuzuncu Yil University

New trial • Gynecology • Infertility • Sexual Disorders

Novel Therapeutic Potential of Serenoa repens in rat PCOS: Insights from Network Pharmacology and In Vivo Studies. (PubMed, J Ethnopharmacol) - "This study provides evidence that S. repens exerts multi-targeted therapeutic effects in PCOS, and highlights S. repens and its marketed supplements as a promising phytotherapeutic option for PCOS management."

Journal • Preclinical • Benign Prostatic Hyperplasia • Polycystic Ovary Syndrome • AR • CYP19A1

A randomized controlled trial comparing combination of letrozole and clomiphene citrate or letrozole alone for ovarian stimulation in infertile women. (PubMed, J Family Med Prim Care) - "In group 2, 4.4% women had hot flushes, 6.7% had nausea and none of them had OHSS. It was concluded that both the regimes i.e. combination of CC plus Letrozole and Letrozole-alone were equally efficacious and safe to use in the treatment of female infertility with Letrozole-alone regime being slightly more effective in terms of endometrial thickness at trigger."

Journal • Gynecology • Infertility • Sexual Disorders

Comparing ovulation induction strategies for unexplained infertility: protocol for a systematic review and network meta-analysis. (PubMed, BMJ Open) - "Letrozole, clomiphene citrate and gonadotropins are widely used, alone or in combination, with or without intrauterine insemination (IUI), but evidence of comparative effectiveness and safety is inconsistent. CRD420251145492. The review was registered prospectively; the review start date is 11 September 2025 and the anticipated end date is 3 March 2026."

Journal • Retrospective data • Infertility • Sexual Disorders

Significance of Follicle-Stimulating Hormone Receptor Gene Single-Nucleotide Polymorphism rs6165/rs6166 Analysis for Infertility-Associated Ovarian Disease Susceptibility Prediction and Optimized Individualized Ovulation Induction/Ovarian Stimulation. (PubMed, Diagnostics (Basel)) - "Recent research clarifies the association of rs6165/rs6166 with susceptibility to infertility-associated ovarian diseases, ranging from polycystic ovarian syndrome, premature ovarian insufficiency, endometriosis, to ovarian cancer, along with response/resistance to ovulation induction/ovarian stimulation with clomiphene citrate, letrozole, metformin, FSH preparations, and adjunctive growth hormone in infertility treatment. The re6165/rs6166 genotype-guided choice of individualized ovulation stimulation preparations has great potential to reduce unexpected poor or high ovarian responses in ovulation induction and ovarian stimulation and improve clinical outcomes in reproductive medicine. Current evidence is insufficient, and further studies are warranted to ascertain its potential for clinical implementation."

Journal • Review • Endometriosis • Gynecology • Infertility • Oncology • Ovarian Cancer • Polycystic Ovary Syndrome • Sexual Disorders • Solid Tumor • Women's Health

Retraction Note To: High Dose of Phytoestrogens Can Reverse the Antiestrogenic Effects of Clomiphene Citrate on the Endometrium in Patients Undergoing Intrauterine Insemination: A Randomized Trial. (PubMed, Reprod Sci) - No abstract available

Journal

Fertility and pregnancy in patients with prolactinoma. (PubMed, Best Pract Res Clin Endocrinol Metab) - "Treatment with dopamine agonists, primarily cabergoline, can achieve normoprolactinemia and restoration of the gonadal axis within 6-12 months in most patients...If the gonadal axis does not recover and fertility is desired, clomiphene citrate and other assisted reproductive techniques may be utilized...Breastfeeding is typically uneventful. This review addresses the principal mechanisms of infertility in hyperprolactinemia, in both women and men, as well as treatment approaches to achieving conception and recommendations for follow-up before, during, and after delivery."

Journal • Review • Infertility • Oncology • Pituitary Gland Carcinoma • Sexual Disorders

Ameliorative effects of Corchorus olitorius leaf ethanolic extract on letrozole-induced polycystic ovary syndrome (PCOS) in rats. (PubMed, Avicenna J Phytomed) - "36 female Wistar rats were divided into six groups (n=6) including Sham, PCOS + vehicle (Dimethyl sulfoxide), PCOS + Clomiphene citrate, PCOS + 200, 400, and 600 mg/kg Corchorus olitorius. olitorius leaf extract showed its ameliorative effects in terms of normalizing the altered vaginal cytology, restoring most parameters, and improving the appearance of ovarian and uterine morphology. These results suggest that C. olitorius leaves ameliorate PCOS symptoms in the studied biochemical and histological parameters."

Journal • Preclinical • Hematological Disorders • Polycystic Ovary Syndrome