clomifene citrate / Generic mfg. - LARVOL DELTA

In Vivo and In Silico Dissection of Triclosan-Induced Reproductive Toxicity: Protective Potentials of Nanoselenium and Phytotherapy. (PubMed, Basic Clin Pharmacol Toxicol) - "This study investigated the protective efficacy of clomiphene citrate, conventional selenium, nanoselenium and Tribulus terrestris extract (TTE) against TCS-induced toxicity in male rats...Among these, nanoselenium and TTE showed the most pronounced protective effects, emphasizing their comparative efficacy in counteracting TCS-induced toxicity. The findings highlight the potential of nanoselenium and TTE as promising protective agents against TCS-related reproductive and hepatic damage."

Journal • Preclinical • Inflammation • CYP17A1 • GPX4 • SOX9

Safety of Clomiphene Citrate and Its Impact on Serum Tumor Markers in Hypogonadal Testicular Cancer Patients After Chemotherapy. (PubMed, Cureus) - "Conclusion This is the first study to assess the use of CC in hypogonadal testicular cancer survivors following chemotherapy. CC was associated with an increase in serum testosterone levels with no associated side effects, false-positive elevation of beta-HCG tumor marker levels, or disease recurrence."

Journal • Endocrine Disorders • Genito-urinary Cancer • Oncology • Solid Tumor • Testicular Cancer

Letter to the editor: critical appraisal of the nationwide study on clomiphene citrate's perinatal outcomes. (PubMed, Fertil Steril) - No abstract available

Journal

Empirical hormonal treatments for idiopathic male infertility: a network meta-analysis comparing antiestrogens and FSH. (PubMed, Eur J Endocrinol) - "Both SERMs and FSH improve sperm concentration and count compared to placebo. Clomiphene at low doses and high-dose FSH may offer the greatest benefit. These findings support a personalized empirical treatment approach and emphasize the need for future trials stratified by clinical phenotype, such as the recently proposed APHRODITE criteria."

Clinical • Journal • Retrospective data • Review • Infertility • Sexual Disorders

Protective effect of aqueous extract of Myrica Esculenta against cyclophosphamide-induced spermatogenesis dysfunction in Wistar rats via antioxidant Signaling pathway. (PubMed, Toxicol Res (Camb)) - "Myrica esculenta fruits contain high levels of chlorogenic acid, caffeic acid, myricetin, quercetin, and ascorbic acid, which have antioxidant, anti-inflammatory, and pharmacological properties...A total of 25 Wistar rats were divided into five groups, each group consisting of 5 animals; 1) normal control (saline 5 mL/kg), 2) CYP (30 mg/kg, i.p.), 3) clomiphene citrate (0.25 mg/kg/i.p.), 4) aqueous Manihot esculenta extract (250 mg/kg/p.o.), 5) aqueous M. esculenta extract (500 mg/kg/p.o.)...These findings highlight its therapeutic potential in managing male infertility. However, further investigations are necessary to elucidate the precise molecular mechanisms underlying its protective effects."

Journal • Preclinical • Infertility • Sexual Disorders • CAT

Integrative Approaches to Ovulation Induction in Polycystic Ovary Syndrome: A Narrative Review of Conventional and Complementary Therapies. (PubMed, Biomedicines) - "This narrative review summarizes the current evidence for ovulation induction in patients with PCOS, including conventional pharmacologic agents, such as clomiphene citrate, letrozole, gonadotropins, and insulin-sensitizing agents, as well as complementary therapies, such as acupuncture and Chinese herbal medicine. We also examine emerging adjuvants, such as vitamin D, omega-3 fatty acids, sildenafil, and antioxidants that may enhance clinical pregnancy rates or improve endometrial receptivity. While robust evidence supports the use of letrozole as a first-line agent, complementary and integrative therapies may offer additional benefits, particularly in treatment-resistant or preference-driven contexts. Further high-quality studies are needed to clarify the role of combined therapeutic strategies in optimizing fertility outcomes for women with PCOS."

Journal • Review • Infertility • Polycystic Ovary Syndrome • Sexual Disorders

Clomiphene Citrate in Men With Hypogonadism-Do we Need to Monitor IGF-1 in All Patients? (PubMed, J Endocr Soc) - No abstract available

Journal • Acromegaly • Endocrine Disorders • IGF1

Working Against the Clock: Depression and Hormonal Imbalance in Shift-Working Men. (PubMed, Urology) - "This study demonstrates the significant impact and association between testosterone levels, shift work, and depressive symptoms. These findings highlight the importance of routine depression screening and counseling for men presenting with hypogonadal symptoms, particularly those engaged in shift work."

Journal • CNS Disorders • Depression • Endocrine Disorders • Mood Disorders • Psychiatry • Sleep Disorder • Suicidal Ideation • Urology

Efficacy and Safety of Clomiphene Citrate for Late-Onset Hypogonadism as Evaluated by Aging Male Symptom Rating Scale Over One Year. (PubMed, Int J Urol) - "This is the first study, to our knowledge, showing the efficacy of treatment with clomiphene citrate for late-onset hypogonadism based on the Aging Males Symptoms rating scale score. Because acceptable efficacy and no adverse events were found for 1 year, we emphasize that clomiphene citrate should be one alternative treatment for testosterone replacement in young patients desiring children or patients who are overly concerned about testicular atrophy, especially those with a low serum luteinizing hormone level."

Journal • Endocrine Disorders • Sexual Disorders

Frequency of Subclinical Hypothyroidism in Subfertile Females and the Effect of Thyroxine Replacement. (PubMed, J Coll Physicians Surg Pak) - "SCH is not uncommon in subfertile females of reproductive age. However, a significant relationship could not be established between SCH and subfertility in the studied patients, and conception rates were low after thyroxine supplementation."

Journal • Endocrine Disorders • Gynecology • Immunology • Infertility • Obstetrics

Modulatory Effects of Lannea welwitschia on Cadmium-Induced Reproductive and Biochemical Dysregulation via Steroidogenic Enzyme Regulation in Female Rats. (PubMed, J Ethnopharmacol) - "Lannea welwitschii bark extract protects against CdCl2-induced female reproductive toxicity by modulating oxidative stress, restoring hormonal balance, and regulating steroidogenesis-related genes, thereby supporting its traditional use and potential therapeutic value for female infertility associated with environmental toxins."

Journal • Preclinical • Gynecology • Hematological Disorders • Infertility • Sexual Disorders • IL6 • TNFA

FREE ANDROGEN INDEX (FAI) PREDICTING RESPONSE AMONG POLYCYSTIC OVARY SYNDROME (PCOS) PATIENTS UNDERGOING CLOMIPHENE CITRATE (CC) OR LETROZOLE (LET) INTRAUTERINE INSEMINATION (IUI) CYCLES (ASRM 2025) - No abstract available

Clinical • Polycystic Ovary Syndrome

COMPARATIVE OUTCOMES OF LETROZOL VERSUS CLOMIPHENE CITRATE FOR OVULATION INDUCTION IN PATIENTS WITH PCOS: A SYSTEMATIC REVIEW AND META-ANALYSIS (ASRM 2025) - No abstract available

Retrospective data • Review • Polycystic Ovary Syndrome

Extended Letrozole Treatment for Ovulation Induction and Clinical Pregnancy in Conventional Treatment-resistant Polycystic Ovary Syndrome Patients: A Prospective Parallel Randomized Clinical Trial. (PubMed, J Obstet Gynaecol India) - "Healthcare professionals should take this trend into account when assessing treatment alternatives, particularly within the framework of personalized patient care, as even slight enhancements in pregnancy rates can have significant effects. IRCT20110908007513N19."

Clinical • Journal • Gynecology • Infertility • Obstetrics • Polycystic Ovary Syndrome • Sexual Disorders

A Case of Heterotopic Pregnancy Resulting in a Live Birth Through Laparoscopic Surgery. (PubMed, Cureus) - "Oral clomiphene citrate was initiated, timing guidance was provided on day 16 after the last menstrual period, and pregnancy was established...Careful management is required to preserve an intrauterine pregnancy while treating ectopic pregnancy. Patients and their families must also be provided with accurate information when laparoscopic surgery is performed under general anesthesia."

Journal • Anesthesia • Infertility • Sexual Disorders

Heterotopic pregnancy following ovulation induction with clomiphene citrate therapy: A case report. (PubMed, Case Rep Womens Health) - "The ectopic pregnancy was managed surgically, and the intrauterine pregnancy progressed to a full-term vaginal delivery. This case calls attention to the importance of physicians maintaining a high index of suspicion for heterotopic pregnancy in patients undergoing ovulation induction, despite reassuring imaging and nonspecific symptoms."

Journal • Pain • Polycystic Ovary Syndrome

Combined Letrozole and Clomiphene Citrate Versus Letrozole Alone in Ovulation Induction for Polycystic Ovarian Syndrome Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials. (PubMed, Reprod Sci) - "Lower-dose combination therapy also increased the proportion of follicles > 15 mm (OR 4.09, 95% CI [1.94, 8.60], P < 0.001), with no significant differences in endometrial thickness, follicular size, or progesterone levels. Side effects were similar, though hot flushes were more common with combination therapy (OR 2.99, 95% CI [1.23, 7.23], P = 0.02). Our results support lower-dose combination therapy for improved ovulation, follicle count, and pregnancy outcomes while reducing miscarriage risk."

Journal • Retrospective data • Review • Infertility • Polycystic Ovary Syndrome • Sexual Disorders

Post-cycle therapy after short-term anabolic-androgenic steroid use: comparative outcomes in recreational bodybuilders. (PubMed, BJU Int) - "Spontaneous hormonal recovery occurs within 6-12 months after AAS cessation, yet PCT facilitates earlier hormonal normalisation. The addition of hCG to CC was associated with superior recovery of semen parameters and testicular volume. These findings underscore the potential short-term benefits of PCT and highlight the need for prospective randomised trials to establish evidence-based treatment protocols."

Journal • Erectile Dysfunction

Hypogonadal Rescue in Post-orgasmic Illness Syndrome: A Case Report. (PubMed, Cureus) - "We report a hormonally responsive POIS phenotype treated with clomiphene citrate and niacinamide...Targeted endocrine modulation with clomiphene and niacinamide produced a clinically meaningful reduction in symptom burden and episode duration in this POIS case, supporting routine hormonal assessment and personalized therapy. Prospective, controlled trials employing validated outcome measures are warranted to establish efficacy and safety."

Journal • Urology

A Case of Ethmocephaly in a Clomiphene Citrate Induced Pregnancy: A Case Report and Literature Review. (PubMed, Clin Case Rep) - "In conclusion, ethmocephaly is a severe and typically fatal condition requiring early prenatal detection for better planning. While there is no clear link between clomiphene use and holoprosencephaly, further research is needed to explore any potential risks and guide clinical practice."

Journal • CNS Disorders • Genetic Disorders

PILOT STUDY: FIRST PREGNANCIES AFTER USING A SIMPLIFIED IVF SYSTEM IN A MOBILE IVF LABORATORY (FIGO 2025) - "Mild ovarian hyperstimulation was performed using clomiphene citrate, low dose gonadotropins, GnRH antagonist and hCG trigger... This study confirms that embryo culture with a simplified IVF system in a mobile IVF laboratory can be done with promising success rates. This can be a valuable tool in areas where access to ART is limited, due to few and expensive IVF centres mainly found in large cosmopolitan centres."

Clinical

Intravenous clomiphene citrate pharmacokinetics in healthy mares as a first step toward use in reproduction. (PubMed, Am J Vet Res) - "IV CC appears to be well tolerated in the mare. Future fertility trials are warranted to assess the potential that CC may have in increasing the efficiency of equine in vitro embryo production."

Journal • PK/PD data

Medically assisted reproduction and breast cancer risk: time for radiologic surveillance guidelines? (EUSOBI 2025) - "We divided the literature into 3 categories, based on the type of infertility drug that was mainly investigated: clomiphene citrate (9 studies), gonadotropins (6 studies) and progesterone (4 studies). To our knowledge, there are no experiences of breast radiologists in this field in the literature. Given the widespread of ART technologies, there is a pressing need to establish radiological surveillance guidelines for women exposed to these treatments, particularly those with additional risk factors such as prolonged infertility or a family history of BC."

Breast Cancer • Infertility • Oncology • Sexual Disorders • Solid Tumor

Letrozole at the Crossroads of Efficacy and Fetal Safety in Ovulation Induction: A Narrative Review. (PubMed, Biomedicines) - "Compared to clomiphene citrate, letrozole is associated with higher ovulation and live birth rates, a lower risk of multiple gestation, and a more favorable endometrial environment. Key clinical strategies-such as early-cycle initiation, lowest effective dosing, and individualized monitoring-optimize therapeutic outcomes while minimizing potential risks. While long-term offspring data remain limited and mechanistic concerns persist, current evidence robustly supports letrozole as a safe and effective option for OI, balancing reproductive success with maternal-fetal safety across a range of infertility indications."

Journal • Review • Breast Cancer • Infertility • Oncology • Polycystic Ovary Syndrome • Sexual Disorders • Solid Tumor

Thyroid Hormones Correlate to the Therapeutic Effect of Ovulation Induction in Infertile Women With Polycystic Ovary Syndrome. (PubMed, Clin Endocrinol (Oxf)) - "Thyroid hormones significantly influence the efficacy of ovulation induction in infertile women with PCOS. Combined T3, T4, and TSH measurements enhance predictive accuracy for therapeutic responses, providing a foundation for personalized treatment strategies."

Journal • Endocrine Disorders • Infertility • Metabolic Disorders • Polycystic Ovary Syndrome • Sexual Disorders