HY-021068 / Hefei Yigong Pharmaceutical - LARVOL DELTA

HY-021068 improves neuronal ferroptosis by activating Nrf2 signaling in APP/PS1 Mice and Aβ1-42-induced HT22 cells. (PubMed, Eur J Pharmacol) - "Molecular docking and cellular thermal shift assay showed that HY had an interaction with Nrf2. These results suggested that HY could ameliorate AD-related cognitive decline and neuronal ferroptosis through activating Nrf2 pathway, positioning it as a promising therapeutic strategy for AD."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Vascular Neurology • BACE1 • DLG4 • DMRT1 • GPX4 • NQO1