CyLow (immediate release cyclosporine) / Sublimity Therap - LARVOL DELTA

A novel conditioning regimen incorporating low-dose cyclophosphamide and thiotepa for haploidentical hematopoietic stem cell transplantation in pediatric patients with severe aplastic anemia at high risk of cardiotoxicity. (PubMed, Transplant Cell Ther) - "The BuCylowTT regimen represents a promising alternative for pediatric patients with SAA at high risk of CT undergoing haploidentical HSCT."

Journal • Acute Graft versus Host Disease • Anemia • Aplastic Anemia • Bone Marrow Transplantation • Cardiovascular • Graft versus Host Disease • Hematological Disorders • Immunology • Pediatrics • Transplantation

Haploidentical allogeneic haematopoietic stem cell transplantation for paroxysmal nocturnal haemoglobinuria: a retrospective analysis. (PubMed, Ann Hematol) - "Haplo-HSCT yields favorable outcomes and is a curative therapy for PNH, serving as a valuable option for severe bone marrow failure patients, with G-CSF/ATG-based haplo-HSCT as a promising alternative strategy."

Journal • Retrospective data • Acute Graft versus Host Disease • Aplastic Anemia • Bone Marrow Transplantation • Cardiovascular • Chronic Graft versus Host Disease • Complement-mediated Rare Disorders • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Paroxysmal Nocturnal Hemoglobinuria • Pulmonary Embolism • Respiratory Diseases • Transplantation

High ratio of resident to exhausted CD4 + T cells predicts favorable prognosis and potentially better immunotherapeutic efficacy in hepatocellular carcinoma. (PubMed, BMC Cancer) - "The ratio of resident to exhausted CD4 + T cells shows promise as a potential biomarker for HCC prognosis and immunotherapy response and SASS6 may serve as a biomarker and therapeutic target for prognostic assessment of HCC."

IO biomarker • Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Oncology • Solid Tumor • CD4 • CD8

Decreased cobalamin sensitivity and biological aging acceleration in the general population. (PubMed, J Nutr Health Aging) - "Decreased cobalamin sensitivity but not cobalamin insufficiency might be associated with biological aging acceleration. Further studies would improve understanding of the underlying mechanisms between decreased cobalamin sensitivity and biological aging acceleration."

Journal

"This @ImperialNHS @ImperialMed #CylowVas regimen is very effective - lower doses #CyP, 2 x #rituximab achieve excellent remission & v low relapse rates. #AASV #Vasculitis @stephenmcadoo @Profcpusey @megan_griffith1 @RealDr_Pepper @THKC1" (,@kidneydoc101)

Clinical