Humulin 70/30, Huminsulin 30/70 (isophane insulin 70% + recombinant human insulin 30%) / Eli Lilly - LARVOL DELTA

Insights into the Structural Coexistence of Hexameric States in Microcrystalline Insulin Formulations in the Solid State. (PubMed, Mol Pharm) - "Recombinant human insulin powder was compared with three commercial Neutral Protamine Hagedorn (NPH) crystalline suspensions: Humulin 70/30, Insugen 70/30, and NovoMix 30. The NovoMix 30 formulation (insulin aspart) exhibits further line broadening, consistent with increased lattice disorder introduced by the ProB28 → Asp substitution. These observations illustrate how solid-state NMR can resolve formulation-dependent conformational heterogeneity and provide structural support for biosimilarity evaluation in solid-state protein therapeutics."

Journal

Pharmacokinetic and pharmacodynamic equivalence of Biocon's biosimilar Insulin 70/30 with US-licensed Humulin® 70/30 formulation in healthy subjects: Results from the RHINE-3 (Recombinant Human INsulin Equivalence-3) study. (PubMed, Diabetes Obes Metab) - "PK/PD equivalence was demonstrated between Biocon's Insulin-70/30 and Humulin-70/30 in healthy subjects. Treatment with Biocon's Insulin-70/30 and Humulin-70/30 was well tolerated."

Journal • PK/PD data • Diabetes • Metabolic Disorders • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus

[VIRTUAL] Cost/waste analysis of insulin dispenses in a community hospital setting (ASHP 2020) - "The most frequently requested insulin was insulin aspart (Novolog) (43%), while NPH/ regular insulin (Humulin 70/30) was requested the least (4%). There were frequent requests to replace insulin vials on the nursing units which led to excessive pharmacy spending. A new process has been developed to dispense individual insulin doses from a secure bin in the automated dispensing cabinet. This new practice will decrease the amount of insulin waste, thus lowering the costs currently associated with the insulin management process."

Clinical • HEOR • Critical care