INT41 / Vybion - LARVOL DELTA

Sustained administration of the full and partial agonists of trace amine associated receptor 1 (TAAR1) induces different effects on the excitability of central monoaminergic neurons (CINP 2026) - "Since the burst-like, or phasic firing of 5-HT (Gartside et al Neuroscience 98:295, 2000) and dopaminergic (Cooper Neurochem Int 41:333, 2002) neurons results in increased release of corresponding neurotransmitter from the nerve terminals, the excitability mode of monoaminergic neurons was assessed. Chronic treatment with the full agonists of TAAR1 might have a robust stimulatory effect on the central dopaminergic neurotransmission. It may also stimulate 5-HT neurotransmission. Chronic treatment with the partial agonists of TAAR1 might have strong stimulatory effect on 5-HT, but they may have lesser effect on dopaminergic neurotransmission."

CNS Disorders

Estimated cost-savings from integrated care for HIV, diabetes and hypertension in sub-Saharan Africa: a cost-minimisation analysis. (PubMed, Glob Health Action) - "From a societal perspective, integrated care for participants with multiple conditions generated mean cost-savings of Int$41.54 (95%CI 29.42-53.67, p < 0.0001) per patient-visit. Integrated care is cost-saving from a societal perspective and should be considered for scale-up in Tanzania, Uganda and similar settings. ISRCTN43896688."

HEOR • Journal • Cardiovascular • Diabetes • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Metabolic Disorders

"Challenge accepted. I nominate @FJ_III @CoachDintz41 . Bigger than baseball! @AmericanCancer https://t.co/MhYhQktaZR" (,@jbasile281)

Oncology

[VIRTUAL] SCURVY IS PREVALENT IN PATIENTS PRESENTING WITH UPPER GASTROINTESTINAL BLEEDING AND PREDICTS INCREASED MORTALITY AND ADVERSE CLINICAL OUTCOMES: A PROSPECTIVE AUSTRALIAN COHORT STUDY (DDW 2021) - "No differences in ICU admission, transfusion requirements, LOS or AIMS65 score were noted.In non-variceal UGIB (n=123), VCD was associated with higher mortality (5.6% vs. 0%, p=0.03) and AEs (composite endpoint 41.7% vs. 24.1%, p=0.05)... VCD is prevalent in patients with UGIB and associated with significantly higher mortality and AEs. Further studies are required to determine the impact of early Vitamin C supplementation following UGIB."

Adverse events • Clinical • Clinical data • Critical care • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Novel Coronavirus Disease • Peptic Ulcer • Pneumonia • Respiratory Diseases • Septic Shock