AiSuTe (tegileridine) / Jiangsu Hengrui Pharma - LARVOL DELTA

Tegileridine vs. sufentanil for postoperative analgesia in general surgery: A prospective, randomized, controlled, non-inferiority trial. (PubMed, Br J Clin Pharmacol) - P1 | "Tegileridine provides non-inferior analgesia to sufentanil FOR PCIA after general surgery, with reduced PONV, faster gastrointestinal recovery and blunted stress response, supporting its potential role in enhanced recovery protocols."

Head-to-Head • Journal • Gastroenterology • Pain • IL6

Tegileridine versus Sufentanil for Postoperative Analgesia in Supratentorial Craniotomy: A Randomized Controlled Trial (ChiCTR) - P=N/A | N=110 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Soochow University; The First Affiliated Hospital of Soochow University

New trial

A Comparative Study of Postoperative Analgesic Efficacy Between Butorphanol and Tegileridine in Gynecological Laparoscopic Surgery: A Randomized Controlled Trial (ChiCTR) - P=N/A | N=180 | Not yet recruiting | Sponsor: Hainan Medical College First Affiliated Hospital; Hainan Medical College First Affiliated Hospital

New trial

Effect of Postoperative Tegileridine Patient-Controlled Intravenous Analgesia on Overall Analgesic Benefit in Elderly Patients Undergoing Major Open Abdominal Surgery: A Prospective, Randomized, Double-Blind, Parallel-Controlled Clinical Trial (ChiCTR) - P=N/A | N=248 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Soochow University; The First Affiliated Hospital of Soochow University

New trial • Pain

The effect of tegileridine on acute pain after total hysterectomy (ChiCTR) - P4 | N=90 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Nanjing Medical University; The First Affiliated Hospital of Nanjing Medical University

New P4 trial • Gynecology • Pain

A Study on the Efficacy Tegileridine Fumarate Injection in Combination with Adductor Canal Block for Postoperative Analgesia afler Total Knee Arthroplasty (ChiCTR) - P4 | N=58 | Recruiting | Sponsor: The Eighth Affiliated Hospital, SunYat-Sen University; The Eighth Affiliated Hospital, SunYat-Sen University

New P4 trial • Orthopedics

Comparing the effects of Tegileridine Fumarate and Sufentanil on brain electrical characteristics and postoperative recovery quality in patients undergoing hysteroscopic surgery (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: The First Hospital of Shanxi Medical University; The First Hospital of Shanxi Medical University

New trial

Biased μ-opioid receptor agonist tegileridine for postoperative analgesia after gynecologic laparoscopy or abdominal surgery: a prospective, double-blind, randomized controlled trial (ChiCTR) - P=N/A | N=124 | Not yet recruiting | Sponsor: Maternal and Child Health Hospital of Jiangxi Province; Maternal and Child Health Hospital of Jiangxi Province

New trial

Dose-response relationship of tegileridine in inhibiting propofol-induced responses to laryngeal mask airway insertion: A sequential trial (ChiCTR) - P=N/A | N=0 | Not yet recruiting | Sponsor: Lanzhou University Second Hospital; Lanzhou University Second Hospital

New trial

Establishing the Median Effective Dose of Tegileridine for Immediate Postoperative Analgesia Following Laparoscopic Colorectal Cancer Surgery: A Sequential Dose-Finding Study. (PubMed, Drug Des Devel Ther) - "This exploratory study provides a preliminary ED50 estimate for tegileridine in immediate post-LCRS analgesia within a multimodal regimen, with a favorable short-term safety profile. However, the wide CI limits these findings; larger studies are needed to validate dose-response relationships and better define clinically relevant effective doses."

Journal • Colorectal Cancer • Oncology • Pain • Solid Tumor

A Trial of Tegileridine Fumarate Lnjection for Prolonged Mechanical Ventilation Abirritation in the Intensive Care Unit (ICU) (clinicaltrials.gov) - P2 | N=121 | Completed | Sponsor: Jiangsu HengRui Medicine Co., Ltd. | Recruiting ➔ Completed

Trial completion • Critical care

Tegileridine for Pain Management Following Total Laparoscopic Hysterectomy: A Randomized Controlled Pilot Trial (ASA 2026) - "Abstract is embargoed at this time."

Clinical • Gynecology • Pain

Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery (clinicaltrials.gov) - P4 | N=152 | Recruiting | Sponsor: Xiangya Hospital of Central South University | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

ED90 of Tegileridine Combined With Propofol for LMA Insertion (clinicaltrials.gov) - P4 | N=109 | Completed | Sponsor: Shiyou Wei | Not yet recruiting ➔ Completed

Trial completion • Anesthesia

ED90 of Tegileridine for Suppressing Hemodynamic Response to Tracheal Intubation: A Biased Coin Up-and-Down Trial (clinicaltrials.gov) - P=N/A | N=108 | Not yet recruiting | Sponsor: Shiyou Wei

Intubation • New trial • Anesthesia

Interpreting Gastrointestinal Recovery After Tegileridine-Based PCIA in Elderly Colorectal Surgery Patients [Letter]. (PubMed, Drug Des Devel Ther) - No abstract available

Journal

ED90 of Tegileridine Combined With Propofol For Painless Gastroscopy (clinicaltrials.gov) - P4 | N=107 | Completed | Sponsor: Shiyou Wei | Not yet recruiting ➔ Completed

Trial completion • Anesthesia • Gastrointestinal Disorder

Effect of tegileridine pretreatment on fentanyl-induced cough during general anesthesia induction: a randomized controlled trial. (PubMed, Front Med (Lausanne)) - P=N/A | "Further active-comparator, dose-finding, and broader safety studies are required before routine clinical adoption. https://www.chictr.org.cn/searchproj.html, identifier: ChiCTR2500115512."

Clinical • Journal • Anesthesia • Cough • Respiratory Diseases

Tegileridine versus Sufentanil Patient-Controlled Intravenous Analgesia for Gastrointestinal Recovery in Elderly Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - "It was associated with better gastrointestinal recovery during the first three postoperative days and fewer adverse events. This regimen may be a safe and effective analgesic option in this population."

Clinical • Journal • Colorectal Cancer • Oncology • Pain • Solid Tumor

Evaluation of the efficacy and safety of tegileridine at different doses in patients with postoperative pain: a meta-analysis of randomized controlled trials. (PubMed, Front Pain Res (Lausanne)) - "This meta-analysis demonstrates that the efficacy of tegileridine was significantly superior to that of placebo, and it had a more favorable safety profile than morphine regarding nausea and vomiting, suggesting its potential as a viable alternative for postoperative acute pain. [https://www.crd.york.ac.uk/prospero/view/CRD420261364062/1/0], PROSPERO CRD420261364062."

Journal • Retrospective data • Review • CNS Disorders • Depression • Pain • Psychiatry

Effect of patient-controlled intravenous analgesia with tegileridine on postoperative pain and recovery after mastectomy (ChiCTR) - P4 | N=112 | Not yet recruiting | Sponsor: Foshan Nanhai District People's Hospital; Foshan Nanhai District People's Hospital

New P4 trial • Pain

Comparison of Analgesic Efficacy and Safety of Tegileridine and Sufentanil in High-Risk Postoperative Nausea and Vomiting (PONV) Patients Undergoing Laparoscopic Surgery: A Prospective Observational Cohort Study (ChiCTR) - P4 | N=800 | Not yet recruiting | Sponsor: The Second Affiliated Hospital of Zhejiang University School of Medicine; The Second Affiliated Hospital of Zhejiang University School of Medicine

New P4 trial

Oliceridine for Postoperative Analgesia in Elderly Abdominal Surgery Patients (ChiCTR) - P4 | N=248 | Not yet recruiting | Sponsor: Cangzhou Central Hosptial; Cangzhou Central Hosptial

New P4 trial

A Comparative Study of the Analgesic Efficacy and Safety of Tegileridine versus Morphine in a High-Risk PONV Population (ChiCTR) - P4 | N=240 | Not yet recruiting | Sponsor: Liyang People's Hospital; Liyang People's Hospital

New P4 trial

The effect of tegileridine on postoperative nausea and vomiting after laparoscopic cholecystectomy (ChiCTR) - P4 | N=182 | Not yet recruiting | Sponsor: The First Peoples Hospital of Lianyungang; The First Peoples Hospital of Lianyungang

New P4 trial