AiSuTe (tegileridine) / Jiangsu Hengrui Pharma - LARVOL DELTA

A Trial of Tegileridine Fumarate Lnjection for Prolonged Mechanical Ventilation Abirritation in the Intensive Care Unit (ICU) (clinicaltrials.gov) - P2 | N=120 | Recruiting | Sponsor: Jiangsu HengRui Medicine Co., Ltd. | Not yet recruiting ➔ Recruiting

Enrollment open • Critical care

EVALUATING ANALGESIC EFFICACY USING BUCHER AND ANCHORED MATCHING-ADJUSTED INDIRECT COMPARISON: A COMPARISON OF ANRIKEFON AND TEGILERIDINE (ISPOR 2026) - "OBJECTIVES: This study compared the analgesic efficacy of two innovative Chinese analgesics, Anrikefon (HSK21542) and Tegileridine (SHR8554), for postoperative abdominal pain to support clinical decision-making. This study employed two indirect treatment comparison (ITC) methods, the Bucher adjusted indirect comparison and the anchored matching-adjusted indirect comparison (MAIC) to evaluate treatment efficacy. Anrikefon and Tegileridine demonstrated similar analgesic efficacy, with Anrikefon showing a numerically favorable effect. By matching baseline characteristics, the MAIC offered more stable and less heterogeneous estimates. Therefore, in the absence of head-to-head trials, MAIC may serve as an complement and enhance the reliability of indirect comparisons."

Clinical • Pain

Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery (clinicaltrials.gov) - P4 | N=152 | Not yet recruiting | Sponsor: Xiangya Hospital of Central South University

New P4 trial • Pain

Effects of Tegileridine used for postoperative analgesia on the quality of postoperative recovery in elderly patients with colorectal tumors (ChiCTR) - P4 | N=92 | Not yet recruiting | Sponsor: Guangxi Medical University Cancer Hospital; Guangxi Medical University Cancer Hospital

New P4 trial • Colorectal Cancer • Solid Tumor

Comparison of Tegileridine with Sufentanil in Multimodal Analgesia for Postoperative Recovery in Gynecologic Open Surgery Under the ERAS Protocol (ChiCTR) - P4 | N=80 | Not yet recruiting | Sponsor: Guangxi Medical University Cancer Hospital; Guangxi Medical University Cancer Hospital

New P4 trial • Gynecologic Cancers

Efficacy and Safety of tegileridine combined with paravertebral block for postoperative pain management in gastric cancer patients (ChiCTR) - P4 | N=100 | Not yet recruiting | Sponsor: Fujian Medical University Union Hospital; Fujian Medical University Union Hospital

New P4 trial • Gastric Cancer • Oncology • Pain • Solid Tumor

Research on the Effects of the Novel Analgesic Tegileridine on Perioperative Neurocognitive Function and Its Mechanisms (ChiCTR) - P4 | N=474 | Not yet recruiting | Sponsor: Jiangsu Province People's Hospital; Jiangsu Province People's Hospital

New P4 trial • Alzheimer's Disease • Cognitive Disorders • Pain

A Comparative Study of Tegileridine Fumarate versus Sufentanil for Postoperative Analgesia Following Laparoscopic Total Hysterectomy: A Prospective, Randomized, Double-Blind, Controlled Clinical Trial Focusing on Quality of Recovery as the Primary Endpoint. (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Liaocheng Second People's Hospital; Liaocheng Second People's Hospital

New trial • Gynecology

Exploring the Safety and Efficacy of Tegileridine for Postoperative Analgesia in Elderly Patients Undergoing Hip Arthroplasty (ChiCTR) - P=N/A | N=226 | Not yet recruiting | Sponsor: The First Affiliated Hospital of University of Science and Technology of China; The First Affiliated Hospital of University of Science and Technology

New trial • Musculoskeletal Diseases • Orthopedics

The Effect of Tegileridine Fumarate Injection on Gastrointestinal Function After Laparoscopic Surgery:A Randomized Controlled Study (ChiCTR) - P=N/A | N=46 | Not yet recruiting | Sponsor: The Affiated Cancer Hospital of Guizhou Medical University; The Affiated Cancer Hospital of Guizhou Medical University

New trial

A Study on the Efficacy and Safety of Tegileridine Fumarate for Postoperative Analgesia after Thoracoscopic Surgery—A Single-Center, Double-Blind, Randomized Controlled Clinical Trial (ChiCTR) - P4 | N=60 | Not yet recruiting | Sponsor: Henan Provincial People's Hospital; Henan Provincial People's Hospital

New P4 trial • Pain

Tegileridine improves postoperative pain in patients undergoing day surgery for laparoscopic cholecystectomy: A randomized controlled trial (ChiCTR) - P4 | N=56 | Not yet recruiting | Sponsor: The Third People's Hospital Yibin; The Third People's Hospital Yibin

New P4 trial • Pain

The Efficacy and Safety of Tegileridine in Moderate to Severe Pain Management Following General Anesthesia in Elderly Total Hip Replacement Patients (ChiCTR) - P=N/A | N=182 | Recruiting | Sponsor: Huaihe Hospital of Henan University; Huaihe Hospital of Henan University

New trial • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain

The Effects of Tegileridine and Sufentanil on Postoperative Nausea and Vomiting in Female Patients Undergoing Laparoscopic Cholecystectomy under Multimodal Antiemetic Strategy: A Prospective, Randomized Controlled Study (ChiCTR) - P=N/A | N=148 | Not yet recruiting | Sponsor: West China Hospital, Sichuan University; West China Hospital, Sichuan University

New trial

The application effect of tegileridine in inhibiting laryngeal mask airway insertion response in elderly patients undergoing urological surgery (ChiCTR) - P=N/A | N=92 | Not yet recruiting | Sponsor: The First People’s Hospital of Lianyungang; The First People’s Hospital of Lianyungang

New trial • Cardiovascular • Hypertension

The effect of tegileridine fumarate on pain scores in patients undergoing laparoscopic total hysterectomy for postoperative pain management (ChiCTR) - P4 | N=16 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Soochow University; The First Affiliated Hospital of Soochow University

New P4 trial • Gynecology • Pain

Comparison of postoperative Analgesia given Sufentanil or Tegileridine in Laparoscopic Cholecystectomy, a prospective, randomized, controlled, blinded study (ChiCTR) - P4 | N=240 | Not yet recruiting | Sponsor: Puyang Oil Field General Hospital; Puyang Oil Field General Hospital

New P4 trial • Gastroenterology • Hepatology

Exploratory Study on the Efficacy of Tegileridine Combined with Butorphanol in Managing Moderate to Severe Postoperative Pain in Gynecological Laparoscopic Surgery Patients (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Chinese People's Liberation Army Northern Theater Command General Hospital; Chinese People's Liberation Army Northern Theater Command General Hospital

New trial • Pain

A Phase II, Multicenter, Randomized, single-Blind, Dose exploration, Positive Comparator Study to Evaluate the Efficacy and Safety of Tegileridine Fumarate lnjection for prolonged mechanical ventilation abirritation in the intensive care unit (ICU) (ChiCTR) - P2 | N=120 | Not yet recruiting | Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University o

New P2 trial • Critical care

Tegileridine Pretreatment for the Prevention of Fentanil-Induced Cough During Anesthesia Induction: A Clinical Study (ChiCTR) - P=N/A | N=210 | Not yet recruiting | Sponsor: Weifang People's Hospital; Weifang People's Hospital

New trial • Anesthesia • Cough • Respiratory Diseases

Effects of Tapentadol on Gastrointestinal Function Recovery in Patients After Lumbar Spine Surgery (ChiCTR) - P4 | N=134 | Not yet recruiting | Sponsor: Shunde Hospital, Guangzhou University of Chinese Medicine; Shunde Hospital, Guangzhou University of Chinese Medicine

New P4 trial • Anesthesia • Orthopedics • GAST

Efficacy and safety of tegileridine for postoperative analgesia in patients undergoing thoracoscopic lung resection (ChiCTR) - P=N/A | N=144 | Not yet recruiting | Sponsor: Nanjing Drum Tower Hospital Group Suqian Hospital; Nanjing Drum Tower Hospital Group Suqian Hospital

New trial

Tegileridine Pretreatment for the Prevention of Sufentanil-Induced Cough During Anesthesia Induction: A Clinical Study (ChiCTR) - P=N/A | N=204 | Completed | Sponsor: Yan‘an Hospital of Kunming City; Yan‘an Hospital of Kunming City

New trial • Anesthesia • Cough • Respiratory Diseases

A Comparative Evaluation of the Safety and Efficacy of Tegileridine and Sufentanil in Gastrointestinal Endoscopy: A Single-Center, Randomized Controlled Trial. (ChiCTR) - P4 | N=676 | Not yet recruiting | Sponsor: Xiangyang Central Hospital; Xiangyang Central Hospital

New P4 trial • Gastroenterology • Gastrointestinal Disorder

Effect of tegileridine fumarate injection on gastrointestinal function recovery after laparoscopic myomectomy: a single-center, randomized, double-blind, positive controlled study (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Chengdu Second People’s Hospital; Chengdu Second People’s Hospital

New trial • Uterine Leiomyoma