amphetamine / Generic mfg. - LARVOL DELTA

Hippocampal perineuronal net degradation identifies prefrontal and striatal circuits involved in schizophrenia-like changes in marmosets. (PubMed, Sci Adv) - "Behaviorally, activity was elevated in a marmoset version of the amphetamine-induced activity test, and impaired probabilistic discrimination learning was seen in an OFC/striatum-dependent task that computational modeling suggests was due to loss of goal-directed behavior. Together, these findings demonstrate that a loss of primate aHipp PNNs is sufficient to induce striatal and prefrontal dysfunction consistent with that observed in humans with schizophrenia."

Journal • CNS Disorders • Psychiatry • Schizophrenia

Synergistic Cardiotoxic Effects of Captagon and Azithromycin in Rat via Oxidative stress, Apoptosis and Upregulation of the PI3K/AKT/NF-kB pathway. (PubMed, Toxicol Lett) - "Fenethylline (Captagon) is a blend of amphetamine and theophylline that functions as a stimulant, while azithromycin (AZ) is a commonly prescribed macrolide antibiotic. Coadministration of AZ and Capta induced cardiotoxicity through oxidative stress, inflammation, and apoptosis pathways. It is important to educate healthcare providers and patients about the potential harmful interactions."

IO biomarker • Journal • Preclinical • Cardiovascular • Inflammation • BAX • BCL2 • CASP3 • CAT • IL1B • IL6 • TNFA

Infective Endocarditis in People Who Inject Drugs-A 5-Year Follow-up: "I've Seen the Needle and the Damage Done". (PubMed, Open Forum Infect Dis) - "Buprenorphine and amphetamine or other stimulant were the most used substances among PWID...Long-term survival of PWID with IE is poor, and they are at increased risk of a new IE episode as compared with non-PWID with community-acquired IE. More efforts in the treatment of addiction are needed."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Psychiatry • Substance Abuse

DEMOGRAPHIC PROFILE, SUBSTANCE USE TRENDS AND ASSOCIATED PSYCHOTIC DISORDERS AMONG VETERANS WITH MENTAL HEALTH CONDITIONS: A RETROSPECTIVE COHORT STUDY OF US VETERANS. (PubMed, ASEAN J Psychiatry) - "In general, substances use was significantly higher, and amphetamines were most used, followed by cannabis codeine, morphine, cocaine, barbiturates, fentanyl, and PCP among veterans with MHC. Psychosis was associated with higher rates of hospitalization, suicide attempts, and suicide death. Among US Veterans with MHC, amphetamine was most used substance associated with higher rates of psychotic disorders, hospitalization, suicide attempts, and death."

Journal • Retrospective data • Bipolar Disorder • CNS Disorders • Depression • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry

Accumbal Dopamine and Acetylcholine Dynamics during Psychostimulant Sensitization. (PubMed, bioRxiv) - "Here, we used dual-color fiber photometry to simultaneously measure DA and ACh in the NAcc shell of mice across repeated injections of cocaine or amphetamine...Despite this lack of sensitization in underlying neuromodulator signaling, the KO mice nevertheless exhibited behavioral sensitization, though at a slower rate than wild-type. These findings suggest that neural sensitization to psychostimulants is dependent on D2R expressed on CINs, but that behavioral sensitization is not dependent on sensitization of these underlying signals."

Journal • CNS Disorders • Psychiatry

Translational Evidence for Dopaminergic Rewiring of the Basal Ganglia in Persons with Schizophrenia. (PubMed, medRxiv) - "1) task-state and resting-state functional connectivity (FC) between dorsal caudate (DCa) and globus pallidus externus (GPe), 2) NM-MRI contrast ratio in substantia nigra voxels associated with psychotic symptom severity, and 3) baseline and amphetamine-induced change in [ 11 C]-(+)-PHNO binding potential in DCa...This phenotype was associated with worse task performance and measures of subcortical dopamine function obtained via neuromelanin-sensitive magnetic resonance imaging and [ 11 C]-(+)-PHNO positron emission tomography. Meaning: This study provides in-vivo evidence that dopaminergic rewiring of the basal ganglia may be a neurodevelopmental mechanism for working memory deficits in schizophrenia, emulating findings from a transgenic mouse model of striatal dopamine dysfunction."

Journal • CNS Disorders • Cognitive Disorders • Psychiatry • Schizophrenia

Nickel-Catalyzed Umpolung Difluoroalkylation of Imines Enables General Access to β-Difluoroalkylated Amines. (PubMed, Angew Chem Int Ed Engl) - "This approach is characterized by its high efficiency, broad substrate scope, high functional group tolerance, and ease of synthesis. The rapid modification of bioactive molecules by the efficient synthesis of difluorinated analogs of key amine moieties present in bioactive molecules, including amphetamine, using the current approach shows the promising potential of this protocol in advancing drug discovery and development."

Journal

Amphetamines: a current epidemic. (PubMed, Front Psychiatry) - No abstract available

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder. (PubMed, EMBO J) - "Treatment with amphetamine or methylphenidate, which are commonly used to treat ADHD, reverses the hyperactivity observed in mice with SELENOT-deficient dopaminergic neurons. Our study demonstrates that SELENOT in mouse dopaminergic neurons maintains proper dopamine signaling in the midbrain against the development of ADHD-like behaviors."

Journal • Preclinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Cognitive Disorders • Mental Retardation • Psychiatry • NR4A2

Cocaine- and amphetamine-regulated transcript (CART) peptide-positive neuron populations in the enteric nervous system of the porcine descending colon depend on age and gender. (PubMed, PLoS One) - "The obtained results suggest that CART in the ENS takes part in neuroplasticity processes occurring during the development, maturation and/or aging of the gastrointestinal tract, as well as that the number of CART-positive neurons is controlled by sex hormones and depends on the gender. However, the elucidation of all aspects connected with the influence of age and gender on the population of CART-positive neurons in the ENS requires further comprehensive studies."

Journal • Preclinical • Gastrointestinal Disorder

Psychoactive substance use in elderly patients: Insights from the addiction in intensive cardiac care units (ADDICT-ICCU) study. (PubMed, Arch Cardiovasc Dis) - "This study highlights the significant prevalence of psychoactive substance use among a large cohort of elderly patients hospitalized in ICCUs. Differential patterns of substance use were observed in elderly and younger patients."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Psychiatry

Sudden unexpected death due to B-cell acute lymphocytic leukaemia (B-ALL) in a 3-year-old child. (PubMed, Forensic Sci Med Pathol) - "Toxicological investigations revealed positive findings of morphine (53.3 ng/ml), as well as amphetamine and THC in femoral blood, respectively, in hair samples. This paper discusses the medicolegal implications of the case (omitted duty of care by the parents)."

Journal • Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • Cough • Fatigue • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Oncology • Pneumonia • Pulmonary Disease • Respiratory Diseases

The psychostimulant drug, fenethylline (captagon): Health risks, addiction and the global impact of illicit trade. (PubMed, Drug Alcohol Depend Rep) - "Fenethylline (street name, captagon) is a synthetic amphetamine-type stimulant that is emerging as a significant public health and security concern, particularly in the Middle East...Strategies such as improved surveillance, public health interventions, and international cooperation are essential to mitigate its escalating risks. Addressing this issue requires a multidisciplinary approach, integrating public health, law enforcement, and policy development to curb its impact on global health and security."

Journal • Review • Cardiovascular • CNS Disorders • Psychiatry

Neurobehavioral Disorders and Cognitive Impairment in Methcathinone Exposure: A Systematic Review of Literature. (PubMed, Curr Neuropharmacol) - "This study concludes that methcathinone poses severe risks, including neurotoxicity for users and developmental harm for offspring, necessitating ongoing research to comprehend associated risks and inform public health interventions."

Journal • Alzheimer's Disease • Behavior Disorders • CNS Disorders • Cognitive Disorders • Mental Retardation • Psychiatry • Vascular Neurology

EHR Trends in First-Time ADHD Diagnoses and Amphetamine Prescriptions Across Age Groups (2021-2024) (ISPOR 2025) - "We observed increases in first-time ADHD diagnoses and amphetamine prescriptions amongst adult populations. These findings highlight the need for further research to understand the drivers behind these trends and their implications for healthcare delivery and public health."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Risks and Benefits of Prescription Stimulants in Older Adults: A Scoping Review (ISPOR 2025) - "Electronically available literature published through March 2024 that documented identifiable efficacy and/or safety outcomes related to prescription amphetamine and/or methylphenidate use among people aged ≥65 years were considered for inclusion. Many studies showed potential benefit of prescription stimulant use in older adults, however, some demonstrated potential risks. Further research is warranted to establish comprehensive guidelines for safe prescribing practices in this population."

Clinical • Review • ADHD (Impulsive Aggression) • Alzheimer's Disease • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Cognitive Disorders • Dementia • Depression • Fatigue • Gastrointestinal Disorder • Insomnia • Mood Disorders • Movement Disorders • Narcolepsy • Oncology • Parkinson's Disease • Psychiatry • Sleep Disorder

Prevalence Trends and Patterns of Perinatal ADHD Stimulant Medication Use in British Columbia, Canada. (PubMed, Pharmacoepidemiol Drug Saf) - "The 11-fold increase in ADHD stimulant medication use during pregnancy and the high rate of discontinuation highlight the need for more research on the risks and benefits of medication for parent and child health."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Hypertension • Psychiatry

Prevalence of the Prescribing of Attention-Deficit Hyperactivity Disorder Medication During Pregnancy: A Systematic Review. (PubMed, J Psychoactive Drugs) - "The most prevalent ADHD medication dispensed during pregnancy was methylphenidate followed by amphetamine-type medications. The prevalence of the prescribing of ADHD medications in pregnancy ranged substantially, with psychostimulant medications most prescribed. Apart from in the Nordic countries, estimates of prevalence were limited."

Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Amphetamine-Induced Psychosis Leading To Homicide, Suicidal Attempts, And Disorientation: A Case Report. (PubMed, J Ayub Med Coll Abbottabad) - "Management was immediate and involved sedation, antipsychotic therapy and cardiovascular support, followed by long term psychiatric care and substance abuse rehabilitation. Here, chronic amphetamine abuse is shown to have profound psychiatric and behavioral effects and to require integrated treatment strategies to meet the complex needs of such patients."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Psychiatry • Substance Abuse • Suicidal Ideation

Evaluating The Efficacy Of Cognitive Behavioural Therapy For Amphetamine Use Disorder: Impact Of Socio-Demographic And Behavioural Factors In Pakistan. (PubMed, J Ayub Med Coll Abbottabad) - "Both the effectiveness of CBT and its suitability to reduce amphetamine use, enhance psychological wellbeing, and improve quality of life among individuals with AUD in Pakistan were demonstrated. The significance of incorporating social demographic factors, and behavioural factors in the development of CBT interventions to ensure maximal treatment effect is underscored."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Cognitive Disorders • Depression • Mood Disorders • Psychiatry

Underreporting of synthetic cathinone poisoning with clinical immunoassays: an experimental and observational study. (PubMed, Ann Clin Biochem) - "This study demonstrates that SC intoxication may be underreported in immunoassay toxicology testing and should always be confirmed by specific mass spectrometry methods."

Journal • Observational data

Profile of cocaine and amphetamine regulated transcript peptide (CARTp) and Corticotropin-releasing factor (CRF) in the brain of Euphlyctis cyanophlyctis during puddle desiccation. (PubMed, Neuropeptides) - "Puddle desiccation induced increase in the expression of CARTp and CRF peptide in the neuroendocrine axis may suggest their involvement in environmental stress induced accelerated metamorphosis. Moreover, elevated expression of CARTp but not CRF peptide in regions regulating energy homeostasis may indicate starvation due to scarcity of food or stress induced appetite suppression."

Journal

Comparison of Insomnia, Depression, and Perceived Social Support among Individuals with Amphetamine Use Disorder (AUD) and Healthy Controls. (PubMed, Alpha Psychiatry) - "Individuals with AUD additionally suffer from insomnia and depression, along with lower perceived social support. Given that standardized intervention programs for insomnia, depression and social competencies exist, such interventions might mitigate mental health issues among individuals with AUD and improve their psychosocial behavior."

Journal • CNS Disorders • Depression • Insomnia • Mood Disorders • Psychiatry • Sleep Disorder • Substance Abuse

Prescription Stimulant Use, Misuse, and Use Disorder Among US Adults Aged 18 to 64 Years. (PubMed, JAMA Psychiatry) - "To examine (1) sex- and age-specific trends in the number of persons dispensed stimulants and trends in dispensed prescription stimulants by prescriber specialty in 2019 through 2022; (2) prevalence of misuse and PSUD by use of prescription amphetamine-type stimulants (hereafter referred to as amphetamines) and methylphenidate; and (3) PSUD prevalence and sociodemographic and behavioral health correlates among persons using prescription stimulants with and without prescription stimulant misuse. High prevalence of prescription stimulant misuse and PSUD (regardless of misuse status) suggests the importance of ensuring clinically appropriate use and of screening for and treating PSUD among all adults prescribed stimulants, especially those using amphetamines. Findings may suggest potential progress in addressing the mental health care gap for middle-aged women and the need for evidence-based clinical guidance and training on benefits and risks of prescription stimulants for..."

Journal

Amphetamine Induced Group I Pulmonary Hypertension: A Case Report of Unforseen Consequences (ATS 2025) - No abstract available

Case report • Clinical • Cardiovascular • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases