amphetamine / Generic mfg. - LARVOL DELTA

A Wireless Wearable Platform for Intravenous Drug Self-Administration in Freely Behaving Rats. (PubMed, bioRxiv) - "By measuring spontaneous locomotion, amphetamine-induced hyperlocomotion and food-reinforced operant responding, we show that WEARIT leaves these behaviors unchanged. Remotely triggered fentanyl infusions yielded reliable delivery with physiological responses confirmed by pulse oximetry, and self-administration acquisition and dose-response functions were comparable to conventional tethered systems. WEARIT removes a longstanding constraint on intravenous pharmacology, opening self-administration paradigms to naturalistic and enriched environments and to concurrent imaging or optogenetic manipulation of the circuits engaged by drug reinforcement."

Journal • Preclinical

Substance cravings, readiness to change, and perceived social support as determinants of treatment motivation for amphetamine-type stimulant use disorder among youths in malaysian rehabilitation centers. (PubMed, Drug Alcohol Depend Rep) - "Furthermore, because age of substance initiation emerged as a key predictor, early prevention programs targeting younger demographics are crucial. Comprehensively addressing these determinants will significantly enhance both preventative efforts and long-term rehabilitation outcomes."

Journal

Advantages and limitations of a programmable sampling unit combined with PDMS passive samplers and TD-GC-MS for detection of amphetamine production waste discharges in the sewage system. (PubMed, Forensic Sci Int) - "Furthermore, event-triggered sampling was enabled via continuous pH measurements due to the often extreme pH values of amphetamine production waste. In addition, the detection of synthesis markers from production waste discharges by direct wastewater sampling in the sewage line with polydimethylsiloxane rods was tested."

Journal

Serotonergic psychedelics and amphetamine shift male rat ultrasonic vocalizations toward call patterns associated with positively valenced states. (PubMed, Prog Neuropsychopharmacol Biol Psychiatry) - "Serotonergic psychedelics, lisuride, and amphetamine alter rat ultrasonic vocalizations and may shift vocal repertoires toward patterns associated with positively valenced states. USV profiles did not parallel HTR and should be viewed as a complementary affective readout rather than a substitute marker of psychedelic-like activity."

Journal • Preclinical

Paternal lactational overnutrition induces sex-dependent hypothalamic neuropeptide programming in offspring. (PubMed, Neuropeptides) - "In adulthood, hypothalamic mRNA expression of the orexigenic neuropeptides neuropeptide Y (NPY) and agouti-related peptide (AgRP) and the anorexigenic neuropeptides proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART), as well as plasma leptin concentrations and food intake, were evaluated...These findings demonstrate that paternal obesity induced by lactational overnutrition is associated with sex-dependent neuroendocrine programming in the next generation, characterized by coordinated remodeling of hypothalamic orexigenic and anorexigenic neuropeptide pathways. This hypothalamic neuropeptide remodeling may contribute to the altered feeding phenotype observed in male offspring and represents a potential central target of paternal metabolic programming."

Journal • Genetic Disorders • Hypothalamic Injury-associated Obesity • Obesity • POMC-null Obesity • LEP

Stimulating Conversation: A Case Report of Extensive Dental Erosions With Medical Use of Amphetamine Salts. (PubMed, Gerodontology) - "This case highlights potential oral health risks with prescription stimulant use in the geriatric population for dental provider awareness."

Journal • Geriatric Disorders

Trauma exposure, acculturation stress, and tobacco, alcohol, cannabis, and amphetamine-type stimulant use among Syrian-origin adolescents under temporary protection in Türkiye: a 12-month longitudinal mediation analysis. (PubMed, Am J Drug Alcohol Abuse) - "Each 1-SD baseline CTQ increase raised odds of any past-month use at follow-up (total effect OR = 2.69, 95% CI 2.13-3.40); the direct effect was OR = 2.04 (95% CI 1.61-2.58), and acculturation stress mediated 28% (indirect OR = 1.32, 95% CI 1.18-1.49). Substance use among displaced Syrian-origin adolescents was elevated, persistent, and age-concentrated. Pediatric and school health services can embed brief, bilingual, trauma-informed screening into routine visits and link identified adolescents - particularly those aged 16-18 years - to confidential, low-threshold referral pathways."

Journal • Mood Disorders • Pediatrics

The Relationship of Postearthquake Trauma With Risk Perception and Substance Use in Southeast Turkey. (PubMed, Int J Addctn Nurs) - "These findings highlight the role of addiction and mental health nurses in identifying at-risk individuals and providing trauma-sensitive care after disasters. Incorporating addiction nursing approaches into disaster protocols can improve health outcomes and reduce maladaptive coping."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry • Sleep Disorder

Cocaine, cannabis, champagne-pharmacological and toxicological references in the lyrics of the German rapper Haftbefehl: a content analysis. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "References to μ-opioid receptor agonists (9.1%) and amphetamine-type substances (7.4%) were less prominent, while there were no references to benzodiazepines...In conclusion, psychotropic substances constitute a prominent stylistic element in Haftbefehl's oeuvre. These findings point to the importance of rap lyrics as a cultural medium that may reflect and shape the approach to drug-related content within music-related youth culture."

Journal

Fentanyl in forensic autopsies: Trends, circumstances, and toxicological findings. (PubMed, Int J Legal Med) - "A structured, variable-based classification framework can meaningfully stratify postmortem fentanyl cases by exposure context using routinely available autopsy data. Systematic contextual assessment should be a standard component of medicolegal fentanyl investigation across diverse forensic settings."

Journal

Hyperdopaminergic States Bias Explorations-Exploitation Trade-Off in Foraging and Impair Survival. (PubMed, Eur J Neurosci) - "Amphetamine treatment during the post-learning phase, but not during learning, impaired survival, indicating that exploration-exploitation bias after learning, rather than impaired learning, accounts for the observed phenotype. Moreover, DATfmn flies showed increased exploratory activity and reduced exploitation of known food sources. These results demonstrate that hyperdopaminergic state disrupts the balance between exploration and exploitation, thereby compromising survival under conditions of limited energy availability."

Journal

Evaluation of a Mass Media Educational Campaign to Increase Secondary School Students' Awareness of Health Risks of Khat Chewing: A Quasi-Experimental Pre-Post Study in Aden, Yemen. (PubMed, Med Sci Monit) - "BACKGROUND Khat is a green leaf with amphetamine-like effects...CONCLUSIONS The customized educational program improved awareness of AHRKC among secondary school students. Age, pocket money, and message exposure frequency were among the factors that influenced the observed program outcomes."

Journal

Pharmacological and non-pharmacological modulation of striatal dopamine release: a meta-analysis of [11C]raclopride PET studies. (PubMed, Mol Psychiatry) - "To address this gap, in this meta-analysis of 92 [11C]raclopride PET studies (n = 1640), we compared the magnitude and regional distribution of dopamine release induced by amphetamine, methylphenidate, ketamine, alcohol, and cognitive challenges with and without reward. They also suggest that [¹¹C]raclopride PET may have limited sensitivity for distinguishing reward-related from non-reward-related dopamine release. These findings have implications for the design and interpretation of future neuroimaging studies of dopaminergic function in health and disease."

Journal • Retrospective data • Review

SIRI, SII, and PNI in psychiatric patients with positive urinary drug metabolites: association with immune and nutritional biomarkers. (PubMed, BMC Psychiatry) - "Differences in SIRI and PNI were observed between psychiatric patients and healthy controls. However, these differences were not consistent across diagnostic and substance-use subgroups, and some associations were attenuated after adjustment for age and sex. These findings indicate variability in inflammatory and immunonutritional indices across psychiatric and substance-use subgroups and warrant further investigation."

Biomarker • Journal • Retrospective data • CNS Disorders • Hematological Disorders • Immunology • Inflammation • Mental Retardation • Psychiatry • Schizophrenia • Systemic Inflammatory Response Syndrome

Pharmacotherapies for Co-Occurring Stimulant Use Disorder and Attention-Deficit/Hyperactivity Disorder: A Network Meta-Analysis. (PubMed, J Clin Psychiatry) - "Pharmacotherapies included methylphenidate (MPH), mixed amphetamine salt (MAS), and bupropion. Stimulant-based pharmacotherapies, particularly higher-dose MPH and MAS, were associated with superior outcomes for both stimulant-use indicators and ADHD symptoms. These findings support consideration of optimized stimulant dosing when treating co-occurring StUD and ADHD, though further trials are warranted to refine clinical recommendations."

Clinical • Journal • Retrospective data • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Understanding and addressing bias in neonatal drug screening practices. (PubMed, J Neonatal Perinatal Med) - "Amphetamine (36.8%) and cannabinoid (38.6%) accounted for the majority of positive substances...However, the proportion of patients screened in the study does not reflect the proportion of patients within each race and ethnicity found among the birthing population. The majority (97.8%) of drug screens obtained did not include documentation of parental consent.ConclusionsSystemic changes need to be made to ensure equitable screening protocols exist for neonatal drug screens as well as ensure parental consent and knowledge of screening results is documented."

Journal

Dual-ionization GC-Orbitrap HRMS workflow for screening, confirmation, and quantitation of selected psychoactive substances including novel psychoactive substances. (PubMed, Eur J Mass Spectrom (Chichester)) - "The method demonstrated consistent performance for selected classes representing amphetamine-type stimulants, synthetic cathinones, and phenethylamine derivatives, with reproducible fragmentation patterns and acceptable matrix effects...Application to spiked forensic powder matrices confirmed the robustness and reliability of the workflow. This dual-ionization GC-Orbitrap HRMS strategy enhances confirmatory capability by combining fragmentation-based identification with molecular ion preservation, providing a robust and complementary approach for the analysis of emerging NPS and demonstrating the utility of dual-ionization strategies for forensic drug analysis."

Journal

Biofeedback for Attention Deficit and Hyperactivity Disorder in children: A pilot study of a multimodal approach of respiratory biofeedback to improve functional impact. (PubMed, Encephale) - "Treatments mainly include psychotherapy and amphetamine derivative-based pharmacotherapy...However, treatment effects, permanence and acceptability need to be assessed in larger and longer cohort studies. Thus, a multimodal biofeedback approach based on respiratory feedback is an innovative preliminary but promising emerging perspective for children presenting ADHD."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Developmental Disorders • Pediatrics • Psychiatry

A Rare Case of Amphetamine-Induced Acute Pancreatitis (ACG 2026) - "Laboratory values on presentation Figure: Figure. CT abdomen and pelvis without contrast demonstrating acute pancreatitis"

Clinical • Bipolar Disorder • Cardiovascular • CNS Disorders • Diabetes • Gastroenterology • Gestational Diabetes • Metabolic Disorders • Mood Disorders • Pancreatitis

Opioid Use Disorder Among Patients With Early-Onset Colorectal Cancer: Prevalence, Trends, and Associated Outcomes in the United States (ACG 2026) - "OUD was strongly associated with polysubstance use disorders (52% vs 21%; OR 3.9; P< 0.001), including cocaine, amphetamine, alcohol, tobacco, and cannabis use... Among 623,680 hospitalizations with EOCRC, 24,685 (4%) had concurrent OUD. OUD prevalence remained relatively stable from 2019â2023, with a modest but significant temporal trend (P-trend< 0.001). Patients with OUD were more commonly White (68%), male (52%), with a mean age of 46 years."

Clinical • Acute Kidney Injury • Addiction (Opioid and Alcohol) • Chronic Obstructive Pulmonary Disease • Colorectal Cancer • Immunology • Infectious Disease • Nephrology • Oncology • Renal Disease • Respiratory Diseases • Septic Shock • Solid Tumor • Substance Abuse • Thrombocytopenia

Prescription Stimulant Therapy and Risk of Constipation in Adults With ADHD: A Propensity-Matched Multicenter Cohort Study (ACG 2026) - "The stimulant cohort included patients receiving amphetamine or amphetamine-like stimulants, excluding prior stimulant exposure and non-stimulant ADHD medication exposure. The non-stimulant cohort included patients receiving atomoxetine, guanfacine, clonidine, or viloxazine, excluding prior non-stimulant exposure and stimulant exposure... After matching, 36,501 patients were included in each cohort. At 1 year, constipation occurred in 617/33,224 stimulant users versus 832/32,541 non-stimulant users (1.9% vs 2.6%; RR 0.726, 95% CI 0.655â0.805; p< 0.001). Stimulant therapy was also associated with lower laxative/constipation medication use (5.3% vs 5.8%; RR 0.916, 95% CI 0.857â0.980; p=0.011) and ileus risk (0.04% vs 0.10%; RR 0.371, 95% CI 0.196â0.701; p=0.001)."

Clinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Psychiatry

Hepatic stearoyl-CoA desaturase 1 suppresses diet-induced hyperphagia and hepatic lipid accumulation through PPARα activation and ketone body signaling. (PubMed, J Biol Chem) - "These effects were accompanied by reduced agouti-related peptide (agrp) expression and increased cocaine- and amphetamine-regulated transcript (cart) and gonadotropin-releasing hormone 2 (gnrh2) expression...Moreover, hepatic scd1 overexpression increased hepatic 3-hydroxy-3-methylglutaryl-CoA synthase 2 (hmgcs2) mRNA expression and elevated β-hydroxybutyrate and acetoacetate levels in both the liver and brain, accompanied by reduced brain AMPKα phosphorylation. Together, these findings identify hepatic SCD1 as a metabolic regulator that suppresses HFD-induced hyperphagia and lipid accumulation, involving lipid-derived PPARα signaling and ketone body-mediated brain energy sensing."

Journal • Metabolic Disorders • Solid Tumor • HMGCS2 • PPARA • SCD

Guidelines for Prevention and Management of Complications of Injection Drug Use- A WikiGuidelines Group Consensus Statement. (PubMed, Am J Med) - "Patients with stimulant use disorder, specifically amphetamine use disorder, should be offered mirtazapine. Further, patients who inject drugs with hepatitis C should be offered treatment, which can be completed in a variety of low-barrier settings. Several other questions did not meet the threshold for clear recommendations; and therefore, clinical reviews are offered instead."

Journal • Review • Hepatitis C • Infectious Disease • Inflammation • Psychiatry • Substance Abuse

Transient receptor potential ankyrin 1 ion channels may control stress adaptation and conditioned fear responses in male mice following footshock. (PubMed, Brain Behav Immun) - "In the EWcp, TRPA1 may modulate trauma-induced neuropeptide cocktail composition. Through influencing astrocyte-microglia interaction, TRPA1 may regulate neuroinflammation in stress-responsive brain areas. Moreover, TRPA1 may diminish fear generalization and promote durable fear extinction."

Journal • Preclinical • Inflammation • Mood Disorders • Oncology • TNFA • TRPA1

Updates in treatment strategies in ADHD (WFSBP 2026) - "Lisdexamfetamine, a prodrug cleaved gradually by red blood cell enzymes, provides smoother pharmacokinetics and lower abuse potential due to slower peak concentrations...OROS-methylphenidate mimics twice-daily dosing through osmotic release, while transdermal methylphenidate bypasses first-pass metabolism and reduces appetite suppression. Serdexmethylphenidate and ion-exchange amphetamine preparations further improve duration and plasma stability...These mechanisms may improve emotional dysregulation and provide faster onset than atomoxetine...Investigational therapies include centanafadine, a triple DAT-NET-SERT inhibitor targeting emotional dysregulation; TAAR-1 agonists, which modulate dopamine and glutamate signaling; and metadoxine extended release, which restores GABA-glutamate balance and may preferentially benefit inattentive ADHD...DAT1 and SERT polymorphisms may predict stimulant or serotonergic treatment response, while COMT Val158Met variants influence..."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Mood Disorders • Psychiatry • Tic Disorders • Tourette Syndrome • COMT