SARS-CoV-2 targeting recombinant methioninase / AntiCancer - LARVOL DELTA

The Role of Viral Infections in the Immunopathogenesis of Type 1 Diabetes Mellitus: A Narrative Review. (PubMed, Biology (Basel)) - "Other viruses-such as mumps, rubella, rotavirus, influenza A (H1N1), and SARS-CoV-2-have been investigated for their potential involvement through direct cytotoxic effects, immune activation, or molecular mimicry...Although definitive causality remains unconfirmed, the complex interplay between genetic predisposition, immune responses, and viral exposure underscores the need for further mechanistic research. Elucidating these pathways may inform future strategies for targeted prevention, early detection, and vaccine or antiviral development in at-risk populations."

Journal • Review • Cytomegalovirus Infection • Diabetes • Herpes Zoster • Immunology • Infectious Disease • Influenza • Metabolic Disorders • Mumps • Novel Coronavirus Disease • Respiratory Diseases • Rotavirus Infections • Rubella • Type 1 Diabetes Mellitus • Varicella Zoster

CovEpiAb: a comprehensive database and analysis resource for immune epitopes and antibodies of human coronaviruses. (PubMed, Brief Bioinform) - "Coronaviruses have threatened humans repeatedly, especially COVID-19 caused by SARS-CoV-2, which has posed a substantial threat to global public health...In addition, we developed an integrated pipeline for epitope prediction named COVEP, which is available from the webpage of CovEpiAb. CovEpiAb is freely accessible at https://pgx.zju.edu.cn/covepiab/."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Immunogenicity assessment of elder hepatocellular carcinoma patients after inactivated whole-virion SARS-CoV-2 vaccination. (PubMed, Expert Rev Vaccines) - "This study aimed to investigate the efficacy and influencing factors of inactivated SARS-CoV-2 vaccine in elder HCC. Our findings highlight the booster effect and protective role of 3 dose. Our results could provide a theoretical foundation for informing decisions regarding SARS-CoV-2 vaccination in elder HCC."

Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Infectious Disease • Novel Coronavirus Disease • Oncology • Respiratory Diseases • Solid Tumor

The role of SARS-CoV-2-mediated NF-κB activation in COVID-19 patients. (PubMed, Hypertens Res) - "A favorable prognosis is linked with timely treatment with NF-κB activation inhibitors, such as TNFα, IL-1β, and IL-6 monoclonal antibodies. However, further clinical researches are still required to clarify the time window, dosage of administration, contraindication, and potential side effects of these drugs, particularly for COVID-19 patients with hypertension, hyperglycemia, diabetes, or other chronic diseases."

Journal • Review • Cardiovascular • Diabetes • Hypertension • Infectious Disease • Inflammation • Metabolic Disorders • Novel Coronavirus Disease • Respiratory Diseases • IL1B • IL6 • TNFA

Letter to Editor "Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs": Important concerns on the validity of this article. (PubMed, Food Chem Toxicol) - No abstract available

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Antibody response to SARS-CoV-2 WT and Omicron BA.4/5 of inactivated COVID-19 vaccine in patients with lung cancer after second and booster immunization. (PubMed, J Hematol Oncol) - "Specifically, total B cells, CD4T cells and CD8T counts were correlated with the humoral response. These results should be taken into consideration for the elderly patients under treatment."

Journal • Infectious Disease • Lung Cancer • Novel Coronavirus Disease • Oncology • Respiratory Diseases • Solid Tumor

Scientific Integrity Requires Publishing Rebuttals and Retracting Problematic Papers. (PubMed, Stem Cell Rev Rep) - "entitled "Innate immunosuppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs" was published in Food and Chemical Toxicology (FCT)...Fighting the spread of false information requires enormous effort while receiving little or no credit for this necessary work, which often even ends up being threatened. This need for more scientific integrity is at the heart of our advocacy, and we call for large support, especially from editors and publishers, to fight more effectively against deadly disinformation."

Journal • Infectious Disease • Novel Coronavirus Disease • Oncology • Respiratory Diseases

Structure-guided pharmacophore based virtual screening, docking, and molecular dynamics to discover repurposed drugs as novel inhibitors against endoribonuclease Nsp15 of SARS-CoV-2. (PubMed, J Biomol Struct Dyn) - "Next, to revalidate the MD simulation studies, we have calculated the binding free energy of each complex using the MM-PBSA procedure. The discovered repurposed drugs can aid the rational design of novel inhibitors for Nsp15 of the SARS-CoV-2 enzyme and may be considered for immediate drug development."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Repurposing of Medicines in the EU: Launch of a Pilot Framework. (PubMed, Front Med (Lausanne)) - "The group's initial plan was impacted by the outbreak of the SARS-CoV-2 pandemic and the launch of the pilot needed to be postponed. This article describes the progress and the activities conducted by the group during this past and yet extraordinary 2020-2021 to keep the project alive and explores on the background of this topic together with the obvious opportunities this health crisis has brought up in terms of repurposing of medicines."

Journal • Launch Europe • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients. (PubMed, J Cell Biochem) - "COVID-19 is a sneaking deadly disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...Finally, we used the molecular docking and molecular dynamics method to identify inherent hits against the ARHGEF1 gene from antiviral, anticancer, and natural product-based libraries. Although the study has an identified significant association of the ARHGEF1 gene in COVID19; and probable compounds targeting it, using in silico methods, these targets need to be validated by both in vitro and in vivo methods to effectively determine their therapeutic efficacy against the devastating virus."

Clinical • Journal • Infectious Disease • Novel Coronavirus Disease • Oncology • Respiratory Diseases