ipamorelin / Helsinn - LARVOL DELTA

The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: anamorelin also exhibits anti-emetic effects via a central mechanism. (PubMed, Physiol Behav) - "In conclusion, anamorelin and ipamorelin administered i.p. had beneficial effects in alleviating cisplatin-induced weight loss during delayed phase, and these effects were seen when centrally administered anamorelin. Anamorelin inhibited cisplatin-induced acute emesis following intracerebroventricular but not intraperitoneal administration, suggesting that brain penetration is important for its anti-emetic mechanism of action."

Journal • Oncology

The influence of ghrelin agonist ipamorelin acetate on the hypothalamic-pituitary-testicular axis in a cichlid fish, Oreochromis mossambicus. (PubMed, Anim Reprod Sci) - "Furthermore, the concentrations of luteinizing hormone (LH) and 11-ketotestosterone (11-KT) in the serum of fish treated with either 5 or 30 µg of IPA were significantly elevated in comparison to the control group. Collectively, these findings suggest that the administration of ghrelin enhances the development of germ cells during the meiosis-I phase and that this effect might be mediated via the stimulation of 11-KT and androgen receptors at the testicular level and LH at the pituitary level in the tilapia."

Journal • AR

[VIRTUAL] Ipamorelin Acetate for the management of postoperative ileus (ASHP 2020) - "Since this study provides the first evidence of the safety and initial data regarding efficacy of ipamorelin, and considering the limited options for treatment of POI, future research is needed to further assess ipamorelin in the recovery of GI function in postoperative open-laparotomy patients."

Gastrointestinal Disorder • Immunology • Inflammation • Pain

Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics. (PubMed, J Exp Pharmacol) - "Here, we investigate the efficacy of peripherally restricted (ipamorelin) and a globally active (HM01) selective ghrelin receptor agonist in an experimental model of non-inflammatory visceral hypersensitivity and somatic mechanical allodynia. Furthermore, visceral and somatic hypersensitivity could be attenuated by a peripherally restricted ghrelin mimetic. These results highlight a potential novel approach for treating acute visceral and somatic pain by ghrelin mimetics."

Journal • Immunology • Neuralgia • Pain • Peripheral Neuropathic Pain

Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. (PubMed, Transl Androl Urol) - "The GHS that will be discussed include sermorelin, growth hormone-releasing peptides (GHRP)-2, GHRP-6, ibutamoren, and ipamorelin. All are potent GH and IGF-1 stimulators that can significantly improve body composition while ameliorating specific hypogonadal symptoms including fat gain and muscular atrophy. However, a paucity of data examining the clinical effects of these compounds currently limits our understanding of GHS' role in the treatment of men with hypogonadism, but does open opportunities for future investigation."

Journal • Review • CNS Disorders • Genetic Disorders • Metabolic Disorders • Muscular Atrophy • Obesity • AR • IGF1