IMD-0560 / Institute of Medicinal Molecular Design - LARVOL DELTA

[VIRTUAL] EXPRESSION PROFILE ANALYSIS OF LONG NONCODING RNAS INDUCED BY IL-1ß IN RHEUMATOID ARTHRITIS FIBROBLAST-LIKE SYNOVIOCYTES (EULAR 2020) - "IMD-0560, an inhibitor of IκB kinase (IKK) was used for the regulation of NF-κB activation... Our study revealed that IL-1 increased the expression of NR_046035, NR_027783, NR_033422, NR_003133, and NR_049759 in RA FLS. In addition, the expression of these lncRNAs was regulated by inhibition of NF-κB activation. Thus, our data suggest that the lncRNAs might be involved in the pathogenesis of RA through NF-κB signaling pathway."

Cardiovascular • Diabetes • Immunology • Metabolic Disorders • Oncology • Rheumatoid Arthritis • Rheumatology

A novel inhibitor of nuclear factor kappa-B kinase subunit gamma mutation identified in an incontinentia pigmenti patient with syndromic tooth agenesis. (PubMed, Arch Oral Biol) - "We identified a novel nonsense IKBKG mutation (c.924C > G; p.Tyr308*) in an IP patient with syndromic tooth agenesis. This research enriches the mutation spectrum of the IKBKG gene."

Clinical • Journal