verapamil intralesional / Stada - LARVOL DELTA

Multimodal Management of Keloid and Hypertrophic Scars: A Review of Current Therapeutic Strategies (AAD 2026) - " Comprehensive literature synthesis examined treatment modalities including intralesional injectables (triamcinolone acetonide [TAC], 5-flurouracil [5-FU], botulinum toxin-A [BTX-A], verapamil, platelet-rich plasma [PRP]), energy-based devices (laser, radiotherapy), and surgical options with adjuvant therapies... Multimodal, individualized approaches combining injectables, energy-based devices, in addition to surgical excision with adjuvant therapy yield optimal outcomes for keloid and hypertrophic scars, improving characteristics and reducing recurrence with acceptable safety."

Review • Fibrosis

Comparative efficacy of intralesional therapies for keloid scars: A Network Meta-Analysis of clinical trials (AAD 2026) - "Results From 51 studies (3,234 participants, 23 interventions), 5-fluorouracil (5-FU) + Corticoids significantly improved keloid reduction compared to corticoids alone...Regarding adverse effects, a significant risk reduction was found for BTX-A (RR = 0.29; 95% CI: 0.09–0.95; p = 0.04) and Verapamil (RR = 0.35; 95% CI: 0.14–0.84; p = 0.01) compared to corticoids; others showed no significant effects. Conclusion This NMA provides a comparative overview, indicating that combination therapies, most notably 5-FU+ corticoids + YAG: Laser, offer the greatest benefit. While data for novel agents (insulin and BTX-A) suggest potential, further research with standardized methodologies and longer-term follow-up is crucial to define optimal treatment algorithms."

Retrospective data • Fibrosis • Immunology • Pruritus

Therapeutic methods and effect on keloid and hypertrophic scars: a systematic review. (PubMed, Front Med (Lausanne)) - "Electronic searches through April 2025 across databases such as PubMed, EMBASE, Cochrane Library, and Web of Science used keywords such as 'keloid', 'occlusive dressings', and 'imiquimod', among others...This study synthesizes findings from 162 studies, exploring a range of treatments including monotherapies and combination therapies, such as local corticosteroid injections, optical therapy, radiation therapy, 5-fluorouracil (5-FU) therapy, bleomycin therapy, verapamil therapy, excision surgery, cryotherapy, and topical treatments, as well as various multi-drug regimens...Anti-fibroblast growth strategies are crucial, aside from physical interventions. Despite the lack of an established gold standard, corticosteroid and excision therapies remain critical benchmarks for evaluating new treatments."

Journal • Review • Fibrosis

Comparison of Intralesional Triamcinolone Acetonide Treatment With Intralesional Verapamil Hydrochloride in Keloids (clinicaltrials.gov) - P=N/A | N=60 | Completed | Sponsor: Muhammad Aamir Latif

New trial • Fibrosis

Modern possibilities of diagnosis and treatment of Peyronie's disease in the Czech context. (PubMed, Cas Lek Cesk) - "Regenerative therapies like platelet-rich plasma (PRP) or mesenchymal stem cells (MSC) offer promising, yet currently experimental results. Optimal care is based on early diagnosis, individualization of conservative treatment, and precise surgical correction; in the Czech Republic, standard approaches include verapamil, LiSWT, and surgery, while biological approaches require further research."

Journal • Review • Erectile Dysfunction • Fibrosis • Pain • Urology

Penile curvature management in Italy: a survey analysis by the Italian Society of Urology. (PubMed, Arch Ital Urol Androl) - "This nationwide survey reveals a significative heterogeneity in PC and PD management in Italy, with frequent reliance on off-label treatments and variable adherence to international guidelines. Economic limitations and regional differences appear to be a primary factor influencing clinical decisions and clinical practice. These findings underline the need for a major dissemination of evidence-based guidelines associated with national healthcare strategies aimed at standardized care and improving patient outcomes."

Journal • Erectile Dysfunction • Urology

Comparative Efficacy and Recurrence Risk of Intralesional Therapies for Hypertrophic Scars and Keloids: A Network Meta-Analysis. (PubMed, Aesthet Surg J) - "Pooled estimates demonstrated that triamcinolone acetonide combined with 5-fluorouracil (TAC+5-FU) achieved the most consistent improvements in treatment efficacy and recurrence control...Verapamil (VER) was associated with significantly lower efficacy compared with TAC, whereas bleomycin (BLM) and 5-FU monotherapies provided intermediate outcomes without statistical superiority. Overall, TAC+5-FU offered the most favorable balance between efficacy and recurrence reduction, while BTA showed strong response efficacy. These findings provide a comprehensive synthesis of intralesional therapies for hypertrophic scars and keloids, support the consideration of combination regimens in scar management, and underscore the need for further well-designed head-to-head trials with standardized endpoints to refine individualized treatment strategies."

Journal • Retrospective data • Fibrosis

Comparison of Effectiveness of Intralesional Triamcinolone Acetonide with Fractional CO2 Laser Against Intralesional Triamcinolone Acetonide with Intralesional Verapamil in the Treatment of Keloids. (PubMed, Indian Dermatol Online J) - "Both the combination groups are safe and efficacious methods to treat keloid. Intralesional verapamil with triamcinolone showed better and faster clinical improvement compared to fractional CO2 laser with intralesional triamcinolone."

Journal • Fibrosis • Immunology

A clinical trial to compare efficacy of intralesional triamcinolone vs intralesional verapamil in patients with keloids/ hypertrophic scars. (ANZCTR) - P4 | N=174 | Recruiting | Sponsor: Noor ul Huda working as resident in khyber teaching hospital Peshawar.

New P4 trial • Fibrosis

Comparison of Intralesional Triamcinolone Versus Verapamil for Keloid Treatment (clinicaltrials.gov) - P4 | N=60 | Not yet recruiting | Sponsor: Nishtar Medical University

New P4 trial • Fibrosis • Immunology

Contemporary nonsurgical management of Peyronie's disease. (PubMed, Curr Opin Urol) - "Herein, we will discuss notable advances in nonsurgical management of Peyronie's disease."

Clinical • Journal • Review • Urology • IFNA1

A review of Peyronie's disease insurance coverage. (PubMed, Sex Med) - "Peyronie's disease (PD) is a fibroproliferative disorder that causes an abnormal curve of the penis resulting in pain, discomfort, and erectile dysfunction with management options including correctional surgery, penile external/internal devices, shock wave therapy (SWT), intralesional Verapamil (IV), and collagenase Clostridium histolyticum injections. Finally, this study only addressed some of the common treatment options of PD and did not expand on all possible treatment options. Differing rates for modalities of treatment may present a barrier for patients to receive individualized and adequate treatment for PD."

Journal • Reimbursement • Review • US reimbursement • Erectile Dysfunction • Pain

Intralesional injection of hyaluronic acid compared with verapamil in acute phase of Peyronie's disease: A prospective randomized clinical trial. (PubMed, Arab J Urol) - "The decrease in penile curvature at 12 weeks after therapy was noticeably better in group A in contrast to group B (24.7 ± 9.72° vs. 30.8 ± 8.63°, p = 0.038). HA is emerging as a valid choice for the treatment of PD in terms of resolution of the acute phase of the disease, and it is plausible to posit that the use of HA may contribute to the stabilization of the disease and decrease the need for the subsequent choice of a possible surgical strategy, with the ability to reduce penile pain and have a stronger impact on penile curvature and patient satisfaction."

Clinical • Journal • Pain

Our Experience at Tertiary Medical College-Intralesional Injection of Triamcinolone Acetonide Versus Injection Verapamil Following Keloidectomy with Fillet Flap in Auricular Keloids. (PubMed, Indian J Otolaryngol Head Neck Surg) - "A recurrence rate of 14.28% was found in 4 of 28 keloids at 12 months postoperatively. The Patient and Observer Scar Assesment Scale scores (POSAS scores) were consistently higher than Beausang scores at 1 year, indicating high patient satisfaction compared to physician assessment in both groups A and B. A keloid recurrence-free interval of 11.36 months was obtained by the Kaplan-Meier survival test (p < 0.05) in group A. Keloid recurrence-free interval of 10.98 months was evaluated by the Kaplan-Meier survival test (p < 0.05) in group B. Among Keloidectomy with fillet flap surgery with intralesional injection of triamcinolone acetonide (group A) and keloidectomy with fillet surgery with intralesional injection of verapamil (group B), at each follow-up the success rate of group B was higher than group A indicating better trend of success in this group in terms of both absence of recurrence and absence of complications without statistically..."

Journal • Fibrosis

Comparative Efficacy of Drug Interventions for Keloids: A Network Meta-analysis. (PubMed, Ann Plast Surg) - "Botulinum toxin A and TAC plus 5-FU appear to have outstanding therapeutic efficacy for keloids. The rate of adverse events was similar among BTA, TAC, 5-FU, and TAC plus 5-FU. Nonetheless, additional reviews of rigorous, large-scale randomized controlled trials are warranted for further validation of our findings."

Clinical • Journal • Retrospective data • Review • Fibrosis

Comparing intralesional triamcinolone and verapamil-triamcinolone injections in keloids: A single-blinded randomised clinical trial. (PubMed, Int Wound J) - "These findings suggest that the combination of verapamil and triamcinolone provides a more effective treatment for keloids, thereby highlighting the potential of verapamil in scar reduction."

Journal • Fibrosis

Bevacizumab as adjuvant therapy in the treatment of keloid: A randomized clinical trial (EADV 2023) - "Intralesional triamcinolone has been established as an effective corticosteroid treatment for keloids, while sporadic reports suggest the efficacy of intralesional verapamil. Our study demonstrates that bevacizumab can be considered an effective and safe adjuvant therapy option for keloid treatment, suggesting its potential as a promising treatment for the management of keloids."

Clinical • Fibrosis

Recurrence rates in the treatment of keloids and hypertrophic scars with intralesional triamcinolone combined with other intralesional agents. (PubMed, Arch Dermatol Res) - "In the treatment of pathologic scar, combination approaches using intralesional agents, such as triamcinolone (TAC), 5-fluorouracil (5FU), verapamil (VER), bleomycin (BLM), and botulinum toxin (BTX), are superior therapies when compared to monotherapy (Yosipovitch et al., J Dermatol Treat 12(2):87-90. There are limitations to this review in that comparisons were made across studies with varying outcome variables, including scar size, injection concentration and interval, and follow-up period. Standardized follow-up periods and recurrence rate reporting are integral to furthering the understanding of these therapies and enhancing patient care."

Journal • Review • Fibrosis

Medical Treatment for Peyronie's Disease: Systematic Review and Network Bayesian Meta-Analysis. (PubMed, World J Mens Health) - "At present, there is no clinical treatment alternatives that have been demonstrated to be effective compared to placebo. Nonetheless, as the frequentist approach has shown that a number of agents are efficacious, further research is expected to develop more effective treatment options."

Journal • Retrospective data • Review • Erectile Dysfunction • Fibrosis

Ledderhose’s disease treated with intralesional injections of corticosteroids (EADV-Sp 2023) - "The treatment of this rare disease receives relatively little. Other than steroids, a wide variety of nonsurgical options exist such as radiation therapy, antiestrogen,Verapamil and Collagenase .Many of these treatment options are promising, but require further studies of sufficient size and power."

Fibrosis • Genetic Disorders • Idiopathic Arthritis • Immunology • Pain • Rare Diseases • Rheumatology • Solid Tumor

Intralesional Hyaluronic Acid and Verapamil Injection in Peyronie's Disease (clinicaltrials.gov) - P=N/A | N=42 | Not yet recruiting | Sponsor: Benha University

New trial • Fibrosis

Understanding the Effects of Actinidin as a Collagenase acting to treat Human Peyronie’s Disease Cells (AUA 2023) - "Intralesional injection of collagenase Clostridium histolyticum is the only FDA approved treatment for PD, however, is no longer available in Canada...The cells were plated on a 96-well plate and treated with their respective treatments: media, saline, verapamil, actinidin at 50, 25 and 10 mg/ml for 24 hours... Our preliminary study suggests the possible effects of actinidin in breaking down PD plaques by compromising the extracellular matrix, membrane-bound proteins, and the cellular membrane of human PD fibroblasts. An increased level of normalized actin in the high concentration actinidin group acts suggests a compromised plasma membrane and a potential mechanism of action. Further studies will investigate the optimal actinidin concentration that can safely reduce the collagen composition of human PD plaques."

Erectile Dysfunction • Fibrosis • Pain • Rheumatology • Urology

Keloid treatments: an evidence-based systematic review of recent advances. (PubMed, Syst Rev) - "This review was limited by heterogeneity of subject characteristics and study outcome measures, small sample sizes, and inconsistent study designs. Larger and more robust controlled studies are necessary to further understand the variety of existing and emerging keloid treatments, including corticosteroids, cryotherapy, intralesional injections, lasers, photodynamic therapy, excision and radiation, pressure dressings, and others."

Journal • Review • Fibrosis

Commentary: A Primer on the History of Intralesional Verapamil Injection for Peyronie's Disease. (PubMed, Urology) - No abstract available

Journal • Fibrosis

A systematic review of non-surgical management in Peyronie's disease. (PubMed, Int J Impot Res) - "Of the intralesional treatments, Collagenase Clostridium Histolyticum showed evidence for improving penile curvature (Range: 16.3-17 degrees, moderate level certainty of evidence). Intralesional Interferon demonstrated some improvement in curvature (Range: 12-13.5 degrees), plaque size (Range: 1.67-2.2 cm) and pain, whilst intralesional calcium channel blockers such as Verapamil showed variable evidence for changes in the plaque size and pain...Intralesional options demonstrate the best potential. Overall, results varied with few high-quality randomised trials present."

Journal • Review • Fibrosis • Pain