carbetocin / Generic mfg. - LARVOL DELTA

Ergometrine Versus Carbetocin to Decrease Blood Loss in Myomectomy (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Cairo University

New trial • Uterine Leiomyoma

EMERGE-CS: Comparison of the Effect of Carbetocin Versus Oxytocin in the Prevention of Postpartum Hemorrhage After Emergency Caesarean Section in Antenatal Low-risk Patients (clinicaltrials.gov) - P=N/A | N=300 | Completed | Sponsor: Ankara Etlik City Hospital

New trial • Hematological Disorders • Postpartum Hemorrhage

Carbetocin versus oxytocin with or without tranexamic acid for preventing postpartum hemorrhage in cesarean delivery: a randomized controlled trial. (PubMed, BMC Pregnancy Childbirth) - No abstract available

Journal • Hematological Disorders • Postpartum Hemorrhage

Carbetocin vs Misoprostol for Postpartum Hemorrhage Prevention (clinicaltrials.gov) - P=N/A | N=146 | Not yet recruiting | Sponsor: Western Galilee Hospital-Nahariya

New trial • Hematological Disorders • Postpartum Hemorrhage

Management of accidental pre-incisional administration of carbetocin in Caesarean delivery. (PubMed, Br J Anaesth) - No abstract available

Journal • Cardiovascular

In reply: Designing and reporting a noninferiority trial: points to ponder. (PubMed, Can J Anaesth) - No abstract available

Head-to-Head • Journal • Anesthesia • Genetic Disorders • Obstetrics

Designing and reporting a noninferiority trial: points to ponder. (PubMed, Can J Anaesth) - No abstract available

Head-to-Head • Journal

Response to "Evaluating inconsistences, generalizability, and heterogeneity in analysis of carbetocin versus oxytocin after cesarean delivery in high-risk women". (PubMed, Arch Gynecol Obstet) - No abstract available

Heterogeneity • Journal

The effect of carbetocin compared with oxytocin to reduce placental retention rates in medical abortion: A randomised controlled trial (ANZCTR) - P4 | N=498 | Not yet recruiting | Sponsor: King Edward Memorial Hospital

New P4 trial

Impact of Denaverine Hydrochloride and Carbetocin on Parturition Ease and Subsequent Fertility in Suckler Cows. (PubMed, Reprod Domest Anim) - "RFM and CM incidence did not significantly differ across groups. These findings support the beneficial role of DH, particularly when combined with CT, in facilitating parturition, improving welfare and enhancing subsequent fertility."

Clinical • Journal

Prophylactic Regimen of Intravenous Oxytocin, Intravenous Tranexamic Acid, and Intramuscular Ergot Derivative for Primary Prevention of Postpartum Hemorrhage in Intrapartum Cesarean Section Versus Intravenous Carbetocin Alone (clinicaltrials.gov) - P=N/A | N=80 | Not yet recruiting | Sponsor: Cairo University

New trial • Hematological Disorders • Postpartum Hemorrhage

Comparison of the Effects of Carbetocin and Oxytocin Injections in the Prevention of Postpartum Hemorrhage. (PubMed, Cureus) - "Carbetocin is superior to oxytocin in limiting postpartum hemorrhage, and a similar safety profile is available as a room-temperature-stable formulation. In addition, carbetocin shows several advantages, like significantly reducing the need for additional uterotonics, procedures, blood transfusions, and longer hospital stays, making it an overall cost-effective drug."

Journal • Hematological Disorders • Postpartum Hemorrhage

A Comparative Study of Carbetocin and Oxytocin in Placental Separation and Postpartum Hemorrhage Control Following Vaginal and Cesarean Deliveries. (PubMed, Ann Afr Med) - "Carbetocin is more effective than oxytocin in achieving faster placental separation, reducing third-stage labor duration, minimizing blood loss, and lowering the risk of atonic PPH in both normal and operative deliveries. Its longer duration of action and reduced need for repeat dosing make it a superior uterotonic agent for PPH prophylaxis."

Journal • Gynecology • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

High incidence of stillbirths in a free farrowing system linked to uterotonic misuse and improper farrowing management: a case report. (PubMed, Porcine Health Manag) - "Herd problems with stillbirths require a comprehensive herd investigation including monitoring the birth management and ruling out potential pathogens. In this case, the routinely administration of carbetocin during parturition led to severe undesirable side effects. A good monitoring during the farrowing process combined with appropriate measures and the omission of prophylactic carbetocin administration enhanced the birth process and thereby piglets' survival."

Journal • Cardiovascular • Inflammation • Respiratory Diseases

Integrated Bioinformatics Analyses of Peripheral Blood Transcriptomes Reveals Shared Molecular Features Underlying the Comorbidity of Schizophrenia and Metabolic Syndrome. (PubMed, J Mol Neurosci) - "In conclusion, immune and inflammatory processes are pivotal in the pathophysiology of SCZ-MetS comorbidity. PGLYRP1 may serve as a central molecular target for this comorbidity, and carbetocin shows promise as a candidate therapeutic, providing a theoretical basis for future experimental validation and potential clinical application."

Journal • CNS Disorders • Inflammation • Metabolic Disorders • Psychiatry • Schizophrenia

Effects of oxytocin receptor ligands on anxiogenic-like effect, social avoidance and changes on medial prefrontal cortex oxytocin receptor expression evoked by chronic social defeat stress in rats. (PubMed, Prog Neurobiol) - "We investigated the effect of systemic administration of the synthetic oxytocin (OXT) analog carbetocin and/or OXT receptor antagonists (atosiban and L-368,899) on social avoidance and anxiogenic-like effect in male rats subjected to chronic social defeat stress (cSDS). Taken together, our study provides evidence for the critical role of the OXT system and its pharmacological manipulation in modulating anxiogenic-like effects evoked by social stress. Furthermore, the region-specific modulation of OXT receptor expression within the mPFC by stress and OXT system pharmacological manipulation emphasize the complex and dynamic nature of OXT receptor regulation in brain regions crucial for emotional processing."

Journal • Preclinical • Mood Disorders • Psychiatry

Author Response. (PubMed, BJOG) - No abstract available

Journal • Obstetrics

Comparative effectiveness of oxytocin, carbetocin, and tranexamic acid for postpartum hemorrhage prevention in cesarean deliveries: a prospective cohort analysis. (PubMed, J Perinat Med) - "Carbetocin combined with TXA was associated with the most favorable hematologic profile. These findings support the use of multimodal pharmacologic strategies for PPH prevention in cesarean births and may inform future protocol development."

HEOR • Journal • Hematological Disorders • Postpartum Hemorrhage

Comparative Effectiveness of Carbetocin Versus Oxytocin in Active Management of the Third Stage of Labour for Preventing Atonic Postpartum Haemorrhage: A Study at a Tertiary Care Centre in Central India. (PubMed, Cureus) - "Although insignificant statistically, carbetocin plays an effective role in preventing PPH when compared to oxytocin, particularly in settings where cold chain maintenance for oxytocin transport and storage remains doubtful. Statistically significant lower mean blood loss with carbetocin can be an added advantage."

HEOR • Journal • Obstetrics • Postpartum Hemorrhage

Adverse Effects of Oxytocin Are More Prevalent than Those Associated with Carbetocin Administration During Cesarean Section. (PubMed, J Clin Med) - "Statistical significance was observed for all of the following reported symptoms: headache, chest pain, burning sensation and heaviness in the chest, and palpitations. Although chest pain, burning and heaviness in the chest, palpitations, and headaches are more common in women giving birth by cesarean section after administration of oxytocin than after administration of carbetocin, this fact appears to be of limited clinical significance from a clinical point of view."

Adverse events • Journal • Hematological Disorders • Pain • Postpartum Hemorrhage

Evaluating inconsistences, generalizability, and heterogeneity in analysis of carbetocin versus oxytocin after cesarean delivery in high-risk women. (PubMed, Arch Gynecol Obstet) - No abstract available

Heterogeneity • Journal

One dose, big impact: Revisiting carbetocin in high-risk polyhydramnios deliveries. (PubMed, Int J Gynaecol Obstet) - "Among women with isolated polyhydramnios, carbetocin offers superior prophylactic control of PPH compared to oxytocin and oxytocin-ergometrine regimens. Its long-acting effect provides sustained uterine contraction, reducing the need for additional interventions. Carbetocin might be especially beneficial in high-risk cases of uterine overdistension, supporting its targeted use in individualized obstetric care."

Journal • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

Oxytocin versus carbetocin for preventing postpartum hemorrhage in patients with polyhydramnios during cesarean delivery: A retrospective cohort study. (PubMed, Int J Gynaecol Obstet) - "This research indicated that carbetocin was as effective as oxytocin in reducing postpartum hemorrhage, particularly during a cesarean delivery for those who had been diagnosed with polyhydramnios. Moreover, cases managed with carbetocin require fewer additional uterotonic drugs."

Journal • Retrospective data • Diabetes • Gestational Diabetes • Hematological Disorders • Metabolic Disorders • Postpartum Hemorrhage

A PROSPECTIVE COMPARATIVE STUDY BETWEEN OXYTOCIN AND CARBETOCIN IN PREVENTION OF POST PARTUM HAEMORRHAGE AFTER VAGINAL AND CAESAREAN DELIVERY (FIGO 2025) - "Hence we conclude that carbetocin can be used as a first line uterotonic in cases of PPH."

Clinical • Postpartum Hemorrhage

ADVANCING REPRODUCTIVE RIGHTS THROUGH EQUITABLE ACCESS TO LIFE-SAVING SERVICES AND MEDICINES FOR POSTPARTUM HEMORRHAGE IN SUB-SAHARAN AFRICA (FIGO 2025) - "National policy documents and service delivery protocols were also reviewed to assess the integration of PPH interventions into clinical practice and utilization, policy environment, and commodities (Oxytocin, tranexamic acid, heat-stable carbetocin and misoprostol). Inequitable access to PPH services and medicines undermines the right to survive childbirth. Integrating life-saving interventions into national protocols, expanding provider scope and strengthening supply chains are critical to reducing preventable maternal deaths. Upholding reproductive rights requires aligning clinical practice with global standards to ensure women receive timely, high-quality obstetric care."

Hematological Disorders • Obstetrics • Postpartum Hemorrhage