carbetocin / Generic mfg. - LARVOL DELTA

Administering carbetocin before electroejaculation in bulls improves semen quality and increases the number of insemination doses. (PubMed, Anim Reprod Sci) - "Carbetocin administration before electroejaculation in bulls marginally improved fresh semen quality and quantity, including motility and the number of fresh semen insemination doses. This may support routine use in artificial insemination programs by making the collection process more efficient."

Journal

Replacing Routine Oxytocin Infusion With Single-Dose Carbetocin at Elective Caesarean Section: A Service Improvement Evaluation of Postpartum Haemorrhage Outcomes. (PubMed, Cureus) - "Conclusion In this service improvement evaluation, replacing routine oxytocin infusion with single-dose carbetocin at elective caesarean section was associated with comparable rates of significant and major postpartum haemorrhage while simplifying postoperative uterotonic administration. The findings support the local safety of this practice change, although interpretation is limited by the retrospective aggregate design and absence of patient-level risk adjustment or additional morbidity outcomes."

Journal • Postpartum Hemorrhage

OLE Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome (clinicaltrials.gov) - P3 | N=168 | Terminated | Sponsor: ACADIA Pharmaceuticals Inc. | Trial completion date: Jun 2029 ➔ Dec 2025 | Enrolling by invitation ➔ Terminated | Trial primary completion date: May 2029 ➔ Dec 2025; Primary efficacy endpoint was not met in the parent study (ACP-101-302). Based on review of available data, continued administration of investigational product in ACP-101-303 was not considered likely to provide significant clinical benefit.

Trial completion date • Trial primary completion date • Trial termination • Prader–Willi syndrome

Five-Year Trends in Obstetric Hemorrhage, Hemostatic Management, and Blood Product Utilization at a Tertiary Maternity Center in Kazakhstan: A Retrospective Time-Series Study. (PubMed, Healthcare (Basel)) - "Carbetocin and tranexamic acid use rose several-fold, while red cell volume per delivery fell by about 48%. The findings support prospective monitoring and patient-level study. Because severe hemorrhage and the surgery used to control it may compromise later fertility, the reproductive outcomes of these women are a priority for further research."

Journal • Retrospective data • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

A Comparative Study on Oxytocin Versus Carbetocin in Prevention of Primary Postpartum Haemorrhage After Childbirth. (PubMed, Niger Med J) - "Carbetocin caused minimal hemodynamic changes compared to the significant hypotensive effects of oxytocin. Carbetocin is superior to oxytocin in preventing primary PPH, offering better efficacy and safety profile through reduced complications."

Journal • Review • Postpartum Hemorrhage

The Prophylactic Role of Tranexamic Acid in Reducing Blood Loss During Cesarean Delivery: A Prospective Randomized Controlled Trial. (PubMed, Cureus) - " This study supports the prophylactic use of TXA during cesarean delivery to reduce intraoperative blood loss. The significant reduction in mean EBL, combined with the absence of major adverse effects, underscores the role of TXA as a safe and effective adjunct to standard uterotonic therapy."

Journal • Cardiovascular • Hematological Disorders • Postpartum Hemorrhage

The Efficacy of Carbitocin in Reduction of Blood Loss During Myomectomy (clinicaltrials.gov) - P1 | N=900 | Not yet recruiting | Sponsor: Alex Ekwueme Federal University Teaching Hospital

New P1 trial

Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome: Results From the Randomized, Placebo-Controlled, Phase 3 Compass PWS Study. (PubMed, Clin Ther) - P3 | "Carbetocin nasal spray did not demonstrate efficacy compared with placebo for hyperphagia in PWS in the 12-week COMPASS PWS study."

Journal • P3 data • Genetic Disorders • Pain • Prader–Willi syndrome • Psychiatry

Carbetocin in the Prevention of Postpartum Hemorrhage after Vaginal Birth: A Systematic Review and Meta-Analysis. (PubMed, Matern Fetal Med) - "Carbetocin administration was associated with reduced blood loss during the first 24 h after VD, a less severe decrease in postpartum hemoglobin levels, and a reduced need for additional uterotonics compared with oxytocin administration. Registration number CRD42023492407."

Journal • Retrospective data • Hematological Disorders • Postpartum Hemorrhage

Prevention and management of postpartum hemorrhage and hypertensive disorders of pregnancy: results from a 31-country rapid assessment. (PubMed, BMC Pregnancy Childbirth) - "Recommendations include prioritizing integration of updated global guidelines; improving uptake through professional education, mentorship, and supervision; quality assurance; strengthening procurement and supply chains to improve access, availability, and quality of essential drugs and commodities; expanding midwives' scope of practice; and improving private sector governance to enhance reporting of important MNH indicators."

Journal • Gynecology • Hematological Disorders • Hypertension • Postpartum Hemorrhage

Strategies for the Identification of Cyclic Peptide Drugs and Their Impurities. (PubMed, J Am Soc Mass Spectrom) - "Applying optimized EThcD conditions and established fragmentation rules, impurities in atosiban and carbetocin were characterized, leading to the identification of three impurities in atosiban and two in carbetocin. This approach demonstrates the effectiveness of EThcD for structural elucidation and impurity profiling of cyclic peptide therapeutics."

Journal

Carbetocin and oxytocin use in emergency cesarean delivery: a prospective observational study of 24-hour bleeding outcomes. (PubMed, BMC Pregnancy Childbirth) - P=N/A | "In this prospective observational non-randomized cohort of antenatally low-risk women undergoing emergency cesarean delivery, no statistically significant between-group differences were observed in additional uterotonic use or predefined 24-hour bleeding-related outcomes. Additional uterotonic use was numerically lower with carbetocin, but the difference was not statistically significant. Induction/augmentation and longer duration of membrane rupture were independently associated with higher odds of additional uterotonic use."

Journal • Observational data • Hematological Disorders • Postpartum Hemorrhage

Untangling Mephedrone-Induced Social Reward in Rats-The Involvement of Oxytocin and Vasopressin V1A Receptors. (PubMed, Genes Brain Behav) - "Behaviorally, social-CPP was abolished by OTR agonism (carbetocin) or AVPV1AR antagonism (SR49059), while OTR antagonism (L-368,899) or peripheral AVP had no effect...Social context modulates peripheral neuropeptides and engages central receptor adaptations in the hippocampus and NAc, influencing behavioral outcomes. This study provides insights into the neurobiological mechanisms through which the social environment alters drug reward."

Journal • Preclinical

Dose-response evaluation of intravenous carbetocin for prevention of postpartum haemorrhage during elective caesarean delivery: A parallel-group randomised controlled trial. (PubMed, Indian J Anaesth) - "No significant dose-response relationship was observed. In low-risk, non-obese women undergoing elective caesarean delivery under spinal anaesthesia, intravenous carbetocin doses ranging from 20 μg to 100 μg resulted in similar uterotonic response and blood-loss outcomes, with no statistically significant differences between the different dose groups."

Journal • Anesthesia • Obesity • Obstetrics • Postpartum Hemorrhage

Timing of carbetocin administration in vaginal deliveries: a double-blind, randomized controlled trial. (PubMed, J Perinat Med) - "Administering carbetocin before placental delivery significantly reduces the incidence of PPH, blood loss, and the need for additional uterotonics. However, the increased rate of manual placenta removal necessitates individualized risk-benefit assessment; pre-placental administration may be most advantageous in women at elevated risk for PPH, in whom the hemorrhagic benefit outweighs the risks associated with manual extraction."

Journal • Hematological Disorders • Postpartum Hemorrhage

Prevention of postpartum haemorrhage: from evidence to implementation at scale. (PubMed, Lancet) - "Oxytocin and carbetocin were the most effective single drugs for PPH prophylaxis, with minimal side-effects...Ergometrine alone and oxytocin plus ergometrine combination are no longer recommended due to hypertension-related safety concerns. A robust implementation approach that engages various stakeholders to promote change, ensures the supply of quality-assured medicines and devices, provides training and support, and secures ongoing political and financial commitment is necessary to translate evidence into global impact."

Journal • Review • Cardiovascular • Diabetes • Gestational Diabetes • Gynecology • Hematological Disorders • Hypertension • Metabolic Disorders • Mood Disorders • Postpartum Hemorrhage • Preventive care

CARBOXY-RCT: Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial (clinicaltrials.gov) - P4 | N=332 | Not yet recruiting | Sponsor: Mansoura University

Head-to-Head • Monotherapy • New P4 trial • Hematological Disorders • Postpartum Hemorrhage

Igniting the spark in six countries to transform the trajectory of postpartum hemorrhage across the globe: An overview of the AMPLI-PPHI project. (PubMed, Int J Gynaecol Obstet) - "Despite updated WHO recommendations and the availability of newer technologies-including heat-stable carbetocin, tranexamic acid as part of a clinical care bundle, misoprostol, and calibrated drapes-adoption and scale-up remain limited due to persistent supply and demand-side barriers. Globally, the project focuses on reducing supply-side barriers to help create the market for affordable and accessible PPH commodities. AMPLI-PPHI also fosters a regional exchange network-propelling shared learning and best practices-to light the spark for transformation in PPH care, thereby reducing maternal deaths from PPH-ensuring every woman, everywhere, has access to lifesaving care."

Journal • Hematological Disorders • Postpartum Hemorrhage

Role of professional associations in the drive for policy change and uptake of new WHO recommendations for the prevention and treatment of postpartum hemorrhage. (PubMed, Int J Gynaecol Obstet) - "The Accelerating Measurable Progress and Leveraging Investments for Postpartum Hemorrhage Impact (AMPLI-PPHI) project, through the professional associations across six countries (Democratic Republic of the Congo, Guinea, India, Kenya, Nigeria, and Zambia), aimed to generate implementation evidence, create an enabling environment, and prepare national supply chains and markets for the adoption of three WHO newly recommended PPH drugs: heat-stable carbetocin, tranexamic acid, and misoprostol for advance distribution, in low- and middle-income countries. The AMPLI-PPHI experience demonstrates that national health professional associations, when supported with adequate financing and technical advocacy skills, can be powerful catalysts of health policy and practice. Formalizing and strengthening the role of professional associations in global and national health policy processes and advocacy is essential for accelerating progress toward achieving maternal health goals..."

Journal • Anesthesia • Gynecology • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

The role of exchange hubs and learning between countries and regions in strengthening the implementation and expansion of essential products for postpartum hemorrhage. (PubMed, Int J Gynaecol Obstet) - "While this article focuses particularly on the work in Guinea, it also shares key lessons learned from all project target countries and their extended exchange hubs. The hubs have created an effective network of professional associations that can share evidence and clinical lessons, accelerating required processes and enabling effective wider adaptation and scale-up of essential and innovative PPH products."

Journal • Gynecology • Hematological Disorders • Obstetrics • Postpartum Hemorrhage • Women's Health

Dual Pathways Coupled to Oxytocin Molecular Signals in Cultured Astrocytes. (PubMed, Cells) - "We found that oxytocin receptors are expressed in both the soma and processes of astrocytes; oxytocin at nanomolar concentrations could induce dual responses in astrocytes, namely facilitation and inhibition of Ca2+ signals and glutamate release; the oxytocin facilitatory and inhibitory effects were duplicated by the biased agonists carbetocin and atosiban, respectively; and the facilitatory and the inhibitory effect were dependent on activation of a Gq and a Gi pathway, respectively. It is concluded that oxytocin effects in astrocytes could duplicate the effects in processes prepared from astrocytes matured in neuron-astrocyte networks, substantiating the use of astrocytes to study astrocytic oxytocin molecular signaling."

Journal

Retraction statement: carbetocin versus oxytocin for prevention of postpartum hemorrhage in obese nulliparous women undergoing emergency cesarean delivery. (PubMed, J Matern Fetal Neonatal Med) - No abstract available

Journal • Hematological Disorders • Obesity • Postpartum Hemorrhage

CUTT-PPH: Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage (clinicaltrials.gov) - P4 | N=120 | Recruiting | Sponsor: Sheba Medical Center | Not yet recruiting ➔ Recruiting

Enrollment open • Hematological Disorders • Postpartum Hemorrhage

Carbetocin vs Oxytocin for prevention of Postpartum Hemorrhage in Women with Obesity undergoing Cesarean Delivery: A Systematic Review and Meta-Analysis. (PubMed, J Gynecol Obstet Hum Reprod) - "Carbetocin was associated with significantly reduced incidence of postpartum hemorrhage compared with oxytocin in obese women undergoing cesarean delivery. These findings suggest potential benefit of carbetocin in this high-risk population; however, larger, high-quality trials are required to confirm these results."

Journal • Retrospective data • Review • Genetic Disorders • Hematological Disorders • Obesity • Postpartum Hemorrhage

Retrospective cost-effectiveness analysis of carbetocin for the prevention of postpartum hemorrhage after vaginal birth: Evidence from a tertiary maternity center in France. (PubMed, Int J Gynaecol Obstet) - "Despite higher drug costs, prophylactic carbetocin significantly reduced severe PPH compared with oxytocin and showed favorable cost-effectiveness in vaginal deliveries. These findings support carbetocin as a valuable alternative for PPH prevention in this setting."

HEOR • Journal • Retrospective data • Hematological Disorders • Postpartum Hemorrhage