carbetocin / Generic mfg. - LARVOL DELTA

Telemedical management of severe postpartum hemorrhagic vaginal discharge in a sow - a case report. (PubMed, Porcine Health Manag) - No abstract available

Journal • Hematological Disorders • Postpartum Hemorrhage

Uterotonics in pregnant patients with cardiac disease: a focused review. (PubMed, Int J Obstet Anesth) - "Oxytocin and its long-acting analogue carbetocin are discussed in detail, alongside alternatives such as carboprost, ergometrine, misoprostol, and adjuncts including calcium and tranexamic acid. Early multidisciplinary planning and protocolised care are essential for optimal outcomes. Prospective studies across different cardiac conditions are needed to inform definitive guidance."

Journal • Review • Cardiomyopathy • Cardiovascular • Coronary Artery Disease • Gynecology • Heart Failure • Hypertension • Postpartum Hemorrhage • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

1067/25: The pilot bioavailability study comparing the absorption of carbetocin (which is used as prevention of heavy bleeding after childbirth) in PABAL 100 ?g/mL Solution for Injection when administered sublingually in the dose of 500 ?g and intramuscularly in the dose of 100 ?g. (clinicaltrialsregister.eu) - P1 | N=4 | Not yet recruiting | Sponsor: Oxytone Bioscience B.V.

New P1 trial

Prophylactic carbetocin versus oxytocin following vaginal delivery among women with high risk for postpartum hemorrhage: A before-and-after study. (PubMed, Acta Obstet Gynecol Scand) - "Prophylactic carbetocin was associated with a similar rate of PPH in high-risk women after vaginal delivery, compared with oxytocin, but significantly reduced the use of oxytocin when carbetocin was used as the first-line agent, although there was no difference in the use of prostaglandins or invasive procedures to manage persistent PPH."

Journal • Hematological Disorders • Postpartum Hemorrhage

Carbetocin - a long-acting oxytocin analogue - increases the blood supply to the reproductive tract of rams. (PubMed, Domest Anim Endocrinol) - "Carbetocin or its interaction with time did not affect blood flow in the marginal or supratesticular arteries or the scrotal surface temperatures. In conclusion, the standard dose of carbetocin transiently reduced internal iliac artery RI, resulting in a temporary increase in blood flow to the accessory sex glands, without altering scrotal skin temperature in rams."

Journal

Effect of dimethyl sulfoxide (DMSO) associated with oxytocin (carbetocin) on collagenase activity (in vitro) and cervical penetrability (in vivo) in sheep. (PubMed, Theriogenology) - No abstract available

Journal • Preclinical

CUTT-PPH: Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage (clinicaltrials.gov) - P4 | N=120 | Not yet recruiting | Sponsor: Sheba Medical Center

New P4 trial • Hematological Disorders • Postpartum Hemorrhage

Carbetocin versus oxytocin for the prevention of uterine atony during cesarean delivery: a real-world retrospective historical control cohort study (2022-2023). (PubMed, Int J Obstet Anesth) - "In this single-center retrospective cohort, carbetocin was associated with reduced administration of additional uterotonics, a lower decrease in postoperative hemoglobin, and reduced transfusion compared with an oxytocin regimen of single bolus plus infusion during cesarean delivery. While these associations were statistically robust after adjustment for measured confounders, the before-and-after study design and potential unmeasured confounding limit causal inference. These findings support carbetocin as an effective option for PPH prophylaxis during cesarean delivery, particularly in settings where sustained uterotonic effect from a single bolus is desirable, though confirmation through randomized trials in diverse settings would strengthen the evidence base."

Journal • Real-world evidence • Retrospective data • Critical care • Hematological Disorders • Postpartum Hemorrhage

Ergometrine Versus Carbetocin to Decrease Blood Loss in Myomectomy (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Cairo University

New trial • Uterine Leiomyoma

EMERGE-CS: Comparison of the Effect of Carbetocin Versus Oxytocin in the Prevention of Postpartum Hemorrhage After Emergency Caesarean Section in Antenatal Low-risk Patients (clinicaltrials.gov) - P=N/A | N=300 | Completed | Sponsor: Ankara Etlik City Hospital

New trial • Hematological Disorders • Postpartum Hemorrhage

Carbetocin versus oxytocin with or without tranexamic acid for preventing postpartum hemorrhage in cesarean delivery: a randomized controlled trial. (PubMed, BMC Pregnancy Childbirth) - No abstract available

Journal • Hematological Disorders • Postpartum Hemorrhage

Carbetocin vs Misoprostol for Postpartum Hemorrhage Prevention (clinicaltrials.gov) - P=N/A | N=146 | Not yet recruiting | Sponsor: Western Galilee Hospital-Nahariya

New trial • Hematological Disorders • Postpartum Hemorrhage

Management of accidental pre-incisional administration of carbetocin in Caesarean delivery. (PubMed, Br J Anaesth) - No abstract available

Journal • Cardiovascular

In reply: Designing and reporting a noninferiority trial: points to ponder. (PubMed, Can J Anaesth) - No abstract available

Head-to-Head • Journal • Anesthesia • Genetic Disorders • Obstetrics

Designing and reporting a noninferiority trial: points to ponder. (PubMed, Can J Anaesth) - No abstract available

Head-to-Head • Journal

Response to "Evaluating inconsistences, generalizability, and heterogeneity in analysis of carbetocin versus oxytocin after cesarean delivery in high-risk women". (PubMed, Arch Gynecol Obstet) - No abstract available

Heterogeneity • Journal

The effect of carbetocin compared with oxytocin to reduce placental retention rates in medical abortion: A randomised controlled trial (ANZCTR) - P4 | N=498 | Not yet recruiting | Sponsor: King Edward Memorial Hospital

New P4 trial

Impact of Denaverine Hydrochloride and Carbetocin on Parturition Ease and Subsequent Fertility in Suckler Cows. (PubMed, Reprod Domest Anim) - "RFM and CM incidence did not significantly differ across groups. These findings support the beneficial role of DH, particularly when combined with CT, in facilitating parturition, improving welfare and enhancing subsequent fertility."

Clinical • Journal

Prophylactic Regimen of Intravenous Oxytocin, Intravenous Tranexamic Acid, and Intramuscular Ergot Derivative for Primary Prevention of Postpartum Hemorrhage in Intrapartum Cesarean Section Versus Intravenous Carbetocin Alone (clinicaltrials.gov) - P=N/A | N=80 | Not yet recruiting | Sponsor: Cairo University

New trial • Hematological Disorders • Postpartum Hemorrhage

Comparison of the Effects of Carbetocin and Oxytocin Injections in the Prevention of Postpartum Hemorrhage. (PubMed, Cureus) - "Carbetocin is superior to oxytocin in limiting postpartum hemorrhage, and a similar safety profile is available as a room-temperature-stable formulation. In addition, carbetocin shows several advantages, like significantly reducing the need for additional uterotonics, procedures, blood transfusions, and longer hospital stays, making it an overall cost-effective drug."

Journal • Hematological Disorders • Postpartum Hemorrhage

A Comparative Study of Carbetocin and Oxytocin in Placental Separation and Postpartum Hemorrhage Control Following Vaginal and Cesarean Deliveries. (PubMed, Ann Afr Med) - "Carbetocin is more effective than oxytocin in achieving faster placental separation, reducing third-stage labor duration, minimizing blood loss, and lowering the risk of atonic PPH in both normal and operative deliveries. Its longer duration of action and reduced need for repeat dosing make it a superior uterotonic agent for PPH prophylaxis."

Journal • Gynecology • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

High incidence of stillbirths in a free farrowing system linked to uterotonic misuse and improper farrowing management: a case report. (PubMed, Porcine Health Manag) - "Herd problems with stillbirths require a comprehensive herd investigation including monitoring the birth management and ruling out potential pathogens. In this case, the routinely administration of carbetocin during parturition led to severe undesirable side effects. A good monitoring during the farrowing process combined with appropriate measures and the omission of prophylactic carbetocin administration enhanced the birth process and thereby piglets' survival."

Journal • Cardiovascular • Inflammation • Respiratory Diseases

Integrated Bioinformatics Analyses of Peripheral Blood Transcriptomes Reveals Shared Molecular Features Underlying the Comorbidity of Schizophrenia and Metabolic Syndrome. (PubMed, J Mol Neurosci) - "In conclusion, immune and inflammatory processes are pivotal in the pathophysiology of SCZ-MetS comorbidity. PGLYRP1 may serve as a central molecular target for this comorbidity, and carbetocin shows promise as a candidate therapeutic, providing a theoretical basis for future experimental validation and potential clinical application."

Journal • CNS Disorders • Inflammation • Metabolic Disorders • Psychiatry • Schizophrenia

Effects of oxytocin receptor ligands on anxiogenic-like effect, social avoidance and changes on medial prefrontal cortex oxytocin receptor expression evoked by chronic social defeat stress in rats. (PubMed, Prog Neurobiol) - "We investigated the effect of systemic administration of the synthetic oxytocin (OXT) analog carbetocin and/or OXT receptor antagonists (atosiban and L-368,899) on social avoidance and anxiogenic-like effect in male rats subjected to chronic social defeat stress (cSDS). Taken together, our study provides evidence for the critical role of the OXT system and its pharmacological manipulation in modulating anxiogenic-like effects evoked by social stress. Furthermore, the region-specific modulation of OXT receptor expression within the mPFC by stress and OXT system pharmacological manipulation emphasize the complex and dynamic nature of OXT receptor regulation in brain regions crucial for emotional processing."

Journal • Preclinical • Mood Disorders • Psychiatry

Author Response. (PubMed, BJOG) - No abstract available

Journal • Obstetrics