carbetocin / Generic mfg. - LARVOL DELTA

A Comparative Study of Carbetocin and Oxytocin in Placental Separation and Postpartum Hemorrhage Control Following Vaginal and Cesarean Deliveries. (PubMed, Ann Afr Med) - "Carbetocin is more effective than oxytocin in achieving faster placental separation, reducing third-stage labor duration, minimizing blood loss, and lowering the risk of atonic PPH in both normal and operative deliveries. Its longer duration of action and reduced need for repeat dosing make it a superior uterotonic agent for PPH prophylaxis."

Journal • Gynecology • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

High incidence of stillbirths in a free farrowing system linked to uterotonic misuse and improper farrowing management: a case report. (PubMed, Porcine Health Manag) - "Herd problems with stillbirths require a comprehensive herd investigation including monitoring the birth management and ruling out potential pathogens. In this case, the routinely administration of carbetocin during parturition led to severe undesirable side effects. A good monitoring during the farrowing process combined with appropriate measures and the omission of prophylactic carbetocin administration enhanced the birth process and thereby piglets' survival."

Journal • Cardiovascular • Inflammation • Respiratory Diseases

Integrated Bioinformatics Analyses of Peripheral Blood Transcriptomes Reveals Shared Molecular Features Underlying the Comorbidity of Schizophrenia and Metabolic Syndrome. (PubMed, J Mol Neurosci) - "In conclusion, immune and inflammatory processes are pivotal in the pathophysiology of SCZ-MetS comorbidity. PGLYRP1 may serve as a central molecular target for this comorbidity, and carbetocin shows promise as a candidate therapeutic, providing a theoretical basis for future experimental validation and potential clinical application."

Journal • CNS Disorders • Inflammation • Metabolic Disorders • Psychiatry • Schizophrenia

Effects of oxytocin receptor ligands on anxiogenic-like effect, social avoidance and changes on medial prefrontal cortex oxytocin receptor expression evoked by chronic social defeat stress in rats. (PubMed, Prog Neurobiol) - "We investigated the effect of systemic administration of the synthetic oxytocin (OXT) analog carbetocin and/or OXT receptor antagonists (atosiban and L-368,899) on social avoidance and anxiogenic-like effect in male rats subjected to chronic social defeat stress (cSDS). Taken together, our study provides evidence for the critical role of the OXT system and its pharmacological manipulation in modulating anxiogenic-like effects evoked by social stress. Furthermore, the region-specific modulation of OXT receptor expression within the mPFC by stress and OXT system pharmacological manipulation emphasize the complex and dynamic nature of OXT receptor regulation in brain regions crucial for emotional processing."

Journal • Preclinical • Mood Disorders • Psychiatry

Author Response. (PubMed, BJOG) - No abstract available

Journal • Obstetrics

Comparative effectiveness of oxytocin, carbetocin, and tranexamic acid for postpartum hemorrhage prevention in cesarean deliveries: a prospective cohort analysis. (PubMed, J Perinat Med) - "Carbetocin combined with TXA was associated with the most favorable hematologic profile. These findings support the use of multimodal pharmacologic strategies for PPH prevention in cesarean births and may inform future protocol development."

HEOR • Journal • Hematological Disorders • Postpartum Hemorrhage

Comparative Effectiveness of Carbetocin Versus Oxytocin in Active Management of the Third Stage of Labour for Preventing Atonic Postpartum Haemorrhage: A Study at a Tertiary Care Centre in Central India. (PubMed, Cureus) - "Although insignificant statistically, carbetocin plays an effective role in preventing PPH when compared to oxytocin, particularly in settings where cold chain maintenance for oxytocin transport and storage remains doubtful. Statistically significant lower mean blood loss with carbetocin can be an added advantage."

HEOR • Journal • Obstetrics • Postpartum Hemorrhage

Adverse Effects of Oxytocin Are More Prevalent than Those Associated with Carbetocin Administration During Cesarean Section. (PubMed, J Clin Med) - "Statistical significance was observed for all of the following reported symptoms: headache, chest pain, burning sensation and heaviness in the chest, and palpitations. Although chest pain, burning and heaviness in the chest, palpitations, and headaches are more common in women giving birth by cesarean section after administration of oxytocin than after administration of carbetocin, this fact appears to be of limited clinical significance from a clinical point of view."

Adverse events • Journal • Hematological Disorders • Pain • Postpartum Hemorrhage

Evaluating inconsistences, generalizability, and heterogeneity in analysis of carbetocin versus oxytocin after cesarean delivery in high-risk women. (PubMed, Arch Gynecol Obstet) - No abstract available

Heterogeneity • Journal

One dose, big impact: Revisiting carbetocin in high-risk polyhydramnios deliveries. (PubMed, Int J Gynaecol Obstet) - "Among women with isolated polyhydramnios, carbetocin offers superior prophylactic control of PPH compared to oxytocin and oxytocin-ergometrine regimens. Its long-acting effect provides sustained uterine contraction, reducing the need for additional interventions. Carbetocin might be especially beneficial in high-risk cases of uterine overdistension, supporting its targeted use in individualized obstetric care."

Journal • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

Oxytocin versus carbetocin for preventing postpartum hemorrhage in patients with polyhydramnios during cesarean delivery: A retrospective cohort study. (PubMed, Int J Gynaecol Obstet) - "This research indicated that carbetocin was as effective as oxytocin in reducing postpartum hemorrhage, particularly during a cesarean delivery for those who had been diagnosed with polyhydramnios. Moreover, cases managed with carbetocin require fewer additional uterotonic drugs."

Journal • Retrospective data • Diabetes • Gestational Diabetes • Hematological Disorders • Metabolic Disorders • Postpartum Hemorrhage

A PROSPECTIVE COMPARATIVE STUDY BETWEEN OXYTOCIN AND CARBETOCIN IN PREVENTION OF POST PARTUM HAEMORRHAGE AFTER VAGINAL AND CAESAREAN DELIVERY (FIGO 2025) - "Hence we conclude that carbetocin can be used as a first line uterotonic in cases of PPH."

Clinical • Postpartum Hemorrhage

ADVANCING REPRODUCTIVE RIGHTS THROUGH EQUITABLE ACCESS TO LIFE-SAVING SERVICES AND MEDICINES FOR POSTPARTUM HEMORRHAGE IN SUB-SAHARAN AFRICA (FIGO 2025) - "National policy documents and service delivery protocols were also reviewed to assess the integration of PPH interventions into clinical practice and utilization, policy environment, and commodities (Oxytocin, tranexamic acid, heat-stable carbetocin and misoprostol). Inequitable access to PPH services and medicines undermines the right to survive childbirth. Integrating life-saving interventions into national protocols, expanding provider scope and strengthening supply chains are critical to reducing preventable maternal deaths. Upholding reproductive rights requires aligning clinical practice with global standards to ensure women receive timely, high-quality obstetric care."

Hematological Disorders • Obstetrics • Postpartum Hemorrhage

REAL WORLD EVIDENCE ANALYSIS ON HEAT-STABLE CARBETOCIN FOR PREVENTION OF POSTPARTUM HEMORRHAGE (FIGO 2025) - "HSC, a synthetic oxytocin analogue, has emerged as a promising WHO-recommended medicine in obstetric care for PPH prevention. Data on the real-world evidence of HSC use could provide further evidence to accelerate the accessibility, introduction, and uptake of this life-saving drug in high-burden settings."

Clinical • HEOR • Real-world • Real-world evidence • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

DOCUMENTATION AND REPORTING OF PPH KEY PERFORMANCE INDICATORS REAL WORLD EXPERIENCE FROM KENYA (FIGO 2025) - "Nearly all women received a uterotonic for PPH prevention, with 97.6% (n = 11.386) receiving heat stable carbetocin and 2.4% receiving oxytocin. Collecting PPH key performance indicators is feasible through modification of existing registers, while employing data quality approaches. Programs should focus on real-time client data documentation, effective reporting and advocacy for inclusion of these indicators into HMIS to enhance data use for decision making, a critical component in improving PPH response."

Clinical • Real-world • Real-world evidence

COMPARATIVE EVALUATION OF OXYTOCIN VS CARBETOCIN FOR PREVENTION OF POST PARTUM HAEMORRHAGE IN CESAREAN AND VAGINAL DELIVERIES IN NORTH INDIA (FIGO 2025) - "Carbetocin use is associated with less incidence of mild and moderate PPH, less use of other oxytocic agent compared with oxytocin with equal safety profile. Carbetocin is superior, cost-effective drug for prevention of PPH than conventional oxytocin in cesarean as well vaginal delivery."

Mood Disorders • Postpartum Hemorrhage

COST-EFFECTIVENESS RESULTS COMPARING HEAT-STABLE CARBETOCIN & OTHER UTEROTONICS IN POSTPARTUM HEAMORRHAGE PREVENTION IN UGANDA (FIGO 2025) - "Heat-stable carbetocin for preventing PPH in Uganda has the potential to reduce PPH events, and subsequently maternal deaths, DALYs, and costs for the public healthcare system. Adopting heat-stable carbetocin will contribute towards achieving the country's Sustainable Development Goal 3.1."

Cost effectiveness • HEOR • Postpartum Hemorrhage

KENYA NATIONAL AND COUNTY-LEVEL STAKEHOLDER PERSPECTIVES ON SCALE-UP OF PPH MEDICINES (FIGO 2025) - "Data was collected 6 months after introduction of heat-stable carbetocin and tranexamic acid at 36 public health facilities in Makueni County, Kenya. National and county-level stakeholders emphasized the importance of a comprehensive approach to scaling up PPH medicines, prioritizing supply chain management, policy reform, healthcare provider training and financing. Successful and sustainable scale-up requires coordinated efforts between government bodies, healthcare systems, and community to enhance maternal health outcomes."

Hematological Disorders • Postpartum Hemorrhage

Driving institutionalization of lifesaving PPH innovations in Kenya through SMART advocacy approach (FIGO 2025) - " Key advocacy wins include development of the first national quantification of products and technologies for PPH prevention and treatment, lowering level of use for heat stable carbetocin and tranexamic acid to all facilities, procurement of 360 000 doses of HSC by government, updating national guidelines, national training package including December 2023 WHO recommendations, development of the first national costed implementation and scale up plan for PPH innovations, and successful advocacy for resources to implement this plan. A structured, consistent, collaborative advocacy approach is effective in driving change in policy and guidelines, which is instrumental in institutionalization of new PPH recommendations. A multi-stakeholder approach that involves consensus building on the priority asks from the government is key."

Clinical • Hematological Disorders • Postpartum Hemorrhage

Scaling up lesser known PPH medications: Generating evidence through AMPLI-PPHI (FIGO 2025) - "Nearly all women received a uterotonic for PPH prevention, with 97.6% (n = 11 386) receiving heat stable carbetocin and 2.4% receiving oxytocin. All 301 (100%) PPH cases used the clinical care bundle (tranexamic acid, uterotonic, and IV fluids) for treatment and no PPH-related maternal deaths were recorded in 2024. Collecting PPH key performance indicators is feasible through modification of existing registers, while employing data quality approaches. Programs should focus on real-time client data documentation, effective reporting and advocacy for inclusion of these indicators into HMIS to enhance data use for decision making."

Carbetocin for the Prevention of Postpartum Hemorrhage: A Systematic Review and Meta-Analysis—A Double-Blind Randomized Controlled Trial at District Hospital Ballari, India (FIGO 2025) - "Carbetocin is more effective than oxytocin in preventing PPH in women undergoing both vaginal and cesarean deliveries, with a statistically significant reduction in PPH incidence, need for additional uterotonic agents, and hemoglobin decline. Its safety profile is comparable to that of oxytocin, making it a viable first-line prophylactic uterotonic in similar clinical settings."

Retrospective data • Review • Hematological Disorders • Postpartum Hemorrhage

Policy-Driven Maternal Health and Cervical Cancer Prevention Initiatives in Nigeria: A Multisectoral Approach to Improving Women's Health (FIGO 2025) - "Key interventions included: (1) antenatal/postnatal education and mental health support (MamaCare360) across 7 states; (2) health worker training in Emergency Obstetric Care and introduction of heat-stable carbetocin for postpartum haemorrhage prophylaxis in selected hospitals; and (3) community mobilization for the national HPV vaccination campaign... Multisectoral, policy-driven interventions by an indigenious African NGO demonstrated notable improvements in maternal and adolescent girls' health outcomes. Strengthening frontline capacity and community engagement led to reduced preventable maternal deaths (especially from PPH) and rapid uptake of a life-saving cervical cancer vaccine. This model illustrates how aligning local programs with global recommendations can accelerate progress toward FIGO's 2025 goals."

Clinical • Cervical Cancer • Obstetrics • Oncology • Postpartum Hemorrhage • Solid Tumor • Women's Health

The Oxytocin Receptor in Spermatozoa May Originate From Both Spermatogenesis and Epididymal Maturation, and Regulates Capacitation. (PubMed, Andrology) - "The presence of the OR in mammalian spermatozoa could originate from both spermatogenesis and epididymal maturation. Moreover, in the male gamete, this receptor regulates sperm capacitation by interacting with its ligand in the female reproductive tract."

Journal • Dyslipidemia

Economic Uncertainty Surrounding Carbetocin for PPH Prophylaxis. (PubMed, BJOG) - No abstract available

Journal

Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital | Initiation date: Apr 2025 ➔ Sep 2025

Trial initiation date • Hematological Disorders • Postpartum Hemorrhage