B7-H3 vaccine / Sequencio Therapeutics - LARVOL DELTA

B7-H3 vaccine induces robust humoral and cellular immunity and inhibits tumor growth in mice (AACR 2026) - "In MC38-hB7-H3 tumors, TIL analysis showed a 2.8-fold increase in CD8α+IFNγ+ T cells.Conclusions Our study demonstrates that the B7-H3 vaccine induces robust humoral and cellular immunity, effectively suppressing the growth of B7-H3-positive tumors in mice. These findings highlight its potential for clinical translation as a therapeutic strategy for B7-H3-overexpressing cancers in humans."

Preclinical • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • CD276 • CD4 • IFNG