oxcarbazepine / Generic mfg. - LARVOL DELTA

Precision dosing of perampanel in pediatric patients receiving oxcarbazepine combination therapy: physiologically based pharmacokinetic modeling and simulation. (PubMed, Expert Rev Clin Pharmacol) - "Additionally, the recommended doses of PER in PER with OXC combination therapy for children aged 4-10 and 10-14 years are 6-12 mg q.n. and 10-12 mg q.n. respectively. The PBPK and DDI models of PER were successfully established, which serve as references for the rational use of this medication in children."

Journal • PK/PD data • Pediatrics

Cleaning validation in pharmaceutical quality control laboratories: a structured protocol for contamination risk mitigation. (PubMed, Daru) - "The proposed strategy provides a structured, statistically grounded framework for developing cleaning validation protocols in QC laboratories, promoting effective contamination control and adherence to regulatory standards."

Journal

What drives hyperammonemic encephalopathy in AED users: monotherapy risks or polypharmacy perils? (PubMed, Front Pharmacol) - "Hyperammonemic encephalopathy (HE) is a serious side effect linked to sodium valproate (VPA)...FAERS reports from the first quarter of 2013 to the third quarter of 2024 were examined for ten frequently prescribed antiepileptic drugs (AEDs): VPA, perampanel (PER), phenytoin (PHT), carbamazepine (CBZ), topiramate (TPM), lamotrigine (LTG), levetiracetam (LEV), oxcarbazepine (OXA), clonazepam (CZP), and zonisamide (ZNS)...Particular attention was given to the effects of VPA in combination with LEV, TPM, olanzapine (OLZ), or quetiapine (QTP) on the risk of HE...This research underscores the possible danger of HE related to AEDs, with a particular focus on the risks tied to VPA and PER when used alone, as well as VPA in conjunction with TPM, OLZ, or QTP. It emphasizes the need to monitor ammonia levels in patients on AEDs, particularly those on polypharmacy."

Journal • Monotherapy • CNS Disorders • Mental Retardation • Psychiatry

Drug-resistant Epilepsy: Which Drugs are Substrates of P-glycoprotein and Which are Not? (PubMed, Curr Neuropharmacol) - "among the anticrisis medications, the following are likely substrates of P-glycoprotein: Phenytoin, Phenobarbital, Oxcarbazepine, Lamotrigine, Topiramate, and Lacosamide (less evidence). The following are probably not substrates: Brivaracetam, Zonisamide, Valproic acid, Perampanel, Gabapentin, and Vigabatrin. We have not obtained enough information about: Carbamazepine, Eslicarbazepine, Levetiracetam, Tiagabine, Felbamate, Pregabalin, Rufinamide, Ezogabine, and Retigabine."

Journal • CNS Disorders • Epilepsy

Oxcarbazepine induced systemic lupus erythematosus: a clinical challenge. (PubMed, An Bras Dermatol) - No abstract available

Journal • Immunology • Inflammatory Arthritis • Lupus • Systemic Lupus Erythematosus

Switching from oxcarbazepine to eslicarbazepine in pediatric patients with focal epilepsy is safe and well-tolerated. (PubMed, Epilepsy Behav) - "Overnight switching from oxcarbazepine to eslicarbazepine is well tolerated in pediatric patients with focal epilepsy. Switching to eslicarbazepine is particularly beneficial for patients experiencing oxcarbazepine-related adverse effects."

Journal • CNS Disorders • Epilepsy • Pediatrics

Pediatric refractory epilepsy related to tuberous sclerosis complex: A retrospective-cohort study of diagnosis and treatment. (PubMed, Seizure) - "Age of onset, infantile spasms, type II lesions, TSC2 mutation status, family history, and clustered seizures were identified as potential risk factors for the development of RE. ASM should be recommended for TSC patients even in cases with subclinical epileptiform EEG discharge. Using vigabatrin and sirolimus earlier in childhood may reduce the occurrence of RE."

Journal • Retrospective data • CNS Disorders • Epilepsy • Pediatrics • TSC2

Sodium Channel Blockers for Vestibular Paroxysmia in Children. (PubMed, Audiol Res) - "To date, oxcarbazepine (OXC) and carbamazepine (CBZ) are the only two molecules prescribed. VP has been identified in pediatric patients and appears to respond to sodium channel blockers in a manner similar to adults. Only a limited number of cases have been reported to date; thus, there is a need to raise awareness about this treatable cause of episodic vertigo in children."

Journal • Review • Otorhinolaryngology • Pediatrics • Vertigo

Optimizing oxcarbazepine therapy for epilepsy in patients aged 0-16 years: a comprehensive study of individualized treatment factors. (PubMed, Eur J Pharmacol) - "This study provides a comprehensive analysis of MHD blood concentration determinants in pediatric epilepsy patients, emphasizing the importance of personalized treatment approaches. These findings offer a valuable reference for optimizing oxcarbazepine therapy, improving therapeutic outcomes, and minimizing adverse effects in children and adolescents with epilepsy."

Journal • CNS Disorders • Epilepsy • Pediatrics

Treating seizures in SYN1-related epilepsy: a systematic review. (PubMed, Seizure) - "Based on our systematic literature review, patients with SYN1-related epilepsy show better seizure frequency reduction when treated with LCM, LTG, CBZ, or OXC, compared to VPA and LEV, despite VPA being the most prescribed anti-seizure medication for this syndrome. Hence, sodium channel blockers appear to represent the best therapeutic option for these patients."

Journal • Review • Behavior Disorders • CNS Disorders • Developmental Disorders • Epilepsy • Mental Retardation • Psychiatry • Napsin A

Crippling trigeminal neuralgia responsive to lumbar puncture (AHS 2025) - "She initially had benefit from carbamazepine, but over time the medication became less effective such that she required additional neuropathic agents, which only provided minimal, temporary relief...MRI brain with contrast and MRA brain without contrast reported a right petrous meningocele and a possible vascular compression on the right CN V. The patient's diagnosis of trigeminal neuralgia was clinically confirmed, her oral medication regiment was optimized, and she underwent three days of infusions with cyproheptadine, methylprednisolone, levetiracetam, magnesium and methocarbamol...Six months later, she remains on moderate doses of gabapentin, oxcarbazepine and acetazolamide and has sustained 80% improvement in her right sided facial pain... This clinical case provides further support for the possible association between IIH causing a meningocele that can be compressive on the trigeminal nerve, implying a relationship between IIH and TN. This case demonstrates how..."

CNS Disorders • Migraine • Neuralgia • Pain • Psychiatry • Suicidal Ideation

Blistering Discovery: A Rare Case of Toxic Epidermal Necrolysis Triggered by Carboplatin and Radiotherapy (EAACI 2025) - "He was diagnosed with TEN and admitted for treatment with subcutaneous etanercept (50mg) and intravenous methylprednisolone (7 mg/day)...Patch testing with where patch tests with multiple anticonvulsants in DMS (carbamazepine 10%, oxcarbazepine 10, phenytoin 10%, phenobarbital 1%, eslicarbazepine 10%, lamotrigine 10%, levetiracetam 10%, and DMSO control, yielded positive results at 96 hours for all components including the DMSO control... Biopsies revealed a "Lichenoid pattern dermatitis with extensive keratinocyte necrosis and eosinophilia" consistent with erythema multiforme. Upon discharge, the patient was advised to avoid aromatic anticonvulsants, platinum agents, and taxanes. One month post-reaction, the Drug-allergy Unit of Hospital Gregorio Marañón evaluated the patient."

Clinical • Dermatitis • Immunology

Effects of antiseizure drugs zonisamide, oxcarbazepine, clobazam, and lacosamide on FOXO1, LIF, and E-cadherin- mediated molecules in rat embryo implantation. (PubMed, Life Sci) - "These results suggest that long-term administration of ZNS, OXC, CLB, and LCM may impair implantation by altering key molecular markers. The findings highlight potential reproductive risks associated with chronic antiepileptic drug exposure during adolescence."

Journal • Preclinical • CNS Disorders • Epilepsy • Hematological Malignancies • Leukemia • Oncology • CDH1 • FOXO1 • LIF

Clinical efficacy of lacosamide monotherapy in children with focal epilepsy and comorbid depression and its impact on peripheral blood interleukin-6 and serotonin expression. (PubMed, Epilepsy Res) - "Lacosamide monotherapy effectively controls seizures and alleviates depressive symptoms in adolescents with focal epilepsy and depression. These benefits may be associated with decreased IL-6 and increased 5-HT levels. Lacosamide also demonstrated a favourable safety profile."

Journal • Monotherapy • CNS Disorders • Depression • Epilepsy • Mood Disorders • Psychiatry • IL6

Efficacy, Safety, and Tolerability of Lacosamide Monotherapy for Focal Seizures in Young Children Aged >=1 Month to <=4 Years: A Real-world Study (ChiCTR) - P=N/A | N=266 | Completed | Sponsor: Children's Hospital of Chongqing Medical University; Children's Hospital of Chongqing Medical University

Monotherapy • New trial • Real-world evidence • CNS Disorders • Epilepsy • Pediatrics

ABCC2 as a novel covariate influencing oxcarbazepine pharmacokinetics in pediatric epilepsy: Insights from population modeling. (PubMed, Drug Metab Dispos) - "Wild-type ABCC2 rs2273697 exhibited a 25% and 14% higher 10-hydroxycarbazepine apparent clearance compared to homozygous and heterozygous variation patients, respectively. Based on our model, an optimized dosing regimen for oxcarbazepine has been proposed aiming for various subgroups of patients."

Journal • PK/PD data • CNS Disorders • Epilepsy • Pediatrics • ABCC2

Optimization and development of a green high performance liquid chromatography method for determination of 8 anti-epileptic drugs and 2 active metabolites in human serum assessed using AGREE, AGREEprep, GAPI and BAGI. (PubMed, Anal Methods) - "The aim of this study was to optimize and develop a green high-performance liquid chromatography (HPLC) method suitable for simultaneous detection of 8 AEDs and 2 active metabolites including primidone (PRM), lamotrigine (LTG), carbamazepine (CBZ) and its active metabolite 10,11-epoxide (CBZE), oxcarbazepine (OXC) and its active metabolite 10,11-dihydro-10-hydroxyl carbamazepine (MHD), phenobarbital (PHB), eslicarbazepine acetate (ESLA), clonazepam (CZP) and diazepam (DZP) in human serum. The results of greenness assessment showed that the proposed method was ecofriendly. Finally, the validated method was successfully applied in the analysis of real serum samples."

Journal • CNS Disorders • Epilepsy

Oxcarbazepine Induced Rhabdomyolysis and Acute Kidney Injury: A Case Report. (PubMed, Case Rep Nephrol) - "In this presented case, oxcarbazepine, which is a preferred drug in the treatment of epilepsy and also in neuropathic pain in clinical practice, triggered rhabdomyolysis and subsequently caused the development of AKI. Through this case report, we aimed to emphasize that some serious side effects should not be forgotten when prescribing drugs in clinical practice."

Journal • Acute Kidney Injury • CNS Disorders • Epilepsy • Nephrology • Neuralgia • Pain • Renal Disease

Unseen Threats: The Impact of Environmental Mycotoxin Exposure on Psychosis and Psychiatric Disorders in a New Jersey Cohort (APA 2025) - "Discharge medications included aripiprazole (20%), lithium (20%), olanzapine (20%), lurasidone (20%), clozapine (20%), haloperidol (20%), gabapentin (10%), divalproex (10%), oxcarbazepine (10%), clonazepam (10%), mirtazapine (10%), and quetiapine (10%)... This study highlights a potential link between environmental mold exposure and psychiatric presentations, with psychotic symptoms observed in 56% of patients. While causation cannot be inferred, the findings underscore the possible role of environmental factors in etiology or exacerbation of psychiatric conditions. This study contributes to a growing body of evidence that expands upon traditional views of psychiatric illness by incorporating environmental factors into the diagnostic framework."

Alzheimer's Disease • Bipolar Disorder • CNS Disorders • Cognitive Disorders • Depression • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia

A Case Study and Literature Review on Psychotic Syndromes in Epilepsy (APA 2025) - "These symptoms rapidly resolved with added risperidone and valproate to his home regimen of oxcarbazepine and levetiracetam. We present a case of amnestic self-castration associated with psychosis in epilepsy. This case highlights diagnostic challenges and the value of further research for early identification and management of psychotic syndromes in epilepsy."

Case study • Clinical • Review • CNS Disorders • Epilepsy • Psychiatry

Burning Up - How Heat Stroke Can Spark GBS (ATS 2025) - "Case Presentation: A 50-year-old female with diabetes mellitus and bipolar disorder (managed with citalopram, high-dose quetiapine, alprazolam, and oxcarbazepine) presented with acute confusion and lethargy...A central line was placed, and sedation was maintained with midazolam... Guillain-Barré Syndrome secondary to heat stroke presents a unique diagnostic challenge. This case highlights the critical role of early diagnosis and intervention, as timely initiation of IVIG may improve prognosis. Further research into the pathophysiological link between heat stroke and GBS could better inform clinical management and enhance awareness of this rare association."

Anesthesia • Bipolar Disorder • Cardiovascular • CNS Disorders • Diabetes • Epilepsy • Infectious Disease • Metabolic Disorders • Mood Disorders • Myositis • Pain • Psychiatry • Respiratory Diseases

Two-Year Retention Rate and Clinical Usefulness of Eslicarbazepine Acetate in Epilepsy Patients. (PubMed, Clin Neuropharmacol) - "Our study demonstrates that treatment with ESL results in favorable retention rates and tolerability among Korean epilepsy patients, which is consistent with data from Western countries. Additionally, our findings suggest that ESL-induced hyponatremia is infrequent and largely asymptomatic when used cautiously and switching from other dibenzazepine ASMs may be a useful option for selected patients."

Journal • Observational data • Retrospective data • Cardiovascular • CNS Disorders • Epilepsy • Heart Failure

13. Trigeminal Neuralgia. (PubMed, Pain Pract) - "Recommendations are based on very low-quality evidence. MVD and radiofrequency are the preferred invasive treatments, although higher-quality evidence is necessary to better assess the risk-benefit ratios."

Journal • Review • CNS Disorders • Multiple Sclerosis • Neuralgia • Oncology • Pain

The Alternative Effects of Electroacupuncture in the Treatment of Trigeminal Neuralgia (clinicaltrials.gov) - P=N/A | N=148 | Not yet recruiting | Sponsor: Yuanyuan Wu

New trial • Neuralgia • Pain

Clinical phenotypic and genetic analysis of three children with Paroxysmal kinesigenic dyskinesia and Self-limited familial infantile epilepsy caused by PRRT2 gene mutation (PubMed, Zhonghua Yi Xue Yi Chuan Xue Za Zhi) - "One case of SeLIE and two cases of PKD caused by PRRT2 gene mutations responded well to anti-seizure drugs. In this study, four variant loci of PRRT2 gene were found: c.583_584dup, c.904G>C, c.649dupC, c.445C>A, among which c.583_584dup were new variants, enriching the variant spectrum of PRRT2 gene."

Journal • Retrospective data • CNS Disorders • Dystonia • Epilepsy • Movement Disorders