dexmedetomidine intranasal (Dex-IN) / Baudax Bio - LARVOL DELTA

Comparison of Oral Chloral Hydrate and Combination of Intranasal Dexmedetomidine and Ketamine for Procedural Sedation in Children (clinicaltrials.gov) - P=N/A | N=136 | Recruiting | Sponsor: Seoul National University Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Anesthesia

[VIRTUAL] Children’s Healthcare of Atlanta “Nose” Best: A medication use evaluation of intranasal dexmedetomidine and intranasal midazolam (ASHP 2020) - "Monitoring parameters (level of consciousness, mental status, blood pressure, heart rate, respiratory rate, oxygen saturation, and adverse effects) were also evaluated at baseline and after administration of respective medication as well as whether or not additional sedatives were needed. A REDCap form was built and utilized to aid in the data collection process."

Clinical • Anesthesia • Epilepsy • Pediatrics

Auditory brainstem response testing using intranasal dexmedetomidine sedation in children: a pilot study. (PubMed, Int J Audiol) - "This allowed for faster time to discharge compared to GA, produced what was felt to be a better quality ABR trace, better utilization of a theatre slot, negated the need for GA in a child and created a less stressful experience for both parent and child according to information from feedback questionnaires."

Clinical • Journal • Anesthesia • Pediatrics

Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol. (PubMed, BMJ Open) - "Study data will be submitted for publication regardless of results. NCT0419525."

Clinical • Head-to-Head • Journal • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain • Pediatrics

Effects of Local Warming on the Peripheral Vein Cross-Sectional Area in Children Under Sedation. (PubMed, J Perianesth Nurs) - "The application of local warming induced mild venodilation in cephalic vein with an increase in CSA by 34% and had little venodilation effect on the basilic vein with an increase in CSA by only 21%."

Clinical • Journal • Anesthesia

The Use of Intranasal Dexmedetomidine and Midazolam for Sedated Magnetic Resonance Imaging in Children: A Report From the Pediatric Sedation Research Consortium. (PubMed, Pediatr Emerg Care) - "This report from the PSRC shows that IN DEX in combination with midazolam is an effective medication regimen for children who require an MRI with sedation."

Clinical • Journal • Anesthesia • Pediatrics

The effect of dexmedetomidine on postoperative behaviour change in children: a randomised controlled trial. (PubMed, Anaesthesia) - "The incidence of negative behaviour in the group who received dexmedetomidine intra-operatively was less at postoperative day 28 (15% compared with 36% in the dexmedetomidine premedication group and 41% in the control group, p<0.001). We conclude that dexmedetomidine does not reduce the incidence of negative behaviour on postoperative day 3 in two to seven-year olds having day case procedures."

Clinical • Journal • Anesthesia • Mood Disorders • Pain • Pediatrics

[VIRTUAL] Mediastinal Mass Biopsy In An Autistic, Obese Patient (ASA 2020) - "Intramuscular ketamine had a mild sedative effect...Airway was maintained with a nasal cannula. He underwent a successful biopsy without apparent anesthetic complications."

Clinical • Anesthesia • Genetic Disorders • Hematological Malignancies • Hodgkin Lymphoma • Lymphoma • Obesity • Oncology

Intranasal Dexmedetomidine Reduces Postoperative Opioid Requirement in Patients Undergoing Total Knee Arthroplasty Under General Anesthesia. (PubMed, J Arthroplasty) - "Intraoperatively administered intranasal dexmedetomidine reduces postoperative opioid consumption and may be associated with a shorter hospital stay in patients undergoing TKA under general anesthesia."

Clinical • Journal • Anesthesia • Orthopedics • Pain

Pre-medication before dental procedures: A randomized controlled study comparing intranasal dexmedetomidine with oral midazolam. (PubMed, Acta Anaesthesiol Scand) - "Intranasal dexmedetomidine provides higher success rate in sedation and parental separation compared to oral midazolam, in older, difficult children."

Clinical • Journal • Anesthesia • Behavior Disorders • Developmental Disorders • Mental Retardation • Psychiatry

Intranasal dexmedetomidine versus oral midazolam premedication to prevent emergence delirium in children undergoing strabismus surgery: A randomised controlled trial. (PubMed, Eur J Anaesthesiol) - P4 | "In paediatric patients undergoing strabismus surgery intranasal dexmedetomidine 2 μg kg premedication decreases the incidence of emergence delirium and PONV, and improves parents' satisfaction compared with oral midazolam."

Clinical • Journal • Anesthesia • CNS Disorders • Ophthalmology • Otorhinolaryngology • Pain • Pediatrics • Strabismus

Efficacy of premedication with intranasal dexmedetomidine for removal of inhaled foreign bodies in children by flexible fiberoptic bronchoscopy: a randomized, double-blind, placebo-controlled clinical trial. (PubMed, BMC Anesthesiol) - "Intranasal dexmedetomidine 1 μg·kg, with its sedative and analgesic effects, reduced the incidences of laryngospasm, breath-holding, and coughing during fiberoptic bronchoscopy for FB removal. Moreover, it reduced postoperative agitation without a prolonged recovery time."

Clinical • Journal • Anesthesia • CNS Disorders • Depression • Pain

Implementation of a Spinal Anesthesia and Sedation Protocol that Reliably Prolongs Infant Spinal Anesthesia: Case Series of 102 Infants who received Spinal Anesthesia for Urologic Surgery. (PubMed, Paediatr Anaesth) - "We describe the successful implementation of an infant spinal anesthesia and sedation protocol and a technique that uniquely provides prolonged surgical anesthesia with a low failure rate. We also report shorter anesthesia time, surgical time, and recovery room length of stay in patients who received spinal anesthesia compared to general anesthesia."

Clinical • Journal • Anesthesia • Urology

Intranasal dexmedetomidine in pediatrics: update of current knowledge. (PubMed, Minerva Anestesiol) - "In summary, available pediatric evidence confirms efficacy and safety of dexmedetomidine for intranasal administration. Pharmacological profile for the various pediatric ages and procedures still needs quality studies and pharmacokinetic in-depth analysis."

Clinical • Journal • Pain • Pediatrics

[VIRTUAL] Pediatric procedural sedation and analgesia in european emergency departments: Surveying the current practice. (EUSEM 2020) - "Of the PS medications, midazolam (100%) and ketamine (91%) were available to most children, whereas propofol (68%) IN fentanyl (47%), chloral hydrate (42%), and IN dexmedetomidine (10%) were less frequently available...Nurse-directed triage protocols were in place in most EDs for paracetamol (99%) and ibuprofen (91%), but rarely for an oral (23%) or intranasal opiate (13%)... PS is prevalent in European EDs but some sedation agents and topical analgesics are not widely available. Guidelines are common but further safety nets and CLS programs are lacking. Barriers to PS implementation include availability of sedation agents, staff shortages, and lack of space."

Clinical • Anesthesia • Mood Disorders • Pain • Pediatrics • Psychiatry

Comparison of ED of intranasal dexmedetomidine sedation in children with acyanotic congenital heart disease before and after cardiac surgery (PubMed, Nan Fang Yi Ke Da Xue Xue Bao) - "In children with acyanotic congenital heart disease, the ED of intranasal dexmedetomidine for TTE sedation increases to 3.38 μg/ kg after cardiac surgery from the preoperative value of 1.84 μg/kg."

Clinical • Journal • Anesthesia • Cardiovascular • Heart Failure • Pediatrics

The 90% effective dose of intranasal dexmedetomidine for procedural sedation in children with congenital heart disease before and after surgery: a biased-coin design up-and-down sequential allocation trial. (PubMed, Acta Anaesthesiol Scand) - "The 90% effective dose of intranasal dexmedetomidine for sedation in children with congenital heart disease was 2.13 μg/kg before cardiac surgery and 3.51 μg/kg after cardiac surgery."

Clinical • Journal • Anesthesia • Cardiovascular • Heart Failure

Intranasal dexmedetomidine combined with local anesthesia for conscious sedation during breast lumpectomy: A prospective randomized trial. (PubMed, Oncol Lett) - "Patient and surgeon satisfaction were greater in the 1.5 µg.kg group compared with the 1 and 2 µg.kg groups. Taken together, the results of the present study suggested that conscious sedation with intranasal dexmedetomidine and local anesthesia may be an effective anesthetic for breast lumpectomy surgery, and that the optimal dose for intranasal dexmedetomidine administration may be 1.5 µg.kg, as it resulted in good sedation and patient satisfaction without adverse effects."

Clinical • Journal • Anesthesia • Pain

Combined intranasal fentanyl and dexmedetomidine plus inhaled nitrous oxide sedation in children needing myringotomy and ventilation tube insertion with a specific handheld device. (PubMed, Int J Pediatr Otorhinolaryngol) - "A combination of intranasal dexmedetomidine, fentanyl, and iNO could be considered as a possible option for procedural sedation in children with OME undergoing procedural sedation for tympanostomy tube placement in children with Solo TTD device."

Clinical • Journal • Pain • Pediatrics

Determination of the 90% effective dose of intranasal dexmedetomidine for sedation during electroencephalography in children. (PubMed, Acta Anaesthesiol Scand) - "The 90% effective dose of intranasal DEX sedation for EEG was 3.28 μg kg in children under 3 years old."

Clinical • Journal • CNS Disorders

Chloral Hydrate Sedation in a Dexmedetomidine Era. (PubMed, Hosp Pharm) - " Despite significant declines in use of chloral hydrate for procedural sedation across the country, local utilization of oral chloral hydrate remains high. Recent declines may be due to high-use clinical sites transitioning to alternative sedatives such as intranasal dexmedetomidine."

Journal

Evaluation of Intranasal Dexmedetomidine as a Procedural Sedative for Ophthalmic Examination of Children With Glaucoma. (PubMed, J Glaucoma) - "IND appears to be a safe and effective procedural sedative for postoperative follow-up examinations of pediatric glaucoma patients at doses of 3 and 3.5 µg/kg. The dose of 3.5 µg/kg was successful in more children."

Clinical • Journal • Anesthesia • Atrial Fibrillation • Cardiovascular • Glaucoma • Ophthalmology • Pediatrics

Oral chloral hydrate versus intranasal dexmedetomidine for sedation of children undergoing computed tomography: a multicentre study. (PubMed, Hong Kong Med J) - No abstract available

Clinical • Journal

Safety and Efficacy of Buccal Dexmedetomidine for MRI Sedation in School-Aged Children. (PubMed, Hosp Pediatr) - "In a selected population of pediatric patients, buccal dexmedetomidine with or without midazolam provides adequate sedation for most MRI studies with few adverse effects, but given a failure rate of almost 20%, modifications to buccal dexmedetomidine dosing should be investigated."

Clinical • Journal • Retrospective data • Pediatrics

Comparison of Intranasal Dexmedetomidine Versus Intranasal Ketamine as Premedication for Level of Sedation in Children Undergoing Radiation Therapy: A Prospective, Randomised, Double-Blind Study. (PubMed, Turk J Anaesthesiol Reanim) - "The patients in group D required more time to awakening, but this difference was not clinically significant. The present study demonstrated that IN dexmedetomidine is superior to IN ketamine to provide procedural sedation for radiotherapy in children."

Clinical • Journal • Oncology • Solid Tumor