losartan/ hydrochlorothiazide / Generic mfg. - LARVOL DELTA

Double trouble: The first reported case of evans syndrome following RSV Vaccination (ASH 2025) - "Her home medications included amlodipine, losartan, hydrochlorothiazide, and she reported receiving the RSV vaccine one week before admission...The patient was started on presumed ITP treatment with a 1g/kg dose of IVIG and high-dose dexamethasone 40 mg for 4 days...Due to refractory thrombocytopenia, the treatment was shifted to rituximab after the development of hemolytic anemia. The patient received a total of 4 doses weekly, along with a prednisone taper starting at 1 mg/kg, resulting in a slow improvement in her counts back to normal...Evans syndrome ideally requires multidisciplinary care and long-term monitoring due to its chronic, relapsing nature. This case highlights the importance of ongoing pharmacovigilance and educating physicians about immune-mediated hematologic complications that can occur post-vaccination, which are rare but potentially severe."

Clinical • Cardiovascular • Dyslipidemia • Hematological Disorders • Hematological Malignancies • Hepatology • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Primary Immunodeficiency • Respiratory Syncytial Virus Infections • Thrombocytopenia • HP

Can Arteriovenous Fistula Creation Cause a Dramatic Spontaneous Doubling of Estimated Glomerular Filtration Rate from 11 to 22 mL/min/1.73 m2 Body Surface Area (BSA) in a Span of Five Months? A Case Report (KIDNEY WEEK 2025) - "He was on Amlodipine 10 mg/d, Losartan-Hydrochlorothiazide 100-25 mg/d, Spironolactone 25 mg/d, insulin and levothyroxine. What are the implications of this observation? Our observations call for further enquiry."

Case report • Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Endocrine Disorders • Hypertension • Metabolic Disorders • Nephrology • Obstructive Sleep Apnea • Renal Disease • Respiratory Diseases • Sleep Apnea • Sleep Disorder

Emulation of a Target Trial of Antihypertensive Medications on Weight Change. (PubMed, J Gen Intern Med) - "We observed small differences in weight change across antihypertensive medications, with lisinopril leading to weight loss and metoprolol and propranolol to modest weight gain. Clinicians should consider potential weight gain when selecting antihypertensive medications."

Journal • Cardiovascular • Hypertension

Severe Hemorrhagic Cheilitis as the Initial Manifestation of Systemic Lupus Erythematosus: A Rare Case Report (EADV 2025) - "Her regular medications included: losartan, hydrochlorothiazide, and atorvastatin...She was started on oral prednisolone 40 mg daily along with HCQ 200mg after excluding any pre-existing maculopathy... Severe hemorrhagic cheilitis is an uncommon mucocutaneous manifestation of SLE and may be misdiagnosed due to its rarity. In this case, lower lip involvement suggested a potential role of photoaggravation. While management guidelines for oral lupus remain limited, systemic corticosteroids and HCQ showed rapid effectiveness."

Case report • Clinical • Dermatology • Epilepsy • Hematological Disorders • Immunology • Inflammatory Arthritis • Lupus • Macular Degeneration • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Retinal Disorders • Systemic Lupus Erythematosus

A rare case report: Pseudoxanthoma elasticum-like papillary dermal elastolysis (EADV 2025) - "Her medical history included type 2 diabetes mellitus and hypertension, managed with metformin, losartan/hydrochlorothiazide, and amlodipine...Treatment with three sessions of intralesional triamcinolone acetonide (10 mg/mL) was initiated... PXE-PDE is a rare and under-recognized condition that requires clinical suspicion and histopathological confirmation. It should be differentiated from PXE to avoid unnecessary systemic investigations. Current treatment options remain limited, and patient response is generally poor."

Case report • Clinical • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders • Type 2 Diabetes Mellitus

A rare case report: Pseudoxanthoma elasticum-like papillary dermal elastolysis (EADV 2025) - "Her medical history included type 2 diabetes mellitus and hypertension, managed with metformin, losartan/hydrochlorothiazide, and amlodipine...Treatment with three sessions of intralesional triamcinolone acetonide (10 mg/mL) was initiated... PXE-PDE is a rare and under-recognized condition that requires clinical suspicion and histopathological confirmation. It should be differentiated from PXE to avoid unnecessary systemic investigations. Current treatment options remain limited, and patient response is generally poor."

Case report • Clinical • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders • Type 2 Diabetes Mellitus

Metformin Associated Lactic Acidosis - A Critical Diagnostic Priority (ATS 2025) - "Her home medications included metoprolol, amlodipine, hydrochlorothiazide, losartan, metformin, insulin glargine and aspart. Furthermore, the level of metformin required to cause toxicity has not been clearly defined. IMPORTANCE OF CASE- With metformin's wide usage for DM and Polycystic Ovary Syndrome, and its recent potential as an anti-aging medication, the awareness around MALA should be increased as it can be a devastating condition as demonstrated by this case."

Anemia • Cardiovascular • Diabetes • Hematological Disorders • Hepatology • Hypertension • Infectious Disease • Liver Failure • Metabolic Disorders • Nephrology • Polycystic Ovary Syndrome • Renal Disease • Septic Shock

Endocrine Crisis and Obstruction: ACTH-producing Small Cell Lung Cancer Presenting With Superior Vena Cava Syndrome (ATS 2025) - "She was started on hydrochlorothiazide-losartan and potassium supplementation...Spironolactone was initiated for hypertension and refractory hypokalemia management...The patient began chemotherapy with cisplatin and etoposide, followed by immunotherapy with durvalumab, and radiation therapy with significant improvement...However, the patient's persistent facial plethora and development of right upper arm swelling, ameliorated by positional changes suggested a concomitant Superior Vena Cava (SVC) syndrome. This case highlights the importance of considering SVC syndrome in the differential diagnosis of a patient who presents with SCLC."

Cardiovascular • Cushing’s Disease • Endocrine Disorders • Hypertension • Lung Cancer • Metabolic Disorders • Myasthenia Gravis • Non Small Cell Lung Cancer • Oncology • Pulmonary Disease • Small Cell Lung Cancer • Solid Tumor

Optimizing Blood Pressure Control: A Randomized Comparative Trial of Losartan/Chlorthalidone vs. Losartan/Hydrochlorothiazide. (PubMed, Cardiol Ther) - P3 | "The study showed that both combinations are effective for hypertension, with losartan/chlorthalidone demonstrating greater efficacy in reducing diastolic blood pressure and achieving target levels. Both treatments exhibited similar and favorable safety profiles."

Clinical • Journal • Cardiovascular • Hypertension

Efficacy and Safety of a Single-pill Fixed Combination of Sufficient Losartan/Hydrochlorothiazide in Chinese Hypertensive Patients (clinicaltrials.gov) - P4 | N=180 | Completed | Sponsor: Shanghai Jiao Tong University School of Medicine | Recruiting ➔ Completed | N=300 ➔ 180 | Trial completion date: May 2024 ➔ Aug 2024 | Trial primary completion date: May 2024 ➔ Aug 2024

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Cardiovascular • Hypertension

Toward a personalized chronotherapy of blood pressure. (PubMed, Biomed J) - "Personalized optimization of treatment timing to best match a healthy circadian BP pattern is recommended, guided by chronobiological analyses of ABPM data collected over several days in view of the large day-to-day variability in all features of the 24-hour BP rhythm."

Journal

A Rare Case of Pulmonary Edema Secondary to Hydrochlorothiazide Use. (PubMed, Case Rep Crit Care) - "Prompt supportive care and discontinuation of the medication is necessary to prevent and manage such a complication. This case report describes a patient who developed noncardiogenic pulmonary edema after taking a combination pill of hydrochlorothiazide-losartan."

Journal • Acute Respiratory Distress Syndrome • Respiratory Diseases

Long-term Medication-Induced Weight Change Across Common Antihypertensive Medications (OBESITY WEEK 2024) - "We focused on seven commonly prescribed antihypertensives (lisinopril, amlodipine, atenolol, hydrochlorothiazide, losartan, metoprolol, propranolol) and employed a target-trial to assess weight change at 6,12, and 24 months post-initiation. We estimated that initiation and adherence to metoprolol and propranolol would result in the most persistent weight gain over time, and adherence to lisinopril would result in weight loss. Our findings suggest that patients and clinicians should consider weight gain when choosing antihypertensive treatments."

Vaping-Induced Acute Tubular Necrosis (KIDNEY WEEK 2024) - "His BP medications included amlodipine, Hydrochlorothiazide, and losartan.On exam, he was hypertensive with a BP of 240/130, appeared volume overloaded, and was progressively hypoxic...Healthcare providers should be aware of the risks associated with e-cigarettes, including potential kidney injury.. . ."

Acute Kidney Injury • Cardiovascular • Hematological Disorders • Hypertension • Inflammation • Nephrology • Pain • Renal Disease • Respiratory Diseases • Tobacco Cessation

Rare case of photoallergy and leukomelanoderma induced by combined hydrochlorothiazide and losartan therapy (EADV 2024) - "Thiazides can induce photosensitivity by a photoallergic or phototoxic mechanism. In our patient, a delayed-onset photoallergy was observed. This reaction has been reported with antihypertensives containing an angiotensin receptor antagonist and hydrochlorothiazide."

Clinical • Atopic Dermatitis • Cardiovascular • Dermatitis • Dermatology • Immunology • Pruritus

Deciphering the role of a causative agent: a challenge in the management of bullous dermatosis (EADV 2024) - "The list of patient ’ s chronic therapy included vildagliptin/metformin, losartan/hydrochlorothiazide, and atorvastatin, with no alterations up till 8 months before the onset of the skin lesions...Patient was treated with intravenous methylprednisolone 0.5mg/kg/day in a tapering schedule and local corticosteroid ointments, exhibiting substantial improvement, without new lesions erupting. This case highlights the complexity of diagnosing bullous pemphigoid, particularly in the context of its resemblance to other dermatological conditions such as scabies and herpes zoster. The patient ’ s presentation underscores the importance of thorough evaluation and consideration of drug-induced factors in autoimmune diseases, as illustrated in this case, given the fact that almost all of the previously mentioned medications could potentially be the cause of the onset of the disease."

Atopic Dermatitis • Bullous Pemphigoid • Cardiovascular • Dermatology • Dermatopathology • Diabetes • Dyslipidemia • Herpes Zoster • Immunology • Infectious Disease • Metabolic Disorders • Pruritus • Pulmonary Arterial Hypertension • Type 2 Diabetes Mellitus • Urticaria • Varicella Zoster

Use and Cost Patterns of Antihypertensive Medications in the United States From 1996 to 2021. (PubMed, Hypertension) - "We explored the associations between patent exclusivity loss, per-pill costs, and Medicare Part D enactment on medication use over time, focusing on the most commonly used medications (lisinopril, amlodipine, losartan, hydrochlorothiazide, and metoprolol)...The increase in antihypertensive medication use over the past decades highlights the significant impact of loss of patent exclusivity on the uptake in the use of specific medications. These findings underscore the complexity of factors influencing medication use, beyond cost reductions alone, and suggest that policies need to consider multiple facets to effectively improve antihypertensive medication accessibility and utilization."

Journal • Cardiovascular • Hypertension

Comparison of the Role of Losartan Alone vs Hydrochlorothiazide Plus Losartan (clinicaltrials.gov) - P=N/A | N=234 | Not yet recruiting | Sponsor: RESnTEC, Institute of Research

New trial • Diabetic Nephropathy • Nephrology • Renal Disease

Resolution of overlapping spectra using chemometric manipulations of UV-spectrophotometric data for the determination of Atenolol, Losartan, and Hydrochlorothiazide in pharmaceutical dosage form. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "The proposed methods were simple, accurate, precise and were applied efficiently for the quantitation of the three components in laboratory-prepared mixtures, and in dosage form showing good recovery values. In addition, the obtained results were compared statistically with each other using ANOVA test showing non-significant difference between them."

Journal • Cardiovascular • Hypertension

Severe Hypokalemia from Heavy Coffee/Cola Consumption Complicated by Rhabdomyolysis, Nephrogenic Diabetes Insipidus and Polyuria-Induced Hydronephrosis (NKF-SCM 2024) - "His medications were metformin, losartan-hydrochlorothiazide and amlodipine...One week later, amiloride was stopped when his serum K rose to 4.6 mEq/L... This case illustrates altered renal potassium handling and downstream effects resulting from heavy coffee/cola consumption. Na+/H+ exchanger downregulation by theophylline-mediated adenosine blockade increases distal Na delivery promoting kaliuresis. High urine flow activates flow-mediated BK channels further promoting kaliuresis."

Cardiovascular • Endocrine Disorders • Hypertension • Metabolic Disorders • Nephrology • Renal Calculi • Type 2 Diabetes Mellitus

EDUCATION FROM DERMATOLOGISTS: THE SIMULTANEOUSLY DEVELOPMENT OF 16 KERATINOCYTIC CANCERS AFTER USE OF METFORMIN IN COMBINATION WITH LOSARTAN/ HYDROCHLOROTHIAZIDE, METOPROLOL AND NIFEDIPINE- IMPORTANT LINKS TO DRUG RELATED (PHOTO)-NITROSO-CARCINOGENESIS AND ONCOPHARMACOGENESIS. (PubMed, Georgian Med News) - "The localization of the tumors in the area of the UV-exposed sites within the potential/actual contamination of the 4 preparations (simultaneously) in the described patient are indicative of a possible pathogenetic influence in the context of the already mentioned Nitroso-(Photo)carcinogenesis. Polycontamination of polymedication remains a so far unresolvable problem."

Biomarker • Combination therapy • Journal • Dermatology • Genetic Disorders • Oncology • Skin Cancer • RAS

Efficacy and Safety of Losartan/Chlorthalidone vs Losartan/Hydrochlorothiazide in Essential Arterial Hypertension (clinicaltrials.gov) - P3 | N=190 | Completed | Sponsor: Laboratorios Silanes S.A. de C.V. | Recruiting ➔ Completed

Trial completion • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension

Single nucleotide polymorphism (SNP) rs4291 of the angiotensin-converting enzyme (ACE) gene is associated with the response to losartan treatment in hypertensive patients. (PubMed, Mol Biol Rep) - "Arterial hypertension is characterized by systolic pressure ≥ 140 mmHg and/or diastolic pressure ≥ 90 mmHg and its treatment consists of the use of antihypertensive drugs, as losartan and hydrochlorothiazide. In conclusion, the presence of the T allele of the rs4291 variant was associated to controled blood pressure when losartan was used as an antihypertensive agent. These results show the importance of pharmacogenetic studies to detect genetic characteristics, enabling therapeutic individuality and reducing costs for the healthcare system."

Journal • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension

CODE STEMI Due to Excessive Ingestion of TUMS (ENDO 2023) - "His medications included hydrochlorothiazide, losartan, amlodipine, atorvastatin, glimepiride, and famotidine. Abstracts presented at a news conference are embargoed until the date and time of the news conference. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO.*"

Atrial Fibrillation • Cardiovascular • Constipation • Diabetes • Diabetic Nephropathy • Endocrine Disorders • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Hypertension • Metabolic Disorders • Myocardial Infarction • Oncology • Pain • Renal Disease

Solitary Fibrous Tumor in an Asymptomatic Patient Followed for 14 Years (ATS 2023) - "Case Report: Female, 71 years old, housewife, non-smoker, controlled hypertensive with losartan, hydrochlorothiazide and carvedilol, with a history of pneumonia in 2008 with pulmonary opacity in the right lower lobe region on radiography. Malignancy markers are: age, tumor size, mitotic activity, presence of necrosis and nuclear pleomorphism. The gold standard treatment is surgical resection with free margins."

Clinical • IO biomarker • Infectious Disease • Novel Coronavirus Disease • Oncology • Pneumonia • Pulmonary Disease • Respiratory Diseases • BCL2 • CD34 • CD99