CBT-1 (tetrandrine) / CBA Pharma - LARVOL DELTA

Identification of Cepharanthine as a Potential Therapy of Acid Sphingomyelinase Deficiency by Reducing Cellular Sphingosylphosphorylcholine. (PubMed, J Inherit Metab Dis) - "Eight compounds, floxuridine, dexamethasone, indacaterol maleate, triethylenethiophosphoramide, cytarabine, doramectin, cepharanthine (CEP), and tetrandrine (TE), were identified to abate the accumulation of SPC in ASMD cells. Additionally, CEP could improve mitochondrial morphology and function, and stimulated lysosome biogenesis by promoting TFEB nuclear translocation in ASMD cells. These results suggest that CEP could potentially be developed as a promising candidate for treating ASMD."

Journal • Frontotemporal Lobar Degeneration • Genetic Disorders • Lysosomal Storage Diseases • Metabolic Disorders • Rare Diseases • TFEB

Anisotropic growth method for constructing stimulus-responsive janus composite nanoparticles for dual-drug delivery in tumor therapy. (PubMed, Colloids Surf B Biointerfaces) - "The MSTNs/PMO surface was functionalized with amino and thiol groups to facilitate the loading of doxorubicin (DOX) and tetrandrine (TET). Cytotoxicity and cellular uptake assays revealed that the system exhibited excellent biosafety and significant targeting ability toward tumor cells. Collectively, these findings suggested that the dual-drug delivery system has potent antitumor therapeutic efficacy and offered a viable strategy for synergistic tumor therapy."

Journal • Oncology

Molecular Mechanisms of Wound Healing: The Role of Medicinal Plants. (PubMed, Life (Basel)) - "Alkaloids, including tetrandrine, oxymatrine, and berberine, inhibit NF-κB signaling, thereby reducing pro-inflammatory cytokines such as IL-1β and TNF-α...Future research should focus on developing advanced drug delivery systems to enhance the stability, bioavailability, and targeted action of plant-derived compounds. Localized and biomaterial-based strategies show promise for sustained release at the wound site, and further preclinical and clinical studies are required to ensure their safety, reproducibility, and efficacy."

Journal • Review • Inflammation • IL1B • TNFA

Effective components of Coptidis Rhizoma and Cinnamomi Cortex in the treatment of renal cell carcinoma and their mechanism of action. (PubMed, Medicine (Baltimore)) - "Three components (quercetin, oleic acid, tetrandrine) were highlighted as particularly effective...In conclusion, the therapeutic effect of the HL-RG combination against RCC is primarily mediated by its bioactive components, QUE, OA, and TET. These components regulate the HIF-1 signaling pathway, activating genes involved in the cellular response to hypoxia and modulating the expression of proteins that control glucose metabolism, cell proliferation, and angiogenesis."

Journal • Genito-urinary Cancer • Metabolic Disorders • Oncology • Renal Cell Carcinoma • Solid Tumor • CAT • CCND1 • EGF • HER-2 • HIF1A • MMP9 • TGFB1

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes. (PubMed, Adv Sci (Weinh)) - "This study develops a biomimetic nanoplatform (MTCA@C) with hollow MnO2 as the core, loaded with tetrandrine and mitochondrial-targeted photosensitizer (Ce6-Apt), and coated with a cell membrane...Notably, the synergistic effect of these three mechanisms cuts off the energy supply of tumor cells, achieving spatiotemporally controlled precision therapy. In summary, a biomimetic nanoplatform is designed that precisely disrupts the interaction between mitochondria and lysosomes to impair the compensatory energy supply of tumors, addressing the challenge of drug resistance in cancer treatment."

Journal • Metabolic Disorders • Oncology

Exploring the mechanism of Stephania tetrandra S. Moore in the treatment of cisplatin resistance against ovarian cancer through integration of network pharmacology and molecular docking. (PubMed, Medicine (Baltimore)) - "Cisplatin resistance is a major contributor to treatment failure in ovarian cancer (OC). Molecular dynamics simulations demonstrated that hesperidin, cissamine and tetrandrine exhibited strong binding affinities toward AURKA, vitamin D receptor, and TTK. Future studies are encouraged to focus on the experimental validation of these compounds and delve deeper into the possible mechanisms of drug resistance, aiming to improve their therapeutic effectiveness and real-world applicability."

Journal • Platinum resistant • B Cell Lymphoma • Lymphoma • Oncology • Ovarian Cancer • Solid Tumor • AURKA • BCL2 • CDK1 • DNMT1 • SMAD7 • TTK

Tetrandrine enhances cognition in SAH rats via gut microbiota CYP51 and TLR4 signaling. (PubMed, Sci Rep) - "Notably, Tet modulated the gut microbiota, restoring microbial diversity and abundance, and this modulation was associated with changes in the CYP51 metabolic pathway. Tet improves cognitive function and reduces neuronal injury in SAH rats by regulating the gut microbiota and its associated CYP51 metabolic pathway, thereby suppressing activation of the TLR4/NF-κB signaling cascade."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Hematological Disorders • Subarachnoid Hemorrhage • Vascular Neurology • IL1B • IL6 • TLR4 • TNFA

Efficient Induction of Autophagic Cell Death through Oxidation Therapy by a Codelivery ROS-Responsive Nanoplatform. (PubMed, Mol Pharm) - "Previous studies have demonstrated that induction of reactive oxygen species (ROS) significantly enhances the cytotoxicity of paclitaxel (Ptx). Tetrandrine (Tet), a potent ROS inducer, synergistically enhances the antitumor effects of Ptx...Moreover, P/T-NPs effectively inhibit the tumor growth compared to either the free drug or their combination therapy. This study integrates tumor microenvironment activation, self-amplified drug release, and ROS-enhanced chemotherapy into a single nanoplatform, offering a promising strategy for targeted cancer therapy."

Journal • Oncology

Multi-scale In Silico and Biochemical Evaluation of Natural Bisbenzylisoquinoline Alkaloids as Aldose Reductase Inhibitors. (PubMed, Protein J) - "Taken together, these data position cepharanthine and dauricine as mechanistically validated, hit-stage starting points for next-generation AR inhibitors, and identify isotetrandrine as an allosteric back-up scaffold. More broadly, the study illustrates a transparent, reproducible computational-experimental workflow for prioritizing structurally complex natural products against redox enzymes implicated in diabetic pathology."

Journal • Diabetes • Metabolic Disorders • AKR1B1

Self-Assembled Carrier Free Oligomeric Proanthocyanidin/Tetrandrine Nanoparticles Ameliorate Osteoarthritis via Anti-Inflammatory and Anti-Ferroptotic Pathways. (PubMed, Int J Nanomedicine) - "The treatment mechanism of anti-inflammation and anti-ferroptosis were also verified. The current research not only offers a new strategy to manage OA but also provides more possibilities for potential application of natural products."

Journal • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology

Randomized RCT Study Protocol on the Effect of Tetrandrine Injection on Radiotherapy for Thoracic Tumors (ChiCTR) - P2 | N=100 | Recruiting | Sponsor: People's Hospital of Chongqin Hechuan; People's Hospital of Chongqin Hechuan

New P2 trial • Esophageal Cancer • Lung Cancer • Oncology • Solid Tumor • Thoracic Cancer

Study on the clinical efficacy and mechanism of tetrandrine in the treatment of patients with lumbar disc herniation (ChiCTR) - P=N/A | N=64 | Not yet recruiting | Sponsor: Affiliated hangzhou first people's hospital, zhejiang university school of medicine; Hangzhou First People's Hospital

New trial • Musculoskeletal Diseases

A single-center exploratory study on the efficacy and safety of tetrandrine tablets in the treatment of interstitial lung disease associated with rheumatoid arthritis (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Army Medical University (Southwest Hospital); The First Affiliated Hospital of Army Medical University (Southwest Hos

New trial • Immunology • Inflammatory Arthritis • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology

Cepharanthine inhibits enterovirus entry by endolysosomal deacidification and exhibits protective activity in vivo. (PubMed, Antimicrob Agents Chemother) - "In this study, we assessed the anti-EV activities of four bisbenzylisoquinoline alkaloids (BBAs): tetrandrine (TET), cepharanthine (CEP), fangchinoline (FAN), and berbamine (BER), as well as their mechanisms of action...Remarkably, administering CEP at a dose of 10 mg/kg provided complete protection to mice infected with EV71 from lethal challenges, significantly reducing viral titers, viral RNA levels, and pathological scores. Collectively, these findings highlight CEP as a promising candidate for the treatment of EV infections."

Journal • Preclinical • Infectious Disease

The Immunoregulatory Function and Therapeutic Potential of Tetrandrine in Connective Tissue Disease-Associated Interstitial Lung Disease. (PubMed, Respir Med) - "Its dual anti-inflammatory and anti-fibrotic profile may complement existing immunosuppressants for CTD-ILD patients with progressive fibrosis while potentially reducing dosage requirements. Therefore, we evaluate tetrandrine's potential for integration into current CTD-ILD management and identify future research directions to facilitate clinical translation by synthesizing current evidence, offering insights for developing natural drug-based therapies."

Journal • Review • Fibrosis • Immunology • Inflammation • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases • Rheumatology

Neuromodulation in chronic insomnia: Targeting the dorsal raphe nucleus. (PubMed, Sleep Med) - "Our objective in the current article is to provide a conceptual model for the exploitation of neuromodulation approaches targeting the DRN as a novel treatment strategy for chronic insomnia. It reviews recent advances in the study of the neurobiology of the DRN, and presents current methodologies for neuromodulation approaches (including transcranial magnetic stimulation, focused ultrasound, and deep brain stimulation paradigms), and discusses how DRN-targeted interventions may offer personalized, biologically informed treatments for individuals with chronic insomnia."

Journal • CNS Disorders • Insomnia • Sleep Disorder

Peripheral immune cell-specific genes in Parkinson's disease uncovered by multi-omics with therapeutic implications. (PubMed, NPJ Parkinsons Dis) - "Drug repurposing analysis identified several candidate compounds, including felodipine, amodiaquine, alprazolam, and tetrandrine, some of which are predicted to cross the blood-brain barrier. Molecular docking simulations further supported strong binding interactions between these compounds and PD-associated targets such as CTSB and ARSA. This integrative approach highlights key immune-cell-specific genes involved in PD and proposes several repurposable drugs with central nervous system potential, paving the way for more targeted therapeutic strategies."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease • CD4 • CD8 • FDFT1 • HLA-DQA1

Lactoferrin functionalized bovine serum albumin nanoparticles for synergistic chemo-gene therapy of lung cancer: Co-delivery of tetrandrine and miRNA-126. (PubMed, Int J Biol Macromol) - "Histopathological findings further verify the superiority of Lf-miRNA-126-Tet@ANPs. These results highlight Lf-miRNA-126-Tet@ANPs as a promising nanoplatform for chemo-gene targeted delivery against lung cancer."

IO biomarker • Journal • Gene Therapies • Lung Cancer • Oncology • Solid Tumor • BCL2 • STAT3

Conscious breathing enhances bidirectional cortical-autonomic modulation: dynamics of EEG band power and heart rate variability. (PubMed, Front Syst Neurosci) - "Data were collected from fifteen healthy subjects during three experimental conditions: a spontaneous breathing state (Rest) and two controlled breathing tasks (CBT 1 and CBT 2)...These findings support a closed-loop model of physiological regulation driven by neural-respiratory entrainment and suggest that respiration can serve as a top-down mechanism for autonomic control. By clarifying how conscious breathing shapes brain-body dynamics, this work lays the foundation for research on neural self-regulation and supports the development of non-pharmacological interventions for improving mental and physiological health."

Journal

Evaluation the inhibitory effect of nicardipine on the metabolism of quetiapine. (PubMed, Front Pharmacol) - "In vitro, two incubation systems of rat liver microsomes (RLM) and human liver microsomes (HLM) were established and optimized to explore potential interactions between five kinds CCBs (nicardipine, dilthiazem, lercanidipine, nimodipine, nitrendipine), five kinds antihypertensive TCM (quercetin, fangchinoline, apigenin, tetrandrine, and berberine) and quetiapine, and to evaluate their underlying inhibition mechanisms. In vivo results indicated that nicardipine could significantly increase the main pharmacokinetic parameters AUC(0-t), , and Cmax of quetiapine, but decrease the AUC(0-t) of its metabolite N-desalkylquetiapine. The findings of this study suggested that nicardipine had inhibited the metabolism of quetiapine, suggesting the dose adjustment or therapeutic drug monitoring of quetiapine should be conducted to achieve individualized therapy."

Journal

Penetrative biomimetic nanovehicle boosts immunotherapy in triple-negative breast cancer via SOS1 blockade. (PubMed, Asian J Pharm Sci) - "Herein, we developed a biomimetic liposomal platform (CCM/Cil-lipo@TD), which integrates cilengitide (Cil)-functionalized breast cancer cell membranes (CCM) to co-deliver tetrandrine (TET) and low-dose docetaxel (DTX) for TNBC therapy. The CCM/Cil-lipo@TD exerted superior tumor inhibition (82.9 %) in 4T1 orthotopic models and effectively inhibited postoperative local recurrence and distant metastasis. Taken together, the Cil-engineered, cell membrane-anchoring CCM/Cil-lipo@TD provides a promising approach for TNBC immunotherapy."

Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer

Stephania tetrandra S. Moore: a promising candidate drug for treating diabetic kidney disease. (PubMed, Front Pharmacol) - "This study focuses on exploring the molecular mechanisms through which the primary active components of S. tetrandra, tetrandrine/sinomenine and fangchinoline, exert renal protective effects via multiple pathways, including regulating inflammatory responses, antagonizing oxidative stress, improving glomerular endothelial function, modulating podocyte damage, and intervening in lipid metabolism disorders. These findings provide a theoretical basis for the development of novel therapeutic agents for DKD."

Journal • Review • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Dyslipidemia • Inflammation • Metabolic Disorders • Nephrology • Renal Disease

Investigating C7 modified tetrandrine derivatives for synthesis anti-hepatocellular carcinoma activity and mechanistic insights. (PubMed, Sci Rep) - "Notably, compound 15 demonstrated significant antiproliferative activity against all tested cell lines, with IC50 values ranging from 3.28 to 6.16 µM, which is superior to the first-line clinical drug 5-fluorouracil. With its remarkable antitumor activity, excellent synthetic process characteristics, and clear apoptosis-inducing mechanism, compound 15 has emerged as a highly promising clinical candidate. This C-7 modification platform provides a viable path for transforming natural product derivatives into clinical therapies for HCC treatment."

Journal • Hepatocellular Cancer • Oncology • Solid Tumor • BAX • BCL2 • CASP3 • FLT1 • PDGFRA • PIK3CD

Tetrandrine improves oxidative stress and pyroptosis of podocytes in diabetic kidney disease by regulating TXNIP/NLRP3/GSDMD signaling pathway. (PubMed, J Mol Histol) - "Following TXNIP overexpressing, podocyte oxidative stress and pyroptosis that TET initially suppressed were subsequently reversed. Our results reveal that TET represses podocyte oxidative stress and pyroptosis through TXNIP/NLRP3/GSDMD pathway, which provides new therapeutic targets for DKD treatment."

Journal • Diabetes • Diabetic Nephropathy • Nephrology • Renal Disease • IL18 • IL1B • NLRP3 • TXNIP

Precision targeted cancer-associated fibroblast nano-regulator enhanced chemo-immunotherapy for triple-negative breast cancer. (PubMed, Biomaterials) - "Here, we designed a nanoparticle co-modified with anisamide and CAF cell membrane (CAFm) to load tetrandrine as a CAF nano-regulator (TET@ACNP), which is able to precisely target and modulate CAFs...TET@ACNP was able to inhibit CAFs activation and reduce collagen secretion, thereby breaking the physical barrier to facilitate the penetration of the first-line chemotherapeutic agent docetaxel (DTX) and the infiltration of cytotoxic T lymphocytes...Our study proposes a comprehensive therapeutic strategy based on the precise targeting and regulation of CAFs in combination with chemotherapy to achieve multifaceted inhibition of TNBC. This is expected to be a universal platform to improve the therapeutic efficacy of different chemotherapeutic agents in various types of stroma-rich tumors."

IO biomarker • Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • CAFs • IGF2