CBT-1 (tetrandrine) / CBA Pharma - LARVOL DELTA

Identification of cellular ion channels that facilitate Hazara nairovirus infection enables selection of clinically approved compounds with anti-nairoviral properties. (PubMed, Sci Rep) - "Consistent with this, we showed that clinically-approved K+ channel blockers quinidine, quinine and dronedarone and clinically-approved Ca2+ channel blockers tetrandrine and nifedipine significantly reduced HAZV activities. Biochemical experiments showed K+ expanded the pH range that promoted entry, potentially allowing endosome escape deeper within the endolysosomal network. These results show clinically-approved channel blockers effectively inhibit HAZV replication, suggesting repurposing existing therapies may represent promising avenues to block nairovirus infection."

Journal • Infectious Disease

Towards identification of novel inhibitors of EGFR mutants through in-silico approach. (PubMed, Cancer Treat Res Commun) - "Among the tested compounds, Tetrandrine, Dauricine, and Olmutinib exhibited robust binding affinities across both wild-type and mutant EGFR configurations, highlighting their potential as effective inhibitors. The integrated approach of combining molecular docking using CB-dock2, ADMET profiling, and Lipinski's rule of five provides a robust framework for preliminary drug candidate screening, potentially accelerating the development of more precise and effective EGFR-targeted therapies. The findings contribute to the growing body of research exploring alternative and more nuanced strategies for inhibiting EGFR-driven oncogenic mechanisms, highlighting the importance of computational methods in identifying novel molecular targets with improved specificity and reduced side effects."

Journal • Oncology • EGFR

Efficacy and safety of tetrandrine in patients with rheumatoid arthritis (TRAL): a multicenter randomized, double-blind, placebo-controlled trial (EULAR 2026) - No abstract available

Clinical • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Effects of astragaloside Ⅳ combined with quercetin on silicosis rats and the mechanism of autophagy (PubMed, Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) - " In August 2023, 36 SPF-grade male Wistar rats were randomly divided into control group, model group, SiO(2)+ASV group, SiO(2)+ QUE group, SiO(2)+ASV+QUE group and SiO(2)+tetrandrine (TET) group, with six rats in each group...Mechanistic studies revealed that the combination of ASV and QUE significantly upregulated AMPK phosphorylation (p-AMPK/AMPK) and the expression of Beclin1, promoted LC3II/LC3I conversion, while simultaneously inhibiting mTOR pathway activation (p-mTOR/mTOR) and the accumulation of p62 (P<0.05) . ASV combined with QUE may enhance SiO(2)-induced autophagy levels in rat lung tissue via the AMPK-mTOR signaling pathway, thereby alleviating pulmonary inflammation and fibrosis in silicosis rats."

Journal • Preclinical • Fibrosis • Immunology • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • BECN1 • IL18 • IL1B • TGFB1

Atomistic simulations identify the Tetrandrine as potent anti-malarial drug candidate against Plasmodium falciparum targeting Heme Detoxification Protein (HDP). (PubMed, J Mol Graph Model) - "Docking analysis revealed that Tetrandrine exhibited the highest affinity for the HDP active site (-13.0 kJ/mol), surpassing Bisnordihydrotoxiferine (-10.2 kJ/mol), Neferine (-9.01 kJ/mol), and Oxytetracycline (-10.9 kJ/mol). The Principal Component Analysis (PCA) and Dynamic Cross Correlation Matrix (DCCM) demonstrated that ligand binding significantly changed the cross-correlation movements of the domains and regulatory flexibility, affecting long-range allosteric communication of the protein as a whole. The MM-PBSA free energy calculations supported the docking findings, as Tetrandrine was found to have higher binding energy, (-30 kcal/mol), suggesting the thermodynamically favorable binding complex."

Journal • Infectious Disease • Malaria

Synergistic Regulation by FaTRAB1 and FaGAPC2 Enhances Strawberry Resistance to Tetranychus urticae through Trichome Density Modulation, Lignin Accumulation, and Insect-Resistant Metabolite Biosynthesis. (PubMed, J Agric Food Chem) - "Multiomics analysis revealed that FaGAPC2 activates phenylpropanoid biosynthesis, boosting levels of hydroferulic acid, kaempferol, and tetrandrine, reducing Tetranychus urticae damage by 61.5-82.8%...FaTRAB1 overexpression enhanced trichome density, pectin/cellulose content, and lignin accumulation by upregulating FaCSE and FaHCT while increasing the leaf thickness, forming a robust mechanical barrier. These findings demonstrate how the FaTRAB1-FaGAPC2 module enhances mite resistance via trichome development, lignin deposition, and insecticidal metabolite synthesis, offering new strategies for breeding pest-resistant strawberries and developing plant-based acaricides."

Journal

A single-center exploratory study on the efficacy and safety of tetrandrine tablets in the treatment of interstitial lung disease associated with rheumatoid arthritis (ChiCTR) - P=N/A | N=60 | Recruiting | Sponsor: The First Affiliated Hospital of Army Medical University (Southwest Hospital); The First Affiliated Hospital of Army Medical University (Southwest Hos | Not yet recruiting ➔ Recruiting | Initiation date: Aug 2025 ➔ Nov 2025

Enrollment open • Trial initiation date • Immunology • Inflammatory Arthritis • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology

Efficacy and safety of Tetrandrine in the treatment of herpes zoster-associated pain (ZAP):A randomized, double-blind, placebo-controlled multicenter trial (ChiCTR) - P4 | N=240 | Not yet recruiting | Sponsor: China-Japan Friendship Hospital; ZHEJIANG JINHUA CONBA BIO-PHARM.CO.,LTD.

New P4 trial • Herpes Zoster • Pain • Varicella Zoster

A clinical trial of Tetrandrine Tablets in combination with Mitotane for the treatment of mitotane-resistant advanced adrenocortical carcinom (ChiCTR) - P=N/A | N=62 | Not yet recruiting | Sponsor: West China Hospital of Sichuan University; West China Hospital of Sichuan University

New trial • Adrenal Cortex Carcinoma • Genito-urinary Cancer • Oncology • Solid Tumor

The Protective Effect and Molecular Mechanism of Tetrandrine on Male Reproductive Damage Caused by Silicon Dioxide. (PubMed, Toxics) - "Transcriptome analysis revealed distinct gene expression patterns at day 7 versus day 42, indicating time-dependent injury mechanisms. Tetrandrine alleviates silica-induced reproductive damage in male mice, suggesting potential therapeutic applications for occupational silica exposure and expanding the understanding of silica toxicity beyond the respiratory system."

Journal • Fibrosis • Immunology • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • FN1 • VIM

Dual Potential of Tetrandrine: Antiangiogenic Efficacy and Safety Liabilities Revealed through In Silico, In Vitro, and Zebrafish Models. (PubMed, Food Chem Toxicol) - "These findings highlight tetrandrine's dual profile: a promising natural antiangiogenic agent with demonstrable efficacy, yet with significant cardiotoxic and developmental liabilities. This study provides crucial mechanistic insight into both its therapeutic and toxicological actions, establishing a translational foundation for its further development."

Journal • Preclinical • Cardiovascular • Oncology • EGFR • MMP13 • SRPK1

Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress. (PubMed, Front Bioeng Biotechnol) - "Additionally, the interaction between APP and CD74 in vascular endothelial cells was diminished, thereby inhibiting biological processes associated with endothelial mesenchymal transition, alleviating pulmonary vascular stenosis, and enhancing the concentration of therapeutic agents in lung tissue. Hydrogen can improve the tissue concentration of tetrandrine by anti-OS-induced EndMT."

Journal • Immunology • Pulmonary Disease • Respiratory Diseases • APP • CD74

Tetrandrine-driven autophagy suppresses SARS-CoV-2 replication by modulating cholesterol and IGF signaling pathways. (PubMed, Cell Death Discov) - "Collectively, our data supports the potential of Tetrandrine as a therapeutic candidate against COVID-19 and warns further evaluation in preclinical and clinical models. Data are available via ProteomeXchange with identifier PXD064448."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A Study to Test Tetrandrine Tablets for Connective Tissue Disease-Related Lung Disease (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: Peking University Third Hospital

New P4 trial • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases • Rheumatology

The protective effects of alkaloids from Stephania tetrandra S. Moore on H9C2 cardiomyocytes. (PubMed, Nat Prod Res) - "Tetrandrine also enhanced glucose consumption (0.62-1.66 nM), lactate production (0.2-0.64 nM), and ATP concentration (5-22 nmoL/mg protein), suggesting metabolic protection. These findings highlight tetrandrine's potential in mitigating myocardial ischemia/reperfusion injury."

Journal • Cardiovascular • Myocardial Ischemia • Reperfusion Injury

Inhaled biomimetic nanoparticles enhance pulmonary delivery of tetrandrine and pirfenidone for the treatment of idiopathic pulmonary fibrosis. (PubMed, Acta Biomater) - "Following inhalation, PCMΦ@PPT has been shown to target and penetrate the dense collagen barrier while evading phagocytosis by macrophages, promoting drug retention in the focus. Finally, co-delivery of PFD and TET blocks the TGF-β signaling pathway, promoting recovery of damaged autophagy in fibroblasts and alleviating IPF progression and restoring lung function."

Journal • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases • TGFB1

Identification of Cepharanthine as a Potential Therapy of Acid Sphingomyelinase Deficiency by Reducing Cellular Sphingosylphosphorylcholine. (PubMed, J Inherit Metab Dis) - "Eight compounds, floxuridine, dexamethasone, indacaterol maleate, triethylenethiophosphoramide, cytarabine, doramectin, cepharanthine (CEP), and tetrandrine (TE), were identified to abate the accumulation of SPC in ASMD cells. Additionally, CEP could improve mitochondrial morphology and function, and stimulated lysosome biogenesis by promoting TFEB nuclear translocation in ASMD cells. These results suggest that CEP could potentially be developed as a promising candidate for treating ASMD."

Journal • Frontotemporal Lobar Degeneration • Genetic Disorders • Lysosomal Storage Diseases • Metabolic Disorders • Rare Diseases • TFEB

Anisotropic growth method for constructing stimulus-responsive janus composite nanoparticles for dual-drug delivery in tumor therapy. (PubMed, Colloids Surf B Biointerfaces) - "The MSTNs/PMO surface was functionalized with amino and thiol groups to facilitate the loading of doxorubicin (DOX) and tetrandrine (TET). Cytotoxicity and cellular uptake assays revealed that the system exhibited excellent biosafety and significant targeting ability toward tumor cells. Collectively, these findings suggested that the dual-drug delivery system has potent antitumor therapeutic efficacy and offered a viable strategy for synergistic tumor therapy."

Journal • Oncology

Molecular Mechanisms of Wound Healing: The Role of Medicinal Plants. (PubMed, Life (Basel)) - "Alkaloids, including tetrandrine, oxymatrine, and berberine, inhibit NF-κB signaling, thereby reducing pro-inflammatory cytokines such as IL-1β and TNF-α...Future research should focus on developing advanced drug delivery systems to enhance the stability, bioavailability, and targeted action of plant-derived compounds. Localized and biomaterial-based strategies show promise for sustained release at the wound site, and further preclinical and clinical studies are required to ensure their safety, reproducibility, and efficacy."

Journal • Review • Inflammation • IL1B • TNFA

Effective components of Coptidis Rhizoma and Cinnamomi Cortex in the treatment of renal cell carcinoma and their mechanism of action. (PubMed, Medicine (Baltimore)) - "Three components (quercetin, oleic acid, tetrandrine) were highlighted as particularly effective...In conclusion, the therapeutic effect of the HL-RG combination against RCC is primarily mediated by its bioactive components, QUE, OA, and TET. These components regulate the HIF-1 signaling pathway, activating genes involved in the cellular response to hypoxia and modulating the expression of proteins that control glucose metabolism, cell proliferation, and angiogenesis."

Journal • Genito-urinary Cancer • Metabolic Disorders • Oncology • Renal Cell Carcinoma • Solid Tumor • CAT • CCND1 • EGF • HER-2 • HIF1A • MMP9 • TGFB1

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes. (PubMed, Adv Sci (Weinh)) - "This study develops a biomimetic nanoplatform (MTCA@C) with hollow MnO2 as the core, loaded with tetrandrine and mitochondrial-targeted photosensitizer (Ce6-Apt), and coated with a cell membrane...Notably, the synergistic effect of these three mechanisms cuts off the energy supply of tumor cells, achieving spatiotemporally controlled precision therapy. In summary, a biomimetic nanoplatform is designed that precisely disrupts the interaction between mitochondria and lysosomes to impair the compensatory energy supply of tumors, addressing the challenge of drug resistance in cancer treatment."

Journal • Metabolic Disorders • Oncology

Exploring the mechanism of Stephania tetrandra S. Moore in the treatment of cisplatin resistance against ovarian cancer through integration of network pharmacology and molecular docking. (PubMed, Medicine (Baltimore)) - "Cisplatin resistance is a major contributor to treatment failure in ovarian cancer (OC). Molecular dynamics simulations demonstrated that hesperidin, cissamine and tetrandrine exhibited strong binding affinities toward AURKA, vitamin D receptor, and TTK. Future studies are encouraged to focus on the experimental validation of these compounds and delve deeper into the possible mechanisms of drug resistance, aiming to improve their therapeutic effectiveness and real-world applicability."

Journal • Platinum resistant • B Cell Lymphoma • Lymphoma • Oncology • Ovarian Cancer • Solid Tumor • AURKA • BCL2 • CDK1 • DNMT1 • SMAD7 • TTK

Tetrandrine enhances cognition in SAH rats via gut microbiota CYP51 and TLR4 signaling. (PubMed, Sci Rep) - "Notably, Tet modulated the gut microbiota, restoring microbial diversity and abundance, and this modulation was associated with changes in the CYP51 metabolic pathway. Tet improves cognitive function and reduces neuronal injury in SAH rats by regulating the gut microbiota and its associated CYP51 metabolic pathway, thereby suppressing activation of the TLR4/NF-κB signaling cascade."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Hematological Disorders • Subarachnoid Hemorrhage • Vascular Neurology • IL1B • IL6 • TLR4 • TNFA

Efficient Induction of Autophagic Cell Death through Oxidation Therapy by a Codelivery ROS-Responsive Nanoplatform. (PubMed, Mol Pharm) - "Previous studies have demonstrated that induction of reactive oxygen species (ROS) significantly enhances the cytotoxicity of paclitaxel (Ptx). Tetrandrine (Tet), a potent ROS inducer, synergistically enhances the antitumor effects of Ptx...Moreover, P/T-NPs effectively inhibit the tumor growth compared to either the free drug or their combination therapy. This study integrates tumor microenvironment activation, self-amplified drug release, and ROS-enhanced chemotherapy into a single nanoplatform, offering a promising strategy for targeted cancer therapy."

Journal • Oncology

Multi-scale In Silico and Biochemical Evaluation of Natural Bisbenzylisoquinoline Alkaloids as Aldose Reductase Inhibitors. (PubMed, Protein J) - "Taken together, these data position cepharanthine and dauricine as mechanistically validated, hit-stage starting points for next-generation AR inhibitors, and identify isotetrandrine as an allosteric back-up scaffold. More broadly, the study illustrates a transparent, reproducible computational-experimental workflow for prioritizing structurally complex natural products against redox enzymes implicated in diabetic pathology."

Journal • Diabetes • Metabolic Disorders • AKR1B1