CH41 / CellarisBio - LARVOL DELTA

First-in-class stabilizing inhibitor of CHD4 that traps and disassembles the NuRD complex (AACR 2026) - "Functionally, CH41 disables CHD4-dependent DNA repair and transcriptional control, re-sensitizing temozolomide-resistant glioblastoma cells. The data establishes CH41 as the first selective CHD4 inhibitor and illustrates how advances in cellular biophysics and cellular target engagement profiling are transforming the discovery of small molecule modulators of challenging transcription factor targets, such as chromatin remodelers."

Brain Cancer • Glioblastoma • Oncology • Solid Tumor • CHD4 • HRD • RAD51 • RBBP4 • TP53BP1 • ZMYND8