BAY 3389934
/ Bayer
- LARVOL DELTA
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November 06, 2024
Treatment with a Novel Small Molecule Dual Factor IIa/Xa Inhibitor Protects Against Coagulopathy and Organ Dysfunction in a Baboon Model of Staphylococcus Aureus Sepsis
(ASH 2024)
- "Conclusion : In a model of sepsis-induced coagulopathy in baboons, the dual FIIa/Xa inhibitor BAY 3389934 reduced the hypercoagulable state strongly and protected from organ damage. Further studies are warranted to explore its full therapeutic potential in the treatment of sepsis-associated DIC."
Anesthesia • Hematological Disorders • Infectious Disease • Septic Shock
October 04, 2025
A Study to Assess the Safety and Effects of Different Doses of an Investigational Drug, BAY 3389934, in Healthy Japanese Volunteers.
(clinicaltrials.gov)
- P1 | N=16 | Recruiting | Sponsor: Bayer | Not yet recruiting ➔ Recruiting
Enrollment open • Infectious Disease • Septic Shock
September 17, 2025
A Study to Assess the Safety and Effects of Different Doses of an Investigational Drug, BAY 3389934, in Healthy Japanese Volunteers.
(clinicaltrials.gov)
- P1 | N=16 | Not yet recruiting | Sponsor: Bayer
New P1 trial • Infectious Disease • Septic Shock
June 30, 2025
A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy
(clinicaltrials.gov)
- P1 | N=32 | Suspended | Sponsor: Bayer | Recruiting ➔ Suspended
Trial suspension • Hematological Disorders • Infectious Disease • Septic Shock
June 17, 2025
Pharmacological profile of BAY 3389934 – a novel rapidly cleared dual FIIa/Xa inhibitor
(ISTH 2025)
- "When administered as constant infusion over 6h together with LPS to simulate a gram- sepsis in rabbits, it reduced the hypercoagulable state and the consumption of fibrinogen and platelets. In a baboon model mimicking a gram+ infection by systemic exposure to heat-inactivated Staphylococcus aureus, constant infusion of BAY 3389934 resulted in strong reduction of organ damage biomarkers in addition to the reduced DIC parameters without increasing the bleeding risk."
Cardiovascular • Hematological Disorders • Infectious Disease • Septic Shock • Thrombosis
June 17, 2025
Pharmacological profile of BAY 3389934 – a novel rapidly cleared dual FIIa/Xa inhibitor
(ISTH 2025)
- No abstract available
Cardiovascular • Venous Thromboembolism
June 12, 2025
Discovery of BAY 3389934 Hydrochloride: A Potent and Selective Small-Molecule Dual Factor IIa/Xa Inhibitor with Short Half-Life for the Acute Treatment of Sepsis-Induced Coagulopathy.
(PubMed, J Med Chem)
- "Herein, we describe the discovery of BAY 3389934 hydrochloride (31), a potent and highly selective, direct dual FIIa/Xa inhibitor, with high solubility suited for i.v. application. This small molecule acts as a metabolically soft active pharmaceutical ingredient (API) due to a labile carboxylic ester group, which is responsible for the desired short pharmacokinetic and pharmacological half-life (t1/2), resulting in a high controllability of the pharmacological action."
Journal • Hematological Disorders • Infectious Disease • Septic Shock
March 19, 2025
A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy
(clinicaltrials.gov)
- P1 | N=32 | Recruiting | Sponsor: Bayer | Not yet recruiting ➔ Recruiting
Enrollment open • Hematological Disorders • Infectious Disease • Septic Shock
March 03, 2025
A Study to Learn About How Safe BAY 3389934 Is, Its Suitable Dose, and How It Affects the Participants with Sepsis Induced Coagulopathy
(clinicaltrials.gov)
- P1 | N=32 | Not yet recruiting | Sponsor: Bayer
New P1 trial • Hematological Disorders • Infectious Disease • Septic Shock
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