Invicorp (aviptadil/phentolamine mesilate) / Regent Pacific Group - LARVOL DELTA

Intracavernosal injection of aviptadil and phentolamine for refractory erectile dysfunction. (PubMed, J Sex Med) - "Almost 60% of the participants with refractory ED were successfully managed through the administration of AvP."

Journal • Erectile Dysfunction • Pain

Cavernous body auto-injection therapy for erectile dysfunction, Aviptadil/Phentolamine (Invicorp®) – an effective alternative for erectile dysfunction (ED) with an excellent side effect profile (DGU 2024) - "Sponsored by Evolan"

Adverse events • Erectile Dysfunction

WS02 Cavernous body auto-injection therapy for erectile dysfunction, Aviptadil/Phentolamine (Invicorp®) an effective alternative for erectile dysfunction (ED) with an excellent side effect profile (DGU 2024) - "Sponsored by Evolan The introduction of phosphodiesterase inhibitors such as sildenafil and others led to high expectations but high drop-out rates due to effectiveness issues and side effects. The combination of VIP and phentolamine (Invicorp®) showed comparable effectiveness with less pain than alprostadil. Invicorp® could be a better alternative, especially for ED patients after RRP or cystectomy."

Adverse events • Erectile Dysfunction • Pain

A comprehensive history of injection therapy for erectile dysfunction, 1982-2023. (PubMed, Sex Med Rev) - "After 40 years, self-injection therapy represents the medication with the highest efficacy and reliability rates and remains a viable option for many couples with ED. The history of this therapy is rich."

Journal • Erectile Dysfunction

"Thank you for the #expertsummary and your comments on the INVICORP article #EAU21" (@donwglee)

[VIRTUAL] Intracavernosal aviptadil with phentolamine mesylate should be offered for treatment of refractory erectile dysfunction (EAU 2021) - No abstract available

Erectile Dysfunction

Reflexions on 50 Years of Sexual Medicine in Urology Focusing on Male Sexual Dysfunctions (PubMed, Aktuelle Urol) - "Starting with the development of hydraulic penile implants in 1973 meanwhile several effective and well-tolerated conservative treatments such as the PDE-5 inhibitors avanafil, sildenafil, tadalafil and vardenafil, transurethral PGE1 (MUSE) and self-injection therapy with a variety of vasoactive drugs like alprostadil, papaverine/phentolamine (bimix), PGE1/papaverine/phentolamine (trimix/triple drug) or VIP (aviptadil)/phentolamine-Invicorp) have been developed for the treatment of ED. Regarding premature ejaculation (PE) meanwhile with oral dapoxetine and topical lidocaine/prilocaine spray two effective treatment options are officially available which may be combined in men with severe PE and with PDE-5 inhibitors in men with PE and ED. Hormonal disorders such as hypogonadism, hyperprolactinemia and thyroid disorders may be linked to male sexual disorders and successfully treated with T-substitution, prolactin inhibitors or thyroid specific medications.Whereas vascular..."

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