modified-release formulation of lovastatin lactone (SYN-010) / Theriva Bio - LARVOL DELTA

"@MarkPimentelMD Is there still a plan to find a cure for IBS-C after cancelling SYN-010 trials?" (@EslamAlbialy)

"@MarkPimentelMD is syn 010 dead? Saw the company stopped trials. Any news for new therapies for methane sufferers? Happy holidays" (@Nick96047577)

Efficacy and Safety of SYN-010 in IBS-C (clinicaltrials.gov) - P2; N=59; Terminated; Sponsor: Cedars-Sinai Medical Center; N=150 ➔ 59; Recruiting ➔ Terminated; Interim Futility Analysis

Clinical • Enrollment change • Trial termination • Constipation • Gastroenterology • Gastrointestinal Disorder • Immunology

A Bioequivalence Pivotal Study of SYN010 HFA Inhaler and Symbicort® 160/4.5 in Healthy Volunteers Without Charcoal Block (clinicaltrials.gov) - P1; N=99; Completed; Sponsor: Intech Biopharm Ltd.

Clinical • New P1 trial • Asthma • Chronic Obstructive Pulmonary Disease • Respiratory Diseases

Efficacy and Safety of SYN-010 in IBS-C (clinicaltrials.gov) - P2; N=150; Recruiting; Sponsor: Cedars-Sinai Medical Center; Trial completion date: Jan 2020 ➔ Oct 2020; Trial primary completion date: Jan 2020 ➔ Oct 2020

Clinical • Trial completion date • Trial primary completion date • Constipation • Immunology

"How is SYN-010 going?" (@eslamsayedmoha2)

"Been waiting on that lovastatin (SYN-010) treatment for years and years. Seems development has completely stalled." (@HisnerRyan)

"When will SYN-010 be available in the market, approximately, doctor?" (@eslamsayedmoha2)

"Does SYN-010 *disable* archaea or actually *eradicate* them?" (@TheRealKiraSue)

"I am male age 63- had appendix removed at age 6- never had any digestive issues, constipation nor diarrhea except when I had an occasional virus. Unscientific I know. I am anxiously awaiting results of syn010 study as well- good luck!" (@walktallamerica)

"When will the SYN-010be available for purchasing" (@dekaosman559)

"How do we get in the clinical trials for SYN-010?" (@Valana7)

Clinical

"Has a sufficient number of patients enrolled in SYN-010 study?" (@eslamsayedmoha2)

Clinical

"@MarkPimentelMD I may be able to travel to LA to participate in the Lovastatin/SYN-010 study. Who should I speak with?" (@pjcomedysports)

"Does SYN-010 help with visceral hypersensitivity?" (@eslamsayedmoha2)

"Dr. Mark. Is there any news when SYN-010 is coming to market?" (@eslamsayedmoha2)

"@MarkPimentelMD What's the latest bit of news on SYN-010?" (@perfectpyles82)

"@MarkPimentelMD Hi Mark. When do you anticipate SYN-010 being available for use?" (@Chipleading)

"SYN-010 is indicated for IBS-C not IBD please correct your article... @SYNBiologics @MarkPimentelMD" (@CornelaSBv)

"SYN-010 ?" (@AlexisAdierom)

"Any news on SYN-010 or news for us methane folks in general?" (@lukejhoward6)

"Any news about syn 010 ?" (@KamranHamza7)

Efficacy and Safety of SYN-010 in IBS-C (clinicaltrials.gov) - P2; N=150; Recruiting; Sponsor: Cedars-Sinai Medical Center; Not yet recruiting ➔ Recruiting

Clinical • Enrollment open