elemene injection / BeiJing Yijiayi Medicine - LARVOL DELTA

Anti-Lung Cancer Effects and Related Mechanisms of α-Caryophyllene In Vitro and In Vivo. (PubMed, Food Sci Nutr) - "In antitumor activity in vitro, α-caryophyllene exhibited obvious selective cytotoxicity, and its cytotoxicity against lung cancer A549 cells (IC50 = 22.94 ± 0.56) was superior to the elemene injection (EI, positive control), while its toxicity against normal cell lines was lower (MRC-5: IC50 = 76.66 ± 2.60 μg/mL, L929: IC50 = 44.04 ± 0.72 μg/mL)...In antitumor activity in vivo, α-caryophyllene effectively suppressed transplanted tumor growth by inducing apoptosis of transplanted tumor cells and was superior to the positive control EI. Therefore, α-caryophyllene has outstanding anticancer properties in vitro and in vivo, showing great potential to become a new anticancer drug in the pharmaceutical field."

Journal • Preclinical • Lung Cancer • Oncology • Solid Tumor • Transplantation • BAX • BCL2 • CASP3 • CASP9 • CCND3 • CCNE2 • CDH2 • CDK2 • CDK4 • CDKN1A • MMP2 • PARP1

Elemene Injection Suppresses Pancreatic Cancer Progress through Regulating Cell Adhesion: A Research Based upon Network Pharmacology and Verification Test. (PubMed, Curr Med Chem) - "The findings of the current study emphasized that elemene injection might control cell attachment, decrease metastasis, and suppresses pancreatic cancer progress. FN1 might be a therapeutic target for pancreatic cancer."

Journal • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor • FN1

β-elemene, a sesquiterpene constituent from Curcuma phaeocaulis inhibits the development of endometriosis by inducing ferroptosis via the MAPK and STAT3 signaling pathways. (PubMed, J Ethnopharmacol) - "This study demonstrates that the inhibitory effect of β-ELE on endometriosis by inducing ferroptosis in vitro and in vivo. Our results revealed that β-ELE exerts anti-endometriosis effects by inducing ferroptosis via the MAPK and STAT3 signaling pathways."

Journal • Endometriosis • Fibrosis • Gynecologic Cancers • Gynecology • Immunology • Oncology • Pain • Women's Health • FTL • GPX4 • MAPK14

Elemene Injection Overcomes Paclitaxel Resistance in Breast Cancer through AR/RUNX1 Signal: Network Pharmacology and Experimental Validation. (PubMed, Curr Pharm Des) - "Elemene Injection (EI) application has exhibited a significant capability to mitigate PTX resistance in BC, which has been achieved through targeted suppression of the AR/RUNX1 axis, revealing a key strategy to overcome chemotherapeutic resistance."

Journal • Breast Cancer • Oncology • Solid Tumor • KLF4 • POU5F1 • RUNX1

Prevalence of inappropriateness of elemene injection for hospitalized cancer patients: a multicenter retrospective study. (PubMed, Front Pharmacol) - "More efforts, especially those to improve the appropriateness of indications, should be made to improve the rational use of elemene, as well as other complementary medicines. Physicians should take caution to avoid inappropriate use when prescribing drugs with limited clinical evidence."

Journal • Retrospective data • Gastrointestinal Cancer • Hepatology • Liver Cancer • Lung Cancer • Oncology • Solid Tumor

The complementary and alternative roles of elemene injection in cancer: an umbrella review. (PubMed, Pharmacol Res) - "EI may be a viable medication for the treatment of cancer although more convincing trials are still required to demonstrate its alternative and complementary benefits. Besides, it seems to have a broad potential for further development in immunotherapy, drug delivery technique, and predictive factor."

IO biomarker • Journal • Review • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor

Clinical benefit and risk of elemene in cancer patients undergoing chemotherapy: a systematic review and meta-analysis. (PubMed, Front Pharmacol) - "Introduction: Elemene injection and oral emulsion, known as elemene, have been utilized have been used in adjuvant therapy for cancer patients in China for more than 20 years... As the treatment time and the number of cycles increased, the efficacy of the elemene combination decreased across various aspects. Thus, shorter duration and fewer cycles are recommended."

Retrospective data • Review • Hematological Disorders • Leukopenia • Oncology • Thrombocytopenia • CD4 • CD8

Effect of Network-Based Positive Psychological Nursing Model Combined With Elemene Injection on Negative Emotions, Immune Function and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy in the Era of Big Data. (PubMed, Front Public Health) - "Compared with CG, EG had notably higher immune function indexes (P < 0.001), lower serum VEGF and MMP-2 levels (P < 0.001), lower HAMA and HAMD scores (P < 0.05), and higher scores of PTGI, physiological function, psychological function, social function and physical function (P < 0.001). The network-based positive psychological nursing model combined with elemene injection is a reliable method to enhance the immune function and QOL of LC patients undergoing chemotherapy and alleviate their negative emotions, which has a high clinical application value."

HEOR • Journal • Retrospective data • Lung Cancer • Oncology • Solid Tumor • MMP2

Investigation on the Efficiency of Chinese Herbal Injections combined with Concurrent Chemoradiotherapy for Treating Nasopharyngeal Carcinoma based on Multidimensional Bayesian Network Meta-analysis. (PubMed, Front Pharmacol) - " Current clinical evidence indicates that Elemene injection combined with CCRT has the best clinical effective rate and that Kangai injection might have a comprehensively better impact on improving performance status and reducing adverse reactions against NPC. Additionally, due to the limitations of this NMA, more multicenter, high-quality, and head-to-head RCTs are needed to properly support our findings."

Journal • Retrospective data • Hematological Disorders • Leukopenia • Mucositis • Nasopharyngeal Carcinoma • Oncology • Solid Tumor • Stomatitis • Thrombocytopenia

Beta-Elemene Reduces the Malignancy of Non-Small Cell Lung Cancer by Enhancing C3orf21 Expression. (PubMed, Front Oncol) - "Such data indicated that beta-elemene treatment attenuated the malignancy of NSCLC cells by up-regulating C3orf21 expression. Our findings may provide new mechanisms underlying the pharmacological action of beta-elemene."

Journal • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CCND1 • MMP2 • MMP9 • MYC • NOTCH1 • PTEN

Anti-Tumor Drug Discovery Based on Natural Product β-Elemene: Anti-Tumor Mechanisms and Structural Modification. (PubMed, Molecules) - "Elemene oral emulsion and elemene injection were approved by the China Food and Drug Administration (CFDA) for the treatment of various cancers and bone metastasis in 1994. To discover better β-elemene-derived anti-tumor drugs with satisfying drug-like properties, researchers have modified its structure under the premise of not damaging the basic scaffold structure. In this review, we comprehensively discuss and summarize the potential anti-tumor mechanisms and the progress of structural modifications of β-elemene."

Journal • Review • Oncology • Solid Tumor

Newly added product (clinicaltrials.gov) - P1, HCC

Pipeline update • Gastrointestinal Cancer • Hepatocellular Cancer • Oncology • Solid Tumor

Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes. (PubMed, Cancer Biol Med) - "Compared to elemene injection, PEG-Lipo-β-E demonstrated a 1.75-fold decrease in clearance, a 1.62-fold increase in half-life, and a 1.76-fold increase in area under the concentration-time curves (AUCs) from 0 hour to 1.5 hours (P < 0.05)...Histological analyses showed that there was no evidence of toxicity to the heart, kidney, liver, lung or spleen. The present study demonstrates PEG-Lipo-β-E as a new formulation with ease of preparation, high EE, good stability, improved bioavailability and antitumor effects."

Journal • PK/PD data • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • Urothelial Cancer

Elemene injection combined with transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: A meta-analysis. (PubMed, Medicine (Baltimore)) - "Based on current findings, TACE + elemene injection may improve the ORR and the 1-year survival rate for HCC patients compared to TACE alone. Arterial perfusion may be superior to intravenous guttae."

Journal • Retrospective data

Elemene injection as adjunctive treatment to platinum-based chemotherapy in patients with stage III/IV non-small cell lung cancer: A meta-analysis following the PRISMA guidelines. (PubMed, Phytomedicine) - "Elemene injection is a safe and effective adjunctive treatment to platinum-based chemotherapy in patients with stage III/IV NSCLC. Elemene injection can improve clinical efficacy, enhance cellular immune function and alleviate the toxicity of chemotherapy. High-quality RCTs with significant survival outcomes and longer follow-ups are warranted to confirm the results further."

Journal • Retrospective data