warfarin / Generic mfg. - LARVOL DELTA

Hypereosinophilic Syndrome with Eosinophilic Myocarditis and Coexisting Autoimmune Hemolytic Anemia: A Case Report. (PubMed, Intern Med) - "The administration of prednisolone (60 mg/day) and warfarin promptly improved her symptoms, eosinophilia, and anemia...Idiopathic HES may involve multiple organs, whereas AIHA arises in diverse conditions, and its coexistence is rare. We herein discuss the differential diagnoses, management, and potential immunopathogenesis of these conditions."

Journal • Anemia • Autoimmune Hemolytic Anemia • Cardiovascular • Eosinophilia • Hematological Disorders • Hypereosinophilic Syndrome • Immunology • Inflammation • Pulmonary Disease • Thrombosis

Cerebral venous thrombosis in pregnancy. (PubMed, BMJ Case Rep) - "Treatment with a two times per day dosing regimen of dalteparin was commenced until elective caesarean section at 37 weeks gestation, after which treatment was changed to warfarin therapy for a further 6 months. Her follow-up recovery was good; she remains asymptomatic. This case highlights difficulties in detecting CVT and treatment of CVT in the third trimester of pregnancy."

Journal • Cardiovascular • Diabetes • Endocrine Disorders • Gestational Diabetes • Hematological Disorders • Metabolic Disorders • Obstetrics • Pain • Thrombosis • Venous Thromboembolism

The catastrophe of catastrophic antiphospholipid syndrome: a case report. (PubMed, Eur Heart J Case Rep) - "Following initial clinical improvement and discharge on warfarin, she was readmitted with critical limb ischaemia and later on she suffered an ischaemic stroke...Catastrophic antiphospholipid syndrome should be considered in patients presenting with simultaneous arterial and venous thrombotic events. Underlying malignancy may contribute to treatment resistance and worsen prognosis, emphasizing the need for early recognition and multidisciplinary management."

Journal • Cardiovascular • Complement-mediated Rare Disorders • Genetic Disorders • Hematological Disorders • Immunology • Infectious Disease • Inflammatory Arthritis • Ischemic stroke • Lung Adenocarcinoma • Lung Cancer • Oncology • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Solid Tumor

BEYOND ANTICOAGULATION: PLEIOTROPIC EFFECTS OF APIXABAN IN NEPHROTIC SYNDROME AND PRIMARY GLOMERULONEPHRITIS (ISN-WCN 2026) - "Prophylactic anticoagulation is often advised, traditionally using warfarin, which has limitations such as dietary restrictions, drug interactions, need for INR monitoring, and bleeding risk. Moreover, apixaban reduced pro-inflammatory and pro-fibrotic cytokines, suggesting benefits beyond anticoagulation. These findings indicate potential renal and vascular protective effects of DOACs in glomerular diseases, warranting confirmation in larger randomized trials."

Cardiovascular • Chronic Kidney Disease • Glomerulonephritis • Lupus Nephritis • Nephrology • Renal Disease • Venous Thromboembolism • IL6 • TGFB1 • TNFA

CATHETER-RELATED SUPERIOR VENA CAVA THROMBOSIS IN HEMODIALYSIS: A CASE OF A LIFE-THREATENING CENTRAL VENOUS OBSTRUCTION (ISN-WCN 2026) - "Anticoagulation with unfractionated heparin was initiated and continued for 7 days then bridged with Warfarin...Prompt identification through clinical assessment and imaging facilitates timely intervention. Thrombolysis constitutes the cornerstone of therapy."

Clinical • Cardiovascular • Hematological Disorders • Mood Disorders • Nephrology • Pulmonary Disease • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Thrombosis

COMPARATIVE OUTCOMES OF APIXABAN VERSUS WARFARIN INITIATION IN PATIENTS ON HEMODIALYSIS WITH NEWLY DIAGNOSED ATRIAL FIBRILLATION (ISN-WCN 2026) - "Dr. Chang has served on a Data Safety Monitoring Board for a trial by Bayer.I did not use generative AI and AI-assisted technologies in the writing process."

Clinical • Atrial Fibrillation • Cardiovascular • Cerebral Hemorrhage • Hematological Disorders • Infectious Disease • Ischemic stroke • Musculoskeletal Diseases • Myocardial Infarction • Orthopedics • Pneumonia • Pulmonary Embolism • Renal Disease • Respiratory Diseases

EFFECTS OF NURSING FACILITY RESIDENCY ON MORTALITY IN PATIENTS INITIATING HEMODIALYSIS: A RETROSPECTIVE COHORT STUDY (ISN-WCN 2026) - "They exhibited lower body weight, lymphocyte counts, intact parathyroid hormone, albumin, phosphorus, and total cholesterol, as well as longer diabetes duration and higher alkaline phosphatase levels. Multivariate analysis, adjusting for age, sex, access type, dementia, malignancy, ischemic heart disease, cerebrovascular accident, heart failure, atrial fibrillation, liver cirrhosis, fracture, coronary artery disease, ejection fraction, lymphocyte count, platelet count, blood urea nitrogen, creatinine, albumin, phosphorus, total cholesterol, use of renin-angiotensin system blockers, beta-blockers, calcium channel blockers, warfarin, hyperlipidemia drugs, calcium-based phosphate binders, sevelamer, antidepressants, and dementia medications, showed that patients who initiated dialysis in a nursing facility had a significantly higher hazard ratio for mortality: 1.658 [95% confidence interval: 1.309–2.100].Conclusion In summary, the current study suggests a correlation..."

Retrospective data • Alzheimer's Disease • Atrial Fibrillation • Cardiovascular • CNS Disorders • Congestive Heart Failure • Coronary Artery Disease • Dementia • Diabetes • Dyslipidemia • Fibrosis • Gastroenterology • Heart Failure • Hepatology • Immunology • Liver Cirrhosis • Metabolic Disorders • Musculoskeletal Diseases

BEYOND CHADS2-VASC: QUESTIONING SYSTEMIC ANTICOAGULATION IN ADVANCED CHRONIC RENAL DISEASE WITH AURICULAR FIBRILATION (ISN-WCN 2026) - "Even the most recent clinical guidelines recommend individualized use of these scales in this subgroup of patients.Regarding treatment, vitamin K antagonist anticoagulants, such as warfarin or acenocoumarol, have historically been the most widely used drugs...In addition, INR control is especially complex in these patients, with increased risk of overanticoagulation.Direct-acting oral anticoagulants, such as apixaban, edoxaban, rivaroxaban and dabigatran, have demonstrated a better safety profile in certain contexts, with lower bleeding risk than vitamin K antagonist anticoagulants...This scale allows a stratification more adjusted to the renal profile and contributes to reduce unnecessary exposure to anticoagulant treatments with significant bleeding risk.It is necessary to promote a multidisciplinary and individualized approach in the assessment of thromboembolic and bleeding risk in this population, integrating the nephrologist in the therapeutic decision-making..."

Metastases • Atrial Fibrillation • Calciphylaxis • Cerebral Hemorrhage • Chronic Kidney Disease • CNS Disorders • Diabetes • Diabetic Nephropathy • Hematological Disorders • Hypertension • Metabolic Disorders • Nephrology • Peripheral Arterial Disease • Pulmonary Arterial Hypertension • Rare Diseases • Renal Disease

COMPARATIVE SAFETY OF ANTICOAGULATION STRATEGIES IN CRITICALLY ILL CKD PATIENTS: AKI AND MORTALITY OUTCOMES (ISN-WCN 2026) - "Log-rank test p<0.001.Conclusion In ICU patients with CKD, warfarin was associated with higher AKI incidence but paradoxically lower mortality compared to alternative anticoagulants. This unexpected finding may reflect reversible kidney injury with enhanced monitoring benefits and warrants confirmation in randomised trials before changing clinical practice."

Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Hematological Disorders • Nephrology • Thrombosis

ANTICOAGULANT - ASSOCIATED ACUTE KIDNEY INJURY: A PHARMACOVIGILANCE ANALYSIS BASED ON FDA ADVERSE EVENT REPORTING SYSTEM (ISN-WCN 2026) - "A).Warfarin had stable low reports, while newer oral anticoagulants (NOACs) showed dramatic trends: Apixaban peaked over 20,000 around 2021, Rivaroxaban near 20,000 in 2015, Dabigatran over 11,000 in 2012. Drugs like Argatroban, Bivalirudin, and Dalteparin had consistently low reports (Fig...Results show heterogeneity in renal ADRs; Fondaparinux and Apixaban signal specific toxicities. Findings can guide pharmacovigilance and clinical decisions for renal risk patients."

Adverse events • Acute Kidney Injury • Nephrology • Renal Disease • ROR1

CALCIPHYLAXIS COMPLICATED BY GASTROINTESTINAL BLEEDING: A CASE REPORT AND LITERATURE REVIEW (ISN-WCN 2026) - "He had no history of warfarin use or diabetes...Treatments such as sodium thiosulfate and surgery can be effective. However, early recognition is crucial to improve outcomes in this devastating complication."

Case report • Clinical • Review • Calciphylaxis • Cardiovascular • Diabetes • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Hypertension • Metabolic Disorders • Rare Diseases • Renal Disease

ASCENDING AORTA THROMBUS AND PULMONARY EMBOLISM IN A CHRONIC KIDNEY DISEASE PATIENT WITH HEAVY ALCHOL CONSUMPTION AND HYPERHOMOCYSTEINEMIA: A CASE REPORT (ISN-WCN 2026) - "He had a previous history of DVT, but had discontinued warfarin therapy 2 months prior due to excessive prolongation of prothrombin time-international normalized ratio (PT-INR)...The multivitamin prescription including folate, therefore, was started, and he has been followed regularly.Conclusion Cobalamine and folic acid are essential cofactors in homocysteine metabolism, and their deficiency can lead to hyperhomocysteinemia, one reason of thrombopilia.In this case, the patient's excessive alcohol consumption and unbalanced diet likely contributed to the development of hyperhomocysteinemia due to vitamin deficiencies, potentially leading to thrombus formation in multiple vascular regions. Moreover, even with apparent reason of thrombophilia, thrombus in ascending aorta is extremely rare."

Case report • Clinical • Cardiovascular • Chronic Kidney Disease • Hematological Disorders • Immunology • Inflammatory Arthritis • Ischemic stroke • Metabolic Disorders • Nephrology • Pulmonary Embolism • Renal Disease • Respiratory Diseases

UNILATERAL RENAL ARTERY THROMBOSIS PRESENTING WITH ACUTE KIDNEY INJURY: DIAGNOSTIC AND THERAPEUTIC CHALLENGES (ISN-WCN 2026) - "Continuous intravenous heparin infusion (10,000 units/24 hours) was started for anticoagulation, followed by percutaneous thrombectomy...Maintenance therapy with warfarin and clopidogrel was given to prevent recurrence...Early vascular imaging is crucial in sudden-onset renal failure with nonspecific laboratory findings2. Long-term antithrombotic therapy may prevent recurrence in idiopathic or hypercoagulable conditions2,3.Conclusion Renal artery thrombosis is an uncommon but critical cause of acute kidney injury that demands prompt recognition and swift intervention"

Acute Kidney Injury • Atherosclerosis • Atrial Fibrillation • Cardiovascular • Diabetes • Diabetic Nephropathy • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Renal Disease • Thrombosis

CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME TRIGGERED BY BULLOUS PEMPHIGOID: A CASE REPORT (ISN-WCN 2026) - "Renal biopsy and positive antiphospholipid antibodies confirmed primary APS, and plasma exchange, corticosteroids, warfarin, and antiplatelet therapy improved renal function from a serum creatinine level of 4.0 mg/dL to 2.0 mg/dL with long-term stability.Five months before admission, he developed generalized bullae and was diagnosed with BP based on an elevated BP180 antibody titer (5760 U/mL). The lesions improved with minocycline, nicotinamide, and prednisolone, and the antibody titer decreased to 1200 U/mL...He was hospitalized and treated with vancomycin, meropenem, intravenous immunoglobulin, and methylprednisolone (40 mg/day), which led to temporary improvement.Results On hospital day 14, inflammation worsened again, accompanied by melena and coagulopathy with a prolonged PT-INR...Autopsy revealed widespread thrombi not only in the gastrointestinal tract but also in multiple systemic organs, leading to the diagnosis of catastrophic antiphospholipid syndrome (CAPS)..."

Case report • Clinical • Bullous Pemphigoid • Cardiovascular • CNS Disorders • Complement-mediated Rare Disorders • Dermatology • Dermatopathology • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Glomerulonephritis • Hematological Disorders • Immunology • Inflammation • Nephrology • Peptic Ulcer • Renal Disease • Thrombosis

Estimating real-world treatment effects in the presence of measurement error and sparse outcome data using propensity score methods. (PubMed, Front Pharmacol) - "The motivational example for this study was the assessment of the treatment effect of the novel oral anti-coagulant Rivaroxaban compared with the previous standard treatment Warfarin for the prevention of future stroke in patients with atrial fibrillation. This study showed that PS methods proposed in the literature may not all perform well for individual datasets. The findings produced recommendations for using PS methods in the estimation of real-world treatment effect when the covariate measurement error and sparse outcome data are present."

HEOR • Journal • Real-world evidence • Atrial Fibrillation • Cardiovascular

Is dabigatran a good alternative to warfarin in patients with atrial fibrillation accompanied by valvular and non-valvular heart diseases? A systematic review and meta-analysis. (PubMed, Tunis Med) - "Dabigatran 150 mg and 110 mg was superior to warfarin in AF patients with NVHD in reducing bleeding particularly ICH; However, no significant difference in reducing S/SE, and mortality. In catheter ablation, dabigatran reduced only groin hematoma. In the VHD subgroup, dabigatran did not show superiority or inferiority to warfarin; further studies are needed. "Non-valvular AF" should be replaced with "type II VHD" to distinguish it from other valvular heart diseases."

Clinical • Journal • Retrospective data • Review • Atrial Fibrillation • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Heart Failure • Hematological Disorders

Managing Postangiography Radial Artery Pseudoaneurysms: Systematic Review of the Published Literature. (PubMed, J Soc Cardiovasc Angiogr Interv) - "Chronic anticoagulant use was reported in 58.3% of patients, with warfarin being the most common agent...Radial artery pseudoaneurysms are rare but potentially serious complications of transradial coronary procedures. Although compression is commonly attempted, invasive treatments offer superior efficacy."

Journal • Review • Cardiovascular • Pain

Warfarin and PPI use: How many of you consider the increased risk of bone fractures (ERA 2026) - No abstract available

Musculoskeletal Diseases • Orthopedics

Warfarin use: how many of you in CKD5D have stopped using it and now use Apixaban or Rivaroxaban (ERA 2026) - No abstract available

Cardiovascular • Chronic Kidney Disease

Clinical analysis of 26 children with long-acting anticoagulant rodenticides (superwarfarin) poisoning. (PubMed, Res Pract Thromb Haemost) - "Long-acting anticoagulant rodenticides have a long incubation period and a long-lasting toxic effect. Patients presented with bleeding and coagulation dysfunction and were initially treated with vitamin K1; maintenance therapy with oral vitamin K1 can prevent recurrence."

Journal • Cerebral Hemorrhage • CNS Disorders • Gastroenterology • Hematological Disorders

Safety and efficacy of rivaroxaban versus warfarin in atrial fibrillation with stage 4 to 5 chronic kidney disease including dialysis. (PubMed, Res Pract Thromb Haemost) - "In patients with AF and advanced CKD including dialysis, rivaroxaban may be associated with improved efficacy and safety compared with warfarin. However, heterogeneity in CKD stages and off-label dosing practices necessitate prospective randomized trials to establish definitive treatment recommendations."

Journal • Atrial Fibrillation • Cardiovascular • Cerebral Hemorrhage • Chronic Kidney Disease • CNS Disorders • Gastroenterology • Hematological Disorders • Nephrology • Renal Disease

Warfarin Patient Self-Management in the US Health Care System: A Nonrandomized Clinical Trial. (PubMed, JAMA Netw Open) - P=N/A | "These results provide critically needed evidence to facilitate and accelerate PSM implementation in the US health care system. ClinicalTrials.gov Identifier: NCT04766216."

Clinical • Journal • Cardiovascular

Perioperative Management of Antithrombotic Therapy in Patients with Thrombotic Antiphospholipid Syndrome. (PubMed, Blood Adv) - "Among 172 patients undergoing 282 interruptions, most (84.9%) received warfarin, and 25% were triple-positive (anti-cardiolipin, anti-β2-glycoprotein I, and lupus anticoagulant)...Guideline-directed perioperative anticoagulation management tailored to individual thrombotic and procedural bleeding risks appears feasible and safe. Our findings support individualized, risk-adapted perioperative anticoagulation management in APS."

Journal • Cardiovascular • Genetic Disorders • Hematological Disorders • Immunology • Inflammatory Arthritis • Venous Thromboembolism

APOTHECARYAF: A Trial of Pharmacist Management of Oral Anticoagulation THerapy in the communitY for AF (clinicaltrials.gov) - P4 | N=14 | Completed | Sponsor: Cedars-Sinai Medical Center | Active, not recruiting ➔ Completed | N=400 ➔ 14

Enrollment change • Trial completion • Atrial Fibrillation • Cardiovascular

Treatment Stability of Warfarin and Acenocoumarol in Patients With Mechanical Heart Valves and Atrial Fibrillation: A One-Year Cohort Study. (PubMed, Acta Med Acad) - "Our unadjusted descriptive results suggested that warfarin, compared to acenocoumarol, may provide more stable and therefore safer anticoagulation control in patients with mechanical heart valves and atrial fibrillation. To confirm this, larger prospective clinical studies are needed in patients with mechanical heart valves with or without atrial fibrillation."

Journal • Atrial Fibrillation • Cardiovascular