CCT244747
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- LARVOL DELTA
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October 15, 2022
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.
(PubMed, Biochem J)
- "Total and phospho proteomic analysis revealed that Eµ-Myc/cRel-/- lymphomas highly resemble wild-type (WT) Eµ-Myc lymphomas treated with an acute dose of the CHK1 inhibitor (CHK1i) CCT244747...We demonstrate that treating WT Eµ-Myc lymphoma cells with the USP1 inhibitor ML323 was highly effective at reducing tumour burden in vivo. Targeting USP1 activity may thus be an alternative therapeutic strategy in MYC-driven tumours."
Journal • Gastrointestinal Cancer • Hematological Malignancies • Hepatocellular Cancer • Lymphoma • Oncology • Osteosarcoma • Sarcoma • Solid Tumor • Targeted Protein Degradation • USP1
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