promethazine / Generic mfg. - LARVOL DELTA

Breaking the Pain Cycle: Hydroflotation With Promethazine and Dexamethasone for Post-laparoscopic Shoulder Pain. (PubMed, Cureus) - "The hydroflotation technique shows promise as a novel intervention for reducing PLSP following MIS. By addressing a significant postoperative complication, this technique has the potential to enhance recovery outcomes and patient satisfaction. Further studies with larger cohorts are needed to validate these findings and assess the broader applicability of this method."

Journal • Inflammation • Musculoskeletal Pain • Pain

A case series of hyperthermia crisis in cough mixture ingestion: Why early cooling save lives. (PubMed, Toxicol Rep) - "Promethazine and ephedrine were detected in all patients...Early recognition and aggressive cooling are critical to reduce mortality. Such cough mixtures should be restricted from being sold as over-the-counter medications."

Journal • Cough • Respiratory Diseases

High-Throughput Screening Using the Self-Controlled Tree-Based Scan Statistic to Identify Medications Associated With Hospitalization for Severe Acute Liver Injury. (PubMed, Pharmacoepidemiol Drug Saf) - "High-throughput screening using tree-based scan statistics detected potentially hepatotoxic drugs for investigation in future pharmacoepidemiology studies."

Journal • CNS Disorders • Gastroenterology • Hepatology • Liver Failure • Pain

Peripheral IV Catheter-Associated Upper Extremity Deep Vein Thrombosis in a Patient with Psychiatric Illness: A Case Report and Literature Review. (PubMed, Int Med Case Rep J) - "We report a 44-year-old man with bipolar affective disorder on haloperidol, promethazine, and carbamazepine...The patient was initially started on low molecular weight heparin, later transitioned to apixaban...Antipsychotics, such as haloperidol and chlorpromazine, may further elevate thrombosis risk. Clinicians must maintain vigilance for UEDVT in patients with unilateral arm swelling post-cannulation, recognizing that prompt ultrasound evaluation and guideline-based anticoagulation are essential to prevent complications."

Journal • Bipolar Disorder • Cardiovascular • CNS Disorders • Hematological Disorders • Mental Retardation • Pain • Psychiatry • Thrombosis • Venous Thromboembolism • Venous Ulcer

Multicenter, Single-Arm Exploratory Phase I Clinical Study (Assessment of Safety and Efficacy) of Fully Human BAFF-R Chimeric Antigen Receptor T-Cell Injection in Relapsed/Refractory BAFF-R-Positive B-Cell Lymphoma (clinicaltrials.gov) - P1/2 | N=20 | Not yet recruiting | Sponsor: Institute of Hematology & Blood Diseases Hospital, China

New P1/2 trial • B Cell Lymphoma • Chronic Lymphocytic Leukemia • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Lymphoma • Marginal Zone Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

Integrating explainable artificial intelligence with multiomics systems biology and electronic health record data mining for personalized drug repurposing in Alzheimer's disease. (PubMed, Brief Bioinform) - "Notably, in a large US de-identified insurance-claims database (n = 364 733), exposure to promethazine, one of the candidate drugs, was associated with a 57%-62% lower incidence of AD versus an active antihistamine comparator (adjusted hazard ratio 0.38; inverse-probability weighted 0.43; both P < .001), providing real-world support for its repurposing potential. In summary, PRISM-ML, as an explainable multiomics analysis pipeline, is readily transferable to other complex diseases, advancing precision medicine."

Journal • Alzheimer's Disease • CNS Disorders

Promethazine Effects on Motion Sickness During Altered Gravity Induced by Parabolic Flight. (PubMed, Aerosp Med Hum Perform) - "Promethazine was effective at mitigating motion sickness symptoms in both 0 g and partial g. Microgravity conditions (0 g) may be more provocative than partial gravity, possibly due to the greater magnitude of sensory conflict. Further research should continue to investigate motion sickness as a function of hypogravity level. Abbott R, Weinrich MM, Keller NW, Wright TJ, Dunbar BJ, Denise P, Kennedy DM, Diaz-Artiles A. Promethazine effects on motion sickness during altered gravity induced by parabolic flight. Aerosp Med Hum Perform. 2025; 96(11):976-984."

Clinical • Journal

Mass spectrometry-based untargeted metabolomics study of polycystic ovary syndrome. (PubMed, J Ovarian Res) - "This study demonstrates distinct alterations in lipid and amino acid metabolism in PCOS and highlights the accumulation of exogenous molecules, including endocrine disruptors, in patient serum. By integrating metabolomic profiling with clinical phenotyping, our findings provide novel insights into PCOS pathophysiology and suggest potential serum biomarkers that may support early diagnosis and personalized therapeutic approaches."

Journal • Metabolic Disorders • Polycystic Ovary Syndrome

Synthesis of β-Cyclodextrin-Calix[4]arene Polymer-Based Chiral Stationary Phase for Chromatographic Separation of Enantiomers. (PubMed, Chirality) - "Compared with the home-made β-cyclodextrin-based chiral column, the prepared β-cyclodextrin-calix[4]arene polymer-based chiral column showed superior enantioseparation performance toward 1-phenylethanol, prothioconazole, promethazine, propranolol, and bisoprolol. These chiral compounds can be separated within 10 min under reversed-phase mode with resolutions ranging from 1.62 to 1.80. These findings will provide an important reference for developing novel supramolecule-based chiral stationary phases."

Journal

Determination of Retention Behavior and pK a Values of Some Phenothiazines with Green Chemistry Approach. (PubMed, ACS Omega) - "Accordingly, for promethazine, promazine, and trimeprazine, the values were calculated as 9.821, 10.407, and 10.110 at 25 °C and 9.787, 9,836, and 10.027 at 37 °C, respectively. The Green Solvent Selection Tool, the Analytical Greenness Metric Approach, the Green Analytical Procedure Index, and the Blue Applicability Grade Index were applied to assess the environmental impacts of both the green and conventional RPLC methods developed in the study."

Journal

Comparative Analysis of Medication Use and Healthcare Utilization in Gastroparesis and Functional Dyspepsia: A Propensity-Matched Cohort Study (ACG 2025) - "We identified 7,329 patients with GP (mean age 47.1±17.6 years; 72.7% female) and 3,950 with FD (mean age 44.7±20.3 years; 69.2% female). After 1:1 matching, 3,420 patients per group were followed for 5 years. GP patients had significantly higher use of metoclopramide (RR 3.4, 95% CI 3.02–3.84, P-value< .0001), erythromycin (RR 2.7, 95% CI 2.24–2.92, P-value< .0001), and antiemetics including ondansetron, promethazine, prochlorperazine, and diphenhydramine (all P-value< .0001)."

HEOR • Dyspepsia • Gastrointestinal Disorder

The Nausea Atlas: Identifying and Characterizing Nausea Subtypes Using Patient-Reported Information (ACG 2025) - "Ondansetron was the most effective anti-nausea medication, followed by promethazine, lorazepam, prochlorperazine, and domperidone. Marijuana was the most effective non-medication treatment, outperforming dronabinol... 745 participants (77% Female; 19% Male), reporting 1200 distinct nausea types/experiences were evaluated. The most represented age range was 31–40 years. 22% of respondents reported their nausea as severely or completely debilitating."

Clinical • Gastrointestinal Disorder • Mood Disorders • Psychiatry

Dystonia in a Dose: Recognizing a Class Effect in Susceptible Patients (ACG 2025) - "This case report describes a young patient who has extrapyramidal side effects to multiple anti-emetics (metoclopramide, promethazine, and prochlorperazine), all of which triggered dystonic reactions, rendering only trimethobenzamide and ondansetron as viable treatment options.Case Description/ A 32-year-old male was admitted to hospital with viral gastroenteritis due to coronavirus infection...The healthcare team promptly responded, and given characteristic dystonic presentation, prior history of dystonia with other medications, and temporal relation with metoclopramide administration, the reaction was identified as a medication-induced extrapyramidal side effect and diphenhydramine was administered...This case emphasizes the need for healthcare providers to be vigilant and proactive when choosing antiemetic agents, particularly for patients with a history of extrapyramidal symptoms. Further research into strategies to prevent medication-related adverse effects,..."

Clinical • CNS Disorders • Dystonia • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Movement Disorders • Novel Coronavirus Disease • Respiratory Diseases

Retrospective Analysis of Anti-Emetics Used for Cannabis Hyperemesis Syndrome to Assess Efficacy of Abortive Medications (ACG 2025) - "Of 2,812 patient encounters, the mean age was approximately 31 years, with 56% male and 44% female patients. Ondansetron was the most commonly administered anti-emetic (60.8%), followed by promethazine (38.7%), lorazepam (12.8%), haloperidol (11.2%), olanzapine (9.1%), and topical capsaicin (7.9%). Tricyclic antidepressants were used in only 1.1% of encounters."

Retrospective data • CNS Disorders • Depression • Diabetes • Gastrointestinal Disorder • Major Depressive Disorder • Metabolic Disorders • Mood Disorders • Psychiatry • Rare Diseases • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus

Lymphoethelial Cyst of the Pancreas: A Case Study (ACG 2025) - "Trials of antiemetics (ondansetron, promethazine, scopolamine) failed to relieve symptoms. This case reinforces the importance of recognizing LECs in the differential diagnosis to avoid overtreatment. Increased awareness and appropriate use of EUS-FNA can prevent unnecessary surgery while ensuring accurate diagnosis."

Case study • Clinical • Cardiovascular • CNS Disorders • CNS Tumor • Depression • Gastroenterology • Hypertension • Pancreatic Cancer • Psychiatry

Repurposed Drugs and Efflux Pump Inhibitors Against Gram-Negative Urinary Tract Pathogenic Bacteria. (PubMed, Antibiotics (Basel)) - "Minimum inhibitory concentrations (MICs) of thioridazine (TZ), promethazine (PMZ), fluoxetine (Fx), sertraline (Sr), phenylalanine arginine β-naphthylamide (PAβN), carbonyl cyanide m-chlorophenyl hydrazone (CCCP), and the glutamine uptake inhibitor V9302 were determined at pH 5-8... TZ reduced biofilm formation in sensitive K. pneumoniae at all pH levels and enhanced ciprofloxacin (CIP) activity, whereas PMZ showed a weaker effect, limited mainly to neutral pH...V9302 was a potent biofilm inhibitor in K. pneumoniae and resistant E. coli and interfered with efflux activity, showing strong effects in acidic environments. Repurposed drugs and EPIs may be useful as antibiotic adjuvants or biofilm inhibitors in treating resistant UTIs."

Journal • Infectious Disease • Nephrology • Pneumonia

Treatment of cannabinoid hyperemesis syndrome: A systematic review and treatment algorithm for consultation-liaison psychiatrists. (PubMed, Gen Hosp Psychiatry) - "An examination of treatment strategies for CHS can allow for more effective care while providing a foundation for further research in treatment. This proposed algorithm is designed to aid in establishing treatment strategies for C-L psychiatrists who assist with managing CHS for patients in general medical settings. The goal of this research is to establish evidence-based treatment guidelines for C-L psychiatrists who are managing patients with CHS in general medical settings. Recognizing the limitations of this algorithm being based on case reports adds to the necessity of further research in this area."

Journal • CNS Disorders • Psychiatry

Development and validation of a green UV-Vis spectrophotometric method for the determination of potassium bromate in bread using promethazine. (PubMed, Food Chem) - "The greenness evaluation confirmed environmental suitability with an Analytical Eco-Scale score of 76, AGREE score of 0.71, and minimal red hues in the GAPI profile. These results support the hypothesis that promethazine can be effectively used in a sustainable spectrophotometric method for potassium bromate determination in bread."

Journal

Dexmedetomidine for Reducing Perioperative Nausea and Vomiting in Cesarean Delivery (ASA 2025) - "Inclusion criteria were >37 weeks gestational age, cesarean delivery, and use of ondansetron and dexamethasone on the same day of surgery...Risk analysis and Kaplan-Meier survival analysis were performed to assess the outcome of intraoperative and perioperative nausea and vomiting by the use of rescue antiemetics (droperidol, promethazine, dimenhydrinate, metoclopramide, prochlorperazine)... Contrary to consistent current research findings, dexmedetomidine use was not associated with a reduced incidence of PONV in cesarean delivery patients. This finding suggests that dexmedetomidine may not have the added benefit of reducing PONV in this population. Further prospective studies are needed to confirm these results and explore the underlying mechanisms."

Anesthesia • Diabetes • Gastroesophageal Reflux Disease • Genetic Disorders • Gynecology • Metabolic Disorders • Obesity

PURPLE DRANK: AN OLD PHENOMENON RETURNS. (PubMed, Psychiatr Danub) - "Purple drank (PD) also known as "lean" or "sizzurp", is a recreational drug typically containing codeine and promethazine hydrochloride, often mixed with soda or alcohol. This drug is not new, in fact it was used in Texas in the 1960s, and became widely popular in the 1990s especially among adolescents and young adults, becoming the "poor man's drug" because it was readily available and not expensive. Several studies suggest that the number of PD abusers today is increasing, and the underestimation of this phenomenon may be related to the fact that PD components are easily available in pharmacies."

Journal • Review

PURPLE DRANK: AN OLD PHENOMENON RETURNS. (PubMed, Psychiatr Danub) - "Purple drank (PD) also known as "lean" or "sizzurp", is a recreational drug typically containing codeine and promethazine hydrochloride, often mixed with soda or alcohol. This drug is not new, in fact it was used in Texas in the 1960s, and became widely popular in the 1990s especially among adolescents and young adults, becoming the "poor man's drug" because it was readily available and not expensive. Several studies suggest that the number of PD abusers today is increasing, and the underestimation of this phenomenon may be related to the fact that PD components are easily available in pharmacies."

Journal • Review

Cannabinoid Hyperemesis Syndrome Treated With Fosaprepitant: A Case Report. (PubMed, Cureus) - "The usual treatment options for nausea and vomiting include fluids and a combination of metoclopramide, ondansetron, promethazine, or prochlorperazine. We present a case where fosaprepitant was utilized for intractable nausea and vomiting when other treatment modalities failed for CHS."

Journal

A Sensitive and Selective Sensor Based on Orthorhombic Copper Molybdate Decorated on Reduced Graphene Oxide for the Detection of Promethazine Hydrochloride. (PubMed, Sensors (Basel)) - "It also demonstrated good cyclic stability, reproducibility, and selectivity in the presence of chlorpromazine and biological and metal compounds. Furthermore, the Cu3Mo2O9/RGO/SPCE sensor displayed satisfactory recoveries for real-time monitoring of PMH in human urine and serum samples. This study delivers a promising electrochemical sensor for the efficient analysis of antipsychotic drug molecules."

Journal • CNS Disorders • Mental Retardation • Psychiatry

Thymol as a Potential Natural Antiemetic: Insights From In Vivo and In Silico Studies. (PubMed, Food Sci Nutr) - "THY was administered orally at doses of 10, 20, and 40 mg/kg, alone or in combination with standard antiemetics ondansetron (ODN), domperidone (DPD), hyoscine butyl bromide (HYS), and promethazine hydrochloride (PRO). The multi-target binding profile and synergistic potential of THY suggest its promise as a natural, broad-spectrum antiemetic. Further receptor-specific studies and trials in chemotherapy-induced emesis models are recommended to validate its clinical potential."

Journal • Preclinical • Gastrointestinal Disorder

Characterisation of Antifungal Resistance to Azoles in Colombian Isolates of Malassezia spp. (PubMed, Mycoses) - "We observed resistance of Colombian Malassezia spp. isolates to azoles, mainly fluconazole, through the expression of efflux pumps and biofilm formation."

Journal • Dermatopathology • ATM