VEGFR1-1084 / Tokyo Medical University - LARVOL DELTA

Intratumoral lymphatic endothelial cell infiltration reflects lymphangiogenesis and lymph node metastasis, but is counterbalanced by immune response and better cancer biology in breast cancer tumor microenvironment (SABCS 2021) - " First we performed gene set enrichment assay using Hallmark and PID collections from MSigDB and found that high iLEC breast cancer enriched Lymphangiogenesis-related gene sets (lymph angiogenesis, S1P meta, S1P1, and S1P3 pathway) and hemoangiogenesis-related gene sets (Angiogenesis, VEGFR1 pathway, and VEGFR2 pathway) (all FDR<0.25)... High iLEC breast cancer reflected lymphangiogenesis and were associated with cancer stem cell-related genes and lymph node metastasis, while low iLEC breast cancers were associated with accelerated cell proliferation and pro-cancer immune cell infiltrations. Unfavorable cancer characteristics on both high and low iLEC groups may explain the lack of difference in patient survival."

Biomarker • Tumor microenvironment • Breast Cancer • Lymphoma • Oncology • Solid Tumor • FLT1 • HRD • IFNG • IL2 • IL6 • STAT5 • TNFA

Molecular investigation of brain tumors progressing during pregnancy or postpartum period: the association between tumor type, their receptors, and the timing of presentation. (PubMed, Clin Neurol Neurosurg) - "Progression of brain tumors during pregnancy is associated with various growth factors as well as sex hormones. The timing of presentation is likely dependent on molecular receptors specific to each tumor type."

Journal • Anaplastic Astrocytoma • Astrocytoma • Brain Cancer • Chordoma • Glioma • Meningioma • Oncology • Solid Tumor • EGFR • ER • FLT1 • HER-2 • KDR • MYC