NTG-101 / Notogen - LARVOL DELTA

A Single Injection of NTG-101 Reduces the Expression of Pain-Related Neurotrophins in a Canine Model of Degenerative Disc Disease. (PubMed, Int J Mol Sci) - "A single intradiscal injection of NTG-101 significantly inhibits the expression of NGFr, BDNF, TrkB and CALCRL proteins in degenerative canine IVDs. These results strongly suggest that NTG-101 inhibits the development of neurotrophins that are strongly associated with painful degenerative disc disease and may have profound effects upon the management of patients living with discogenic pain."

Journal • Preclinical • Musculoskeletal Diseases • Pain • BDNF • CALCRL • NGF • NGFR • NTRK2

A comparative study of mesenchymal stem cell transplantation and NTG-101 molecular therapy to treat degenerative disc disease. (PubMed, Sci Rep) - "Our results also demonstrated suppression of inflammation induced p38 and NFκB resulting in inhibition of catabolic genes, but activation of Smad-2/3, Erk-1/2 and Akt-dependent signaling inducing anabolic genes in IVD-NP on treatment with NTG-101. In conclusion, a single injection of NTG-101 into the degenerative disc demonstrated superior benefits compared to stem cell transplantation."

Journal • Bone Marrow Transplantation • Immunology • Inflammation • Musculoskeletal Diseases • Transplantation • POU5F1 • SMAD2