Chirocaine (levobupivacaine) / Purdue, AbbVie - LARVOL DELTA

Ultrasound-Guided Costoclavicular Brachial Plexus Block Using 0.5% Levobupivacaine Alone or With Dexamethasone as an Adjuvant for Upper Arm Surgical Anesthesia and Postoperative Analgesia: A Randomized Study. (PubMed, Cureus) - "The addition of dexamethasone to 0.5% levobupivacaine for CCB significantly enhances block efficacy, providing faster onset and prolonged duration, and extends postoperative analgesia compared to 0.5% levobupivacaine alone. This combination of levobupivacaine and dexamethasone can be a valuable option for optimizing regional anesthesia in upper limb surgeries."

Journal • Anesthesia • Pain

Use of Dextran and Magnesium in Thoracic Paravertebral Block for Thoracic Surgery: A Case Report. (PubMed, A A Pract) - "In this case report, the author combined dextran and magnesium with levobupivacaine in TPVB as part of multimodal analgesia for a patient with recurrent lung cancer undergoing VATS, which resulted in satisfactory pain control and sensory blockade up to 3 days postoperatively. Nonetheless, the findings of this study are at most exploratory and call for further research to prove the efficacy and safety of this combination."

Journal • Lung Cancer • Oncology • Pain • Solid Tumor

A Randomized Trial Comparing Ultrasound Guided Modified Pectoral Block Versus Erector Spinae Block for Post Mastectomy Pain Management: A Comparative Analysis. (PubMed, Clin Breast Cancer) - "We found that while the modified PECS block offered better postoperative pain relief, the ESP block facilitated physiotherapy, although this advantage was achieved at the cost of less effective pain management. Both blocks showed no adverse effects."

Journal • Anesthesia • Pain

EFFECT OF ULTRASOUND-GUIDED MAXILLARY NERVE BLOCK IN TONSILLECTOMY: A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED TRIAL (ASRA-SPRING 2025) - "Anesthesia & Postoperative Management General Anesthesia (GA): Propofol, remifentanil (BIS-guided), IV acetaminophen (15 mg/kg, max 1000 mg)...Regional Block Intervention Group: Bilateral MaxNB (5 mL 0.375% levobupivacaine per side)...Rescue NSAIDs (flurbiprofen 50 mg)...Median [IQR] cumulative fentanyl consumption also did not differ significantlyBlock: 50 [20–170] µg/day (5 [2–17] mg MME) Placebo: 40 [0–140] µg/day (4 [0–14] mg MME) p = 0.62 All secondary outcomes were also not significantly different...Combination of maxillary and glossopharyngeal nerve blocks was not evaluated. Conclusion MaxNB did not provide significant pain relief or reduce opioid use."

Clinical • Anesthesia • CNS Disorders • Hematological Disorders • Immunology • Mental Retardation • Pain • Psychiatry

Comparing General Anesthesia With Single Injection Peribulbar Block With 3 Different Drugs (clinicaltrials.gov) - P=N/A | N=55 | Completed | Sponsor: Research Institute of Ophthalmology, Egypt | Recruiting ➔ Completed

Trial completion • Anesthesia • Ophthalmology • Pediatrics • Strabismus

PABLO: TAP Block Versus Local Anesthesia Wound Infiltration for Postoperative Pain Relief After Appendicectomy in Children (clinicaltrials.gov) - P=N/A | N=110 | Completed | Sponsor: Centre Hospitalier Universitaire de Besancon | Recruiting ➔ Completed

Trial completion • Anesthesia • Gastroenterology • Gastrointestinal Disorder • Pain • Pediatrics

Postoperative analgesic effect of adding neostigmine to levobupivacaine in ultrasound-guided spermatic cord block for testicular sperm extraction surgery. (PubMed, J Anaesthesiol Clin Pharmacol) - "Moreover, the total amount of postoperative analgesic consumption was remarkably decreased in group N when compared to group C without statistically remarkable divergence concerning complications between both groups. Adding neostigmine to a local anesthetic solution in US-SCB proved to detain the first analgesic request postoperatively with reduced perioperative analgesia consumption, without significant side effects."

Journal • Anesthesia • Pain

Intertransverse Process Block to Improve Quality of Recovery After Cardiac Surgery With Sternotomy (clinicaltrials.gov) - P=N/A | N=100 | Not yet recruiting | Sponsor: Chinese University of Hong Kong

New trial • Cardiovascular • Pain

Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block (clinicaltrials.gov) - P4 | N=40 | Recruiting | Sponsor: Chinese University of Hong Kong | Trial completion date: Sep 2024 ➔ Sep 2026 | Trial primary completion date: Sep 2024 ➔ Sep 2026

Trial completion date • Trial primary completion date • Musculoskeletal Diseases

Minimum Effective Local Anesthetic Volume for Ultrasound Guided Superior Trunk Block (clinicaltrials.gov) - P=N/A | N=25 | Recruiting | Sponsor: Chinese University of Hong Kong | Trial completion date: Aug 2024 ➔ Aug 2026 | Trial primary completion date: Jul 2024 ➔ Jul 2026

Trial completion date • Trial primary completion date • Anesthesia • Musculoskeletal Diseases

Comparing Different Doses of Intravenous Dexamethasone for Prolonging Analgesia After a Single-Shot Ultrasound-Guided Supraclavicular Brachial Plexus Block: A Prospective Randomized Study. (PubMed, Cureus) - "All patients received an ultrasound-guided SCBPB, followed by general anesthesia (GA) and were randomly allocated into four groups using computer-generated randomization: group 1: 0.5% levobupivacaine (20 ml) + 8 mg IV dexamethasone; group 2: 0.5% levobupivacaine (20 ml) + 4 mg IV dexamethasone; group 3: 0.5% levobupivacaine (20 ml) + 2 mg IV dexamethasone; group 4 (control): 0.5% levobupivacaine (20 ml) + IV 0.9% normal saline. Conclusion Intravenous dexamethasone significantly prolongs analgesia following SCBPB, with 8 mg providing the longest duration (103% increase vs. control). However, 4 mg may offer a balance between efficacy and minimal side effects, particularly in avoiding postoperative hyperglycemia."

Journal • Anesthesia • Diabetes • Pain

Continuous femoral nerve block as pain management following total knee arthroplasty: a systematic review. (PubMed, Arch Orthop Trauma Surg) - "Ropivacaine combined with dexmedetomidine might be the best compound for continuous femoral nerve block to manage pain following TKA during the first PODs. Further high-quality investigations are necessary to validate these findings in clinical settings."

Journal • Review • Orthopedics • Pain

Subpectoral Plexus Block With Multi-level TPVB for Surgical Anesthesia During Primary Breast Cancer Surgery (clinicaltrials.gov) - P=N/A | N=100 | Recruiting | Sponsor: Chinese University of Hong Kong | Enrolling by invitation ➔ Recruiting | Trial completion date: Mar 2025 ➔ Mar 2026 | Trial primary completion date: Mar 2025 ➔ Mar 2026

Enrollment status • Trial completion date • Trial primary completion date • Anesthesia • Breast Cancer • Oncology • Solid Tumor

Optimal local anesthetic for spinal anesthesia in patients undergoing ambulatory non-arthroplasty surgery: a systematic review and Bayesian network meta-analysis of randomized controlled trials. (PubMed, Can J Anaesth) - "Evidence supports 2-chloroprocaine for short-duration spinal anesthesia in the ambulatory setting."

Journal • Retrospective data • Anesthesia • Orthopedics

Catheter-Based Regional Anesthetic Techniques for Comprehensive Pain Management and Early Mobilization After Cardiac Sternotomy: A Report of Two Cases. (PubMed, Cureus) - "The scheduled intermittent 0.25% levobupivacaine boluses provided analgesia that coincided with the patients' early mobilization activities, potentially contributing to their rehabilitation progress...These catheter-based techniques provide extended, adaptable analgesia during the critical early mobilization period after cardiac surgery, balancing effective pain control with safety considerations. Further research is needed to compare these different approaches systematically and identify optimal strategies for diverse cardiac surgical procedures."

Journal • Anesthesia • Cardiovascular • Pain

An injectable controlled-release local anesthetic formulation of levobupivacaine based on a temperature-responsive polymer: Evaluation of analgesia, motor impairment, and histological toxicity in rats. (PubMed, J Anesth) - "A single injection of controlled-release levobupivacaine gel almost safely inhibited hyperalgesia for 12 h in a rat model. However, further research is needed on its effects on the surrounding tissue."

Journal • Preclinical • Anesthesia • Inflammation • Pain

Clinical observation of bilateral lumbar plexus nerve block after laparoscopic total hysterectomy using bupivacaine liposomes and levobupivacaine hydrochloride (ChiCTR) - P=N/A | N=156 | Not yet recruiting | Sponsor: The Second Affiliated Hospital of Hainan Medical College; The Second Affiliated Hospital of Hainan Medical College

New trial • Gynecology

Anesthetic Management With Peripheral Nerve Blocks and Sedation for Popliteal Artery Aneurysm Repair in a Patient With Severe Pulmonary Dysfunction: A Case Report. (PubMed, Cureus) - "Sciatic, femoral, and obturator nerve blocks with 0.25% levobupivacaine provided effective analgesia...The patient was discharged on postoperative day 15 without pneumonia or respiratory failure. This case underscores the utility of PNBs and sedation in mitigating PPCs like pneumonia."

Journal • Anesthesia • Cardiovascular • Chronic Obstructive Pulmonary Disease • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

The Immune Response of Breast Cancer Patients Treated With Levobupivacaine Using Paravertebral or Superficial Chest Blocks (clinicaltrials.gov) - P=N/A | N=100 | Active, not recruiting | Sponsor: University of Rijeka | Not yet recruiting ➔ Active, not recruiting

Enrollment closed • Breast Cancer • Oncology • Solid Tumor

TAP ALIF: Echo-guided Transverse Abdominal Plane Block (TAP) in Anterior Lumbar Arthrodesis (ALIF) (clinicaltrials.gov) - P=N/A | N=80 | Recruiting | Sponsor: Clinique Saint Jean, France | Trial completion date: Dec 2025 ➔ Oct 2026

Trial completion date

Levobupivacaine versus ropivacaine for brachial plexus block: A systematic review and meta-analysis of randomised controlled trials. (PubMed, Indian J Anaesth) - "Levobupivacaine is significantly associated with a longer duration of sensory and motor block in patients undergoing BPB for upper limb surgery compared to ropivacaine, with a similar safety profile. However, there was no difference regarding the time to onset of the sensory or motor block."

Journal • Retrospective data • Anesthesia • Orthopedics • Pain

Exploring the Hidden Therapeutic Potential of Local Anaesthetics: Antioxidant and Antimicrobial Effects. (PubMed, Turk J Anaesthesiol Reanim) - No abstract available

Journal • Anesthesia

Intertransverse Process Block With Catheter Placement for Postoperative Pain Management in a Patient With Alcoholic Liver Disease and Portal Hypertension: A Case Report. (PubMed, Cureus) - "Analgesia was maintained with intermittent boluses of 0.25% levobupivacaine (10 mL bilaterally, twice daily) for three postoperative days, supplemented with intravenous patient-controlled analgesia (IV-PCA) fentanyl (baseline infusion 10 μg/hour, bolus dose 10 μg, lockout time 10 minutes). ITPB with catheter placement provided safe and effective analgesia in a patient with portal hypertension, enabling early mobilization and rehabilitation without risking complications associated with epidural techniques. This approach represents a viable alternative to epidural analgesia in high-risk patients with compromised liver function and vascular abnormalities."

Journal • Anesthesia • Cardiovascular • Fibrosis • Gastroenterology • Hematological Disorders • Hepatocellular Cancer • Hepatology • Hypertension • Immunology • Liver Cirrhosis • Oncology • Pain • Portal Hypertension • Solid Tumor

Levobupivacaine versus bupivacaine in peribulbar block for ophthalmic surgeries: a systematic review and meta-analysis. (PubMed, Can J Ophthalmol) - "As a result of conducting this meta-analysis, we conclude that there is no significant difference between levobupivacaine and bupivacaine in terms of akinesia score, time to onset of anesthetic effect, verbal pain scales, postoperative diplopia, or incidence of systemic hypotension."

Journal • Retrospective data • Anesthesia • Hypotension • Ophthalmology • Pain

Ultrasound-guided transversus abdominis plane block as an adjunctive anesthesia technique in elderly patients with combined massive ascites: a case report and literature review. (PubMed, Front Med (Lausanne)) - "Preoperatively, 30 mL of 0.2% levobupivacaine was injected into the TAP under ultrasound guidance...Postoperatively, the patient reported minimal pain and experienced no adverse effects. These findings highlight the effectiveness of ultrasound-guided TAP block as an auxiliary anesthesia technique, providing enhanced analgesia, promoting hemodynamic stability, and improving overall anesthetic outcomes in older patients with substantial ascites."

Journal • Anesthesia • Oncology • Ovarian Cancer • Pain • Solid Tumor