Chirocaine (levobupivacaine) / Purdue, AbbVie - LARVOL DELTA

Long-Term Outcomes of Ultrasound-Guided Percutaneous Bilateral Cardiac Sympathetic Denervation in Patients With Refractory Arrhythmic Storm: A Prospective Cohort Study. (PubMed, J Cardiothorac Vasc Anesth) - "BCSD is safe and effective for controlling arrhythmic events in refractory arrhythmic storm, significantly reducing ventricular arrhythmias during the first 6 months after the procedure and providing temporary stabilization for nearly 12 months with few adverse effects. Furthermore, it is associated with a 58% 12-month overall survival rate."

Journal • Cardiovascular • Transplantation

Esketamine as an Adjuvant to Levobupivacaine in Thoracic Paravertebral Block for Thoracoscopic Lung Cancer Surgery: A Retrospective Propensity Score-Matched Cohort Study (ChiCTR) - P=N/A | N=328 | Completed | Sponsor: Yixing Hospital of Traditional Chinese Medicine; Yixing Hospital of Traditional Chinese Medicine

New trial • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor

Analgesia PTG: Evaluation of Three Different Antalgic Blocks in Total Knee Prosthesis (clinicaltrials.gov) - P=N/A | N=141 | Completed | Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | Trial completion date: Sep 2025 ➔ May 2026 | Initiation date: May 2024 ➔ Feb 2025 | Trial primary completion date: Jan 2025 ➔ Oct 2025

Trial completion date • Trial initiation date • Trial primary completion date

Intrathecal Ropivacaine Versus Levobupivacaine for Infraumbilical Surgery: A Randomized Double-Blind Trial. (PubMed, Cureus) - "The prolonged sensory block with levobupivacaine resulted in less postoperative pain and reduced the need for early rescue analgesia, but at the cost of prolonged motor blockade. Both drugs are more cardiostable than bupivacaine and can be used safely as alternatives to bupivacaine."

Journal • Anesthesia • Cardiovascular • Pain

Segmental Thoracic Spinal Anesthesia as a Primary Anesthetic Strategy for Awake Thoracic Surgery in a High-Risk Patient with Bronchopleural Fistula and Difficult Airway (ASA 2026) - "Low-dose intrathecal levobupivacaine with fentanyl at T7-T8 achieved effective T4-T10 blockade, preserving spontaneous ventilation and avoiding airway instrumentation. Surgery was completed uneventfully with stable hemodynamics and excellent recovery. This case highlights STSA as a safe, organ-sparing alternative in carefully selected high-risk thoracic patients."

Clinical • Surgery • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Septic Shock

Comparative Efficacy and Safety of Intrathecal Bupivacaine, Levobupivacaine, and Ropivacaine for Cesarean Spinal Anesthesia: A Systematic Review and Network Meta-analysis (ASA 2026) - "Abstract is embargoed at this time."

Retrospective data • Review • Anesthesia

Comparative Safety of Intrathecal Levobupivacaine Versus Bupivacaine for Cesarean Delivery: A Systematic Review and Meta-Analysis (ASA 2026) - "Abstract is embargoed at this time."

Retrospective data • Review • Anesthesia

Transversal ultrasound-guided approach to the popliteal ssciatic nerve block in the supine position: feasibility, effectiveness, and safety in lower-limb surgery. (PubMed, Scand J Pain) - "The ultrasound-guided transversal approach to the popliteal sciatic nerve block in the supine position is a feasible, safe, and effective technique that provides logistical and comfort advantages for both patient and operator. Its safety and efficacy profile make it an attractive alternative to classical approaches, particularly in scenarios where patient mobilization is limited or risky. Future comparative studies with larger sample sizes are needed to confirm these findings and assess its applicability in ambulatory surgery."

Journal • Observational data • Anesthesia • Cardiovascular • Pain

Wound infiltration with local anesthetics during cesarean delivery with intrathecal opioids: A systematic review and meta-analysis of randomized control trials. (PubMed, Pregnancy (Hoboken)) - "Single-dose local anesthetic wound infiltration-of levobupivacaine, ropivacaine, or bupivacaine-administered subfascial at the time of cesarean delivery with intrathecal opioids is associated with reduced postoperative morphine consumption. The pain intensity scores at rest or with movement at 24 h postoperatively are decreased yet not significantly different, but significantly decreased at 48 h with movement and maternal side effects are comparable."

Journal • Retrospective data • Anesthesia • Dermatology • Pain • Pruritus

Pharmacokinetics of 0.25% levobupivacaine with clonidine following caudal epidural administration in children (ANZCTR) - P3 | N=50 | Completed | Sponsor: Royal Children's Hospital | Not yet recruiting ➔ Completed

Trial completion

Analgesic Efficacy of Bilateral Superficial Cervical Plexus Block Using Levobupivacaine vs Ropivacaine for Thyroid Surgery Under General Anesthesia. (PubMed, Cureus) - "Conclusions In this comparative observational study, BSCPB with 0.25% levobupivacaine provided a significantly longer duration of analgesia and lower postoperative VAS pain scores than 0.25% ropivacaine in thyroid surgery, indicating superior analgesic efficacy as measured by these validated, prespecified outcome measures, with reduced rescue analgesic requirements and a similar safety profile. Levobupivacaine is preferable to ropivacaine for BSCPB in thyroidectomy under general anesthesia."

Journal • Anesthesia • Otorhinolaryngology • Pain

Analgesia PTG: Evaluation of Three Different Antalgic Blocks in Total Knee Prosthesis (clinicaltrials.gov) - P=N/A | N=141 | Completed | Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

New trial

Ultrasound-guided lateral pterygoid muscle block as an adjunct to multimodal analgesia for impacted third molar extraction: a two-center retrospective exploratory study. (PubMed, J Dent Anesth Pain Med) - "All patients received standardized intraoperative multimodal analgesia (intravenous acetaminophen and dexamethasone) and wound local infiltration; the LPM group (n = 27) additionally received an ultrasound-guided LPM block with 10 ml of 0.25% levobupivacaine, whereas the NE group (n = 21) received wound infiltration alone. An adjunctive ultrasound-guided LPM block was associated with lower recorded early postoperative pain scores after impacted third molar extraction. These hypothesis-generating findings require confirmation in the ongoing ALPINE randomized controlled trial (jRCT1031250592)."

Journal • Retrospective data • Anesthesia • Orthopedics • Pain

Ultra-low dose continuous spinal anesthesia for major orthogeriatric surgery in a high cardiovascular risk patient on chronic aspirin therapy: A case report. (PubMed, Saudi J Anaesth) - "Continuous spinal anesthesia (CSA) was performed using an ultra-low dose of 6.25 mg 0.25% isobaric levobupivacaine (3.75 mg + 2.5 mg) without adjuvants, preserving the possibility of incremental dosing if necessary. The patient remained spontaneously breathing room air with an SpO2 >98%. The presented case demonstrates that ultra-low dose CSA may represent a valuable option for reducing the perioperative risk in carefully selected high-risk orthogeriatric patients."

Journal • Anesthesia • Cardiovascular • Coronary Artery Disease • Diabetes • Geriatric Disorders • Heart Failure • Hypertension • Metabolic Disorders • Orthopedics • Renal Disease

The Effect of Bilateral Intermediate Cervical Plexus Block on the Surgical Stress Response Following Total Thyroidectomy (clinicaltrials.gov) - P4 | N=48 | Not yet recruiting | Sponsor: University Hospital Dubrava

Biomarker • New P4 trial

Ultrasound-Guided Greater Occipital Nerve Block Across Headache Phenotypes: Outcomes and Determinants of Response in a Prospective Cohort. (PubMed, Pain Ther) - "Across chronic headache phenotypes, a single ultrasound-guided proximal (C2) GONB was associated with clinically meaningful 1-month improvements in pain, impact, sleep, and attack frequency. Response, however, was not uniform: higher baseline pain intensity and the cluster phenotype identified the patients most likely to benefit, whereas a rheumatic comorbidity marked probable non-responders. These predictors offer a practical basis for patient selection and should be confirmed prospectively."

Journal • CNS Disorders • Migraine • Neuralgia • Pain

Evaluation of the Impact of a Mobile App (LoAD Calc) on the Calculation of Maximum Safe Doses of Local Anesthetics: Randomized Controlled Trial. (PubMed, JMIR Mhealth Uhealth) - "Participants completed 10 clinical vignettes featuring various patient characteristics, comorbidities, and medication interactions requiring maximum safe dose calculations for lidocaine, levobupivacaine, and ropivacaine. LA overdoses were significantly less likely when the LoAD Calc app was used in simulated clinical vignettes, without increasing calculation time or underdose rates. Given its high usability score and the improvement in practitioner confidence, clinical implementation could be considered and may contribute to improving patient safety and dose calculation standardization."

Clinical • Journal • Anesthesia

Esketamine as an Adjuvant to Levobupivacaine in Thoracic Paravertebral Block for Thoracoscopic Lung Cancer Surgery: A Retrospective Propensity Score-Matched Cohort Study. (PubMed, J Pain Res) - "However, residual confounding cannot be excluded, and the 8.5% psychomimetic event rate does not support routine adoption of the 0.5 mg/kg regimen. Prospective randomized dose-finding trials are warranted."

Journal • Retrospective data • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pain • Solid Tumor

Surgeon-delivered non-ultrasound-guided TAP blocks enhance recovery in DIEP flap breast reconstruction: A prospective comparative cohort study. (PubMed, J Plast Reconstr Aesthet Surg) - "A single-dose, surgeon-delivered, non-ultrasound guided TAP blocks provide effective, opioid-sparing analgesia and enhances recovery following DIEP flap reconstruction. This simple, reproducible and cost-effective technique offers surgeons direct control of postoperative analgesia and represents a valuable addition to ERAS pathways. Randomised trials are now warranted."

Journal • Addiction (Opioid and Alcohol) • Anesthesia • Constipation • Gastroenterology • Gastrointestinal Disorder • Pain

Successful Treatment of Hamstring Tendinopathy in a Nonathlete with Ultrasound-Guided Injection to the Ischial Tuberosity: A Case Report. (PubMed, Reports (MDPI)) - "Ultrasound-guided injection of levobupivacaine and dexamethasone produced immediate but temporary relief. After 18 injections, her pain improved from a numerical rating scale score of 10 to 0-1; This case demonstrates that proximal hamstring tendinopathy can develop in nonathletes due to lifestyle-related mechanical loading. Characteristic clinical findings and ultrasound evaluation are essential for diagnosis, and ultrasound-guided injection combined with exercise and activity modification provided sustained symptom improvement."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Phase 1 single-centre, placebo and levobupivacaine controlled study in healthy volunteers to assess the safety, tolerability, efficacy, and pharmacokinetics of LL10, a novel long-acting local anaesthetic. Response to Br J Anaesth 2026; 137: 287-8. (PubMed, Br J Anaesth) - No abstract available

Journal • P1 data • PK/PD data • Anesthesia

TAP ALIF: Echo-guided Transverse Abdominal Plane Block (TAP) in Anterior Lumbar Arthrodesis (ALIF) (clinicaltrials.gov) - P=N/A | N=80 | Completed | Sponsor: Clinique Saint Jean, France | Recruiting ➔ Completed

Trial completion

Extrafascial out-of-plane continuous interscalene block using the C6 transverse process as a bony landmark: a case series. (PubMed, Korean J Anesthesiol) - "Continuous levobupivacaine infusion was maintained for 24 hours as part of multimodal analgesia...Given the absence of a control group, findings should be interpreted as hypothesis-generating. The C6 bony endpoint may improve reproducibility."

Journal • Anesthesia • Musculoskeletal Pain • Pain

A prospective randomized study to evaluate the effect of epidural volume extension with normal saline in combined spinal epidural anesthesia for lower limb surgeries using intrathecal hyperbaric levobupivacaine. (PubMed, Anesth Pain Med (Seoul)) - "Adequate intraoperative anesthesia was achieved in all patients with timely epidural supplementation when required. EVE with normal saline in CSEA using intrathecal hyperbaric levobupivacaine results in faster onset and greater cephalad sensory blockade with comparable hemodynamic effects; however, it may be associated with earlier block regression in longer surgical procedures."

Journal • Anesthesia

Comparative Study of Hyperbaric Bupivacaine Versus Levobupivacaine for Rapid Sequence Spinal Anesthesia in Category 1 and 2 Cesarean Sections. (PubMed, Cureus) - "Conclusion In conclusion, both fixed doses of bupivacaine and levobupivacaine are effective and reliable for RSSA in Category 1 and 2 CS. Hyperbaric bupivacaine demonstrated more favorable motor block properties, whereas levobupivacaine was linked to improved hemodynamic stability."

Clinical • Journal • Anesthesia • Cardiovascular • Hypotension • Obstetrics