Chirocaine (levobupivacaine) / Purdue, AbbVie - LARVOL DELTA

Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery (clinicaltrials.gov) - P2 | N=60 | Completed | Sponsor: Assiut University | Active, not recruiting ➔ Completed

Trial completion • Breast Cancer • Oncology • Solid Tumor

Comparison of Dexmedetomidine In Ultrasound-Guided Supraclavicular Brachial Plexus Block Versus Intramuscular Administration In Upper Limb Surgeries. (PubMed, AANA J) - "All patients received 2% lidocaine (10 mL) + 0.5% levobupivacaine (10 mL) + normal saline (5 mL). The onset and duration of blockade were comparable between the two groups. Onset and duration of brachial plexus block are comparable whether dexmedetomidine is given perineurally or intramuscularly as an adjunct to local anesthetic."

Clinical • Journal • Anesthesia

Thoracic Intervertebral Foramen Blocks Compared to Midpoint-to-Pleura Transverse Process Blocks for the Management of Acute Rib Fracture Pain. (PubMed, Pain Physician) - "For patients with rib fractures, the CTIFB offered superior pain management, fewer requests for opioids, and better respiratory function than did the CMTPB."

Clinical • Journal • Aesthetic Medicine • Anesthesia • Critical care • Infectious Disease • Musculoskeletal Diseases • Neuralgia • Orthopedics • Pain • Pneumonia • Respiratory Diseases

Clinical study on the application of levobupivacaine liposome injection for upper trunk brachial plexus block in postoperative analgesia after shoulder arthroscopy: A single-center randomized controlled prospective study (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: Zhongnan Hospital of Wuhan University; Zhongnan Hospital of Wuhan University

New trial • Orthopedics

Comparison of Ultrasound-guided Continuous Erector Spine Plane Block and Epidural Block for Postoperative Analgesia in Laparoscopic Nephrectomy: A Prospective Interventional Study. (PubMed, Ann Afr Med) - "ESPB is a suitable and better alternative to epidural block for postoperative analgesia in laparoscopic nephrectomy, in the context of ease administration and unilateral block."

Journal • Anesthesia • Cardiovascular • Infectious Disease • Pain • Respiratory Diseases

A comparative study of clonidine and dexmedetomidine as an adjuvant to levobupivacaine for caudal analgesia in children undergoing below umbilical surgeries: A randomized double-blind controlled trial. (PubMed, Agri) - "Dexmedetomidine (1 µg/kg) added to 0.2% levobupivacaine (1 ml/kg) for caudal block provides prolonged analgesia with better sedation scores when compared to clonidine (1 µg/kg) with 0.2% levobupivacaine (1 ml/kg) for below umbilical surgeries in pediatric patients, without increasing the incidence of adverse effects. Hence, we would recommend the use of 1 µg/kg dexmedetomi-dine as an adjuvant to 0.2% levobupivacaine."

Clinical • Journal • Anesthesia • Pain • Pediatrics

Is there a benefit to adding dexamethasone to levobupivacaine in ultrasound-guided adductor canal block following anterior cruciate ligament reconstruction? (PubMed, Front Med (Lausanne)) - "Three patients in the non-dexamethasone group reported rebound pain (χ 2 = 0.2564; p = 0.61), while blood glucose levels were significantly higher in the dexamethasone group (χ 2 = 4.329; p = 0.037). The addition of dexamethasone to the local anesthetic during ACB after ACL reconstruction is not supported due to the lack of benefits related to postoperative pain levels and the associated increase in glucose levels."

Journal • Anesthesia • Pain

Ultralow concentration levobupivacaine 0.0625% for continuous wound infusion after open abdominal surgery: a prospective observational study. (PubMed, Anaesth Rep) - "Six patients (12%) required intravenous morphine rescue in the first 48 h, with a median dose of 3 mg. Continuous wound infusion with levobupivacaine 0.0625% after open abdominal surgery was feasible and associated with minimal opioid use. These findings provide preliminary evidence supporting the feasibility of an ultralow concentration regimen."

Journal • Observational data • Anesthesia • Pain

Comparison of Analgesic Efficacy of Hyperbaric Levobupivacaine With or Without Clonidine in Patients Undergoing Intramedullary Nailing for Fracture Femur Under Subarachnoid Block: A Randomised Controlled Trial. (PubMed, Cureus) - "No major side effects were observed in either of the groups except one patient (6.7%) in group LC and one patient (6.7%) in group LN developed nausea, and five patients (33.3%) in group LC and three patients (20.0%) in group LN had shivering, which was managed promptly. Conclusion Addition of 15 mcg of clonidine to 3 mL (15 mg) of 0.5% hyperbaric levobupivacaine provides a longer duration of effective analgesia with minimal side effects."

Journal • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain

Comparison of levobupivacaine versus ketamine and levobupivacaine for ultrasound-guided adductor canal block in patients undergoing unilateral total knee replacement: A randomized, double-blinded study. (PubMed, J Anaesthesiol Clin Pharmacol) - "Patients in Group L had significantly higher numerical rating scale compared to Group LK at rest at 4, 6, and 12 h and on movement at 2, 4, 6, and 12 h postoperatively. The addition of ketamine to levobupivacaine in ACB resulted in prolongation of the pain-free interval, decreased requirement for rescue analgesia, and better pain control during rest and movement."

Clinical • Journal • Musculoskeletal Diseases • Orthopedics • Pain

Effect of different doses of intrathecal morphine on postoperative fentanyl consumption in open live donor hepatectomy - A double-blind, randomized controlled trial. (PubMed, J Anaesthesiol Clin Pharmacol) - "Group C exhibited a higher incidence of side effects when compared to groups B and A, respectively (35 vs. 13 vs. 5, P < 0.001). A dose of 200 μg of ITM provides effective postoperative pain control in patients undergoing open live donor hepatectomy and results in fewer opioid-related side effects, compared to 300 and 400 μg doses."

Journal • Anesthesia • Pain • Transplantation

A Randomized Controlled Trial Comparing Intrathecal 0.5% Hyperbaric Levobupivacaine and 0.75% Hyperbaric Ropivacaine for Elective Caesarean Section. (PubMed, Cureus) - "Levobupivacaine provides a denser and more prolonged sensory and motor block suitable for procedures requiring extended anaesthesia and postoperative analgesia. Ropivacaine offers superior haemodynamic stability, quicker motor recovery, and more favourable immediate neonatal outcomes. Both agents are safe and effective for spinal anaesthesia in caesarean section, and the choice should be guided by clinical priorities."

Clinical • Journal • Anesthesia • Hypotension

Comparison of effects of 0.5 % levobupivacaine with buprenorphine and nalbuphine in ultrasound-guided supraclavicular brachial plexus block- A Randomised Control Trial. (PubMed, F1000Res) - "Buprenorphine as an adjuvant to 0.5% levobupivacaine in ultrasound-guided supraclavicular brachial plexus block significantly shortens the onset of sensorimotor blockade and enhances the duration of blockade when compared to nalbuphine. Both the adjuvants delayed the time for request of rescue analgesia compared to plain levobupivacaine."

Clinical • Journal • Anesthesia • Orthopedics

TAP ALIF: Echo-guided Transverse Abdominal Plane Block (TAP) in Anterior Lumbar Arthrodesis (ALIF) (clinicaltrials.gov) - P=N/A | N=80 | Recruiting | Sponsor: Clinique Saint Jean, France | Trial primary completion date: Sep 2025 ➔ Sep 2026

Trial primary completion date

Role of Cytokines in Wound Healing Following Wound Catheter Analgesia in Rats. (PubMed, Vet Sci) - "Meloxicam and buprenorphine increased TGF-β1 expression, but their vascular effects differed considerably. Meloxicam induced a marked increase in angiogenesis, but the newly formed vessels were structurally immature, displaying uniformly narrow lumina and poor architectural organisation, which led to their subsequent regression. In contrast, buprenorphine supported the formation of more mature vascular structures, characterised by wider vessel lumina and a more organised vascular network. These findings demonstrate that adjuvants used with levobupivacaine can significantly modify angiogenic and apoptotic responses and should be carefully considered when selecting multimodal local analgesia strategies after surgery."

Journal • Preclinical • Pain • CASP3 • TGFB1

Comparison of Analgesic Efficacy of Intrathecal Levobupivacaine With and Without Oral Tizanidine in Lower Limb Surgeries: A Prospective Randomized Study (clinicaltrials.gov) - P4 | N=64 | Completed | Sponsor: All India Institute of Medical Sciences, Rishikesh

New P4 trial • Pain

SAH-BLOCK: Efficacy of Scalp Block in Managing Post Subarachnoid Hemorrhage Headache in Critically Ill Patients. A Single Centre Randomized Controlled Trial (clinicaltrials.gov) - P=N/A | N=22 | Recruiting | Sponsor: Hamad Medical Corporation

New trial • Cardiovascular • CNS Disorders • Hematological Disorders • Migraine • Pain • Subarachnoid Hemorrhage

Efficacy and Safety of 5 µg and 10 µg Dexmedetomidine With Hyperbaric Levobupivacaine in Lower-Limb Surgeries Under Spinal Anesthesia: A Randomized Controlled Study. (PubMed, Cureus) - " Both doses enhanced SA characteristics. The 10 µg dose produced faster onset and longer duration of block but with a higher incidence of manageable hemodynamic effects. Selection of dose should balance the need for prolonged anesthesia with safety considerations."

Journal • Anesthesia • Cardiovascular • Hypotension • Orthopedics

Factors associated with severe pain during the active phase of pushing despite labor epidural analgesia: a secondary analysis on a prospective cohort study. (PubMed, Int J Obstet Anesth) - "In this cohort, 9.5% of women experienced severe pain during the active phase of pushing despite labor epidural analgesia (PIEB and PCEA), which was associated with rapid cervical change and fetal macrosomia. These findings suggest potential roles of incomplete sacral analgesia and enhanced somatic nociception, but require confirmation in future studies."

Journal • Pain

Comparison of motor and haemodynamic profiles of epidural 0.5% Levobupivacaine with 0.75% Ropivacaine in patients undergoing elective below umbilical surgery. (PubMed, Med J Malaysia) - "Both levobupivacaine 0.5% and ropivacaine 0.75% effectively provide epidural anaesthesia for surgeries below the umbilicus. Levobupivacaine achieved maximum motor block more quickly than ropivacaine, but overall motor block duration was similar. Haemodynamic parameters were stable with no significant differences between the two groups."

Clinical • Journal • Anesthesia • Cardiovascular

Exploring the Therapeutic Potential of Ferroptosis in Gastric Cancer. (PubMed, Cancer Manag Res) - "It also summarizes other drugs such as 6-Thioguanine, Polymerase theta, levobupivacaine and clinical application drugs, which target ferroptosis, the effect of them in treating GC. This review highlights the potential of ferroptosis induction in GC treatment, providing new avenues for clinical intervention. Finally, this review looks forward to the translational prospects of targeting ferroptosis in the development of GC treatment, offering key insights for future research directions and therapeutic strategies."

Journal • Review • Gastric Cancer • Oncology • Solid Tumor

Phase 1 single-centre, placebo and levobupivacaine controlled study in healthy volunteers to assess the safety, tolerability, efficacy, and pharmacokinetics of LL10, a novel long-acting local anaesthetic. (PubMed, Br J Anaesth) - P1 | "The 1.26%/0.325% LL10 was tolerated in healthy volunteers at doses up to 40 ml (equivalent to 7/1.81 mg kg-1). LL10 produced prolonged local anaesthesia in FNB compared with levobupivacaine 0.325%, but not in s.c. infiltration or transversus abdominus plane block."

Journal • P1 data • PK/PD data • Anesthesia • Cardiovascular • Pain

Investigation of Antibacterial Effect of Levobupivacaine on Staphylococcus Aureus (clinicaltrials.gov) - P=N/A | N=40 | Completed | Sponsor: Dokuz Eylul University

New trial

Clinical Experience With Thoracic Segmental Spinal Anesthesia in High-Risk Surgical Patients. (PubMed, Case Rep Anesthesiol) - "Each patient received isobaric levobupivacaine combined with dexmedetomidine via thoracic or thoracolumbar spinal injection. It provides excellent intraoperative conditions, avoids the systemic effects of GA, and facilitates rapid recovery. With proper technique and patient selection, TSSA offers a valuable alternative to GA in complex surgical cases."

Journal • Anesthesia • Cardiovascular • Pain

Analgesic Efficacy of Combinational Continuous Suprainguinal Fascia Iliaca Block and Pericapsular Nerve Group Block: A Retrospective Observational Study. (PubMed, Anesthesiol Res Pract) - "In 40 patients who underwent elective total hip arthroplasty via anterior approach (April, 2023-April, 2024), suprainguinal fascia iliaca block and PENG block were performed with 25 mL of 0.2% levobupivacaine before induction of general anesthesia...In the remaining 17 patients, rebound pain was observed in 2 (12% [95% confidence interval: 0%-27%]). We conclude that in the patients who underwent total hip arthroplasty via anterior approach, combinational use of continuous suprainguinal fascia iliaca block and PENG block may frequently be insufficient to prevent postoperative acute pain but may be effective in reducing the incidence of rebound pain."

Journal • Observational data • Retrospective data • Anesthesia • Orthopedics • Pain