VRC-HIVDNA016-00-VP / National Institute of Allergy and Infectious Diseases - LARVOL DELTA

Deciphering HIV vaccine induce antibody response according to ethnicity (HIVR4P 2024) - "We also assessed the specific effect of sex assigned at birth, age, geographic location, and crystallizable fragment receptor (FcR) polymorphism frequencies of single nucleotide polymorphisms (SNPs are single nucleotide differences in paired chromosomes). We retrospectively analysed data from the HVTN 204 vaccine trial, a multiclade HIV-1 DNA Plasmid Vaccine, VRC-HIVDNA016-00-VP, followed by a Multiclade Recombinant Adenoviral Vector HIV-1 Vaccine boost, VRCHIVADV014-00-VP conducted in HIV-1 uninfected adult participants from South Africa and the United States... We found that Black South Africans displayed distinct antibody profile compared to White Americans. It is not clear whether these population differences are due to ethnicity or some other geographic factors. The observed impact of genetics, geographic location and ethnic background on HIV-specific Ab immune responses to the HVTN 204 vaccine warrants further investigation of additional vaccine-induced humoral..."

Human Immunodeficiency Virus • Infectious Disease