DFI 205 / DFI Bio - LARVOL DELTA

Bispecific CD20xCD40 Antibodies Achieve Multi-Lineage Modulation of Humoral and Cellular Immunity (ACR Convergence 2026) - "Combined CD20/CD40 targeting enables dual humoral and cellular mechanisms via B cell depletion and modulation of CD40+ myeloid populations and T cell compartments in NHPs, with no overt safety signal. This pan-immune multifactorial immunomodulation may be required for durable immune reset. These findings support the development of CD20xCD40 bispecific antibodies in Systemic Autoimmune Rheumatic Diseases (SARDs)."

Bispecific • First-in-human • IO biomarker • Immune Modulation • Immunology • Inflammation