Undisclosed selective SMARCA2 degrader therapeutics / Foghorn Therap, Eli Lilly - LARVOL DELTA

Lilly Announces Details of Presentations at 2024 American Association for Cancer Research (AACR) Annual Meeting (PRNewswire) - "Eli Lilly and Company...announced that preclinical data for agents targeting Nectin-4, KRAS G12D, and BRM (SMARCA2) will be presented at the American Association for Cancer Research (AACR) Annual Meeting....The presentations will include new preclinical data for a fully human monoclonal anti-Nectin-4 antibody conjugated to a novel topoisomerase I inhibitor and a highly potent and orally administered inhibitor of KRAS G12D that is selective against wild-type KRAS. In addition, preclinical data on a potent and selective BRM (SMARCA2) inhibitor for the treatment of BRG1 (SMARCA4) mutated cancers will be presented in collaboration with Foghorn Therapeutics. Investigational New Drug (INDs) applications are planned for all three programs in 2024."

IND • Preclinical • Solid Tumor