Cervidil (dinoprostone) / Ferring - LARVOL DELTA

Comparison of the sequential use of mifepristone and dinoprostone vaginal insert with dinoprostone vaginal insert as the only method for induction of labor in very unripe cervix: a secondary analysis of a multicenter real-word evidence study. (PubMed, Int J Gynaecol Obstet) - "These findings suggest that the sequential use of mifepristone prior to dinoprostone administration enhances the likelihood of successful labor induction in women with a very low Bishop score. The study highlights the importance of optimizing cervical ripening methods to improve labor outcomes."

Journal • Obstetrics

Drug exposure before and during pregnancy and thromboembolic events: a disproportionality analysis from the FAERS database. (PubMed, Int J Surg) - "Drawing on the FAERS database, we have provided a list of drugs with risk signals for PTEs in this exploratory study. Our findings highlight the importance of considering both before and during-pregnancy drug exposures when assessing thromboembolism risk. More well-designed studies are warranted for drugs whose association with PTEs is not fully understood."

Journal • Cardiovascular

Induction of Labor - Comparison Propess With Prostaglandin E2 Vaginal Gel and Balloon Catheter (clinicaltrials.gov) - P4 | N=140 | Recruiting | Sponsor: HaEmek Medical Center, Israel | Not yet recruiting ➔ Recruiting

Enrollment open

Induction of Labor After Fetal Demise in Third Trimester-A Retrospective Cohort Study. (PubMed, Clin Pract) - "Objectives: The aim of our study was to assess the efficacy and safety of two different labor induction methods in patients after fetal demise beyond 28 weeks, with an unfavorable cervix: misoprostol-prostaglandin E1 analog (PGE1) and dinoprostone-prostaglandin E2 analog (PGE2)... Our findings support the use of a PGE1 regimen for third-trimester labor induction after fetal demise, when no contraindications exist. This approach appears to improve the efficiency of induction and may enhance overall patient care by reducing intervention needs."

Journal • Retrospective data • Pain

A meta-analysis and systematic review of the effect of dinoprostone in full term pregnancy labor induction. (PubMed, Afr J Reprod Health) - "Comparative analysis revealed Dinoprostone's longer medication to-delivery interval but superior safety profile versus Misoprostol, particularly in 5 min Apgar scores. These findings provide robust evidence for clinical decision-making regarding prostaglandin-based labor induction protocols."

Journal • Retrospective data • Review • Gynecology • Obstetrics

Induction of Labor: A Narrative Review for Clinical Use. (PubMed, Cureus) - "Mechanical methods, such as a Foley catheter, and pharmacological agents (e.g., misoprostol and dinoprostone), facilitate cervical ripening...Future research should refine success metrics and optimize combined mechanical-pharmacological strategies to improve efficacy and reduce adverse events, ensuring a balanced risk-benefit profile across diverse clinical contexts. This narrative review synthesizes current evidence on IOL, encompassing definitions, indications, methods, clinical scenarios, complications, and outcomes, emphasizing collaborative decision-making between healthcare providers and pregnant individuals."

Journal • Review • Gynecology • Obstetrics

Oral misoprostol (PGE1) vs vaginal dinoprostone (PGE2) for labor induction: individual participant data meta-analysis of randomized controlled trials. (PubMed, Ultrasound Obstet Gynecol) - "IOL with oral misoprostol or vaginal dinoprostone results in comparable rates of vaginal delivery and composite perinatal and maternal adverse outcomes."

Journal • Retrospective data • Review • Gynecology • Obstetrics

Oral misoprostol versus vaginal dinoprostone for term labor induction among women requiring oxytocin before 4 cm: A secondary analysis of the STOPOXY trial. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "In women requiring early oxytocin during labor induction, oral misoprostol and vaginal dinoprostone showed comparable efficacy, safety, and childbirth experience, allowing the choice to be guided by patient preferences and clinical context."

Journal • Diabetes • Gestational Diabetes • Metabolic Disorders

Comparison of the effectiveness and safety of vaginal and sublingual low-dose misoprostol versus vaginal dinoprostone for labor ınduction: A retrospective cohort study. (PubMed, PLoS One) - "According to the results of the study, low-dose vaginal or sublingual misoprostol was found to be more effective and safer than vaginal dinoprostone pessary in labor induction."

Clinical • Journal • Retrospective data • Critical care • Obstetrics

Bishop Score vs. Transvaginal Ultrasound (TVS) for Predicting Successful Labor Induction by Prostaglandins in a Tertiary Healthcare Center. (PubMed, J Pharm Bioallied Sci) - "The labor was induced with the tablet misoprostol or dinoprostone gel...The TVS cervical score had better sensitivity and specificity than the Bishop score. TVS is an objective method for assessing the cervix before induction and can be used as an adjunct to the Bishop score."

Journal • Obstetrics

Predicting delivery time after dinoprostone induction: insights from clinical experience and population variability. (PubMed, Ir J Med Sci) - No abstract available

Journal

The Effect of Introducing Dinoprostone Vaginal Inserts (DVI) in Cases of Term Prelabor Rupture of Membranes With Unfavorable Cervix. (PubMed, Cureus) - "In PROM with an unfavorable cervix, DVI use did not increase adverse outcomes and was associated with reduced oxytocin use. While differences in delivery timing were not statistically significant, DVI may provide clinical benefits, supporting the need for further prospective studies."

Journal • Hematological Disorders • Postpartum Hemorrhage

COMPARISON OF DINOPROSTONE REGIMENS FOR LABOR INDUCTION AT TERM (FIGO 2025) - "Spacing PG induction at longer intervals may be better option to improve vaginal birth and reduce cesarean rate. Name of public trials registry in which the study has prospective registration: Clinical trial Registry of India. URL of registration: https://ctri.nic.in/Clinicaltrials/rmaindet.php?trialid=86718&EncHid=11644.86593&modid=1&compid=19."

Cardiovascular • Cholestasis • Hepatology • Hypertension • Small for Gestational Age

INDUCTION METHODS IN THIRD-TRIMESTER INTRA UTERINE FETAL DEATHS AT A TERTIARY CENTRE IN INDIA: A CROSS-SECTIONAL STUDY (FIGO 2025) - "Induction methods included Misoprostol (PGE1) only, Dinoprostone gel (PGE2) only, Intracervical Foley's catheter (mechanical) only and a combination of these... Early induction of third trimester IUD is a good option since it is associated with successful deliveries within 24 h, and with less morbidity. Women need to be counseled regarding expectant management versus induction based on high-risk factors and the success of induction. Although there is a need for uniform protocols for induction in such cases, this study can help obstetricians make an informed decision on the method can be chosen for induction in such cases."

Observational data • Long-acting Reversible Contraceptives • Obstetrics

Liquid chromatography-mass spectrometry-based metabolomics study of the protective mechanism of Shenji Guben decoction on chronic obstructive pulmonary disease. (PubMed, J Tradit Chin Med) - "This study evaluated the protective effect of SJGB decoction against COPD and provided insights into its potential mechanisms in COPD treatment."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Prediction Model for Successful Induction of Labor by Fetal Middle Cerebral Artery Pulsatility Index and Obstetric Factors in Term Pregnancy: A Prospective Cohort Study. (PubMed, Obstet Gynecol Int) - "IOL was performed with intracervical prostaglandin E2 gel (3 g gel/0.5 mg dinoprostone) applied 6 h apart if needed, not more than 2 doses, followed by oxytocin infusion for up to 6 h... A model comprising MCA PI, CL, and BS has an excellent prediction value to assess the response to IOL in women at term pregnancy. When a single parameter has to be evaluated, CL is the best maternal factor to predict the success of induction."

Journal • Obstetrics

Drug-associated postpartum hemorrhage: a comprehensive disproportionality analysis based on the FAERS database. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "In terms of the number of cases, the top three drugs that induce PPH were oxytocin (ROR [95% CI]: 1985.51 [1650.23-2388.91]), dinoprostone (ROR [95% CI]: 751.23 [549.82-1026.42]), and misoprostol (ROR [95% CI]: 193.58 [140.47-266.76])...This study identified and ranked drugs associated with PPH and analyzed the occurrence time of ADEs. We emphasized the need for personalized monitoring strategies during the perinatal period and highlighted the long-term risks of PPH caused by the use of chronic disease drugs during pregnancy."

Journal • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

Cervical Ripening Before Induction of Labour at Term: a Randomised Comparison of Prostin vs Propess (clinicaltrials.gov) - P3 | N=0 | Withdrawn | Sponsor: Institut National de la Santé Et de la Recherche Médicale, France | N=446 ➔ 0 | Completed ➔ Withdrawn

Enrollment change • Trial withdrawal

Does a Second Cervical Ripening Procedure Improve Vaginal Delivery Outcomes in Primiparous Women with an Unfavourable Cervix? A before-and-after French study. (PubMed, J Gynecol Obstet Hum Reprod) - "A second cervical ripening procedure for women with persistent low Bishop scores was not significantly associated with reduced caesarean section rates. Further studies are needed to evaluate whether combining cervical ripening methods can enhance vaginal delivery rates."

Journal

Role of the Bishop Score in Predicting Successful Induction of Vaginal Delivery: A Systematic Review of Current Evidence. (PubMed, Cureus) - "Prostaglandins, particularly dinoprostone and misoprostol, show superior effectiveness in women with unfavorable scores (≤3-4), while simpler interventions suffice when scores are ≥6...In the context of vaginal birth after cesarean (VBAC), Bishop score contributes to risk stratification and induction planning, but its predictive value must be contextualized within broader clinical factors. Overall, the Bishop score remains a valuable component of labor management; however, the evolving landscape of obstetric care calls for its integration with modern technologies and evidence-based adjuncts to optimize induction outcomes and ensure patient-centered decision-making."

Journal • Review • Obstetrics • FN1 • IGFBP1

Pain Management for IUD Insertion: A Review of the Clinical Evidence on Pharmacologic and Nonpharmacologic Options. (PubMed, Obstet Gynecol Surv) - "More research is necessary to discern the effectiveness of certain nonsteroidal anti-inflammatory drugs, dinoprostone, transcutaneous electrical nerve stimulation, and acupuncture. Despite common practice to offer ibuprofen prior to IUD insertion, topical and injectable lidocaine formulations are more effective at reducing pain. Further research is necessary to strengthen recommendations, elucidate the efficacy of other adjunctive options, and optimize clinic workflow, but these findings suggest that lidocaine-based analgesics may represent the future of IUD insertion pain management. Providers can utilize this summary to offer individualized, evidence-based pain management options for patients seeking an IUD."

Journal • Review • Cough • Long-acting Reversible Contraceptives • Pain • Respiratory Diseases • Women's Health

Timing of Prostin E2 Administration After Poor Response to Propess: Impact on Induction-to-Birth Interval and Maternal/Neonatal Outcomes. (PubMed, Medicina (Kaunas)) - "A multivariable analysis identified gestational age (β = 3.33; p = 0.015) and Bishop score after 24 h of PGE2 (β = -1.99; p < 0.001) as being independent predictors of labor duration. administering Prostin E2 to patients who had a poor response after Propess use was safe; additionally, adding it at the 8th hour after Propess initiation could result in a shorter induction-to-birth interval."

Journal • Retrospective data

Induction of labor with dinoprostone in hypertensive disorders of pregnancy: comparative analysis with normotensive pregnant women. (PubMed, Colomb Med (Cali)) - "Adverse events, except for tachysystole, were more frequent in the hypertensive group but did not reach statistical significance. Dinoprostone is effective in hypertensive pregnant women, including those receiving magnesium sulfate, with no significant differences compared to normotensive women."

Clinical • Journal • Retrospective data • Cardiovascular • Gynecology • Hypertension • Obstetrics

IV PAPAVERINE Prior to Propess for Labor Induction (clinicaltrials.gov) - P4 | N=110 | Completed | Sponsor: Western Galilee Hospital-Nahariya | Not yet recruiting ➔ Completed | Trial completion date: Aug 2026 ➔ Mar 2025 | Trial primary completion date: Aug 2026 ➔ Mar 2025

Trial completion • Trial completion date • Trial primary completion date • Pain

Machine learning algorithms to predict epidural-related maternal fever: a retrospective study. (PubMed, Front Pharmacol) - "Furthermore, the LR-based nomogram identified eight significant predictors of ERMF, including neutrophil percentage, first stage of labor, amniotic fluid contamination during membrane rupture, artificial rupture of membranes, chorioamnionitis, post-analgesic antimicrobials, pre-analgesic oxytocin, post-analgesic oxytocin, and dinoprostone suppositories. Optimally applying logistic regression models can enable rapid and straightforward identification of ERMF risk and the implementation of rational therapeutic measures, in contrast to machine learning models."

Journal • Retrospective data • Obstetrics • Pain