Cervidil (dinoprostone) / Ferring - LARVOL DELTA

Association of Labor-Related Medications With Molar Hypomineralization: An Experimental Study in Rats. (PubMed, Pediatr Dent) - "The rats were divided into four groups: one rat received 0.143 mg/Kg of dinoprostone, 0.714 mg/Kg of pethidine, and 0.036 mg/Kg of haloperidol; another rat received 0.143 mg/Kg of dinoprostone alone; a third rat was administered 0.714 mg/Kg of pethidine and 0.036 mg/Kg of haloperidol; the last rat served as a control group and received no treatment. Significant differences (P<0.001) were found in magnesium and phosphorus levels in the group administered pethidine and haloperidol, indicating a significant impact on the mineral composition of teeth. The results suggest that medications administered during delivery could influence dental mineralization, potentially contributing to the development of molar hypomineralization."

Journal • Preclinical

Nulliparous Women's Experience in the Immediate Postpartum Period After Cervical Ripening According to the Method: A Prospective Observational Study. (PubMed, J Clin Med) - " A prospective observational study included 340 nulliparous women with a singleton fetus in cephalic presentation and cervical ripening at term (≥37 weeks) for maternal and/or fetal disease using a cervical ripening balloon (CRB, 33.8%), dinoprostone vaginal insert (PG, 32.7%), oral misoprostol (M, 3.8%), or repeated methods (R, 29.7%)...After adjustment, maternal experience and childbirth were similar between methods used alone for cervical ripening. Nulliparous women who required repeated methods for cervical ripening at term had significantly worse experiences of ripening and childbirth in the immediate postpartum period compared to PG, CRB, or M used alone, regardless of the mode of delivery and maternal and neonatal morbidity."

Journal • Observational data • Obstetrics • Pain

Comparative Study of Vaginal Misoprostol Tablet Versus Dinoprostone Insert in Induction of Labor: A Prospective Interventional Analysis. (PubMed, Cureus) - "Dinoprostone, while slower, shows better fetal outcomes and fewer complications, making it a preferable option for high-risk pregnancies. Tailoring the choice of induction agent based on patient-specific factors is essential."

Journal • Critical care • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

Misoprostol Versus Dinoprostone in Induction of Labor (clinicaltrials.gov) - P=N/A | N=200 | Completed | Sponsor: Al-Azhar University

New trial

Fuzheng Xuanfei Huashi prescription suppresses inflammation in lipopolysaccharide-induced lung injury in mice toll-like recptor 4/nuclear transcription factor κB and cyclooxygenase-2/prostaglandin E2 pathway. (PubMed, J Tradit Chin Med) - "These findings were suggested that FZXF prescription suppresses inflammation in LPS-induced pneumonia in mice via TLR4/NF-κB and COX-2/ PGE2 pathway."

IO biomarker • Journal • Preclinical • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases • RELA • TLR4

Inpatient vaginal dinoprostone vs outpatient balloon catheters for cervical ripening in induction of labor: An individual participant data meta-analysis of randomized controlled trials. (PubMed, Acta Obstet Gynecol Scand) - "Balloon catheter used in an outpatient labor induction setting probably leads to fewer vaginal births compared to vaginal dinoprostone in an inpatient setting. In pre-planned subgroup analysis, for pregnant women with underweight/normal weight, both inpatient vaginal dinoprostone and outpatient balloon catheter methods are viable options, but balloon catheter has a lower vaginal birth rate in women with overweight and obesity during pregnancy. The perinatal and maternal safety profiles are comparable."

Journal • Retrospective data • Review • Genetic Disorders • Obesity

Uterine hyperstimulation in cervical ripening with oral misoprostol versus dinoprostone vaginal pessary: A real-life single-center descriptive study. (PubMed, J Gynecol Obstet Hum Reprod) - "In this group of women, uterine tachysystole and uterine tachysystole with fetal heart rate abnormalities occurred less frequently after cervical ripening with oral misoprostol than after ripening with a dinoprostone pessary."

Journal

Increasing cervical penetrability in sheep by long-acting treatments with oxytocin (Carbetocin) and/or prostaglandin E2 (Dinoprostone). (PubMed, Domest Anim Endocrinol) - "The increasing cervical penetrability induced by Cb, but not by Dp, could be explained by an increase in MMP-2-dependent collagen degradation. Furthermore, combined treatment with Cb and Dp did not enhance the effects induced by each hormone administered separately."

Journal • MMP2

Evaluating the impact of red blood cell parameters on outcomes of dinoprostone-induced labor: a retrospective study. (PubMed, Ginekol Pol) - "The study highlights the importance of a nuanced approach to managing anemia in pregnancy, emphasizing the necessity for individualized treatment strategies. Our findings contribute to the ongoing discourse on anemia management during pregnancy, underscoring the need for more targeted research to develop evidence-based guidelines."

Journal • Retrospective data • Hematological Disorders • Obstetrics

Safety and effectiveness of different modes of labor induction among pregnant women delivering at referral hospitals in Dar es Salaam, Tanzania: a cohort study. (PubMed, BMC Pregnancy Childbirth) - "Oxytocin was the most effective and safest method for labor induction within 24 h, resulting in favorable maternal and neonatal outcomes. Healthcare workers should prioritize oxytocin for timely deliveries, while considering alternatives like dinoprostone, misoprostol, and balloon catheter based on individual patient needs and clinical circumstances."

Journal

Induction of Labor - Comparison Propess with Prostaglandin E2 Vaginal Gel and Balloon Catheter (clinicaltrials.gov) - P4 | N=140 | Not yet recruiting | Sponsor: HaEmek Medical Center, Israel

New P4 trial

Comparison of the Effectiveness, Safety, and Satisfaction of Different Methods for Labor Induction (clinicaltrials.gov) - P4 | N=200 | Not yet recruiting | Sponsor: University Medical Centre Ljubljana

New P4 trial

Misoprostol vaginal tablet and Dinoprostone pessary for induction of labor at term ——propensity score matching method(PSM) (ChiCTR) - P=N/A | N=200 | Completed | Sponsor: Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Electronic Science and Technology of China; Chengdu Women’s a

New trial

OFC: Outpatient Induction of Labour Using Intracervical Foley Catheter (clinicaltrials.gov) - P=N/A | N=88 | Terminated | Sponsor: Hospital Kemaman | N=288 ➔ 88 | Not yet recruiting ➔ Terminated; Poor recruitment

Enrollment change • Trial termination

Identification of promising cancer target proteins of major sesquiterpene lactones from Vernonia spp. (PubMed, J Biomol Struct Dyn) - "This suggested that their relative binding-free energy was similar to that of well-established ligands; including PD169316, dinoprostone, and Pu-H54...Vernolide-A, vernolide-B, and vernodalin may potentially inhibit the proliferation, survival, angiogenesis, and migration of cancer cells through their strong affinity for a variety of cancer-related molecules. Additional laboratory experimental designs; including in vitro and in vivo studies, are suggested to further our computational findings."

Journal • Oncology • CDC37 • HSP90AA1

Efficacy and safety of misoprostol compared with dinoprostone for labor induction at term: an updated systematic review and meta-analysis of randomized controlled trials. (PubMed, Front Med (Lausanne)) - "This meta-analysis demonstrates that intravaginal misoprostol is an effective and safe alternative to dinoprostone for labor induction at term. Misoprostol achieved comparable efficacy and safety outcomes while requiring less oxytocin augmentation, supporting its potential as a practical induction agent in clinical settings."

Journal • Retrospective data • Review • Obstetrics

Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis. (PubMed, Health Technol Assess) - "The CHOICE cohort set out to compare outcomes of cervical ripening using dinoprostone (a prostaglandin) at home with in-hospital cervical ripening from 39 weeks of gestation...81. See the NIHR Funding and Awards website for further award information."

HEOR • Journal • Observational data • Infectious Disease • Novel Coronavirus Disease • Obstetrics

Comparing the safety of a single balloon catheter to dinoprostone for inducing labor in pregnant women with group B Streptococcus vaginal colonization: An observational study. (PubMed, Medicine (Baltimore)) - "Additionally, there were no reported cases of neonatal group B Streptococcus infection following balloon induction in pregnant women with vaginal GBS colonization. In relation to maternal and neonatal adverse events, the study findings indicated that labor induction using a BC was deemed safe for women who were colonized with group B Streptococcus, provided that prophylactic antibiotics were administered either at the onset of labor or when the membranes ruptured."

Clinical • Journal • Observational data • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases • Septic Shock

Logistics for achieving delivery: A secondary analysis of the home induction randomised controlled trial. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "Outpatient cervical ripening is an efficient and useful option for dealing with the logistical challenges facing busy Labour Wards, with the majority of nulliparous patients delivering within 48 h, including time spent at home. This resource-friendly option requires less time within the hospital setting for a carefully selected cohort."

Journal

Balancing Cost and Care Dinoprostone Utilization for Cervical Ripening at an Obstetric Hospital (ASHP 2024) - No abstract available

Clinical • Obstetrics

Common molecular basis for MASH and hepatitis C revealed via systems biology approach. (PubMed, Front Oncol) - "Potential drugs screening shows that Budesonide and Dinoprostone may benefit patients, and cellular experiments showed that Budesonide effectively inhibited the expression of genes related to glycolipid metabolism, fibrosis, and inflammatory factors. We extracted 10 hub genes between MASH and hepatitis C, and performed a series of analyses on the genes. Molecular docking and in vitro studies have revealed that Budesonide can effectively suppress the progression of MASH and hepatitis C. This study can provide novel insights into the potential drug targets and biomarkers for MASH and hepatitis C."

Journal • Fibrosis • Gastroenterology • Hepatitis C • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Cancer • Liver Cirrhosis • Liver Failure • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Oncology • Solid Tumor • CCL2 • CXCL9 • IL15 • ITGAM • PTPRC • STAT1 • TLR4 • VCAM1

Role of Mifepristone in Induction of Labor in Full-Term Pregnancy. (PubMed, Cureus) - "In both groups, a post-intervention assessment was done after 24 hours, intracervical dinoprostone gel was administered with a maximum of three doses, six hours apart, if the Bishop score was ≤6. Birth outcomes were consistent in both groups with no neonatal mortality. Conclusion Oral mifepristone has proved as a promising agent as a uterine sensitizer in inducing labor as it has significantly decreased induction to delivery time."

Journal

Pain Management During Intrauterine Device Insertion in Nulliparous Women: A Scoping Review. (PubMed, Cureus) - "Ibuprofen is the current recommended analgesic; however, studies show that there was no significant reduction in pain found when ibuprofen is used. Alternatively, 500 mg of naproxen sodium taken prior to IUD insertion showed a significant reduction in post-IUD insertion pain (p=0.01) but did not show any significant reduction in pain during cervical grasping or during IUD insertion into the uterus...Furthermore, cervical softening and dilation with dinoprostone 3 mg and misoprostol 3 mg demonstrated a reduction in pain during all stages of IUD insertion and after insertion (p<0.01)...Additionally, there has been some research examining the impact of verbal analgesics, which involves the provider using a calm, soothing voice and slow speech to put the patient at ease, and the role that anxiety about IUD insertion can influence pain, but further research is needed to determine its significance. This research provides valuable insight into enhancing the improvement of..."

Journal • Review • Long-acting Reversible Contraceptives • Mood Disorders • Musculoskeletal Pain • Pain • Psychiatry

Comparison of the efficacy and safety of dinoprostone and double-balloon catheters in cervical ripening: a propensity score matching retrospective study. (PubMed, Ginekol Pol) - "Dinoprostone is associated with a lower puerperal infection rate and improved Bishop score in IOL without an increased success rate of vaginal delivery."

Journal • Retrospective data • Hematological Disorders • Infectious Disease • Postpartum Hemorrhage

Comparison of outcomes of labor induction with dinoprostone vaginal insert (PROPESS) and double balloon cook catheter in term nulliparous pregnancies. (PubMed, J Obstet Gynaecol Res) - "The effectiveness of delivery was comparable between the two groups. The PROPESS group resulted in a high successful VD rate within 24 h, although accompanied by NRFHR occurrence. Two cases with fetal presentation change (cephalic to breech) and four cases with umbilical cord prolapse were observed in the DBC group. PROPESS, oxytocin augmentation, and amniotomy were associated with VD interval within 24 h."

Journal