Cervidil (dinoprostone) / Ferring - LARVOL DELTA

A microbiota-host axis mediates prostaglandin sensitivity: Lactobacillus crispatus as a biomarker and regulator of human labor induction. (PubMed, NPJ Biofilms Microbiomes) - "In this prospective cohort of 85 term pregnant women undergoing labor induction with Propess® (prostaglandin E2), we combined full-length 16S rRNA sequencing of the vaginal microbiota, untargeted metabolomics of vaginal secretions, and transcriptomic analysis of cervical stromal cells exposed to Lactobacillus crispatus supernatant to identify predictive factors and underlying mechanisms...Our results identify vaginal L. crispatus as a key biomarker for labor induction sensitivity and elucidate a potential mechanism by which it primes the cervix for prostaglandin response. These findings provide a novel microbiota-host interaction framework for personalizing induction strategies in precision obstetrics."

Biomarker • Journal • Obstetrics

Induction of Labor in Late-Term and Post-Term Pregnancies Using Double-Balloon Catheter for Cervical Ripening: Predictors of Prolonged Labor Across Four Combined Augmentation Protocols in a Retrospective Cohort Study. (PubMed, J Clin Med) - "The protocols comprised DBC alone or in combination with oxytocin, dinoprostone, or misoprostol...DBC combined with misoprostol achieved the shortest delivery interval but carried the highest risk of hyperstimulation, whereas DBC combined with oxytocin offered the most favorable uterine activity profile. Post-ripening cervical reassessment, particularly changes in the Bishop score, enables evidence-based risk stratification and may guide the selection of individualized protocols."

Journal • Retrospective data

Endothelin-1 upregulates cyclooxygenase-2 expression and prostaglandin E2 synthesis in human periodontal ligament cells-an in vitro study. (PubMed, J Orthod Sci) - "ET-1 upregulates COX-2 expression and PGE2 synthesis in hPDL cells through an ERK-independent pathway, while exerting no significant effect on VEGF expression. Further studies are warranted to assess the therapeutic potential of ET-1 in accelerating OTM."

Journal • Preclinical • EDN1 • HPDL • PTGS2

Role of ultrasound parameters in the prediction of failure of induction of labor using Dinoprostone. (PubMed, Tunis Med) - "Ultrasound can be very useful in predicting the failure of labor induction. The threshold values that we found should be tested and validated in future studies to create a model to predict failure of labor."

Journal

Case Report: Successful treatment of pityriasis rubra pilaris with deucravacitinib. (PubMed, Front Immunol) - "Initial treatment with topical dinoprostone and mometasone furoate cream was ineffective. This case suggests that deucravacitinib exhibits favorable efficacy and safety in the treatment of PRP. However, due to the low incidence of PRP, which makes large-scale controlled trials difficult, and the lack of recognized treatment guidelines, more clinical studies are needed in the future to further verify the potential of deucravacitinib in the treatment of PRP."

Journal • Dermatology • Infectious Disease • Inflammation • Pruritus • TYK2

PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM) (clinicaltrials.gov) - P=N/A | N=450 | Recruiting | Sponsor: National Hospital of Obstetrics and Gynecology | Not yet recruiting ➔ Recruiting

Enrollment open

Construction of a nomogram model for predicting vaginal birth after induction of labor in pregnant women with fetal growth restriction at term. (PubMed, Front Med (Lausanne)) - "These pregnancies underwent labor induction with dinoprostone or Cook's double balloon...The nomogram model could be utilized to inform patients with FGR about their success of vaginal delivery during labor induction. Moreover, this model established a foundation for clinical intervention and the development of personalized medical treatment strategies."

Journal

Effects and Pain Levels in Nulliparous Pregnant Women Undergoing Cervical Ripening With the Controlled-Release Dinoprostone Vaginal Delivery System (PROPESS) Compared With Mechanical Methods. (PubMed, Cureus) - "Conclusions The cervical ripening effect of PROPESS was not significantly different from that of mechanical methods in women requiring cervical ripening. PROPESS also had the potential benefit of being pain-free during cervical ripening."

Journal • Pain

Methods of induction of labour: a network meta-analysis. (PubMed, Cochrane Database Syst Rev) - "For women without previous caesarean section and a mix of women with or without previous caesarean section, there was no clear evidence that any of the IoL methods were more effective than vaginal misoprostol (≤ 50 μg) for the outcomes of failure to achieve vaginal delivery within 24 hours, caesarean section due to non-reassuring fetal status, and perinatal death. Nitric oxide donors, osmotic cervical dilators, balloon catheters, and oral misoprostol (≤ 50 μg) probably reduce the risk of uterine hyperstimulation with changes in the heartbeat of the baby before birth."

Clinical • Journal • Retrospective data • Review

PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM) (clinicaltrials.gov) - P=N/A | N=450 | Not yet recruiting | Sponsor: National Hospital of Obstetrics and Gynecology

New trial

Which causes less pain? A comparison of misoprostol and dinoprostone in labor induction. (PubMed, Ceska Gynekol) - "Pain scores should be considered when selecting a cervical ripening agent. Misoprostol may be associated with lower pain levels."

Clinical • Journal • Pain

Repurposing FDA-Approved Drugs as Hendra Virus RNA-Dependent RNA Polymerase Inhibitors: A Comprehensive Computational Drug Discovery Approach. (PubMed, Viruses) - "Based on the highest energy, four FDA-approved drugs selected were menadiol diphosphate (-49.88 kcal/mol), masoprocol (-39.69 kcal/mol), pamidronic acid (-34.29 kcal/mol), and dinoprostone (-46.90 kcal/mol). With strong conformational stability and pharmacokinetic profile, masoprocol and menadiol diphosphate showed the most stable and energetically favorable interactions within the RdRp active site. These findings suggest their potential as repurposed therapeutic candidates against Hendra virus infection and they provide a structural basis for the development of broad-spectrum paramyxovirus inhibitors, justifying additional experimental confirmation."

FDA event • Journal • Infectious Disease

Effect of vaginal pH on the efficacy of the dinoprostone vaginal insert for cervical ripening in patients with an unfavorable bishop score. (PubMed, Rev Bras Ginecol Obstet) - "There was a weak correlation between vaginal pH and changes on the Bishop Score with dinoprostone vaginal insert use (ρ = -0.123; p = 0.3). Vaginal pH does not appear to be a major influencer of the efficacy of dinoprostone vaginal insert for cervical ripening."

Journal • Observational data

Oral Misoprostol for Induction of Labour: An Initial Australian Experience. (PubMed, Aust N Z J Obstet Gynaecol) - "In a setting with an early artificial rupture of membranes (ARM) protocol, oral misoprostol did not provide clear advantages over vaginal PGE2. Further research is needed to optimise induction protocols in the Australian context."

Journal • Obstetrics

Incidence of Uterine Tachysystole with Prostaglandins for Labor Induction: A Comparative Review of Misoprostol and Dinoprostone (ASHP 2025) - No abstract available

Review

Retrospective Analysis of Labor Induction Agents: Impact of Dinoprostone versus Misoprostol on Cesarean Deliveries (ASHP 2025) - No abstract available

Retrospective data

Comparison of the sequential use of mifepristone and dinoprostone vaginal insert with dinoprostone vaginal insert as the only method for induction of labor in very unripe cervix: a secondary analysis of a multicenter real-word evidence study. (PubMed, Int J Gynaecol Obstet) - "These findings suggest that the sequential use of mifepristone prior to dinoprostone administration enhances the likelihood of successful labor induction in women with a very low Bishop score. The study highlights the importance of optimizing cervical ripening methods to improve labor outcomes."

Journal • Obstetrics

Drug exposure before and during pregnancy and thromboembolic events: a disproportionality analysis from the FAERS database. (PubMed, Int J Surg) - "Drawing on the FAERS database, we have provided a list of drugs with risk signals for PTEs in this exploratory study. Our findings highlight the importance of considering both before and during-pregnancy drug exposures when assessing thromboembolism risk. More well-designed studies are warranted for drugs whose association with PTEs is not fully understood."

Journal • Cardiovascular

Induction of Labor - Comparison Propess With Prostaglandin E2 Vaginal Gel and Balloon Catheter (clinicaltrials.gov) - P4 | N=140 | Recruiting | Sponsor: HaEmek Medical Center, Israel | Not yet recruiting ➔ Recruiting

Enrollment open

Induction of Labor After Fetal Demise in Third Trimester-A Retrospective Cohort Study. (PubMed, Clin Pract) - "Objectives: The aim of our study was to assess the efficacy and safety of two different labor induction methods in patients after fetal demise beyond 28 weeks, with an unfavorable cervix: misoprostol-prostaglandin E1 analog (PGE1) and dinoprostone-prostaglandin E2 analog (PGE2)... Our findings support the use of a PGE1 regimen for third-trimester labor induction after fetal demise, when no contraindications exist. This approach appears to improve the efficiency of induction and may enhance overall patient care by reducing intervention needs."

Journal • Retrospective data • Pain

A meta-analysis and systematic review of the effect of dinoprostone in full term pregnancy labor induction. (PubMed, Afr J Reprod Health) - "Comparative analysis revealed Dinoprostone's longer medication to-delivery interval but superior safety profile versus Misoprostol, particularly in 5 min Apgar scores. These findings provide robust evidence for clinical decision-making regarding prostaglandin-based labor induction protocols."

Journal • Retrospective data • Review • Gynecology • Obstetrics

Induction of Labor: A Narrative Review for Clinical Use. (PubMed, Cureus) - "Mechanical methods, such as a Foley catheter, and pharmacological agents (e.g., misoprostol and dinoprostone), facilitate cervical ripening...Future research should refine success metrics and optimize combined mechanical-pharmacological strategies to improve efficacy and reduce adverse events, ensuring a balanced risk-benefit profile across diverse clinical contexts. This narrative review synthesizes current evidence on IOL, encompassing definitions, indications, methods, clinical scenarios, complications, and outcomes, emphasizing collaborative decision-making between healthcare providers and pregnant individuals."

Journal • Review • Gynecology • Obstetrics

Oral misoprostol (PGE1) vs vaginal dinoprostone (PGE2) for labor induction: individual participant data meta-analysis of randomized controlled trials. (PubMed, Ultrasound Obstet Gynecol) - "IOL with oral misoprostol or vaginal dinoprostone results in comparable rates of vaginal delivery and composite perinatal and maternal adverse outcomes."

Journal • Retrospective data • Review • Gynecology • Obstetrics

Oral misoprostol versus vaginal dinoprostone for term labor induction among women requiring oxytocin before 4 cm: A secondary analysis of the STOPOXY trial. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "In women requiring early oxytocin during labor induction, oral misoprostol and vaginal dinoprostone showed comparable efficacy, safety, and childbirth experience, allowing the choice to be guided by patient preferences and clinical context."

Journal • Diabetes • Gestational Diabetes • Metabolic Disorders

Comparison of the effectiveness and safety of vaginal and sublingual low-dose misoprostol versus vaginal dinoprostone for labor ınduction: A retrospective cohort study. (PubMed, PLoS One) - "According to the results of the study, low-dose vaginal or sublingual misoprostol was found to be more effective and safer than vaginal dinoprostone pessary in labor induction."

Clinical • Journal • Retrospective data • Critical care • Obstetrics