Cervidil (dinoprostone) / Ferring - LARVOL DELTA

Prediction Model for Successful Induction of Labor by Fetal Middle Cerebral Artery Pulsatility Index and Obstetric Factors in Term Pregnancy: A Prospective Cohort Study. (PubMed, Obstet Gynecol Int) - "IOL was performed with intracervical prostaglandin E2 gel (3 g gel/0.5 mg dinoprostone) applied 6 h apart if needed, not more than 2 doses, followed by oxytocin infusion for up to 6 h... A model comprising MCA PI, CL, and BS has an excellent prediction value to assess the response to IOL in women at term pregnancy. When a single parameter has to be evaluated, CL is the best maternal factor to predict the success of induction."

Journal • Obstetrics

Drug-associated postpartum hemorrhage: a comprehensive disproportionality analysis based on the FAERS database. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "In terms of the number of cases, the top three drugs that induce PPH were oxytocin (ROR [95% CI]: 1985.51 [1650.23-2388.91]), dinoprostone (ROR [95% CI]: 751.23 [549.82-1026.42]), and misoprostol (ROR [95% CI]: 193.58 [140.47-266.76])...This study identified and ranked drugs associated with PPH and analyzed the occurrence time of ADEs. We emphasized the need for personalized monitoring strategies during the perinatal period and highlighted the long-term risks of PPH caused by the use of chronic disease drugs during pregnancy."

Journal • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

Cervical Ripening Before Induction of Labour at Term: a Randomised Comparison of Prostin vs Propess (clinicaltrials.gov) - P3 | N=0 | Withdrawn | Sponsor: Institut National de la Santé Et de la Recherche Médicale, France | N=446 ➔ 0 | Completed ➔ Withdrawn

Enrollment change • Trial withdrawal

Does a Second Cervical Ripening Procedure Improve Vaginal Delivery Outcomes in Primiparous Women with an Unfavourable Cervix? A before-and-after French study. (PubMed, J Gynecol Obstet Hum Reprod) - "A second cervical ripening procedure for women with persistent low Bishop scores was not significantly associated with reduced caesarean section rates. Further studies are needed to evaluate whether combining cervical ripening methods can enhance vaginal delivery rates."

Journal

Role of the Bishop Score in Predicting Successful Induction of Vaginal Delivery: A Systematic Review of Current Evidence. (PubMed, Cureus) - "Prostaglandins, particularly dinoprostone and misoprostol, show superior effectiveness in women with unfavorable scores (≤3-4), while simpler interventions suffice when scores are ≥6...In the context of vaginal birth after cesarean (VBAC), Bishop score contributes to risk stratification and induction planning, but its predictive value must be contextualized within broader clinical factors. Overall, the Bishop score remains a valuable component of labor management; however, the evolving landscape of obstetric care calls for its integration with modern technologies and evidence-based adjuncts to optimize induction outcomes and ensure patient-centered decision-making."

Journal • Review • Obstetrics • FN1 • IGFBP1

Pain Management for IUD Insertion: A Review of the Clinical Evidence on Pharmacologic and Nonpharmacologic Options. (PubMed, Obstet Gynecol Surv) - "More research is necessary to discern the effectiveness of certain nonsteroidal anti-inflammatory drugs, dinoprostone, transcutaneous electrical nerve stimulation, and acupuncture. Despite common practice to offer ibuprofen prior to IUD insertion, topical and injectable lidocaine formulations are more effective at reducing pain. Further research is necessary to strengthen recommendations, elucidate the efficacy of other adjunctive options, and optimize clinic workflow, but these findings suggest that lidocaine-based analgesics may represent the future of IUD insertion pain management. Providers can utilize this summary to offer individualized, evidence-based pain management options for patients seeking an IUD."

Journal • Review • Cough • Long-acting Reversible Contraceptives • Pain • Respiratory Diseases • Women's Health

Timing of Prostin E2 Administration After Poor Response to Propess: Impact on Induction-to-Birth Interval and Maternal/Neonatal Outcomes. (PubMed, Medicina (Kaunas)) - "A multivariable analysis identified gestational age (β = 3.33; p = 0.015) and Bishop score after 24 h of PGE2 (β = -1.99; p < 0.001) as being independent predictors of labor duration. administering Prostin E2 to patients who had a poor response after Propess use was safe; additionally, adding it at the 8th hour after Propess initiation could result in a shorter induction-to-birth interval."

Journal • Retrospective data

Induction of labor with dinoprostone in hypertensive disorders of pregnancy: comparative analysis with normotensive pregnant women. (PubMed, Colomb Med (Cali)) - "Adverse events, except for tachysystole, were more frequent in the hypertensive group but did not reach statistical significance. Dinoprostone is effective in hypertensive pregnant women, including those receiving magnesium sulfate, with no significant differences compared to normotensive women."

Clinical • Journal • Retrospective data • Cardiovascular • Gynecology • Hypertension • Obstetrics

IV PAPAVERINE Prior to Propess for Labor Induction (clinicaltrials.gov) - P4 | N=110 | Completed | Sponsor: Western Galilee Hospital-Nahariya | Not yet recruiting ➔ Completed | Trial completion date: Aug 2026 ➔ Mar 2025 | Trial primary completion date: Aug 2026 ➔ Mar 2025

Trial completion • Trial completion date • Trial primary completion date • Pain

Machine learning algorithms to predict epidural-related maternal fever: a retrospective study. (PubMed, Front Pharmacol) - "Furthermore, the LR-based nomogram identified eight significant predictors of ERMF, including neutrophil percentage, first stage of labor, amniotic fluid contamination during membrane rupture, artificial rupture of membranes, chorioamnionitis, post-analgesic antimicrobials, pre-analgesic oxytocin, post-analgesic oxytocin, and dinoprostone suppositories. Optimally applying logistic regression models can enable rapid and straightforward identification of ERMF risk and the implementation of rational therapeutic measures, in contrast to machine learning models."

Journal • Retrospective data • Obstetrics • Pain

Safety and Efficacy of Oral Mifepristone for Cervical Ripening in Single Live Intrauterine Term Unscarred Pregnancies. (PubMed, J Pharm Bioallied Sci) - "A reassessment of BS was done after 24 hours and if needed (in BS < 6), 0.5 mg instilled dinoprostone was given intracervical in 1-3 doses at 6-hour intervals. Mean APGAR scores at the 1st and 5th minute were 8 and 9 respectively. Mifepristone is efficacious and safe for inducing labor and cervical ripening in subjects with full-term pregnancy."

Journal

Outpatient or Inpatient Setting for Cervical Ripening Before Induction of Labour: An Individual Participant Data Meta-Analysis. (PubMed, BJOG) - "Overall effectiveness, perinatal and maternal safety are comparable between outpatient setting cervical ripening with a mechanical method and inpatient with any method."

Journal • Retrospective data • Review • Metabolic Disorders

COLIGROW: Cook´s Balloon Versus Dinoprostone for Labor Induction of Term Pregnancies With Fetal Growth Restriction (clinicaltrials.gov) - P3 | N=172 | Completed | Sponsor: Hospital Universitario 12 de Octubre | Recruiting ➔ Completed | Trial completion date: Sep 2025 ➔ May 2025

Trial completion • Trial completion date

Gemeprost Versus Dinoprostone in First Trimester Miscarriages (clinicaltrials.gov) - P2 | N=101 | Completed | Sponsor: National University of Malaysia | Recruiting ➔ Completed | N=174 ➔ 101 | Trial completion date: Nov 2025 ➔ Oct 2024 | Trial primary completion date: Nov 2025 ➔ Oct 2024

Enrollment change • Trial completion • Trial completion date • Trial primary completion date

Are the novel labor induction algorithms associated with increased efficiency and vaginal delivery rates? (PubMed, J Obstet Gynaecol Can) - "Combined methods of labor preinduction are more effective in reducing induction delivery interval and equally safe. Preinduction of labor by prostaglandins in a woman with a previous cesarean section should consider predictors of successful vaginal delivery. It is worth considering preinduction of labor with Foley catheter maintained for a shorter time in both primiparous and multiparous women."

Journal • Review

Rupture of membrane at term. Titled oral misoprostol: a most effective labor induction method compared to vaginal prostaglandin: Titled oral Misoprostol in tPROM induction. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "Titled oral Misoprostol seemed a safe and effective method for labor induction in women with tPROM and a low Bishop score. It significantly reduced the need for oxytocin augmentation, shortened induction-to-delivery time, and maintained similar maternal, delivery and neonatal outcomes compared to vaginal PGE2. Oral Misoprostol should be considered a viable alternative in this population."

Journal

Comparison of perinatal outcomes using oral misoprostol, vaginal misoprostol, and intracervical dinoprostone for induction of labor. (PubMed, Ceska Gynekol) - "The highest success rate of vaginal delivery was achieved with the use of low-dose oral misoprostol. The disadvantage of this method is a significant increase in the time from the start of induction to the delivery of the fetus. There was no difference in the occurrence of severe perinatal complications between the induction methods."

Clinical • Journal

What Has Been Discovered Since 2014 About Pain Mitigation in Outpatient Hysteroscopy Without General Anesthesia? (ACOG 2025) - "Of 2,537 publications, 28 evaluated pain mitigation for outpatient hysteroscopy. The largest categories of interventions were vaginal prostaglandins, oral interventions, and intrauterine anesthetic installations. The most common medication utilized was misoprostol followed by lidocaine, dinoprostone, and tramadol."

Clinical • Anesthesia • Gynecology • Novel Coronavirus Disease • Pain

Ultrasound-guided insertion of controlled-release dinoprostone vaginal delivery system (PROPESS). (PubMed, J Med Ultrason (2001)) - No abstract available

Journal

Use of dinoprostone vaginal insert followed by mechanical dilation for poor cervical maturation shorten the time length for uterotonics administration. (PubMed, Taiwan J Obstet Gynecol) - "Low BMI was a factor that facilitates the effectiveness of DVI. A cervical maturation approach using DVI in combination with a mechanical dilator reduced the time of uterotonics administration among populations with extremely poor cervical maturation."

Journal

Topical Dinoprostone vs. Foley's Catheter: A Systematic Review and Meta-Analysis of Cervical Ripening Approaches. (PubMed, Healthcare (Basel)) - " In comparison with dinoprostone, Foley's catheter is equally effective and well tolerated. We recommend Foley's catheter use for women with a previous caesarian delivery and in low-resource settings."

Journal • Retrospective data • Review • Critical care • Hematological Disorders • Infectious Disease • Obstetrics • Postpartum Hemorrhage

The Impact of Maternal Obesity on the Duration of Labor Stages in Dinoprostone-Induced Vaginal Delivery. (PubMed, J Clin Med) - "However, the duration of the active phase of labor and total induced labor were significantly longer in the obese group. An increased BMI in pregnant women is associated with a longer active phase and overall labor duration during dinoprostone-induced delivery."

Journal • Genetic Disorders • Obesity

Obstetric Use of Prostaglandin Preparations Compared to Mechanical Methods for Cervical Ripening in Pregnancies With Premature Rupture of Membranes at Term. (PubMed, Cureus) - "Background We examined the difference in obstetric outcomes between the cases using dinoprostone and those using mechanical methods in pregnant women requiring cervical ripening following premature rupture of the membranes (PROMs) at term...The clinical intrauterine infection in the cases of the mechanical methods group occurred more than 2 days after the start of cervical ripening; however, there was no case of neonatal infection in the two groups. Conclusions There were differences in the characteristics of the effects between the two methods in pregnant women with PROM who have an unfavorable cervix; however, there were no differences in the final perinatal outcome."

Journal • Infectious Disease • Obstetrics

Association of Labor-Related Medications With Molar Hypomineralization: An Experimental Study in Rats. (PubMed, Pediatr Dent) - "The rats were divided into four groups: one rat received 0.143 mg/Kg of dinoprostone, 0.714 mg/Kg of pethidine, and 0.036 mg/Kg of haloperidol; another rat received 0.143 mg/Kg of dinoprostone alone; a third rat was administered 0.714 mg/Kg of pethidine and 0.036 mg/Kg of haloperidol; the last rat served as a control group and received no treatment. Significant differences (P<0.001) were found in magnesium and phosphorus levels in the group administered pethidine and haloperidol, indicating a significant impact on the mineral composition of teeth. The results suggest that medications administered during delivery could influence dental mineralization, potentially contributing to the development of molar hypomineralization."

Journal • Preclinical

Nulliparous Women's Experience in the Immediate Postpartum Period After Cervical Ripening According to the Method: A Prospective Observational Study. (PubMed, J Clin Med) - " A prospective observational study included 340 nulliparous women with a singleton fetus in cephalic presentation and cervical ripening at term (≥37 weeks) for maternal and/or fetal disease using a cervical ripening balloon (CRB, 33.8%), dinoprostone vaginal insert (PG, 32.7%), oral misoprostol (M, 3.8%), or repeated methods (R, 29.7%)...After adjustment, maternal experience and childbirth were similar between methods used alone for cervical ripening. Nulliparous women who required repeated methods for cervical ripening at term had significantly worse experiences of ripening and childbirth in the immediate postpartum period compared to PG, CRB, or M used alone, regardless of the mode of delivery and maternal and neonatal morbidity."

Journal • Observational data • Obstetrics • Pain