Cervidil (dinoprostone) / Ferring - LARVOL DELTA

Self-reported maternal health three months after cervical ripening according to the method: A prospective cohort study among nulliparous women. (PubMed, J Gynecol Obstet Hum Reprod) - "No statistically significant association was observed between cervical ripening method and self-reported health status at 3 months postpartum. These findings should be interpreted cautiously given the limited sample size and observational design."

Journal

Trends of induction of labor with success rates: Experience of a tertiary care center. (PubMed, Int J Gynaecol Obstet) - "PGE2 was effective for induction of labor in this cohort. The vaginal tablet was associated with a higher observed vaginal delivery rate than the pessary; however, this finding should be interpreted cautiously because formulation selection was not randomized and was based on availability. Individualized assessment, method selection, and fetal monitoring remain important. Women with relevant medical comorbidities should be counseled regarding their increased risk of cesarean delivery. Further prospective multicenter studies comparing efficacy, maternal safety, and neonatal outcomes are warranted."

Journal • Diabetes • Gynecology • Metabolic Disorders • Obstetrics • Type 1 Diabetes Mellitus • Women's Health

Does giving patients a choice of cervical ripening method improve women satisfaction? (PubMed, Gynecol Obstet Fertil Senol) - "Offering women a choice of cervical ripening method is not associated with a significant improvement in overall satisfaction. This choice nevertheless appears to strengthen their willingness to recommend the method to a friend or relative."

Journal • Gynecology • Obstetrics

Development and validation of a predictive nomogram for cesarean delivery in term singleton pregnancies complicated by small for gestational age undergoing labor induction. (PubMed, Sci Rep) - "Four factors were independently associated with the outcome: maternal age (aOR 1.08, 95% CI 1.01-1.15), admission weight (aOR 1.04, 95% CI 1.01-1.07), induction with dinoprostone versus a Cook double balloon (aOR 2.08, 95% CI 1.13-3.81), and Bishop score after cervical ripening (aOR 0.65, 95% CI 0.54-0.80)...Among term singleton pregnancies with SGA already undergoing induction of labor, the proposed nomogram may support post-ripening dynamic risk assessment for cesarean delivery and serve as an adjunct to clinical judgment for counseling, intrapartum surveillance, and perinatal preparedness. External validation in independent multicenter cohorts is warranted."

Journal • Retrospective data • Small for Gestational Age

Letter to: "Oral Misoprostol Versus Vaginal Dinoprostone for Labor Induction: A Systematic Review and Meta-Analysis". (PubMed, J Obstet Gynaecol Res) - No abstract available

Journal • Retrospective data

Vaginal Misoprostol Compared to Vaginal Dinoprostone for Induction of Labour: A Systematic Review and Meta-Analysis. (PubMed, BJOG) - "Vaginal misoprostol is more effective for achieving vaginal birth in 24 h, reducing time to birth and oxytocin use when compared to vaginal dinoprostone. It does not seem to increase caesarean birth and has a similar side-effect profile. At lower doses (25-μg), it is likely to be similarly effective with a lower incidence of uterine hyperstimulation. This information can be used to support discussions around choice of induction agent."

Journal • Retrospective data • Review

Comparing the Safety Profiles of Vaginally Administered Misoprostol and Dinoprostone: A Retrospective Pharmacovigilance Study. (PubMed, J Vis Exp) - "However, because FAERS is a spontaneous reporting system subject to underreporting, reporting bias, and the inability to establish causality, the results should be interpreted with caution. Further prospective studies are warranted to validate these safety observations."

Adverse events • Clinical • Journal • Retrospective data • Pain • Postpartum Hemorrhage

Safety of prostaglandins in the peripartum period in case of sickle-cell disease: A multicenter cohort study. (PubMed, Pregnancy (Hoboken)) - "Secondary outcomes were vaso-occlusive crises requiring intravenous morphine and/or intensive care admission...In 106/411 (25.8%), they were used to induce labor, with Prostaglandin E2 (dinoprostone gel or pessary) for 95 patients and misoprostol for 11 patients...Among patients with postpartum hemorrhage, rates were respectively 2/11 (18.2%) versus 9/49 (18.4%; p = 0.99). The use of prostaglandins in patients with sickle-cell disease for labor induction or for postpartum hemorrhage appeared safe, within the limitations of a retrospective study."

Journal • Beta-Thalassemia • Cardiovascular • Critical care • Genetic Disorders • Hematological Disorders • Obstetrics • Postpartum Hemorrhage • Sickle Cell Disease • Venous Thromboembolism

Comparison of Efficacy and Safety Between Vaginal Misoprostol Tablets and Dinoprostone Insert for Labor Induction in a Pilot Study. (PubMed, J Vis Exp) - "No significant differences were seen in postpartum hemorrhage or neonatal outcomes. Misoprostol 25 µg vaginal tablets achieved comparable 24 h vaginal delivery rates to dinoprostone, with reduced tocolytic use in this pilot cohort."

Clinical • Journal • Hematological Disorders • Postpartum Hemorrhage

Safety and Efficacy of Sequential Labor Induction Methods After Failed Primary Induction of Labor: A Retrospective Cohort Study. (PubMed, Cureus) - "Sequential induction following failed primary IOL was associated with acceptable maternal and neonatal outcomes in the study cohort, and the strategies involving dinoprostone formulations may be associated with a reduced likelihood of cesarean delivery in selected patients. Prospective studies with standardized protocols and multivariable adjustment are required to determine the optimal sequencing strategy."

Journal • Retrospective data • Critical care • Obstetrics

Oral Misoprostol Versus Vaginal Dinoprostone for Labor Induction: A Systematic Review and Meta-Analysis. (PubMed, J Obstet Gynaecol Res) - "Oral misoprostol is associated with reduced cesarean birth and probably reduces the need for oxytocin augmentation, while vaginal dinoprostone is associated with higher rates of vaginal birth within 24 h and probably a shorter induction-to-birth interval. Maternal and neonatal safety outcomes appear comparable; these findings support consideration of oral misoprostol in selected populations and settings, while acknowledging underlying clinical and methodological heterogeneity."

Clinical • Journal • Retrospective data • Review • Critical care

Maternal satisfaction with induction of labour by dinoprostone vaginal insert or cervical ripening balloon associated with oral misoprostol: an observational study. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "Other subjective outcomes were similar, except for a greater discomfort experienced at CRB insertion, with scores 2.3 ± 1.3 vs 1.6 ± 1.3 reported at the corresponding item of the survey (p 0.008), and for its permanence in situ, scoring 2.7 ± 1.1 vs 1.7 ± 1.2 in the two groups (p 0.001). After adjustement for obstetric factors, mode of delivery resulted independently associated with maternal satisfaction (p < 0.001) IoL with dinoprostone vaginal insert or CRB with oral misoprostol resulted in a similar subjective satisfaction among women needing cervical ripening."

Journal • Observational data • Obstetrics

Pharmacologic cervical ripening strategies and time-related outcomes: a community hospital cohort study. (PubMed, AJOG Glob Rep) - "In this community hospital cohort, misoprostol was associated with shorter induction durations than dinoprostone, with efficiency gains primarily driven by outcomes in multiparous patients. These findings suggest that pharmacologic agent selection for cervical ripening can meaningfully influence obstetric workflow."

Journal • Cervical Cancer • Critical care • Obstetrics

A Randomized Controlled Trial to Compare Vaginal Dinoprostone Pessary with Intracervical Dinoprostone Gel for Pre-induction Cervical Ripening. (PubMed, J Obstet Gynaecol India) - "Dinoprostone vaginal pessary is faster and better tolerated than cervical gel for cervical ripening at term. The IDI, mode of delivery, and maternal and neonatal outcomes were similar in pessary versus gel groups."

Journal

Oral Misoprostol +/- Double-Balloon Catheter Versus Vaginal Insertion of Dinoprostone for Induction of Labour at Full-Term. (PubMed, Geburtshilfe Frauenheilkd) - "Despite a longer induction duration, the length of inpatient stay remains unchanged. In first-time mothers without rupture of membranes, it results in fewer caesarean sections compared with dinoprostone vaginal insert."

Journal

Comparison between Vaginal Dinoprostone and Double-Balloon Catheter for Labor Induction in Low-Risk Pregnancies. (PubMed, Clin Ter) - "Both vaginal dinoprostone and the double-balloon catheter were effective and relatively safe methods for labor induction in low-risk pregnancies. No statistically significant differences were detected between vaginal dinoprostone and the double-balloon catheter."

Clinical • Journal • Observational data • Gynecology • Infectious Disease • Obstetrics

Comparison of Different Methods of Labor Induction and Their Maternal and Neonatal Outcomes: A Systematic Review and Meta-Analysis. (PubMed, Cureus) - "A lower occurrence of uterine tachysystole was also identified in specific comparisons. These findings support individualized selection of induction methods based on clinical context and patient characteristics, with emphasis on balancing effectiveness and safety."

Journal • Retrospective data • Review • Obstetrics

Predictive Value of Abdominal Subcutaneous Fat Thickness for Dinoprostone-Induced Labor Success in Obese Pregnant Women: A Prospective Observational Study. (PubMed, J Clin Med) - "Compared with generalized metrics such as BMI, ultrasonographic measurement of ASFT provides a more precise and clinically relevant assessment of regional maternal adiposity. These findings suggest that incorporating pre-induction ASFT evaluation into routine obstetric practice could improve risk stratification and help clinicians design individualized, precision-based dosing strategies for obese parturients."

Journal • Observational data • Genetic Disorders • Obesity • Obstetrics

MISODINO: Efficacy and Safety of Oral Misoprostol 25 μg vs. Vaginal Dinoprostone in Induction of Labor at Term (clinicaltrials.gov) - P=N/A | N=706 | Completed | Sponsor: Centre Hospitalier Universitaire, Amiens | Recruiting ➔ Completed

Trial completion

Delivery Outcomes in the First 3 Years Following the Clinical Introduction of the Dinoprostone Vaginal Insert in Japan. (PubMed, J Obstet Gynaecol Res) - "This first multicenter real-world evaluation demonstrates that the insert is effective and generally safe for cervical ripening and labor induction in Japan."

Journal • Gynecology • Obstetrics

The Functional Study of Prostaglandin E2 via EP Receptor on Pacemaker Activity in Interstitial Cells of Cajal from Murine Colon. (PubMed, Chonnam Med J) - "Low concentrations of PGE2 activated EP3 receptors, leading to excitation of pacemaker activity through regulation of ANO1 and T-type Ca2+ channels in colonic ICC. In contrast, higher concentrations of PGE2 activated EP4 receptors and opened ATP-sensitive K+ channels, resulting in inhibition of pacemaker activity in colonic ICC."

Journal • Preclinical • ANO1

Misoprostol for labor induction: an alternative to dinoprostone? A retrospective observational study. (PubMed, BMC Pregnancy Childbirth) - "The standardized oral misoprostol protocol proved safe and effective for labor induction in patients with an unfavorable cervix. Compared with vaginal dinoprostone, misoprostol showed similar neonatal outcomes and maternal advantages, including higher vaginal delivery rates and reduced postpartum hemorrhage, supporting its use in routine obstetric practice."

Journal • Observational data • Retrospective data • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

Double-Balloon Catheter Alone or Combined with Oxytocin, Dinoprostone, or Misoprostol for Labor Induction in Late- and Post-Term Pregnancies: A Retrospective Cohort Study. (PubMed, Int J Womens Health) - "DBC plus oxytocin offered the most balanced effectiveness-safety profile, whereas DBC plus dinoprostone was associated with slower labor progression and less favorable operative outcomes. Protocol selection should be individualized according to maternal risk, urgency of delivery, and available intrapartum monitoring capacity."

Journal • Retrospective data

PeRinatal Outcomes with ACTive versus expectant management of women with Pre-labor Rupture Of Membranes: a phase III, open-label, randomized controlled multicentric trial (clinicaltrialsregister.eu) - P2/3 | N=1400 | Recruiting | Sponsor: Azienda Ospedaliero Universitaria Di Modena | Not yet recruiting ➔ Recruiting

Enrollment open

An Isolated Rectal Buttonhole Tear During Vaginal Delivery: A Rare Case Report. (PubMed, Int J Womens Health) - "This case highlights the importance of maintaining a high index of suspicion for rectal buttonhole tears. Routine combined vaginal and rectal examination prior to suturing is essential to ensure accurate diagnosis and to prevent missed injuries and subsequent morbidity."

Journal • Obstetrics