aminophylline / Generic mfg. - LARVOL DELTA

THE EFFECT OF INTRAVENOUS AMINOPHYLLINE ON PREVENTING ACUTE KIDNEY INJURY IN SICK NEONATES – A MULTICENTRIC DOUBLE BLINDED, RANDOMISED, PLACEBO-CONTROLLED CLINICAL TRIAL (ISN-WCN 2026) - "These findings suggest potential renoprotective benefit beyond asphyxiated neonates and support further evaluation of aminophylline as an adjunct for AKI prevention across diverse neonatal critical care populations. Larger adequately powered studies are warranted to confirm its protective role and define the subgroups most likely to benefit."

Clinical • Acute Kidney Injury • Cardiovascular • Infectious Disease • Nephrology • Pulmonary Arterial Hypertension • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock • LCN2

Cardioprotective effects of the ranolazine in myocardial infarction mediated by stimulation of the endogenous mediators involved in ischemic preconditioning. (PubMed, Acta Cir Bras) - "ranolazine can be a pharmacological alternative to surgical ischemic preconditioning utilized prior to interventional procedures like coronary artery bypass graft surgery and heart transplantation, offering improved patient compliance."

Journal • Cardiovascular • Myocardial Infarction • Reperfusion Injury • Transplantation • MB

Safety, Efficacy, and Outcomes of the Modified Rotational Atherectomy Approach: A Real-World Single-Center Experience. (PubMed, Indian Heart J) - "The use of TPM can be avoided during RA, and slow/no reflow incidence can be reduced with pretreatment aminophylline and adrenaline. Small burr sizes with a slow rotation speed and short runs are key for safe and effective calcium ablation with this debulking modality."

Journal • Real-world evidence • Acute Coronary Syndrome • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders

Aminophylline Prophylaxis in Infants Treated with Therapeutic Hypothermia to Reduce Acute Kidney Injury: A Pilot Randomized Clinical Trial (PAS 2026) - No abstract available

Clinical • Acute Kidney Injury • Nephrology • Renal Disease

TRENDS OF MYOCARDIAL PERFUSION RESERVE IN AN ADOLESCENT POST-HEART TRANSPLANT POPULATION (ACC 2026) - "Standard regadenoson stress protocol was followed for hyperemic response followed by aminophylline reversal. MPR is associated with LV mass and trends lower in adolescent HT patients than reported adult cut offs despite absence of high-grade CAV. Limited stress CMR-derived MPR data exists in adolescent HT population. Future studies are warranted to establish normal pediatric MPR values and delineate the relationship between MPR and LV mass post HT."

Clinical • Cardiovascular • Transplantation

Current Treatments for Pediatric Critical Asthma: An Interim Analysis From the CATCHUP Study (SCCM 2026) - "During hospital admission, 134 (33.7%) received ipratropium, 136 (34.2%) received intermittent IV magnesium, 52 (13.1%) received continuous IV magnesium, 45 (11.3%) received IV terbutaline, and 28 (7.0%) received IV aminophylline. Pharmacologic treatments and respiratory support management varies between patients, with ipratropium and magnesium being the most common adjunctive medications and HFNC and NIV both being common support devices used."

Clinical • Acute Lung Injury • Asthma • Immunology • Infectious Disease • Pediatrics • Respiratory Diseases • Septic Shock

Solubility-Permeability-Matrix Interplay in Percutaneous Absorption Exemplified by Theophylline. (PubMed, AAPS PharmSciTech) - "The stratum corneum represents the main barrier to transdermal drug delivery, particularly for hydrophilic and ionized compounds such as aminophylline...These findings highlight the critical role of drug solubility and enhancer molecular properties in the transdermal delivery of hydrophilic drugs. In addition, matrix parameters like thickness, hydration and release properties need to be properly engineered for making optimal use of the involved solubility-permeability interplay."

Journal

COST-EFFECTIVENESS AND BUDGET IMPACT OF CAFFEINE CITRATE VERSUS AMINOPHYLLINE FOR APNEA OF PREMATURITY ACROSS A PUBLIC HEALTHCARE SYSTEM IN MEXICO (ISPOR 2026) - "This study evaluates the cost-effectiveness and budget impact of Peyona® (caffeine citrate; CC) compared with aminophylline for the treatment of apnea of prematurity from the perspective of the ISSSTE in Mexico. A cost-effectiveness analysis combined with a budget impact analysis was conducted from the institutional perspective of ISSSTE. CC represents a cost-effective and cost-saving alternative to aminophylline for the management of apnea of prematurity within ISSSTE, supporting efficient resource allocation and long-term economic sustainability of neonatal care programs."

Cost effectiveness • HEOR • Prematurity

Comparative efficacy of doxophylline-ambroxol combination versus aminophylline in the management of acute exacerbations of COPD: A retrospective case-control study. (PubMed, Pak J Pharm Sci) - "Doxophylline-ambroxol combination therapy is more effective than aminophylline in improving pulmonary function and reducing inflammation in AECOPD, with equivalent safety."

Clinical • Journal • Retrospective data • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases

Methylxanthine Treatment in Neonates Admitted to the Special Care Unit: An Observational Study in Low-Resource Settings. (PubMed, Children (Basel)) - "Overall, the treatment was appropriately given to most eligible neonates, although a considerable subgroup of very preterm infants did not receive aminophylline prophylaxis. Further studies may investigate the reasons for protocol incompliance regarding aminophylline treatment and healthcare staff's opinions on such an aspect."

Journal • Observational data

Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures (clinicaltrials.gov) - P=N/A | N=106 | Recruiting | Sponsor: Cairo University | Not yet recruiting ➔ Recruiting

Enrollment open

Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures (clinicaltrials.gov) - P=N/A | N=106 | Not yet recruiting | Sponsor: Cairo University

New trial

Determination of Non-Cytotoxic Antiviral Concentrations of Phosphoric Acid Derivatives and Nucleotide Base Analogues In Vitro. (PubMed, Bull Exp Biol Med) - "Overall, purine and indole analogues were less toxic for cultured mammalian cells than the test phosphoric acid derivatives. Purine analogue aminophylline had the lowest cytotoxicity, but exhibited maximum antiviral activity."

Journal • Preclinical

Anaphylaxis and Cardiac Arrest Induced by Initial Intravenous Ceftriaxone: A Case Report. (PubMed, Am J Case Rep) - "She had been taking cefuroxime and aminophylline, with no known antibiotic allergies. No complications were noted at 1-month follow-up. CONCLUSIONS An initial intravenous dose of ceftriaxone may trigger rare but serious anaphylactic reactions, even in patients without a history of drug allergy, underscoring the need for vigilant monitoring during administration."

Journal • Allergy • Cardiovascular • Cough • Critical care • Dermatology • Immunology • Infectious Disease • Pneumonia • Respiratory Diseases • Urticaria

Pharmacological treatment for apnoea of prematurity-the need for an individualised approach. (PubMed, Front Pediatr) - "Caffeine (or in some developing countries, aminophylline or theophylline) is usually given as first-line treatment, whereas doxapram is sometimes used as an adjunct therapy. We propose potential pharmacodynamic biomarkers and explore avenues for future research which will enable the testing and translation of these biomarkers for use in the neonatal unit. A personalised approach for apnoea treatment is essential to mitigate the negative short and long-term effects of both apnoea and its treatment in premature infants, ensuring that treatment can be provided at the right time and with the correct dose."

Journal • Review

Prophylactic efficacy and safety of intravenous aminophylline compared to intravenous normal saline for post-dural puncture headache in cesarean section patients: A systematic review and metaanalysis (EHF-EHC 2025) - "IV aminophylline use was associated with reduced PDPH incidence at 48 hours and shortened PDPH duration in cesarean patients, suggesting a lowcost prophylactic option. No consistent effect was seen on severity or intensity, and AE data remain inconclusive. These findings are hoped to inform PDPH protocols regarding low-cost alternatives to techniques such as epidural blood patches."

Retrospective data • Review • Pain

Characterization of Aminophylline Use for Methotrexate Toxicity in Pediatric Oncology Patients (ASHP 2025) - No abstract available

Clinical • Pediatrics

A Retrospective Study Exploring Aminophylline Therapy and Renal Outcomes in Critically Ill Pediatric Patients (ASHP 2025) - No abstract available

Retrospective data • Pediatrics

Characterization of Aminophylline Use for Methotrexate Toxicity in Pediatric Oncology Patients (ASHP 2025) - "Hosted by the Section of Clinical Specialists and Scientists"

Clinical • Pediatrics

Comparative Effects of Aminophylline, Caffeine, and Doxapram in Hypoxic Neonatal Dogs Born by Cesarean Section. (PubMed, Animals (Basel)) - "Aminophylline, caffeine, and doxapram supported postnatal resuscitation in hypoxic neonatal puppies; however, caffeine demonstrated superior improvement in Apgar recovery, suggesting its potential as a preferred pharmacological adjunct in neonatal canine resuscitation protocols."

Journal • Anesthesia • CNS Disorders • Depression • Obstetrics • Psychiatry • TNNI3

Methylxanthines: The Major Impact of Caffeine in Clinical Practice in Patients Diagnosed with Apnea of Prematurity. (PubMed, J Clin Med) - "Methylxanthines, including caffeine, theophylline, and aminophylline, have emerged as the primary pharmacological intervention for this condition...No external funding was received for this review. No registration record exists for this systematic review."

Journal • Review • Bronchopulmonary Dysplasia • Critical care • Pulmonary Disease • Respiratory Diseases

S100A12 as a key biomarker in a neutrophil-associated gene prediction model for sepsis diagnosis. (PubMed, Medicine (Baltimore)) - "SHAP analysis highlighted S100A12 as the most influential driver gene and identified theophylline, aspirin, and aminophylline as potential targeting compounds. In conclusion, sepsis patients show increased peripheral neutrophils, an RF model based on 4 neutrophil-associated genes demonstrates strong diagnostic ability, and S100A12 serves as a key biomarker for sepsis."

Biomarker • Journal • Critical care • Infectious Disease • Septic Shock • HLA-DMB • RETN • S100A12

Early aminophylline is a potential therapy for preventing bronchopulmonary dysplasia in premature infants: a retrospective study. (PubMed, BMC Pediatr) - "In conclusion, early use of aminophylline may be associated with a decreased incidence of BPD in premature infants without significant adverse reactions."

Journal • Retrospective data • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases

ACUTE/SUBACUTE METHOTREXATE NEUROTOXICITY IN CHILDHOOD ALL: 13-YEAR EXPERIENCE AT A PEDIATRIC ONCOLOGY REFERENCE CENTER (SIOP 2025) - "Background and Aims: Methotrexate (MTX) is a folate antagonist widely used in the treatment of pediatric Acute Lymphoblastic Leukemia (ALL), playing a crucial role in the prophylaxis and treatment particularly the central nervous system (CNS). MTX-induced NT is a serious complication in the treatment of pediatric ALL. Cranial MRI, particularly FLAIR and diffusion-weighted sequences, is essential for early diagnosis and differentiation from other neurological conditions. Prophylactic treatment with aminophylline has shown efficacy in preventing and reducing acute neurotoxicity symptoms, allowing uninterrupted MTX treatment."

Clinical • Acute Lymphocytic Leukemia • CNS Disorders • Epilepsy • Hematological Malignancies • Infectious Disease • Leukemia • Pediatrics

ADHERENCE TO REVEFENACIN ASSOCIATED WITH REDUCTIONS IN EXACERBATIONS AND HEALTH CARE COSTS FOLLOWING A COPD-RELATED HOSPITALIZATION (CHEST 2025) - "Moderate exacerbations were defined as an outpatient COPD visit accompanied by a filled prescription for a course of theophylline, aminophylline, or an oral corticosteroid or oral antibiotic within 7 days of the outpatient visit. Patients with COPD who were hospitalized, prescribed nebulized revefenacin post-discharge, and adhered to their medication demonstrated statistically significant reductions in both exacerbations and healthcare costs compared to patients who did not adhere to prescribed revefenacin. CLINICAL IMPLICATIONS: Results demonstrate that revefenacin can be effective in reducing COPD exacerbations and the associated costs, though adherence to medication remains critical."

Adherence • Clinical • HEOR • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases • Squamous Cell Carcinoma