aminophylline / Generic mfg. - LARVOL DELTA

Comparative Effects of Aminophylline, Caffeine, and Doxapram in Hypoxic Neonatal Dogs Born by Cesarean Section. (PubMed, Animals (Basel)) - "Aminophylline, caffeine, and doxapram supported postnatal resuscitation in hypoxic neonatal puppies; however, caffeine demonstrated superior improvement in Apgar recovery, suggesting its potential as a preferred pharmacological adjunct in neonatal canine resuscitation protocols."

Journal • Anesthesia • CNS Disorders • Depression • Obstetrics • Psychiatry • TNNI3

Methylxanthines: The Major Impact of Caffeine in Clinical Practice in Patients Diagnosed with Apnea of Prematurity. (PubMed, J Clin Med) - "Methylxanthines, including caffeine, theophylline, and aminophylline, have emerged as the primary pharmacological intervention for this condition...No external funding was received for this review. No registration record exists for this systematic review."

Journal • Review • Bronchopulmonary Dysplasia • Critical care • Pulmonary Disease • Respiratory Diseases

Prophylactic efficacy and safety of intravenous aminophylline compared to intravenous normal saline for post-dural puncture headache in cesarean section patients: A systematic review and meta-analysis (EHF-EHC 2025) - "These findings are hoped to inform PDPH protocols regarding low-cost alternatives to techniques such as epidural blood patches. Further high-quality, adequately powered trials with standardized outcome definitions and AE monitoring are needed, however, for more definitive conclusions."

Retrospective data • Review • Pain

S100A12 as a key biomarker in a neutrophil-associated gene prediction model for sepsis diagnosis. (PubMed, Medicine (Baltimore)) - "SHAP analysis highlighted S100A12 as the most influential driver gene and identified theophylline, aspirin, and aminophylline as potential targeting compounds. In conclusion, sepsis patients show increased peripheral neutrophils, an RF model based on 4 neutrophil-associated genes demonstrates strong diagnostic ability, and S100A12 serves as a key biomarker for sepsis."

Biomarker • Journal • Critical care • Infectious Disease • Septic Shock • HLA-DMB • RETN • S100A12

Early aminophylline is a potential therapy for preventing bronchopulmonary dysplasia in premature infants: a retrospective study. (PubMed, BMC Pediatr) - "In conclusion, early use of aminophylline may be associated with a decreased incidence of BPD in premature infants without significant adverse reactions."

Journal • Retrospective data • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases

ACUTE/SUBACUTE METHOTREXATE NEUROTOXICITY IN CHILDHOOD ALL: 13-YEAR EXPERIENCE AT A PEDIATRIC ONCOLOGY REFERENCE CENTER (SIOP 2025) - "Background and Aims: Methotrexate (MTX) is a folate antagonist widely used in the treatment of pediatric Acute Lymphoblastic Leukemia (ALL), playing a crucial role in the prophylaxis and treatment particularly the central nervous system (CNS). MTX-induced NT is a serious complication in the treatment of pediatric ALL. Cranial MRI, particularly FLAIR and diffusion-weighted sequences, is essential for early diagnosis and differentiation from other neurological conditions. Prophylactic treatment with aminophylline has shown efficacy in preventing and reducing acute neurotoxicity symptoms, allowing uninterrupted MTX treatment."

Clinical • Acute Lymphocytic Leukemia • CNS Disorders • Epilepsy • Hematological Malignancies • Infectious Disease • Leukemia • Pediatrics

ADHERENCE TO REVEFENACIN ASSOCIATED WITH REDUCTIONS IN EXACERBATIONS AND HEALTH CARE COSTS FOLLOWING A COPD-RELATED HOSPITALIZATION (CHEST 2025) - "Moderate exacerbations were defined as an outpatient COPD visit accompanied by a filled prescription for a course of theophylline, aminophylline, or an oral corticosteroid or oral antibiotic within 7 days of the outpatient visit. Patients with COPD who were hospitalized, prescribed nebulized revefenacin post-discharge, and adhered to their medication demonstrated statistically significant reductions in both exacerbations and healthcare costs compared to patients who did not adhere to prescribed revefenacin. CLINICAL IMPLICATIONS: Results demonstrate that revefenacin can be effective in reducing COPD exacerbations and the associated costs, though adherence to medication remains critical."

Adherence • Clinical • HEOR • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases • Squamous Cell Carcinoma

REAL-WORLD EFFECTIVENESS OF BUDESONIDE/GLYCOPYRROLATE/FORMOTEROL FUMARATE ON COPD EXACERBATIONS AMONG US MEDICARE PATIENTS: RESULTS FROM THE US ARCTOS STUDY (CHEST 2025) - "Moderate exacerbations were defined as an outpatient COPD visit accompanied by a filled prescription for a course of theophylline, aminophylline, or an oral corticosteroid or oral antibiotic within 7 days of the outpatient visit... Medicare Fee-for-Service patients with a diagnosis of COPD who were treated with BGF demonstrated meaningful reductions in the rate of COPD exacerbations, inclusive of severe exacerbations, in a real-world setting. CLINICAL IMPLICATIONS: Results suggest that BGF is an excellent treatment option to reduce exacerbations in patients who meet GOLD E criteria and can potentially inform clinical guidelines and future research. Funding: The funding for this study was provided by AstraZeneca PLC"

Clinical • Medicare • Real-world • Real-world effectiveness • Real-world evidence • Reimbursement • US reimbursement • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases

Mulberry (Morus alba l.) leaf improves arachidonic acid metabolism disorder in chronic obstructive pulmonary disease. (PubMed, Phytomedicine) - "ARA metabolic dysregulation contributes to COPD pathogenesis, and (±)12-HETE, 15(S)-HETE, and (±)11-HETE may serve as potential biomarkers for COPD. MLWE exert therapeutic effects by modulating ARA metabolism, ameliorating oxidative stress, and suppressing inflammatory responses, offering a novel strategy for COPD prevention and treatment."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Metabolic Disorders • Oncology • Pulmonary Disease • Respiratory Diseases • ALOX15 • CAT • IL10 • IL1B • IL6 • LOX • TNFA

Clinical characteristics of hospitalized children with bronchiolitis before and after the COVID-19 pandemic: a single-center study. (PubMed, Med Glas (Zenica)) - "There was a significant reduction in antibiotic in the post-COVID group (p=0.0173), and a significant increase in the use of aminophylline and inhalation therapy drugs in the post-COVID group...Conclusion This study reveals a significant increase in the severity of bronchiolitis and an increase in RSV cases after the COVID-19 pandemic. Keywords: anti-bacterial agents,coinfection, oxygen inhalation therapy,respiratory syncytial virus infections, vaccination."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections

Prevention of Cisplatin-induced Nephrotoxicity (clinicaltrials.gov) - P2/3 | N=24 | Not yet recruiting | Sponsor: Mahidol University | Trial completion date: Sep 2025 ➔ Sep 2026 | Trial primary completion date: Sep 2025 ➔ Sep 2026

Trial completion date • Trial primary completion date • Acute Kidney Injury • Nephrology • Pediatrics • Renal Disease

Management of water submersion in pre-hospital (EUSEM 2025) - "The treatment included the administration of hydrocortisone hemisuccinate to prevent airway inflammation and an infusion of NaCl 0.9% with aminophylline for bronchodilation. Following an allergy test, 1g Ceftriaxone was administered to prevent sepsis.The patient was transferred to the ambulance, where the decision for endotracheal intubation was made to allow aspiration of the water from the lungs. The procedure was initiated with 2 mg Midazolam for anxiolysis, followed by preoxygenation and rapid sequence intubation (RSI) with Fentanyl, Etomidate, and Succinylcholine...Aspiration and lavage of the lungs were performed to prevent potential complications such as sepsis and acute respiratory failure.Following these procedures, the patient was reassessed, awakened, extubated, and transported to the hospital conscious and cooperative, GCS being 15.The patient had a favorable evolution, was discharged in good health without complications. We chose to present this case to..."

Clinical • Immunology • Infectious Disease • Inflammation • Respiratory Diseases • Septic Shock

Methotrexate-induced acute neurotoxicity in patients with osteosarcoma: a case report. (PubMed, J Med Case Rep) - "To the knowledge of these authors, this is the largest compilation of cases of methotrexate-induced neurotoxicity involving patients with osteosarcoma. There is no standard treatment for methotrexate-induced neurotoxicity. In our review we discuss dextromethorphan, aminophylline, and ketamine use in the treatment of methotrexate-induced neurotoxicity. Methotrexate is a crucial, first-line treatment for osteosarcoma and if safe, would be beneficial to continue even after acute neurotoxicity. Unfortunately, methotrexate is often discontinued after the first episode of neurotoxicity, owing to fear of recurrence on rechallenge. In our review, 5 of 16 patients were known to be rechallenged with methotrexate. None had recurrence of neurotoxicity with subsequent methotrexate treatment. While our study is limited by the number of cases, our findings suggest that methotrexate rechallenge in patients with osteosarcoma could be considered. Our review adds to the limited existing..."

Journal • Review • Acute Lymphocytic Leukemia • CNS Disorders • Epilepsy • Gastrointestinal Disorder • Hematological Malignancies • Leukemia • Oncology • Osteosarcoma • Sarcoma • Solid Tumor

Electromotive Drug Administration in the Porcine Ureter: First In Vivo Application for Ureteral Dilation. (PubMed, J Endourol) - "Neither aminophylline nor isoproterenol with EMDA resulted in a significant increase in ureteral size compared with their respective NS controls (aminophylline vs NS, 0.3 Fr vs -0.6 Fr, p = 0.344; isoproterenol vs NS, 0.1 Fr vs -0.4 Fr, p = 0.125). In this first report, EMDA-mediated in vivo delivery of alfuzosin into the porcine ureter acutely increased ureteral distensibility."

Journal • Preclinical

Mortality in the Sepsis-3 Era: A Systematic Review of Multicenter Randomized Controlled Trials. (PubMed, Shock) - "These included three studies from China-two evaluating herbal anti-inflammatory compounds and one evaluating aminophylline-and one European study assessing corticosteroid therapy in vasopressor-dependent septic shock...These findings suggest that despite extensive efforts, most interventions have not reduced mortality in multicenter sepsis trials. Future research should focus on optimizing trial design, refining patient selection, and incorporating patient-centered outcomes beyond mortality."

Journal • Critical care • Infectious Disease • Septic Shock

Protective role of salbutamol against aminophylline-induced arrhythmias in an hPSC-based cardiac model (ERS 2025) - "These findings were validated using hPSC-CMs derived from two distinct cell lines (CCTL4 and CCTL12). Conclusion Our results suggest that salbutamol, beyond its bronchodilator properties, may increase the cardiovascular safety of aminophylline by reducing its arrhythmogenic potential."

Cardiovascular • Pulmonary Disease • Respiratory Diseases

Aminophylline in acute exacerbation of COPD: Utility and treatment effects in hypercapnic respiratory failure (ACUTE): A pilot observational study. (PubMed, Lung India) - "Aminophylline did not affect the length of hospital or ICU stay but improved hypercapnia and dyspnea severity in patients with refractory COPD exacerbations. We believe it should be used in severe acidotic COPD exacerbations unresponsive to conventional therapies, with an aim to correct hypercapnia."

Journal • Observational data • Chronic Obstructive Pulmonary Disease • Critical care • Immunology • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases

Moxifloxacin-Induced Seizures: A Case Report. (PubMed, Cureus) - "We present a case of a 63-year-old woman with a history of pulmonary fibrosis and depression, treated chronically with aminophylline and fluvoxamine, who presented with a generalized tonic-clonic seizure after repeated courses of moxifloxacin. This case highlights the need for increased clinical vigilance even in younger patients without renal or hepatic impairment. Moxifloxacin-associated seizures, though rare, must be considered in the differential diagnosis of new-onset seizures, especially in patients exposed to prolonged or repeated fluoroquinolone therapy."

Journal • CNS Disorders • Depression • Epilepsy • Hepatology • Immunology • Psychiatry • Pulmonary Disease • Respiratory Diseases

Continuous positive airway pressure versus methylxanthine for apnoea in preterm infants. (PubMed, Cochrane Database Syst Rev) - "From the single, small included study, performed more than 40 years ago, we are very uncertain whether there is any clinically meaningful difference in the effect of CPAP and theophylline on apnoea of prematurity. Both interventions, CPAP and theophylline, have largely been replaced by nasal prong CPAP and caffeine or aminophylline in modern neonatal care, limiting the applicability of these findings to current practice. However, since caffeine is not readily available in some low- and middle-income countries, and CPAP access remains limited in certain settings, further research may still be relevant. If further trials are conducted, these should use modern CPAP delivery methods and caffeine rather than theophylline. This is the second update of a review first published in 1998."

Clinical • Journal • Review • Bronchopulmonary Dysplasia • Cardiovascular • Mood Disorders • Pulmonary Disease • Respiratory Diseases

An effective fluorescence strategy based on xanthine oxidase catalysis and the carbon dots' specific response to ·OH for aminophylline pharmacokinetic studies. (PubMed, Mater Today Bio) - "Furthermore, the developed fluorescence strategy was controllably applied to PK studies in rats administered intravenous AMP (11.25 mg/kg and 22.50 mg/kg), yielding parameters consistent with clinical data. These findings underscore the potential of CA/EDA-CDs for rapid and accurate AMP detection, addressing the clinical need for a simple and rapid monitoring method."

Journal • PK/PD data

Oxygen uptake in human donor corneas: the centripetal gradient and its changes in culture and correlation with wounds and aminophylline treatment. (PubMed, bioRxiv) - "We conclude that the centripetal pattern of O 2 U is conserved across species and in the human cornea. Combined, our results suggest the functional and clinical significance of the mesoscopic metabolism pattern for further study and the use of aminophylline as a therapeutic agent to increase O 2 U and enhance corneal wound healing."

Journal

Microneedle-assisted iontophoretic transdermal administration of adrenergic antagonists does not modulate palmar sweating induced by static exercise in healthy young adults. (PubMed, Auton Neurosci) - "The efficacy of terazosin and propranolol on the palm was assessed by administering α- and β-adrenergic agonists (phenylephrine and salbutamol combined with aminophylline, respectively) in follow-up studies, whereas bretylium efficacy was verified by evaluating cold-induced palmar cutaneous vasoconstriction. The bretylium administration effectively abolished cold-induced cutaneous vasoconstriction (P = 0.006). In conclusion, this study demonstrates that transdermal administration of bretylium, terazosin, and propranolol does not alter palmar sweating induced by IKE exercise, implying the absence of adrenergic modulation."

Journal

Intravenous Bronchodilators in Pediatric Critical Asthma: A Systematic Review and Network Meta-Analysis. (PubMed, Pediatr Pulmonol) - "In this network meta-analysis comparing different IV adjunct bronchodilators, IV MgSO4 was ranked first followed by IV SABA, and then IV methylxanthines. Given these findings and the favorable safety profile, ease of use, and low cost, IV MgSO4 appears most promising the first adjunct IV bronchodilator, however, further large high-quality trials are still needed before it can be endorsed as routine first-line agent."

Clinical • Journal • Retrospective data • Review • Asthma • Critical care • Immunology • Pediatrics • Pulmonary Disease • Respiratory Diseases

Trends and predictors of in-hospital survival among asphyxiated neonates admitted at Kilimanjaro Christian Medical Center, Northern Tanzania: Retrospective Cohort Study. (PubMed, Sage Open Pediatr) - "Antenatal care (ANC) stages (AHR: 0.74; 95% CI: 0.62-0.89), gestation age (AHR: 0.81; 95% CI: 0.76-0.86), birth weight (AHR: 1.19; 95% CI: 1.12-1.26), mode of delivery (AHR: 1.69; 95% CI: 1.60-1.78), Aminophylline (AHR: 1.56; 95% CI: 1.52-1.60), oxygen (AHR: 1.32; 95% CI: 1.23-1.42), resuscitation (AHR: 1.32; 95% CI: 1.24-1.42) and HIE(AHR: 1.85; 95% CI: 1.79-1.91) were all independent significant predictors of survival. There is a need for health professionals to remain vigilant and promptly assess and stabilize the airway, breathing, and circulation, initiate resuscitation, provide oxygen, administer medications such as aminophylline to neonates who are diagnosed with birth asphyxia."

Journal • Retrospective data

Heart Rhythm Changes in Patients With Atrial Fibrillation After Cardiopulmonary Bypass: a Retrospective Analysis (clinicaltrials.gov) - P=N/A | N=106 | Completed | Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital | Not yet recruiting ➔ Completed | Trial completion date: Sep 2026 ➔ May 2025 | Trial primary completion date: Jul 2026 ➔ Jan 2025

Trial completion • Trial completion date • Trial primary completion date • Atrial Fibrillation • Cardiovascular