THDG3 / Deck Therap - LARVOL DELTA

Developing Novel Drug Candidates In An Ovine Model Of Neonatal Hypoxic-Ischemic Encephalopathy - An Overview Of Neurobehavioral Outcomes (PAS 2024) - "We studied lambs that were treated with azithromycin, low- and high-dose caffeine, THDG3, clemastine and combined azithromycin and caffeine. Overall, perinatal caffeine administration demonstrated greatest benefit: ability to feed on Day 2 (p=0.0256) and increased activity on Day 1 (p=0.0034) and 2 (p=0.0391). A higher dose, as well as combined postnatal caffeine and azithromycin administration, along with THDG3, demonstrated significant toxicity and were discontinued early."

CNS Disorders