Camposomes (camptothecin nanosomal) / Aphios - LARVOL DELTA

Molecular insights into drug-induced GDF15 regulation in cancer cells and cardiomyocytes: implications for precision medicine (News-Medical) - "In the present study, researchers...used human-induced pluripotent stem cell-derived (hiPSC)-CMs to examine how drug-induced cardiotoxicity impacts GDF15 expression...GDF15 levels measured for sub-lethal and highest drug concentrations were three-fold increased by DNA-damaging drugs [etoposide, camptothecin, amsacrine, idarubicin, and doxorubicin]...Around 64% of cluster C cell lines were doxorubicin-responsive...Two-thirds of cluster D cell lines had mutations in B-Raf proto-oncogene, serine/threonine kinase (BRAF), and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta...Topoisomerase inhibitors (doxorubicin) and DNA-interacting drugs were most potent in inducing GDF15....Overall, the findings indicate that the risk of GDF15 overexpression and cachexia can be minimized through a personalized selection of anti-cancer drugs."

Preclinical • Cachexia