Undisclosed TIGIT ETB
/ Molecular Templates
- LARVOL DELTA
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October 06, 2022
Engineered toxin body targeting TIGIT depletes Tregs in the tumor microenvironment and reduces tumor burden in mice
(SITC 2022)
- "6 Here, we demonstrate the efficacy and pharmacodynamic (PD) effects of TIGIT ETB in a hTIGIT/PD-1 expressing humanized mouse model...Conclusions These data demonstrate that targeting TIGIT using our Engineered Toxin Body platform promotes tumor regression through elimination of TIGIT/PD-1 co-expressing immune cells within the TME. Our data supports using ETB as a monotherapy to target TIGIT and represents a wholly novel approach for modulating TIGIT within the TME."
Preclinical • Tumor microenvironment • Oncology • Solid Tumor • CD4 • PVR • TIGIT
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