testosterone gel / Generic mfg. - LARVOL DELTA

Type I Interferon priming in Macrophages is associated with poor responses in Patients with Advanced Prostate Cancer (IMMUNOLOGY 2026) - "BAT reprograms circulating monocytes, conferring a Type I IFN signature that is mirrored by macrophages in tumors from patients with poor therapeutic response. Type I IFN has been associated with resistance to other cancer therapies and could play an important role in limiting immune control of prostate cancer following BAT. Critically, BAT reprograms tumor immunity and our results provide an attractive target to improve this therapy."

Clinical • Metastases • CNS Disorders • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • AR • HSPA5 • IFNA1

The competitive side of social living: Maternal hormonal programming and phenotypic outcomes in blue tit offspring. (PubMed, Horm Behav) - "Breathing rate had a non-linear, positive relationship with yolk testosterone concentration but was, unexpectedly, lower in high-density areas. Together, these findings suggest that competitive environments increase maternal testosterone transfer, likely promoting more competitive and less social offspring phenotypes."

Journal

Obesity impairs spermatogenesis via Leydig cell ferroptosis induced by liver-derived exosomal miR-122-5p. (PubMed, Commun Biol) - "Exosomal miR-122-5p induces ferroptosis in Leydig cells by inhibiting stearyl-CoA desaturase 2 expression, reducing testosterone synthesis and impairing spermatogenesis. Collectively, these findings highlight the impact of liver-derived exosomal alterations on testosterone production in HFD, revealing a regulatory pathway in the liver-testes axis."

Journal • Genetic Disorders • Infertility • Obesity • Sexual Disorders • MIR122

Final oncological outcomes of the randomized phase II trial ARNEO: neoadjuvant degarelix with or without apalutamide prior to radical prostatectomy for high-risk prostate cancer (AUA 2025) - "At 3 years follow-up, no statistically significant difference in terms of BCR was observed between patients treated with neoadjuvant DEG+APA or DEG alone. MRD was not associated with improved BCR-free survival. However, ypT2 and SCD disease following neoadjuvant hormonal therapy was highly associated with improved BCR-free survival, suggesting that ypT2 and SCD disease might be used as a surrogate endpoints for improved BCR-free survival in future surgical trials investigating neoadjuvant hormonal therapy."

Clinical • P2 data • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

The impact of transdermal testosterone treatment on quality of life in women with diminished ovarian reserve: secondary analysis of a randomized controlled trial. (PubMed, Hum Reprod) - P3 | "Considering the available evidence, including the current study, premenopausal women are unlikely to benefit from testosterone treatment with regard to wellbeing and QOL. This study provides further evidence that testosterone should not be seen as a treatment for low wellbeing or QOL."

HEOR • Journal • Infertility • Sexual Disorders

Survey on fertility management and outcomes after cellular therapies, on behalf of the EBMT cellular therapy and immunobiology working party (ASH 2025) - "Importantly, this study includes some of the first documented cases of livebirths following CAR T-cell therapy, emphasizing the need for more comprehensive research into its long-term reproductive effects. Establishing formal guidelines with standardized fertility counselling andpreservation protocols will be essential to ensure equitable, informed, and proactive fertility care forpatients undergoing this transformative treatment."

Hematological Malignancies • Immunology

Allosteric Cooperativity Mechanism Investigation of Orthosteric and Allosteric Ligands in Modulating AR Activity: A Molecular Dynamics Study. (PubMed, J Chem Inf Model) - "However, existing orthosteric ligand-binding pocket (LBP) antagonists [e.g., enzalutamide (ENZ)] encounter significant obstacles due to resistance-conferring mutations in the LBP. Multiple short- and/or long-range BF3→AF2 and LBP→AF2 signaling transition pathways are involved, such as F673→Y834→L722→L812→L744→V746→L873→ENZ→L880/V889/V891. These mechanistic insights establish the foundation for developing novel AR BF3 antagonist and LBP-BF3 combination therapies, suggesting a promising avenue for enhancing the efficacy and overcoming the resistance in castration-resistant prostate cancer treatment."

Journal • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • AR

Recurrent life threatening UTIs in a child with Prader V Salt-wasting Congenital Adrenal Hyperplasia (ENDO 2025) - "At that time, the family was asked to change her name and her gender to female, and she was started on hydrocortisone and fludrocortisone. Early CAH diagnosis is critical to prevent severe medical and social complications. While the timing of genital surgery in children with differences in sex development remains controversial, multidisciplinary evaluation is critical, especially for CAH patients, to minimize severe complications. Many adult patients report preferring genital surgery in early childhood."

Clinical • Cardiovascular • Congenital Adrenal Hyperplasia • Endocrine Disorders • Heart Failure • Hypotension • Infectious Disease • Nephrology • Septic Shock • Urology • CYP1A2 • CYP21A2

Safety and Efficacy of Once-Daily Osilodrostat in Cushing's Syndrome to Improve Cortisol Circadian Rhythm and Quality of Life: A Multi-Center Study (ENDO 2025) - "This study provides the first evidence that once-daily evening Osilodrostat effectively and safely restores circadian cortisol rhythms in CS, improving quality of life and sleep. These findings support further investigation of chronotherapy-based strategies in CS management."

Clinical • HEOR • Cushing’s Disease • Endocrine Disorders • Liver Failure • Nephrology • Renal Disease

The Androbactome and the Gut Microbiota-Testis Axis: A Narrative Review of Emerging Insights into Male Fertility. (PubMed, Int J Mol Sci) - "Recognizing the androbactome as a modifiable determinant of male fertility may open new avenues for personalized diagnosis, risk stratification, and adjunctive therapy in regard to idiopathic infertility. The integration of multi-omics platforms to characterize microbial and metabolomic signatures promises to enrich diagnostic algorithms and guide precision interventions, but rigorously controlled longitudinal and interventional studies are required to secure a translational impact."

Journal • Review • Endocrine Disorders • Infertility • Inflammation • Sexual Disorders • Transplantation

An Exploratory Research to Evaluate the 30 Most Common Pulmonary Embolism Drugs in the Food and Drug Administration Adverse Event Reporting System. (PubMed, Clin Respir J) - "In our study, we filtered 30 common drugs that could cause PE through the FAERS public database, which provides theoretical support for drug selection in the treatment of malignant tumors and IMID."

Adverse events • Journal • Cardiovascular • Oncology • Pulmonary Embolism • Respiratory Diseases • Solid Tumor

Associations of Handgrip Strength and Testosterone With Cerebral White Matter Hyperintensity and Microstructural Injury. (PubMed, J Cachexia Sarcopenia Muscle) - "Our study revealed that greater HGS was linearly associated with reduced WMH volume and less white matter microstructural injury, mediated by STT. Improving muscle function may contribute to deferring white matter damage and preventing stroke and dementia, offering a feasible secondary prevention measure for CSVD."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Dementia

Current clinical practice for patients with Complete Androgen Insensitivity Syndrome (CAIS) across reference centres of the European Reference Network on Rare Endocrine Conditions (Endo-ERN) (ESPE-ESE 2025) - "In conclusion, the current care for CAIS patients even in RC is heterogenous and would benefit from a centralized approach referring patients to centres with expertise in the management of the condition, especially closing the gaps in the transition of patients from paediatric to adult care. The need of longitudinal multicentre studies in order to elaborate standardized guidelines to optimize CAIS care across Europe was shared by all experts and would help clinicians in therapeutic choices and management strategies."

Clinical • Late-breaking abstract • Osteoporosis • Pediatrics • Rheumatology

A case of Multiple Neuroendocrine Tumors in MEN1: Cushing's Disease, Prolactinoma, and Multiple Pancreatic NETs including Insulinoma. (ESPE-ESE 2025) - "Hypercalcemia was temporarily controlled with zoledronic acid, deferring parathyroidectomy...Due to persistent CD and confirmed insulinoma without localization, cabergoline, lanreotide, and continuous glucose monitoring were initiated. Metyrapone started 1 month after improved cortisol levels (24-hour urinary free cortisol: 61.6 µg/24h), with documented symptomatic hypoglycemia post-metyrapone despite prior initiation of lanreotide. The patient is awaiting a 68- Ga-NOTA-exendin-4 PET scan in Switzerland to localize the insulinoma and guide for possible minimal invasive treatment options, along with the potential consideration of reoperation for CD and parathyroidectomy...Management of MEN1 requires careful prioritization, as not all conditions can be addressed simultaneously. Localizing the insulinoma is crucial to minimize the risks associated with invasive pancreatic surgery, while timely treatment of CD is essential due to its associated complications."

Clinical • Cardiovascular • Cushing’s Disease • Endocrine Cancer • Endocrine Disorders • Genetic Disorders • Hypertension • Hypoglycemia • Metabolic Disorders • Neuroendocrine Tumor • Obesity • Oncology • Solid Tumor • GAST

Sexual health in adult women with complete androgen insensitivity syndrome: a single centre cross-sectional study. (PubMed, J Endocrinol Invest) - "Sexual dysfunction and body uneasiness are worryingly common in CAIS. Preservation of gonads and HRT do not guarantee adequate sexual function nor optimal hormone levels. Psychological and sexual aspects must be considered in the management and therapeutic choices for these patients, as they highly impact quality of life."

Journal • Observational data • Sexual Disorders • AR

Utility of Primary Care Physicians in a Urology Men's Health Clinic (AUA 2025) - "PCPs in a multidisciplinary clinic can provide care for a range of urologic issues and reduce need for urologist consultation. This study demonstrates the utility of PCPs in optimization of urologist consultation. Presenting issues may be predictive of the need for urologist referral and guide multidisciplinary clinic triage."

Clinical • Urology

New horizons in Klinefelter syndrome: current evidence, gaps and research priorities. (PubMed, Endocr Rev) - "Above all, solid registries and extensive prospective longitudinal studies are needed to enrol people with KS to determine their evolving needs as they progress through their lifespan. These studies would be best initiated with international collaboration to ensure the results apply to all those with this condition worldwide."

Journal • Cardiovascular • Endocrine Disorders • Genetic Disorders • Immunology

Is there a relationship between testosterone and androgen receptor with prostatectomy outcomes? (PubMed, Can J Urol) - "  Lower levels of testosterone were related to lower rates of erectile function recovery at the end of 24 months after RRP, in addition to conferring higher rates of BCR and higher ISUP grades in biopsy.  Furthermore, patients with total testosterone < 300 ng/dL had higher expression of AR, but no difference in BCR rates."

Journal • Retrospective data • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • Urology • AR

Age disparity in couples and the sexual and general health of the male partner. (PubMed, Andrology) - "In subjects with sexual dysfunctions (as in the general population) age-different relationships increase as a function of male ageing. A greater Δ age (M-F) is associated with specific men and relationship features and a higher risk of MACE."

Journal • Cardiovascular • Endocrine Disorders • Erectile Dysfunction • Sexual Disorders

rtestim: Time-varying reproduction number estimation with trend filtering. (PubMed, PLoS Comput Biol) - "Our methodology remains accurate even under some process misspecifications and is computationally efficient, even for large-scale data. The implementation is easily accessible in a lightweight R package rtestim."

Journal • Infectious Disease

Exploring a Case Study on Navigating Complexities in Endocrine Health and Reproductive Challenges (ENDO 2024) - "Her treatment included metformin, but it was interrupted when she relocated to the United States.Upon her arrival in the U.S., her medical course took an unexpected turn as further evaluations revealed elevated salivary cortisol (++), and a 24-hour urine free cortisol recorded 94.2 mcg (normal 4-50 mcg), indicating hypercortisolism...Ensuring proper hydrocortisone levels became crucial for her well-being and the fetus, prompting a collaborative approach with obstetricians and maternal-fetal medicine specialists for optimal pregnancy care.Despite ongoing PCOS effects, including hirsutism, treatment options were limited by pregnancy constraints, deferring Aldactone due to its contraindication during pregnancy.Continuous monitoring included hormonal assessments, metabolic panels, and thyroid tests, aiming to balance adrenal insufficiency, PCOS symptoms, and a healthy pregnancy.This case emphasizes challenges in differentiating PCOS from adrenal Cushing's due to..."

Case study • Clinical • Cushing’s Disease • Endocrine Disorders • Infertility • Nephrology • Obstetrics • Polycystic Ovary Syndrome • Renal Disease • Sexual Disorders

SI01-08. The State of TRT: Feeling the Impact of Trends in Practice and Patient Care (ENDO 2024) - "DESCRIPTION Join us for a presentation and discussion on the results of an inaugural landmark TRT Sermo survey of 303 Endocrinologists, Urologists, PCPs and other specialists sponsored by JATENZO® (testosterone undecanoate) capsules. For questions about how the sponsor will handle your information or to unsubscribe from their marketing communications, please contact the sponsor directly or refer to its privacy policy. For questions related to how the Endocrine Society shares information, please refer to the Society's Privacy Policy."

Clinical • Urology

Oncological outcomes of neoadjuvant degarelix with apalutamide (ARNEO trial) versus standard of care prior to radical prostatectomy for high-risk prostate cancer: a propensity score matched analysis (AUA 2024) - "After 3 years of follow-up, no statistically significant difference in terms of rising PSA was observed between patients treated with neoadjuvant degarelix+APA or SOC. However, patients treated with intensified neoadjuvant treatment experienced improved metastatic disease-free survival and reduced need for adjuvant treatment. We await results after full follow-up of the ARNEO study to fully compare these cohorts."

Clinical • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

The bitter truth: Testicular adrenal rest tissue (TART) in congenital adrenal hyperplasia (CAH) and infertility (AUA 2024) - "TART is commonly associated with a reduction in fertility, particularly related to the decrease in sperm density. There is an element of obstructive azoospermia but endocrine consequences of poorly controlled CAH are also likely to be relevant. Comprehensive structured management of these patients including optimisation of endocrine status and surgical treatment including microTESE and early sperm cryopreservation are appropriate interventions."

Congenital Adrenal Hyperplasia • Endocrine Disorders • Infertility • Oncology • Pediatrics • Sexual Disorders

037IC - Vasectomy Reversals 2024 for the General Urologist: Patient Focused Vasectomy Reversal Techniques and Care, Reducing Costs, Increasing Success (AUA 2024) - "We will identify relevant issues and challenges urologists encounter when performing vas reversals, focusing on topics and solutions that are not routinely addressed in general review courses on male fertility and vas reversals. Bonus at end  vasectomy reversals I wish I didn't do  what "red flags" did I miss or ignore?"

Clinical • Fibrosis • Gynecology • Infectious Disease • Musculoskeletal Pain • Novel Coronavirus Disease • Pain • Urology