BAR502 / BAR Pharmaceuticals - LARVOL DELTA

BAR-502-001: To Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BAR502 in Healthy Subjects (clinicaltrials.gov) - P1 | N=43 | Completed | Sponsor: BAR Pharmaceuticals s.r.l. | Recruiting ➔ Completed

First-in-human • Trial completion • Metabolic Dysfunction-Associated Steatohepatitis

SYNERGISTIC EFFICACY OF THE DUAL GPBAR1/FXR AGONIST BAR502 AND TIRZEPATIDE IN A MURINE MODEL OF METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE WITH ALCOHOL (METALD) (UEGW 2026) - No abstract available

Preclinical • Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease

Pharmacologic activation of the bile acid receptor TGR5 attenuates platelet activation and aggregation (ISTH 2026) - "Effect of bile acids, BAR501 and BAR502 on platelet activation Page 2 Table or Figure Upload (2) Figure 2. Effect of bile acids, BAR501 and BAR502 on platelet adhesion/aggregation DOI*10.1016/j.rpth.2026.105182"

Cardiovascular • Coronary Artery Disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

DUAL FXR/GPBAR1 AGONISM WITH BAR502 CORRECTS BILE ACID SIGNALING IMBALANCE AND MITIGATES INFLAMMATION AND FIBROSIS IN PSC (DDW 2026) - No abstract available

Fibrosis • Immunology • Inflammation

BAR-502-001: To Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BAR502 in Healthy Subjects (clinicaltrials.gov) - P1 | N=52 | Recruiting | Sponsor: BAR Pharmaceuticals s.r.l. | Trial completion date: Sep 2025 ➔ Jul 2026 | Trial primary completion date: Aug 2025 ➔ May 2026

Trial completion date • Trial primary completion date • Metabolic Dysfunction-Associated Steatohepatitis

BAR-502-001: To Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BAR502 in Healthy Subjects (clinicaltrials.gov) - P1 | N=52 | Recruiting | Sponsor: BAR Pharmaceuticals s.r.l. | Not yet recruiting ➔ Recruiting

Enrollment open • Hepatology • Metabolic Dysfunction-Associated Steatohepatitis