DS-8190
/ Daiichi Sankyo
- LARVOL DELTA
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October 26, 2020
Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models.
(PubMed, Arterioscler Thromb Vasc Biol)
- "This study demonstrates the potential of DS-8190a as a novel therapeutic for atherosclerosis. This is also the first report describing that a small-molecule direct LCAT activator achieved HDL cholesterol elevation in monkey and reduction of atherosclerotic lesion area with enhanced HDL function in rodent."
Journal • Atherosclerosis • Cardiovascular • Dyslipidemia
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