DS-8190 / Daiichi Sankyo - LARVOL DELTA

Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models. (PubMed, Arterioscler Thromb Vasc Biol) - "This study demonstrates the potential of DS-8190a as a novel therapeutic for atherosclerosis. This is also the first report describing that a small-molecule direct LCAT activator achieved HDL cholesterol elevation in monkey and reduction of atherosclerotic lesion area with enhanced HDL function in rodent."

Journal • Atherosclerosis • Cardiovascular • Dyslipidemia