drotaverine hydrochloride / Generic mfg. - LARVOL DELTA

Change in different classes of chronic back pain suspicious of axial spondyloarthritis: a latent transition analysis of the SPACE cohort. (PubMed, RMD Open) - "Transitions between the four classes over 2 years were basically inexistent, highlighting the unlikelihood of developing new class-defining features of axSpA after an initial clinical workup."

Journal • Ankylosing Spondylitis • Back Pain • Immunology • Inflammatory Arthritis • Musculoskeletal Pain • Pain • Seronegative Spondyloarthropathies • Spondylarthritis

Evaluation of the mechanism of action of paracetamol, drotaverine, and peppermint oil and their effects in combination with hyoscine butylbromide on colonic motility: human ex-vivo study. (PubMed, Front Pharmacol) - "Drotaverine, paracetamol, and peppermint oil were tested alone and in combination with hyoscine butylbromide on (1) spontaneous contractility induced by isometric stretch (in the presence of 1 µM tetrodotoxin) and (2) contractility induced by 10-5 M carbachol and after (3) electrical field stimulation-induced selective stimulation of excitatory (in the presence of 1 mM Nω-nitro-L-arginine and 10 µM MRS2179) and (4) inhibitory (under non-adrenergic, non-cholinergic conditions) pathways. Peppermint oil is synergic with hyoscine butylbromide suggesting that a combination therapy may be more effective in treating patients. In contrast, at therapeutic concentrations, paracetamol does not modify colonic contractility, suggesting that the association of paracetamol and hyoscine butylbromide has independent analgesic and antispasmodic properties."

Combination therapy • Journal • Preclinical • Gastrointestinal Disorder • Pain

COULD THERE BE GENDER-SPECIFIC DISCRIMINATIVE FEATURES FOR AXIAL SPONDYLOARTHRITIS AND INFLAMMATORY BACK PAIN CHARACTERISTICS IN PARTICULAR? (EULAR 2024) - "In the evaluation of IBP characteristics, we found that improvement with exercise and alternating gluteal pain items of IBP were significantly higher in female axSpA patients in comparison with female nonSpA patients... The results of the present study showed that even in patients with IBP according to physician there could be some differentiating factors for the diagnosis of axSpA. Also our results revealed that gender might have an impact not only for the diagnosis axSpA but also IBP."

Ankylosing Spondylitis • Back Pain • Immunology • Inflammatory Arthritis • Musculoskeletal Pain • Pain • Seronegative Spondyloarthropathies • Spondylarthritis • CRP

CHANGE OVER 2 YEARS IN DIFFERENT PHENOTYPES OF CHRONIC BACK PAIN SUSPICIOUS OF AXIAL SPONDYLOARTHRITIS: A LATENT TRANSITION ANALYSIS OF THE SPONDYLOARTHRITIS CAUGHT EARLY (SPACE) COHORT (EULAR 2024) - "Background: Sepriano et al have identified four phenotypes of chronic back pain suspicious of axial spondyloarthritis (axSpA) in the Spondyloarthritis Caught Early (SPACE) cohort, reflecting an expert-free judgement of the construct of axSpA.[1] They were labelled as: "pure axSpA" ("axial") representing individuals with positive axial imaging and a familial/genetic predisposition for axSpA; "axSpA with peripheral signs" ("IBP+peripheral") with participants characterized by peripheral involvement and inflammatory back pain (IBP), "axial Spondyloarthritis at risk" ("at risk"), a phenotype with a familial/genetic predisposition to axSpA but an otherwise low probability of other features and a "no Spondyloarthritis" ("no SpA") phenotype depicting participants with a very low probability for any SpA associated feature... Transitions between the four classes over two years were basically..."

Ankylosing Spondylitis • Back Pain • Dermatology • Immunology • Inflammatory Arthritis • Musculoskeletal Pain • Pain • Psoriasis • Seronegative Spondyloarthropathies • Spondylarthritis

Molecular Characterization of Methicillin-Susceptible Staphylococcus aureus, ST2867 Isolates Carrying Fusidic Acid Resistance Determinant fusB (ASM Microbe 2024) - " The isolates were resistant to fusidic acid (MIC:16-64 µg/ml ), penicillin G (n=37), erythromycin (n=28), tetracycline (n=2), and ciprofloxacin (n=2), and were positive for BlaZ, BlaI, BlaR, msr(A), tet(K)...No spa type was assigned for eight isolate... The study demonstrated the presence of a plasmid-mediated fusB in ST2867-MSSA isolates in different hospitals in Kuwait which highlights the carriage and transmission of antibiotic resistance in rare MSSA clones."

Infectious Disease • Septic Shock

Smart green spectrophotometric assay of the ternary mixture of drotaverine, caffeine and paracetamol in their pharmaceutical dosage form. (PubMed, BMC Chem) - "In addition, greenness assessment of the proposed methods was investigated. The application of the proposed method was extended to analyse tablet dosage form and performing invitro dissolution testing."

Journal

Spectrofluorimetric Protocol for Estimation of Commonly Used Antispasmodic Drotaverine. Fluorescence Quenching Study. (PubMed, J Fluoresc) - "After method validation in respect to ICH guidelines, it was applied to determine drotaverine in its commercial preparation. By comparing with other reported method, the developed and validated fluorimetric protocol is capable for estimation of drotaverine in commercial preparation with good accuracy and excellent precision."

Journal

Smart chemometrics-assisted spectrophotometric methods for efficient resolution and simultaneous determination of paracetamol, caffeine, drotaverine HCl along with three of their corresponding related impurities. (PubMed, BMC Chem) - "The combination of four subintervals [10, 12, 14, and 17] produced the highest efficiency model. Furthermore, these methods may be an applicable substitute to HPLC ones in quality control laboratories during rush of analyses where several samples have to be analyzed in a short time."

Journal

Pharmacotherapy for gastric and intestinal cramping pain: Current and emerging therapies. (PubMed, Expert Opin Pharmacother) - "Consensus dictates that antispasmodics such as hyoscine-N-butyl bromide and mebeverine should be the primary treatment for GICP...Currently, several antispasmodics are undergoing clinical trials, including drotaverine, alverine, pinaverium bromide, fenoverine, tiropramide, otilinium bromide, trimebutine, and peppermint oil...Recent studies have shown that fixed-dose combinations of antispasmodics + NSAIDs or two different antispasmodics can improve patient compliance and synergistically reduce GICP. Therefore, it is recommended that the global availability and accessibility of these products be enhanced."

Journal • Review • Gastroenterology • Gastrointestinal Disorder • Pain

Comparison of Cost-Effectiveness With Clinical Efficacy of Drotaverine Hydrochloride and Valethamate Bromide in Acceleration of Labor (ISPOR-EU 2023) - "Both Drotaverine hydrochloride and Valethamate bromide demonstrate significant effectiveness in cervical dilatation and acceleration of the first stage of labor. However, Drotaverine hydrochloride exhibits superior clinical effectiveness and cost-effectiveness compared to Valethamate bromide."

Clinical • Cost effectiveness • HEOR

The Influence of the Intergranular Superdisintegrant Performance on New Drotaverine Orodispersible Tablet Formulations. (PubMed, Pharmaceutics) - "The in vitro release of drotaverine from ODTs showed that all formulations presented amounts of active substance released greater than 85% at 10 min. The main objective, developing 30 mg DROT-ODTs for children aged between 6 and 12 years by incorporating the API in FDGs, was successfully achieved."

Journal

Early identification of sacroiliitis in patients with suspected spondyloarthritis: A challenging task. (PubMed, Curr Rheumatol Rev) - "SIJ MRI is a highly specific method in the detection of sacroiliitis, but with a moderate sensitivity. SIJ CT scan, usually known as the third option after radiography and MRI, has much greater diagnostic utility than it has been documented previously."

Journal • Ankylosing Spondylitis • Immunology • Musculoskeletal Diseases • Rheumatology • Seronegative Spondyloarthropathies • Spondylarthritis

Computer-aided design of an eco-friendly imprinted polymer decorated sensors augmented by self-validated ensemble modeling designs for the quantitation of drotaverine hydrochloride in dosage form and human plasma. (PubMed, J AOAC Int) - "This work presents the first ever application of both the innovative SVEM designs and MD/QM simulations in the optimization and fabrication of drotaverine-sensitive and selective MIP-decorated PVC sensors."

Journal

Staphylococcus nasal colonization in three species of non-human primates. (PubMed, Braz J Microbiol) - "Eight (8) spa types were identified among the S. aureus strains. A major cluster was identified, corresponding to a new spa type t20455, and no spa types found in this study were seen before in Brazil."

Journal • Infectious Disease

Drotaverine to shorten the duration of labour in primigravidas: a randomised, double-blind, placebo-controlled trial. (PubMed, Afr Health Sci) - "However, more evidence is needed to explore its role in active phase of labour among primigravid women. Trial registration number: PACTR201810902005232."

Journal • Pain

RP-HPLC Method for Simultaneous Determination of Paracetamol, Caffeine, Drotaverine HCl and their Related Impurities with Dissolution Profiling of their Tablets and Greenness Profile Assessment. (PubMed, Biomed Chromatogr) - "Moreover, the greenness profile was assessed using three different tools, namely; National Environmental Methods Index, Analytical Eco-Scale and Analytical GREEnness Metric Approach. The acquired results assert the agreement of the assay with green chemistry principles."

Journal

Acupuncture vs. antispasmodics in the treatment of irritable bowel syndrome: An adjusted indirect treatment comparison meta-analysis. (PubMed, Front Physiol) - "Trimebutine and acupuncture had greater improvements than placebo, but no significant difference was shown between groups. Cimetropium, drotaverine, and acupuncture were all better than placebo in improving abdominal pain. Acupuncture was preferred over pinaverium in relieving global IBS symptoms, and acupuncture had lower adverse events than most antispasmodics."

Retrospective data • Review • Gastrointestinal Disorder • Immunology • Pain

Self-Medication with Drotaverine among Patients with Common Abdominal Symptoms and Treatment Efficacy from the Perspectives of Patients and General Practitioners-An Observational, Retrospective, Cross-Sectional Study Using Real-World Data. (PubMed, J Clin Med) - "The GPs perceived drotaverine as more useful, effective, and tolerable than other drugs for abdominal pain or cramps. Drotaverine significantly reduced the severity of all symptoms for which it was taken, and it was perceived as effective and tolerable."

Journal • Observational data • Real-world evidence • Retrospective data • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Nephrology • Pain • Renal Calculi • Urology

Prevalence of axSpA in Patients Treated for Chronic Back Pain in Chiropractic Clinics: the Oregon Chiropractic Axial Spondyloarthritis Study (ORCAS) – an Interim Analysis (EULAR 2022) - "Based on the assessment, patients were categorized as radiographic axSpA, non-radiographic axSpA, peripheral SpA, or no SpA... More than 10% of patients attending chiropractic clinics for musculoskeletal complaints had undiagnosed SpA conditions, with axSpA being the most common. Educational efforts targeted at chiropractors to suspect and refer appropriate cases to rheumatologists are needed. Table 1."

Clinical • Ankylosing Spondylitis • Back Pain • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Arthritis • Inflammatory Bowel Disease • Musculoskeletal Pain • Ocular Inflammation • Ophthalmology • Pain • Psoriasis • Psoriatic Arthritis • Seronegative Spondyloarthropathies • Spondylarthritis • Uveitis • CRP

Drotaverine Hydrochloride Superporous Hydrogel Hybrid System: a Gastroretentive Approach for Sustained Drug Delivery and Enhanced Viscoelasticity. (PubMed, AAPS PharmSciTech) - "Statistical analysis showed significant (P < 0.05) increase in bioavailability 2.7 folds with doubled Tmax (4 h) compared to the marketed product (2 h). These results declared that the superporous hydrogel hybrid systems could be a potential gastroretentive approach for the sustained delivery of drugs with short residence time with enhanced viscoelasticity."

Journal • Gastrointestinal Disorder

Eluxadoline Versus Antispasmodics in the Treatment of Irritable Bowel Syndrome: An Adjusted Indirect Treatment Comparison Meta-analysis. (PubMed, Front Pharmacol) - "Drotaverine, otilonium, cimetropium, pinaverium, and eluxadoline 100 mg had significantly high the relief of global IBS symptomss, for which drotaverine [RR, 2.45 (95% CI, 1.42 to 4.22), P-score = 0.95] was ranked first. But eluxadoline had more reported adverse events. Antispasmodics are still the first choice for the treatment of IBS."

Journal • Retrospective data • Review • Gastrointestinal Disorder • Immunology • Pain

The Influence of Oral Drotaverine Administration on Materno-Fetal Circulation during the Second and Third Trimester of Pregnancy. (PubMed, Medicina (Kaunas)) - " Drotaverine has no statistically significant influence on the MCA and Uma PI. The oral administration of drotaverine has an impact on PI rtUta and the mean PI Uta."

Journal • Infertility • Obstetrics • Sexual Disorders

Compatibility of Drotaverine Hydrochloride with Ibuprofen and Ketoprofen Nonsteroidal Anti-Inflammatory Drugs Mixtures. (PubMed, Materials (Basel)) - "Results show that drotaverine-based pharmaceutical forms for pain treatment may be obtained at 0.9 respectively 0.8 molar fractions of ibuprofen and ketoprofen which is advantageous because the maximum allowed daily dose of Ibu is about 6 times higher than those of D-HCl and Ket. The obtained eutectics may be a viable option for the treatment of pain associated with cancer therapy."

Journal • Inflammatory Arthritis • Oncology • Pain

Occurrence of pharmaceuticals in the Eastern Gulf of Finland (Russia). (PubMed, Environ Sci Pollut Res Int) - "Among 18 pharmaceuticals previously detected in influent waters of Saint-Petersburg WWTPs, 7 compounds (caffeine [81% of samples], carbamazepine [81%], ketoprofen [60%], diclofenac [23 %], ciprofloxacin, trimethoprim, and clarithromycin) were recorded in seawater samples in a range of measured concentrations from 0.1 to 4452 ng L. Antibiotics were presented in trace concentrations...The remaining compounds were located in decreasing frequency as follows: ketoprofen, trimethoprim, drotaverine, tetracycline, and ciprofloxacin...Petersburg with its population over 5 million and freshwater input by the Neva River (high urbanization of the territory with a potent dilution factor). We discussed the suitable set of anthropogenic markers for the Russian part of the Gulf of Finland."

Journal

Phenazopyridine and fosfomycin for the acute cystitis treatment: results of multicenter randomized study (PubMed, Urologiia) - "Phenazopyridine has a pronounced analgesic effect and is proved to be an effective and safe drug in patients with acute uncomplicated cystitis."

Clinical • Journal • Infectious Disease • Musculoskeletal Pain • Nephrology • Pain