hypochlorous acid (PR022) / XenoTherapeutics - LARVOL DELTA

Human iPSCs derived from cryopreserved testicular somatic cells enable germline regeneration in childhood cancer survivors. (PubMed, Hum Reprod Open) - "Childhood cancer patient-derived hiPSCs represent a powerful platform to investigate and address a broad range of long-term, cancer therapy-related complications. These hiPSCs and their derived germ cells may be used not only to develop in vitro gametogenesis protocols, but also to investigate mechanisms of cancer therapy toxicity and resistance among different patients, to identify early biomarkers of adverse outcomes, and to screen for germ cell protective agents. Importantly, cancer patient-specific hiPSCs have applications that extend well beyond germline, enabling regenerative strategies targeting other treatment-related sequelae through the generation of relevant somatic cell types."

Journal • Infertility • Oncology • Pediatrics • Sexual Disorders • Transplantation

Likelihood of childbirth in women with one versus two ovaries: a Swedish population-based study of women treated with unilateral oophorectomy for benign indications. (PubMed, Hum Reprod Open) - "This large population-based study demonstrates a significant association between unilateral oophorectomy for benign indications and a reduced likelihood of subsequent childbirth; however, causality cannot be inferred from these observational data."

Journal • Gynecology • Infertility • Obstetrics • Oncology • Sexual Disorders

Early transcriptional states of spermatogonia and marker expressions in the prepubertal human testis following chemotherapy-induced depletion. (PubMed, Hum Reprod) - "Our observations suggest that alkylating agents have dose-dependent effects on all spermatogonial subpopulations. However, spermatogonial subtypes expressing the protein markers UTF1 and PIWIL4 were more resistant to chemotherapy-induced depletion of the spermatogonial pool, potentially representing true reserve stem cells. The identification of reserve stem cells could provide a valuable method for evaluating the fertility potential of testicular tissue collected for fertility preservation in prepubertal and peripubertal boys."

Journal • Infertility • Oncology • Pediatrics • FGFR3 • KIT

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparib. (PubMed, EBioMedicine) - "Exploiting the loss of drug-metabolizing enzyme gene activity in tumor cells following loss of heterozygosity could present a promising therapeutic strategy for targeted cancer treatment."

Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Hepatology • Liver Cancer • Oncology • Solid Tumor

Prior exposure to alkylating agents negatively impacts testicular organoid formation in cells obtained from childhood cancer patients. (PubMed, Hum Reprod Open) - "Our observations suggest that SOX9 expression may serve as a putative indicator of TO formation, indicating a critical role of Sertoli cells in promoting organoid formation, seminiferous tubule integrity, and testicular function in pre- and peri-pubertal testicular tissue."

Journal • Oncology • Pediatrics • SOX9 • YBX1

A 20-year overview of fertility preservation in boys: new insights gained through a comprehensive international survey. (PubMed, Hum Reprod Open) - "Given the research advances, it is reasonable to suggest that cryopreserved immature testicular tissue will in the future be used clinically to restore fertility. The growing number of patients undergoing this procedure necessitates collaboration between centres to better harmonize clinical and research protocols evaluating tissue function and clinical outcomes in these patients."

Journal • Oncology • Pediatrics

A Survey Study Identifying Challenging Explosive Ordnance Disposal (eod) Operation Tasks By Public Safety Technicians (ACSM 2023) - "Approved for Public Release PR2022_70722PURPOSE: Heightened physiological responses and muscle activation during general explosive ordnance disposal (EOD) operations have been observed... While there is a slight discrepancy regarding the operation challenges based on either experience or knowledge, there is a consensus regarding the most difficult tasks. In an upcoming human subjects study, we will examine muscle activation patterns while in motion to further understand the potential impact of EOD PPE on the human body."

Clinical

Precision medicine for liver tumours with quantitative MRI and whole genome sequencing (Precision1 trial): study protocol for observational cohort study. (PubMed, BMJ Open) - P=N/A | "This study was reviewed by the NHS Health Research Authority and given favourable opinion by the Brighton and Sussex Research Ethics Committee (REC reference: 20/PR/0222). Research findings will be discussed with a patient and public involvement and engagement group, presented at relevant scientific conferences and published in open access journals. NCT04597710."

Journal • Observational data • Gastrointestinal Cancer • Hepatology • Liver Cancer • Oncology • Solid Tumor

Hypochlorous Acid in the Fight Against COVID-19 - "Upon recommendations from both the American Academy of Ophthalmology and the American Optometric Association, ophthalmologists and optometrists have been advised to restrict their care to urgent and emergent cases only. This has resulted in many eye care practices across the country closing entirely, not only because of fear of the virus, but because of difficulties in obtaining personal protective equipment (PPE) and lacking appropriate protocols for patient flow and disinfection. Protection against this unforgiving virus has become a paramount concern for healthcare providers and patients alike."

Online posting

Realm Therapeutics provides clinical update, including results from a Phase 2 study of PR013 in allergic conjunctivitis (PRNewswire) - “Realm Therapeutics plc…provides an update on the Company's clinical programs….Enrollment for its Phase 2 Atopic Dermatitis study of PR022, a topical gel, is on track and the Company continues to expect to report top-line results in Q3 2018.”

P2 data • Atopic Dermatitis • Dermatitis • Immunology • Inflammation