dexmedetomidine / Generic mfg. - LARVOL DELTA

Determining Reintubation Risk Factors and Effects on Outcomes in the Surgical ICU. (PubMed, J Intensive Care Med) - "In the full-cohort model, atrial fibrillation, spinal cord injury, alcohol withdrawal, ventilator-associated pneumonia (VAP), combined propofol-dexmedetomidine sedation, and admitting service were independently associated with RI; VAP timing relative to RI was uncertain...Patient-specific risk assessment may help guide risk-stratified post-extubation monitoring and respiratory support. The exploratory subgroup findings require prospective validation."

Intubation • Journal • Addiction (Opioid and Alcohol) • Anesthesia • Atrial Fibrillation • Cardiovascular • CNS Disorders • Critical care • Infectious Disease • Orthopedics • Pneumonia • Respiratory Diseases

Effect of Early Dexmedetomidine Addition on Prognosis in Mechanically Ventilated Patients Under Propofol Sedation: A Target Trial Emulation Study. (PubMed, Ann Pharmacother) - "In mechanically ventilated patients receiving propofol sedation, early initiation of DEX was associated with a reduced risk of 28-day mortality but increased odds of bradycardia and severe hypotension. These findings indicate that the potential benefits of early DEX use should be carefully weighed against its cardiovascular safety risks in clinical practice. Further prospective studies are warranted to validate the present results."

Journal • Acute Kidney Injury • Anesthesia • Cardiovascular • Critical care • Hypotension • Nephrology • Renal Disease

Dexmedetomidine for Intraoperative Shivering in Scheduled Elective Cesarean Delivery (clinicaltrials.gov) - P4 | N=0 | Withdrawn | Sponsor: Mayo Clinic | N=40 ➔ 0 | Recruiting ➔ Withdrawn

Enrollment change • Trial withdrawal

Comparison of analgesic efficacy of dexamethasone and dexmedetomidine as an adjuvant to local anaesthetic in transversus thoracic muscle plane block in adult patients undergoing median sternotomy: A randomised controlled trial. (PubMed, Heart Lung) - "Both dexamethasone and dexmedetomidine improved TTPB analgesia. Dexmedetomidine significantly prolonged the duration of analgesia, whereas 24-hour postoperative opioid consumption was comparable between the adjuvant groups."

Journal • Anesthesia • Cardiovascular • Pain

Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures (clinicaltrials.gov) - P2/3 | N=100 | Not yet recruiting | Sponsor: Assiut University

New P2/3 trial • Musculoskeletal Diseases • Orthopedics • Pain

Comparison of three sedation regimens for complex bronchoscopic procedures: an observational study on efficacy, safety, and satisfaction. (ERS 2026) - "Aims: To compare safety, efficacy, and satisfaction of: 1) Midazolam+Fentanyl (M+F), 2) Dexmedetomidine+Fentanyl (D+F), and 3) NORA. D+F is as safe and effective as M+F, significantly reducing rescue benzodiazepine needs. Importantly, D+F empowers pulmonologists to autonomously manage complex cases with high stability, providing a key alternative to NORA. While NORA remains the gold standard for patient comfort, it involves longer procedural and recovery times."

Clinical • Observational data • Cough • Respiratory Diseases

Sedation strategy and ventilator liberation in acute respiratory failure: A multicenter analysis (ERS 2026) - "Early benzodiazepine exposure is associated with increased failure to liberate from mechanical ventilation, whereas benzodiazepine sparing strategies particularly dexmedetomidine are associated with more favorable ventilator liberation trajectories after accounting for competing mortality risk."

Clinical • Respiratory Diseases

Dexmedetomidine Combined With Transcutaneous Vagus Nerve Stimulation (taVNS) Can Reduce the Incidence of PTSD in Trauma Patients After Surgery (clinicaltrials.gov) - P=N/A | N=300 | Recruiting | Sponsor: Affiliated Hospital of Nantong University | Not yet recruiting ➔ Recruiting

Enrollment open • CNS Disorders • Post-traumatic Stress Disorder

Demedetomidine and Remifentanil in Electroconvulsive Therapy (ECT) (clinicaltrials.gov) - P4 | N=24 | Not yet recruiting | Sponsor: Inonu University

New P4 trial • Anesthesia

Efficacy and safety of sedation induced with cipepofol alone versus a dexmedetomidine plus propofol regimen for patients requiring mechanical ventilation: a randomized, open-label, non-inferiority trial. (PubMed, Ann Intensive Care) - "Furthermore, cipepofol elicited fewer hypotensive events than dexmedetomidine/propofol. Large-scale, multicenter studies are warranted to confirm our findings."

Head-to-Head • Journal • Anesthesia • Critical care • Hypotension

Short-term outcomes across sedation practice patterns in mechanically ventilated patients with bacterial pneumonia: a nationwide cohort study. (PubMed, Ann Intensive Care) - "Tracheostomy was more frequent with combined sedation than with both comparators, whereas 28-day ventilator-free days did not differ. Combined sedation was not associated with a lower risk of the composite outcome of in-hospital death and functional decline at discharge, compared with propofol-based sedation; however, a lower risk was observed compared with dexmedetomidine-based sedation."

Journal • Anesthesia • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Renoprotective Effects of Dexmedetomidine Versus Dopamine in High-Risk Renal Patients Undergoing Off-Pump Coronary Artery Bypass Grafting:A Prospective, Randomized, Comparative Study. (PubMed, J Cardiothorac Vasc Anesth) - "Dexmedetomidine infusion was superior to dopamine in improving urine output and eGFR in high-risk renal patients undergoing OPCAB, although differences in serum creatinine and BUN were not clinically significant. Neither drug prevented AKI beyond the control group. Dexmedetomidine may offer a favorable renal physiological profile in this patient population, warranting further investigation with more sensitive biomarkers."

Journal • Acute Kidney Injury • Anesthesia • Cardiovascular • Critical care • Diabetes • Hypertension • Metabolic Disorders • Nephrology • Renal Disease

Identification of immune key genes in sepsis and the regulatory effects of dexmedetomidine based on transcriptome analysis and machine learning (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi) - "The results demonstrated that DEX treatment reduced the expression of sepsis-related proteins, including KCNMA1, cyclin B2 (CCNB2), and NEDD4 E3 ubiquitin protein ligase (NEDD4), and suppressed inflammatory cytokine levels by downregulating KCNMA1. Conclusion DEX suppresses the development of sepsis by downregulating KCNMA1 expression."

Journal • Infectious Disease • Septic Shock • Targeted Protein Degradation • CCNB2 • CD4 • NEDD4 • UBR5

Awake Fiberoptic Intubation for Segmental Mandibulectomy in a Patient with Follicular Ameloblastoma of the Anterior Mandible: A Case Report. (PubMed, Int Med Case Rep J) - "Topical anesthesia was achieved by combining nebulized 2% lidocaine (4 mL, 80 mg) with the spray-as-you-go technique (2-4 mL of 2% lidocaine)...Sedation was achieved with dexmedetomidine (loading dose 1 µg/kg over 10 minutes, then maintenance at 0.4 µg/kg/hour)...No episodes of desaturation occurred. This report highlights the practical adaptability of the DAS sTOP framework for AFOI when HFNO availability is limited, demonstrating that low-flow nasal oxygen combined with dual-method topicalization and a single sedative agent may serve as a feasible alternative."

Intubation • Journal • Anesthesia • Oncology

Comparison of the efficacy of different interventions for rebound pain after brachial plexus block in upper extremity surgery: A systematic review and network meta-analysis. (PubMed, Eur J Anaesthesiol) - "In patients undergoing upper-extremity surgery with brachial plexus block, current network meta-analysis findings suggest that continuous nerve block is associated with a lower incidence of rebound pain and reduced pain scores at 12 and 24 h postoperatively, although further validation is still required. We recommend that continuous nerve block may be considered for patients at high risk of rebound pain to balance efficacy and safety. Given the limited certainty of evidence, these findings should be regarded as exploratory and hypothesis-generating rather than definitive conclusions."

Journal • Retrospective data • Pain

A Study on the Efficacy of Low-Awareness Suggestive Cognitive Behavioral Therapy for Refractory Chronic Insomnia (ChiCTR) - P=N/A | N=124 | Not yet recruiting | Sponsor: Xiangcheng People's Hospital of Suzhou City; Suzhou Xiangcheng People’s Hospital

New trial • CNS Disorders • Insomnia • Sleep Disorder

Evaluation of the efficacy and safety of epidural hydromorphone for analgesia in radical esophagectomy (ChiCTR) - P=N/A | N=190 | Not yet recruiting | Sponsor: Zhejiang Cancer Hospital; Zhejiang Cancer Hospital

New trial • Esophageal Cancer • Oncology

Study on Efficacy and Safety of Dimefline for Enhancing Early Postoperative Recovery Quality Following Laparoscopic Surgery Under General Anesthesia: A Prospective, Randomized Controlled Clinical Study (ChiCTR) - P=N/A | N=96 | Not yet recruiting | Sponsor: Shanghai Minhang District centeral hospital; Shanghai Minhang District centeral hospital

New trial • Anesthesia

Comparison of the brain-protective effects of dexmedetomidine administered via nasal route and intravenous route in elderly patients undergoing laparoscopic surgery (ChiCTR) - P=N/A | N=166 | Recruiting | Sponsor: The First Affiliated Hospital of Dalian Medical University; The First Affiliated Hospital of Dalian Medical University

New trial

Dexmedetomidine combined with sevoflurane in anesthesia maintainance: a randomized double-blind study (ChiCTR) - P=N/A | N=92 | Not yet recruiting | Sponsor: Cancer Hospital Chinese Academy of Medical Sciences; Cancer Hospital Chinese Academy of Medical Sciences

New trial • Anesthesia • Oncology

Electroencephalographic Fingerprints of Dexmedetomidine-Based Regimens during Pediatric Procedural Sedation: A Prospective Observational Cohort Study (ChiCTR) - P=N/A | N=210 | Completed | Sponsor: Children's Hospital of Chongqing Medical University; Children's Hospital of Chongqing Medical University

New trial • Anesthesia • CNS Disorders • Pediatrics

Effects of Preoperative Stellate Ganglion Block Combined with Dexmedetomidine on Postoperative Sleep Quality in Patients Undergoing Laparoscopic Gynecological Surgery (ChiCTR) - P=N/A | N=100 | Completed | Sponsor: Huai'an Second People's Hospital; Huai'an Second People's Hospital

New trial • Gynecology

A Randomized Controlled Study on the Effects of Dexmedetomidine on Peripheral Blood Lymphocyte Subsets and Inflammatory Factors in Patients with Sepsis and Colorectal Cancer (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: Chongqing University Cancer Hospital; Chongqing University Cancer Hospital

New trial • Colorectal Cancer • Infectious Disease • Oncology • Septic Shock • Solid Tumor

DEXMEDETOMIDINE VS PROPOFOL FOR ICU SEDATION IN MECHANICALLY VENTILATED ADULTS: A PROPENSITY-MATCHED ANALYSIS OF POSTVENTILATION COMPLICATIONS (CHEST 2026) - No abstract available

Clinical • Critical care

The efficacy of intraoperative dexmedetomidine on delayed graft function in patients receiving a kidney transplant: The KEYSTONE trial proposal. (TTS 2026) - "They will check study information, join meetings, and help explain the results in clear, simple language. Potential impact: This trial will test the efficacy of an existing approved medicine that has shown promise to ameliorate ischaemia-reperfusion injury in proof-of-concept studies, which will inform future research and ultimately clinical practice and important clinical outcomes for kidney transplant recipeients."

Clinical • Chronic Kidney Disease • Nephrology • Reperfusion Injury • Transplantation