diclofenac sodium XR
/ Generic mfg.
- LARVOL DELTA
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November 03, 2020
Nanonet-nano fiber electrospun mesh of PCL-chitosan for controlled and extended release of diclofenac sodium.
(PubMed, Nanoscale)
- "DS-NNEMs also enhanced 3T3 cell adhesion, viability, and proliferation in the nanonet-nano fiber network through the controlled release of DS. The presented EN technology-based biodegradable NNEM material is not only limited for the controlled release of hydrophilic anti-inflammatory drugs, but also can be a suitable platform for loading and release of antiviral drugs."
Journal
January 30, 2015
A Within-subject Study to Evaluate the Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Compared to Placebo in Subjects Experiencing Delayed Onset Muscle Soreness
(clinicaltrials.gov)
- P3; N=102; Completed; Sponsor: Novartis; Recruiting -> Completed
Trial completion • Biosimilar • Pain
September 10, 2019
Application of simplex lattice design for the development of extended release tablets of model drug diclofenac sodium.
(PubMed, Ther Deliv)
- " The rate of drug release was primarily dictated by the proportion of hydroxypropyl methylcellulose and was also affected by the proportion of dicalcium phosphate and the method of processing (direct compression/wet granulation). Polynomial equations constructed for directly compressed and wet-granulated formulations could successfully predict the extent of drug release at an arbitrary time point of 3 h. Simplex lattice design is a viable tool to predict the drug release patterns of extended release formulations."
Journal
August 12, 2013
MHRA reviews over-the-counter availability of diclofenac
(Pulsetoday)
- "The European Medicines Agency recently ruled that systemic diclofenac should no longer be used by people with serious underlying heart or circulatory conditions, such as heart failure and heart disease, after concluding the risk of cardiovascular complications associated with its use outweigh the benefits....Now the UK Medicines and Healthcare Regulatory Agency (MHRA) has announced it will consult doctors and other healthcare professionals on whether oral preparations of diclofenac should stop being classed as pharmacy medicines, or whether they should just have stronger product information warnings and fewer listed indications."
Adverse events • European regulatory
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