CXB-7138
/ CoBX Bio
- LARVOL DELTA
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March 18, 2026
CXB-7138, A novel GSPT1/ZFP91 dual molecular glue degrader, for targeted treatment of pancreatic ductal adenocarcinoma
(AACR 2026)
- "CXB-7138 is a first-in-class CRBN-recruiting dual molecular glue degrader targeting GSPT1 and ZFP91 through a nontraditional scaffold. Its broad antiproliferative activity, molecularly defined sensitivity patterns, and strong in vivo efficacy position CXB-7138 as a highly promising therapeutic strategy for PDAC, a malignancy in urgent need of new treatment options."
Oncology • Pancreatic Ductal Adenocarcinoma • CRBN • GSPT1 • SMAD4
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