carbamazepine ER tablet / Generic mfg. - LARVOL DELTA

A Study to Learn if the Study Medicine Called Carbamazepine Changes How the Body Processes PF-07220060 (clinicaltrials.gov) - P1 | N=14 | Completed | Sponsor: Pfizer | Not yet recruiting ➔ Completed

Trial completion

Controlled release of carbamazepine at Therapeutically relevant doses using photocrosslinkable polyanhydrides. (PubMed, Int J Pharm) - "Additionally, delayed release systems are demonstrated, allowing controlled onset times ranging from 2 to 10 h by varying the monomer composition. This approach provides a practical and efficient system for high-dose controlled-release carbamazepine delivery, offering a versatile and effective platform for enhanced epilepsy treatment."

Journal • CNS Disorders • Epilepsy

A Study to Learn if the Study Medicine Called Carbamazepine Changes How the Body Processes PF-07220060 (clinicaltrials.gov) - P1 | N=14 | Not yet recruiting | Sponsor: Pfizer

New P1 trial

A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants (clinicaltrials.gov) - P1 | N=60 | Completed | Sponsor: Cerevel Therapeutics, LLC | Recruiting ➔ Completed

Trial completion

A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants (clinicaltrials.gov) - P1 | N=60 | Recruiting | Sponsor: Cerevel Therapeutics, LLC

New P1 trial

"@pharmabe Novartis is toch zo'n 'innovatief bedrijf' hé 🧐. Zowel Tegretol CR 200 als 400mg zijn NIET beschikbaar. Al staat er op #Farmastatus van wel. Zelfde met Apocard, Pentasa 4g,... Het is vooral aan de farma-industrie om dit te voorkomen." (@DavidVergucht)

"Eu estou desesperado @Novartis o tegretol cr, sumiu do RJ. Vcs pararam de produzir?" (@ointersexo)

Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency (clinicaltrials.gov) - P2; N=20; Terminated; Sponsor: Washington University School of Medicine; N=30 ➔ 20; Recruiting ➔ Terminated

Clinical • Enrollment change • Trial termination • Alpha-1 Antitrypsin Deficiency • Fibrosis • Gastroenterology • Genetic Disorders • Hepatology • Immunology • Liver Cirrhosis • Pulmonary Disease • Respiratory Diseases

A Pharmacokinetic Evaluation of a Pectin-Based Oral Multiparticulate Matrix Carrier of Carbamazepine. (PubMed, Adv Pharmacol Pharm Sci) - "AUC (176.20 ± 7.97 µg.h/mL), C (8.45 ± 0.71 μg/mL), T (12 ± 1.28 h), and t (13.75 ± 3.28 h) of formulation A showed a moderately enhanced and comparable pharmacokinetic profile to Tegretol CR (AUC: 155 ± 7.15 µg.h/mL, C : 8.24 ± 0.45 μg/mL, T : 8.0 ± 2.23 h, and t : 13.51 ± 2.87 h). Findings from the study suggest that formulations of CPH pectin had the potential to control and maintain therapeutic concentrations of carbamazepine in circulation over a period of time in the rat model."

Journal • PK/PD data • CNS Disorders • Epilepsy

Yuyu Pharma to supply 5 Novartis drugs in Korea (Korea Biomedical Review) - "Yuyu Pharma...has signed a deal with Novartis Korea to exclusively supply the latter's five prescription drugs for athlete's foot, dyslipidemia, and epilepsy in Korea. Under the accord, Yuyu Pharma would supply...Tegretol (ingredient: carbamazepine) series for epilepsy to all domestic medical institutes from August."

Licensing / partnership • CNS Disorders • Epilepsy

The efficacy and tolerability of extended release carbamazepine in adult patients with new-onset epilepsy using epileptiform activity index (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "Carbamazepine is an effective and promising drug for initial monotherapy of FE. Its use in the treatment of FE results in a 4.3-fold decrease of EAI (p<0.001), which reflects the efficacy of treatment. EAI is an additional objective measure of treatment efficacy."

Clinical • Journal • CNS Disorders • Epilepsy

"@NovartisTurkiye Merhaba, piyasada bulunmayan Tegretol CR 400 için bir çözüm öneriniz var mıdır?" (@ironikutopya)

"J B Chemicals gets @US_FDA approval for #CarbamazepineER Tablets https://t.co/sCglZI1kf6 | #pharma #pharmanews #Covid19India #IndiaIncfightsCovid19" (@ExpPharma)

FDA event • Infectious Disease • Novel Coronavirus Disease